Previously Diagnosed Reticulum Cell Hyperplasia in Decalcified Rat Bone Marrow Stain Positive for Ionized Calcium Binding Adapter Molecule 1 (Iba1): A Monocytic/Macrophage Cell Marker.

abstract：:Groups of C57BL6 mice of each sex were assigned to one of 2 dietary regimens, ad libitum (AL) or dietary restriction (DR), to study effects of food restriction on body weight, survival, and neoplasia. The AL and DR groups were subdivided into a scheduled sacrifice group for examination at 6-mo intervals, and a lifetim...

journal_title：Toxicologic pathology

authors： Blackwell BN,Bucci TJ,Hart RW,Turturro A

更新日期：1995-09-01 00:00:00

abstract：:Repeated intraperitoneal injections of crocidolite asbestos fibers induced diffuse malignant mesotheliomas in mice. A series of mesothelial cell lines was isolated from mice at different stages in the development of these tumors. The cell lines isolated from mice with mesotheliomas recapitulated their growth pattern i...

journal_title：Toxicologic pathology

authors： Goodglick LA,Vaslet CA,Messier NJ,Kane AB

更新日期：1997-11-01 00:00:00

abstract：:Sections of thymus from New Zealand white rabbits used as controls in 28-day and 91-day percutaneous toxicity studies conducted at different laboratories were morphometrically assessed. Measurements of total thymic area, medullary area, and cortical area were greater for 28-day vs 91-day studies conducted at a given l...

journal_title：Toxicologic pathology

authors： Maurer JK,Gibbons BA,Bruce RD

更新日期：1990-01-01 00:00:00

abstract：:Bioabsorbable implants can be advantageous for certain surgical tissue bioengineering applications and implant-assisted tissue repair. They offer the obvious benefits of nonpermanence and eventual restoration of the native tissue's biomechanical and immunological properties, while providing a structural scaffold for h...

journal_title：Toxicologic pathology

authors： Rousselle SD,Ramot Y,Nyska A,Jackson ND

更新日期：2019-04-01 00:00:00

abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...

journal_title：Toxicologic pathology

authors： Bulger RE

更新日期：1986-01-01 00:00:00

abstract：:S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced nephrotoxicity in vivo was investigated in New Zealand White rabbits. A primary emphasis in these studies was further characterization of DCVC-induced nephrotoxicity using a variety of serum and urinary analytes, including sodium dodecyl sulfate-polyacrylamide gel electr...

journal_title：Toxicologic pathology

authors： Davis JW,Blakeman DP,Jolly RA,Packwood WH,Kolaja GJ,Petry TW

更新日期：1995-07-01 00:00:00

abstract：:The usefulness of isolated adult cardiac myocytes, both in suspension and in culture, as a model system for measuring cardiotoxicity is evaluated. It has been suggested that isolated adult myocytes should preferably be cultured for such experimentation, as this restores the cells to a physiological preference for fatt...

journal_title：Toxicologic pathology

authors： Haworth RA,Goknur AB,Cook MG,Decker RS

更新日期：1990-01-01 00:00:00

abstract：:Residency in cities with high air pollution is associated with neuroinflammation and neurodegeneration in healthy children, young adults, and dogs. Nonsteroidal anti-inflammatory drugs may offer neuroprotection. The authors measured the plasma concentrations of 3-nitrotyrosine and the cerebro-spinal-fluid concentratio...

journal_title：Toxicologic pathology

authors： Calderón-Garcidueñas L,Mora-Tiscareño A,Gómez-Garza G,Carrasco-Portugal Mdel C,Pérez-Guillé B,Flores-Murrieta FJ,Pérez-Guillé G,Osnaya N,Juárez-Olguín H,Monroy ME,Monroy S,González-Maciel A,Reynoso-Robles R,Villarreal-Calderon

更新日期：2009-08-01 00:00:00

abstract：:Ribonucleic acid (RNA) interference (RNAi) is a recently discovered phenomenon whereby the introduction of double stranded (ds) RNA into the cytoplasm of the cell results in the specific and efficient degradation of complementary messenger (m) RNA and, therefore, reduced protein production. It was discovered by chance...

journal_title：Toxicologic pathology

authors： Martineau HM,Pyrah IT

更新日期：2007-04-01 00:00:00

abstract：:The histologic effect of 400 mg/M2/day of hydrocortisone, given alternatively from day 7 to day 19 after birth, was studied on the spleen of the immunologically immature rat. Two days after the cessation of treatment, the periarteriolar lymphatic sheaths were found to be largely depleted of small lymphocytes. Immunope...

journal_title：Toxicologic pathology

authors： el Fouhil AF,Iskander FA,Turkall RM

更新日期：1993-01-01 00:00:00

abstract：:In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...

journal_title：Toxicologic pathology

authors： Ozaki M,Ozaki K,Watanabe T,Uwagawa S,Okuno Y,Shirai T

更新日期：2005-01-01 00:00:00

abstract：:A significant correlation exists between average daily food consumption and 2-yr survival in control ad libitum (AL)-fed Sprague-Dawley (SD) rats. SD rats were fed Purina Rodent Chow 5002 or a modified chow, 5002-9, with lower protein, fat, metabolizable energy and increased fiber AL or by dietary restriction (DR) to ...

journal_title：Toxicologic pathology

authors： Keenan KP,Smith PF,Hertzog P,Soper K,Ballam GC,Clark RL

更新日期：1994-05-01 00:00:00

abstract：:The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identi...

journal_title：Toxicologic pathology

authors： Pinkney AE,Harshbarger JC,Rutter MA,Sakaris PC

更新日期：2019-02-01 00:00:00

abstract：:A delay in the exposure of initiated rats to orotic acid (OA) beyond a specific time frame results in a progressive loss of promotional effect in liver carcinogenesis. The current study was designed to ascertain whether the loss of promotional effect could be counteracted by pre-exposing the initiated animals to other...

journal_title：Toxicologic pathology

authors： Laconi E,Vasudevan S,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1987-01-01 00:00:00

abstract：:This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks. A total of 120 chicks were divided equally into 4 groups and were fed poultry mash without ...

journal_title：Toxicologic pathology

authors： Garg UK,Pal AK,Jha GJ,Jadhao SB

更新日期：2004-05-01 00:00:00

abstract：:Some developmental dual-acting PPARalpha/gamma agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats orally dosed with ragaglitazar, using a newly developed flow c...

journal_title：Toxicologic pathology

authors： Oleksiewicz MB,Thorup I,Nielsen HS,Andersen HV,Hegelund AC,Iversen L,Guldberg TS,Brinck PR,Sjogren I,Thinggaard UK,Jørgensen L,Jensen MB

更新日期：2005-01-01 00:00:00

abstract：:Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine have been used extensively in biomedical research, there is a paucity of information in the...

journal_title：Toxicologic pathology

authors： Helke KL,Nelson KN,Sargeant AM,Jacob B,McKeag S,Haruna J,Vemireddi V,Greeley M,Brocksmith D,Navratil N,Stricker-Krongrad A,Hollinger C

更新日期：2016-04-01 00:00:00

abstract：:Mixed-function oxidase (MFO) induction in the mouse liver results in a rapid and sustained centrilobular hypertrophy associated with a hyperplastic response. In many studies, the long-term sequela of prolonged exposure is an increased incidence of lesions considered to be adenomas. Studies have shown in aged control m...

journal_title：Toxicologic pathology

authors： Butler WH

更新日期：1996-07-01 00:00:00

abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...

journal_title：Toxicologic pathology

authors： Hottendorf GH

更新日期：1985-01-01 00:00:00

abstract：:Osteogenic Protein-1 (OP-1) is a bone morphogen involved in tissue repair and development. We have shown that OP-1 is downregulated during acute ischemic renal injury. Here we report the use of the rat remnant kidney model (RRKM) to evaluate changes in kidney OP-1 expression during chronic injury, and determine if tre...

journal_title：Toxicologic pathology

authors： Dube PH,Almanzar MM,Frazier KS,Jones WK,Charette MF,Paredes A

更新日期：2004-07-01 00:00:00

abstract：:Slc:Wistar male rats treated with human natural tumor necrosis factor alpha (hn TNF-alpha, 3 X 10(5) Japan reference units/kg intravenously) for 3 months showed histologic vacuolation of basophils in the anterior pituitary, hyperplasia of the thyroidal follicular epithelium, and hyperplasia of the testicular interstit...

journal_title：Toxicologic pathology

authors： Kakinuma C,Hamada Y,Futamura Y,Kuwayama C,Shimoi A,Shibutani Y

更新日期：1999-07-01 00:00:00

abstract：:Groups of 5 male beagle dogs were treated orally with hydralazine tablets in gelatin capsules at a dose of 12 or 24 mg/kg twice a day (6 hours apart) for 2 consecutive days. Five male dogs treated with empty gelatin capsules served as untreated controls. Clinical findings and heart rate changes during treatment and te...

journal_title：Toxicologic pathology

authors： Mesfin GM,Shawaryn GG,Higgins MJ

更新日期：1987-01-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a chemical used in the production of fluoropolymers. Its persistence in the environment and presence in humans and wildlife has raised health concerns. Liver tumor induction by PFOA is thought to be mediated in rodents by PPAR-alpha. A recent US EPA scientific advisory board questioned...

journal_title：Toxicologic pathology

authors： Wolf DC,Moore T,Abbott BD,Rosen MB,Das KP,Zehr RD,Lindstrom AB,Strynar MJ,Lau C

更新日期：2008-06-01 00:00:00

abstract：:Toxicogenomics using a reference database can provide a better understanding and prediction of toxicity, largely by creating biomarkers that tie gene expression to actual pathology events. During the course of building a toxicogenomic database, an observation was made that a number of non-steroidal anti-inflammatory c...

journal_title：Toxicologic pathology

authors： Tugendreich S,Pearson CI,Sagartz J,Jarnagin K,Kolaja K

更新日期：2006-01-01 00:00:00

abstract：:The mouse liver is the primary target site for carcinogenesis of more than 200 chemicals (including pesticides, food additives, pharmaceuticals, and industrial intermediates) tested in long-term toxicity safety assessment assays. Mouse liver tumors develop through defined morphological stages (similar to those found i...

journal_title：Toxicologic pathology

authors： Ward JM,Shibata MA,Devor DE

更新日期：1996-01-01 00:00:00

abstract：:Conazoles are a class of azole based fungicides used in agriculture and as pharmaceutical products. They have a common mode of antifungal action through inhibition of ergosterol biosynthesis. Some members of this class have been shown to be hepatotoxic and will induce mouse hepatocellular tumors and/or rat thyroid fol...

journal_title：Toxicologic pathology

authors： Wolf DC,Allen JW,George MH,Hester SD,Sun G,Moore T,Thai SF,Delker D,Winkfield E,Leavitt S,Nelson G,Roop BC,Jones C,Thibodeaux J,Nesnow S

更新日期：2006-01-01 00:00:00

abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...

journal_title：Toxicologic pathology

authors： Kashida Y,Kato M

更新日期：1997-11-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) refers to a decline in renal function following exposure to iodinated contrast media (CM). The present study was initiated to explore the role of known human risk factors (spontaneous hypertension, diabetes, protein-losing nephropathy) on CIN development in rodent models and to deter...

journal_title：Toxicologic pathology

authors： Rouse RL,Stewart SR,Thompson KL,Zhang J

更新日期：2013-01-01 00:00:00

abstract：:A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular d...

journal_title：Toxicologic pathology

authors： Swartley OM,Foley JF,Livingston DP 3rd,Cullen JM,Elmore SA

更新日期：2016-07-01 00:00:00

abstract：:This report documents the histological changes in nude mouse skin and in human skin xenografts on nude mice following exposure to phenyldichloroarsine (PDA), a vesicant arsenical. Under light microscopy, we observed in PDA-treated human skin grafts: 1) degeneration of epidermal cell nuclei (apparent by 2 hr after expo...

journal_title：Toxicologic pathology

authors： McGown EL,van Ravenswaay T,Dumlao CR

更新日期：1987-01-01 00:00:00