Abstract：
:Absorbable metallic implants have been under investigation for more than a century. Animal and human studies have shown that magnesium (Mg) alloys can be safely used in bioresorbable scaffolds. Several cardiovascular and orthopedic biodegradable metallic devices have recently been approved for use in humans. Bioresorbable Mg implants present many advantages when compared to bioabsorbable polymer or nonabsorbable metallic implants, including similar strength and mechanical properties as existing implant-grade metals without the drawbacks of permanence or need for implant removal. Imaging visibility is also improved compared to polymeric devices. Additionally, with Mg-based cardiovascular stents, the risk of late stent thrombosis and need for long-term anti-platelet therapy may be reduced as the host tissue absorbs the Mg degradation products and the morphology of the vessel returns to a near-normal state. Absorbable Mg implants present challenges in the conduct of preclinical animal studies and interpretation of pathology data due to their particular degradation process associated with gas production and release of by-products. This article will review the different uses of Mg implants, the Mg alloys, the distinctive degradation features of Mg, and the challenges confronting pathologists at tissue collection, fixation, imaging, slide preparation, evaluation, and interpretation of Mg implants.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Chagnon M,Guy LG,Jackson Ndoi
10.1177/0192623318816936subject
Has Abstractpub_date
2019-04-01 00:00:00pages
390-400issue
3eissn
0192-6233issn
1533-1601journal_volume
47pub_type
杂志文章,评审abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311422080
更新日期：2011-12-01 00:00:00
abstract：:Partial hepatectomy (PH) and neonatal rat short-term liver focus models were used to examine the effects of selected chemicals that had been previously tested in the National Toxicology Program (NTP) 2-yr carcinogenicity studies. C.I. Solvent Yellow 14, monuron, chlorendic acid, and 4-hydroxyacetanilide were tested fo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623389017004110
更新日期：1989-01-01 00:00:00
abstract：:Recent advances in immunocytochemical techniques allow the localization of specific antigens in tissue sections. The work reported here attempts to evaluate the application of antibody-labeled, disease-related protein, followed by microscopy and computerized image analysis. Using an experimental anti-tumor, polyclonal...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338701500308
更新日期：1987-01-01 00:00:00
abstract：:Duplications of the gastrointestinal tract are exceedingly rare in laboratory animals. We report a case of a communicating intestinal duplication in a 17-wk-old Sprague-Dawley (SD) rat. The duplication was present in the mesenteric border of the ileum, and both proximal and distal ends were communicated with the lumen...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600216
更新日期：1998-03-01 00:00:00
abstract：:Aminoglycoside antibiotics are ototoxic in mammals and birds, including recently hatched chicks, but chicken embryos are insensitive to the ototoxicity of gentamicin, kanamycin, and streptomycin. To determine whether or not the insensitivity is due to a lack of antibiotic distribution to the avian cochlea, the distrib...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339402200103
更新日期：1994-01-01 00:00:00
abstract：:In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230590908231
更新日期：2005-01-01 00:00:00
abstract：:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300309
更新日期：1985-01-01 00:00:00
abstract：:Glucokinase activators (GKAs) are being developed for the treatment of type 2 diabetes. The toxicity of 4 GKAs (PF-04279405, PF-04651887, piragliatin, and PF-04937319) was assessed in mice, rats, dogs, and/or monkeys. GKAs were administered for 2 to 8 weeks. Standard endpoints, glucose, and insulin were assessed. All ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623314526006
更新日期：2014-06-01 00:00:00
abstract：:The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to p...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623316631844
更新日期：2016-06-01 00:00:00
abstract：:The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic act...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262338701500310
更新日期：1987-01-01 00:00:00
abstract：:Expression of antigens in cells and tissues can be readily studied immunohistochemically with the use of antibodies. A panel of antibodies to cell-specific markers can be used to diagnose lesions, including tumors, in the hematopoietic and lymphoid systems. This review discusses the use of readily available antibodies...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623311430695
更新日期：2012-01-01 00:00:00
abstract：:This continuing education course presented at the Society of Toxicologic Pathology's 31st Annual Symposium explored and defined the many roles that toxicologic pathologists serve Good Laboratory Practice (GLP)-conducted toxicology and carcinogenicity studies. ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313506521
更新日期：2014-01-01 00:00:00
abstract：:Reticulum cell hyperplasia (RCH) was a term used for many years by the National Toxicology Program (NTP) to describe a certain non-neoplastic bone marrow lesion of rats. Retrospective microscopic evaluation of RCH lesions and immunohistochemistry analyses were performed to reassess and further characterize these lesio...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623319890610
更新日期：2020-02-01 00:00:00
abstract：:Novel biomarkers are often required in the preclinical development of biopharmaceuticals in order to characterize pharmacologic and toxicologic effects and to establish pharmacodynamic and pharmacokinetic relationships. Flow cytometry is uniquely suited for measurement of these biomarkers. Large numbers of single cell...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339902700107
更新日期：1999-01-01 00:00:00
abstract：:The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230390175002
更新日期：2003-01-01 00:00:00
abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309351722
更新日期：2009-12-01 00:00:00
abstract：:The 2018 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Indianapolis, Indiana, at the Society of Toxicologic Pathology's 37th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This arti...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623318800734
更新日期：2018-12-01 00:00:00
abstract：:There has been a substantial increase in the number and efficacy of laboratory biomarkers for the evaluation of human cardiac injury over the last decade. The advantages of these over traditional laboratory tests have encouraged adoption of comparable markers in nonclinical studies for cardiac injury assessment. Of pa...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230500519816
更新日期：2006-01-01 00:00:00
abstract：:The new Appendix A of the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, which gives guidelines for accommodation and care of animals and was approved on June 15, 2006, was the main reason the authors decided to investigate the origins of the regulatio...
journal_title：Toxicologic pathology
pub_type： 传,历史文章,杂志文章,评审
doi：10.1177/0192623309345871
更新日期：2009-10-01 00:00:00
abstract：:Epidemiological associations have been made between the new onset of childhood rhinitis/asthma and exposures to elevated ambient levels of ozone, a commonly encountered gaseous air pollutant. Our laboratory was the first to find that mice repeatedly exposed to ozone develop nasal type 2 immunity and eosinophilic rhini...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623319873872
更新日期：2019-12-01 00:00:00
abstract：:In the constantly evolving field of toxicologic pathology, a pathologist's career is often characterized by multiple career transitions. However, these transitions can be challenging and/or overwhelming and may require a shift in focus, strategic approach, and acquisition of new skills and expertise. In order to provi...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317736299
更新日期：2017-10-01 00:00:00
abstract：:A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of bone alkaline phosphatase (BALP) with wheat germ lectin and differential inhibition with levamisole for determination of intestinal alkaline phosphatase (IALP). Th...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339402200607
更新日期：1994-11-01 00:00:00
abstract：:2,3-Pentanedione (PD) is a component of artificial butter flavorings. The use of PD is increasing since diacetyl, a major butter flavorant, was associated with bronchiolitis obliterans (BO) in workers and has been removed from many products. Because the toxicity of inhaled PD is unknown, these studies were conducted t...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311431946
更新日期：2012-04-01 00:00:00
abstract：:Toxicology of the male reproductive system has received increased interest in recent years partly fuelled by the growing reports of falling sperm counts and rising reproductive disorders in the human population. Recently revised regulatory guidelines for the safety assessment of pharmaceuticals and chemicals on reprod...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339702500201
更新日期：1997-03-01 00:00:00
abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300305
更新日期：1985-01-01 00:00:00
abstract：:One application of genomics in drug safety assessment is the identification of biomarkers to predict compound toxicity before it is detected using traditional approaches, such as histopathology. However, many genomic approaches have failed to demonstrate superiority to traditional methods, have not been appropriately ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230500321213
更新日期：2005-01-01 00:00:00
abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230701230361
更新日期：2007-04-01 00:00:00
abstract：:The spleen contains hematopoietic and lymphoid elements, is a primary site of extramedullary hematopoiesis, and removes degenerate and aged red blood cells as well as particulate materials and circulating bacteria from the blood supply. Lesions of this important component of the immune system may center on the red pul...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230600867750
更新日期：2006-01-01 00:00:00
abstract：:The toxicity of polybrominated diphenyl ethers (PBDEs), flame-retardant components, was characterized in offspring from Wistar Han dams exposed by gavage to a PBDE mixture (DE71) starting at gestation day 6 and continuing to weaning on postnatal day (PND) 21. Offspring from the dams underwent PBDE direct dosing by gav...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311429973
更新日期：2012-01-01 00:00:00
abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339302100502
更新日期：1993-09-01 00:00:00
