Increased incidence of hepatic foci and nodules in rats given one or two doses of 1,2-dibromoethane.

abstract：:Most available data on the involvement of p53 in rodent carcinogenesis are based on results of the end point of chemically or virally induced carcinogenesis, i.e., tumors. To investigate the role of altered p53 expression in early stages of rodent hepatocarcinogenesis in a systematic way, we treated male Wistar rats f...

journal_title：Toxicologic pathology

authors： Wirnitzer U,Töpfer R,Rosenbruch M

更新日期：1998-09-01 00:00:00

abstract：:Historical control tumor data are useful in the interpretation of long-term rodent carcinogenicity bioassays, especially to assess the occurrence of rare tumors and marginally increased tumor incidences. The major prerequisites to compare historical control data with studies under evaluation are the validity and consi...

journal_title：Toxicologic pathology

authors： Deschl U,Kittel B,Rittinghausen S,Morawietz G,Kohler M,Mohr U,Keenan C

更新日期：2002-01-01 00:00:00

abstract：:Zibotentan, an endothelin-A receptor antagonist, has been used in the treatment of various cardiovascular disorders and neoplasia. Castrated athymic nude mice receiving zibotentan for a preclinical xenograft efficacy study experienced weight loss, gastrointestinal bloat, and the presence of an audible respiratory clic...

journal_title：Toxicologic pathology

authors： Esvelt MA,Freeman ZT,Pearson AT,Harkema JR,Clines GT,Clines KL,Dyson MC,Hoenerhoff MJ

更新日期：2019-02-01 00:00:00

abstract：:Slc:Wistar male rats treated with human natural tumor necrosis factor alpha (hn TNF-alpha, 3 X 10(5) Japan reference units/kg intravenously) for 3 months showed histologic vacuolation of basophils in the anterior pituitary, hyperplasia of the thyroidal follicular epithelium, and hyperplasia of the testicular interstit...

journal_title：Toxicologic pathology

authors： Kakinuma C,Hamada Y,Futamura Y,Kuwayama C,Shimoi A,Shibutani Y

更新日期：1999-07-01 00:00:00

abstract：:Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of cellular differentiation during critical stages of morphogenesis. The goal of this study was to document uterine epit...

journal_title：Toxicologic pathology

authors： Suen AA,Jefferson WN,Williams CJ,Wood CE

更新日期：2018-07-01 00:00:00

abstract：:The outcome of cardiac ischemic events depends not only on the extent and duration of the ischemic stimulus but also on the myocardial intrinsic tolerance to ischemic injury. Cardiac ischemic tolerance reflects myocardial functional reserves that are not always used when the tissue is appropriately oxygenated. Ischemi...

journal_title：Toxicologic pathology

authors： Golomb E,Nyska A,Schwalb H

更新日期：2009-08-01 00:00:00

abstract：:This report demonstrates the advantages of using a noninvasive soft tissue imaging technique--magnetic resonance imaging (MRI)--to monitor liver regeneration after 70% partial hepatectomy in the rat in a longitudinal manner. Six animals were scanned prior to and on 6 subsequent occasions up to 9 days after surgical re...

journal_title：Toxicologic pathology

authors： Hockings PD,Roberts T,Campbell SP,Reid DG,Greenhill RW,Polley SR,Nelson P,Bertram TA,Kramer K

更新日期：2002-09-01 00:00:00

abstract：:ZD7114, [(S)-4-[2-(2-hydroxy-3 phenoxypropylamine)ethoxy]-N-(2-methoxyethyl) phenoxyacetamide], and ZD2079, [(R)-N-(2-[4- (carboxymethyl)phenoxy]ethyl)-N-(beta-hydroxyphenethyl)ammonium chloride], are beta 3-adrenoceptor stimulants with selectivity for brown adipose tissue. ZD7144 is the hydrochloride salt of the S-en...

journal_title：Toxicologic pathology

authors： Waghe M,Westwood R,Nunn G,Kalinowski A,Aldridge A

更新日期：1999-03-01 00:00:00

abstract：:To determine if additive or synergistic toxic effects would occur, adult male rats were exposed orally to lead carbonate (2,000 mg/kg) for 9 days before trichloroethylene (TCE), 2,000 mg/kg, was given concurrently for an additional 7 days. Comparisons were made with groups of vehicle-treated rats and rats given only l...

journal_title：Toxicologic pathology

authors： Nunes J,Ehrich M,Robertson J

更新日期：2001-07-01 00:00:00

abstract：:S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced nephrotoxicity in vivo was investigated in New Zealand White rabbits. A primary emphasis in these studies was further characterization of DCVC-induced nephrotoxicity using a variety of serum and urinary analytes, including sodium dodecyl sulfate-polyacrylamide gel electr...

journal_title：Toxicologic pathology

authors： Davis JW,Blakeman DP,Jolly RA,Packwood WH,Kolaja GJ,Petry TW

更新日期：1995-07-01 00:00:00

abstract：:The carcinogenic potential of misoprostol, a synthetic prostaglandin E1 analogue with anti-ulcer potential, was evaluated in CD Sprague-Dawley rats. The compound was given daily by gavage at 24, 240, and 2,400 micrograms/kg, up to 150 times the daily human dose for 2 years. Necropsies were done on all animals and the ...

journal_title：Toxicologic pathology

authors： Dodd DC,Port CD,Deslex P,Regnier B,Sanders P,Indacochea-Redmond N

更新日期：1987-01-01 00:00:00

abstract：:One application of genomics in drug safety assessment is the identification of biomarkers to predict compound toxicity before it is detected using traditional approaches, such as histopathology. However, many genomic approaches have failed to demonstrate superiority to traditional methods, have not been appropriately ...

journal_title：Toxicologic pathology

authors： Fielden MR,Eynon BP,Natsoulis G,Jarnagin K,Banas D,Kolaja KL

更新日期：2005-01-01 00:00:00

abstract：:Overexpression of c-myc and transforming growth factor-alpha (TGF-alpha) has been frequently observed in human hepatocellular carcinoma (HCC),suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant transformation, we...

journal_title：Toxicologic pathology

authors： Calvisi DF,Thorgeirsson SS

更新日期：2005-01-01 00:00:00

abstract：:The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...

journal_title：Toxicologic pathology

authors： Radi ZA,Khan NK

更新日期：2006-01-01 00:00:00

abstract：:2,3-Pentanedione (PD) is a component of artificial butter flavorings. The use of PD is increasing since diacetyl, a major butter flavorant, was associated with bronchiolitis obliterans (BO) in workers and has been removed from many products. Because the toxicity of inhaled PD is unknown, these studies were conducted t...

journal_title：Toxicologic pathology

authors： Morgan DL,Jokinen MP,Price HC,Gwinn WM,Palmer SM,Flake GP

更新日期：2012-04-01 00:00:00

abstract：:Mouse renal cell tumors (RCTs) were induced in male CBA mice by 5 subcutaneous injections of 8 mg 1,2-dimethylhydrazine (DMH)/kg body weight once a week. After a lag period of 2 yr kidneys were removed, and serial cryostat sections of the kidneys were histochemically analyzed for the following parameters: glycogen con...

journal_title：Toxicologic pathology

authors： Ahn YS,Chemeris GY,Turusov VS,Bannasch P

更新日期：1994-07-01 00:00:00

abstract：:Microminipigs have become an attractive animal model for toxicology and pharmacology studies and for human disease models, owing to their manageable size. Although there are numerous reports of spontaneous age-related lesions in mice, rats, dogs, and monkeys, those in minipigs are scarce. In the present study, spontan...

journal_title：Toxicologic pathology

authors： Kangawa A,Nishimura T,Nishimura T,Otake M,Enya S,Yoshida T,Shibata M

更新日期：2019-10-01 00:00:00

abstract：:Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the normal heart histology. It is therefore crucial to understand the normal v...

journal_title：Toxicologic pathology

authors： Chanut F,Kimbrough C,Hailey R,Berridge B,Hughes-Earle A,Davies R,Roland K,Stokes A,Casartelli A,York M,Jordan H,Crivellente F,Cristofori P,Thomas H,Klapwijk J,Adler R

更新日期：2013-01-01 00:00:00

abstract：:Female mammals are born with a finite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopuase in women). Exposure of women to known ovotoxicants, such as contaminants in cigarette smoke, ...

journal_title：Toxicologic pathology

authors： Hoyer PB,Devine PJ,Hu X,Thompson KE,Sipes IG

更新日期：2001-01-01 00:00:00

abstract：:Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...

journal_title：Toxicologic pathology

authors： Trotta Mde R,Cajaiba DM,Parra OM,Dagli ML,Hernandez-Blazquez FJ

更新日期：2014-01-01 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI3Ks) regulate intracellular signaling events for multiple cell surface receptors. Phosphatidylinositol 3-kinase δ, 1 of 4 class I PI3K isoforms, is primarily found in leukocytes and regulates immune cell functions. Here, we report changes in the immune and digestive systems that were ...

journal_title：Toxicologic pathology

authors： Werner JA,Ishida K,Wisler J,Karbowski C,Kalanzi J,Bussiere J,Monticello TM

更新日期：2020-12-01 00:00:00

abstract：:Determining the carcinogenic potential of materials to which humans have significant exposures is an important, complex, and imperfect exercise. Not only are the methods for such determinations protracted and expensive and use large numbers of animals, extrapolation of data from such studies to human risk is imprecise...

journal_title：Toxicologic pathology

authors： Jacobson-Kram D

更新日期：2010-01-01 00:00:00

abstract：:Lung cancer is the most common cause of cancer-related deaths in humans worldwide. There is strong evidence that the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play an important role in carcinogenesis caused ...

journal_title：Toxicologic pathology

authors： Kovi RC,Johnson CS,Balbo S,Hecht SS,O'Sullivan MG

更新日期：2018-02-01 00:00:00

abstract：:The administration of mesenchymal stromal cells (MSCs) provides an exciting emerging therapeutic modality for the treatment of peripheral arterial disease, a condition that is associated with critical limb ischemia as its end stage. Placental-derived MSCs, termed PLX-PAD cells, are stable adhesive stromal cells isolat...

journal_title：Toxicologic pathology

authors： Ramot Y,Meiron M,Toren A,Steiner M,Nyska A

更新日期：2009-08-01 00:00:00

abstract：:Sprague-Dawley CD rats received daily oral doses (45 mg/kg) of the cationic amphiphilic tricyclic antidepressant imipramine HCl (Tofranil) for up to two years. Representative specimens of liver, lung, spleen, mesenteric lymph node, retina and dorsal root ganglion were examined for myeloid bodies (MB). The extent that ...

journal_title：Toxicologic pathology

authors： Spaet RH,Sullivan DJ,Diener RM

更新日期：1983-01-01 00:00:00

abstract：:Histopathologic examination of the testis from juvenile rats is often necessary to characterize the safety of new drugs for pediatric use and is a required end point in male pubertal development and thyroid function assays. To aid in evaluation and interpretation of the immature testis, the characteristic histologic f...

journal_title：Toxicologic pathology

authors： Picut CA,Remick AK,de Rijk EP,Simons ML,Stump DG,Parker GA

更新日期：2015-04-01 00:00:00

abstract：:Sections of thymus from New Zealand white rabbits used as controls in 28-day and 91-day percutaneous toxicity studies conducted at different laboratories were morphometrically assessed. Measurements of total thymic area, medullary area, and cortical area were greater for 28-day vs 91-day studies conducted at a given l...

journal_title：Toxicologic pathology

authors： Maurer JK,Gibbons BA,Bruce RD

更新日期：1990-01-01 00:00:00

abstract：:Oltipraz, developed as an antischistosomal agent, protects against the hepatotoxicity of many xenobiotics and is known to be an effective inhibitor of experimental carcinogenesis in rodents. In the present study, we investigated its effects on the development of lesions in LEC rats, established as a mutant strain char...

journal_title：Toxicologic pathology

authors： Nakamura H,Nishikawa A,Furukawa F,Kasahara K,Miyauchi M,Okazaki K,Imazawa T,Uchida K,Hirose M

更新日期：2002-03-01 00:00:00

abstract：:Mixed-function oxidase (MFO) induction in the mouse liver results in a rapid and sustained centrilobular hypertrophy associated with a hyperplastic response. In many studies, the long-term sequela of prolonged exposure is an increased incidence of lesions considered to be adenomas. Studies have shown in aged control m...

journal_title：Toxicologic pathology

authors： Butler WH

更新日期：1996-07-01 00:00:00

abstract：:In the Federal Register of January 10, 2000 (65 FR 1399), FDA published a draft guidance entitled "Photosafety Testing." The notice gave interested persons an opportunity to submit comments. As a result of the comments, certain sections of the guidance were reworded to improve clarity. A final guidance was published i...

journal_title：Toxicologic pathology

authors： Jacobs AC,Brown PC,Chen C,Ellis A,Farrelly J,Osterberg R

更新日期：2004-07-01 00:00:00