Generalized cellular hypertrophy is induced by a dual-acting PPAR agonist in rat urinary bladder urothelium in vivo.

abstract：:The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic act...

journal_title：Toxicologic pathology

authors： Caspritz G,Hadden J

更新日期：1987-01-01 00:00:00

abstract：:The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...

journal_title：Toxicologic pathology

authors： Radi ZA,Khan NK

更新日期：2006-01-01 00:00:00

abstract：:We examined the localization and expression of the nuclear oncoprotein c-myc and the cytoplasmic membrane-associated oncoprotein c-ras in rainbow trout cell lines derived from both normal and tumor tissue in order to question whether c-myc and ras oncoprotein immunostaining was increased in cells derived from tumors c...

journal_title：Toxicologic pathology

authors： Carter CA,Ellington WW,Van Beneden RJ

更新日期：1996-05-01 00:00:00

abstract：:High-resolution digitalizing of histology slides facilitates the development of computational alternatives to manual quantitation of features of interest. We developed a MATLAB-based quantitative histological analysis tool (QuHAnT) for the high-throughput assessment of distinguishable histological features. QuHAnT val...

journal_title：Toxicologic pathology

authors： Nault R,Colbry D,Brandenberger C,Harkema JR,Zacharewski TR

更新日期：2015-04-01 00:00:00

abstract：:Effective wound healing leads to restoration of tissue integrity and occurs through a highly organized multistage process involving various cell types. Currently, methods for wound healing assessment lack a structured system for analysis of quantitative parameters. We have established a unique quantitative assessment ...

journal_title：Toxicologic pathology

authors： Braiman-Wiksman L,Solomonik I,Spira R,Tennenbaum T

更新日期：2007-10-01 00:00:00

abstract：:Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of cellular differentiation during critical stages of morphogenesis. The goal of this study was to document uterine epit...

journal_title：Toxicologic pathology

authors： Suen AA,Jefferson WN,Williams CJ,Wood CE

更新日期：2018-07-01 00:00:00

abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...

journal_title：Toxicologic pathology

authors： Treumann S,Buesen R,Gröters S,Eichler JO,van Ravenzwaay B

更新日期：2015-08-01 00:00:00

abstract：:Duplications of the gastrointestinal tract are exceedingly rare in laboratory animals. We report a case of a communicating intestinal duplication in a 17-wk-old Sprague-Dawley (SD) rat. The duplication was present in the mesenteric border of the ileum, and both proximal and distal ends were communicated with the lumen...

journal_title：Toxicologic pathology

authors： Elangbam CS,Clevidence KJ,Jackson CB,Holson JF

更新日期：1998-03-01 00:00:00

abstract：:The outcome of cardiac ischemic events depends not only on the extent and duration of the ischemic stimulus but also on the myocardial intrinsic tolerance to ischemic injury. Cardiac ischemic tolerance reflects myocardial functional reserves that are not always used when the tissue is appropriately oxygenated. Ischemi...

journal_title：Toxicologic pathology

authors： Golomb E,Nyska A,Schwalb H

更新日期：2009-08-01 00:00:00

abstract：:More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues. Formulating these compounds as pure drug nanoparticles is one ...

journal_title：Toxicologic pathology

authors： Merisko-Liversidge EM,Liversidge GG

更新日期：2008-01-01 00:00:00

abstract：:Selenoprotein P is an abundant extracellular protein that is expressed in liver, brain, and other tissues. Studies in mice with the selenoprotein P gene deleted (Sepp-/- mice) have implicated the protein in maintaining brain selenium. Sepp-/- mice fed a normal or low selenium diet develop severe motor impairment and d...

journal_title：Toxicologic pathology

authors： Valentine WM,Hill KE,Austin LM,Valentine HL,Goldowitz D,Burk RF

更新日期：2005-01-01 00:00:00

abstract：:Although arsenic exposure causes liver disease and/or hepatoma, little is known about molecular mechanisms of arsenic-induced liver toxicity or carcinogenesis. We investigated the effects of arsenic on expression of cancer-related genes in a rat liver following subchronic exposure to sodium arsenate (1, 10, 100 ppm in...

journal_title：Toxicologic pathology

authors： Cui X,Li S,Shraim A,Kobayashi Y,Hayakawa T,Kanno S,Yamamoto M,Hirano S

更新日期：2004-01-01 00:00:00

abstract：:We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...

journal_title：Toxicologic pathology

authors： Kato M,Takada S,Kashida Y,Nomura M

更新日期：1995-05-01 00:00:00

abstract：:Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 w...

journal_title：Toxicologic pathology

authors： Gray RH,Adam-Rodwell GA,Maris D,Haskins JR,Stoner GD

更新日期：1995-11-01 00:00:00

abstract：:The handling-induced dark neuron is a histological artifact observed in brain samples handled before fixation with aldehydes. To explore associations between dark neurons and immunohistochemical alterations in mouse brains, we examined protein products encoded by Cav3 (neuronal perikarya/neurites), Rbbp4 (neuronal nuc...

journal_title：Toxicologic pathology

authors： Soontornniyomkij V,Chang RC,Soontornniyomkij B,Schilling JM,Patel HH,Jeste DV

更新日期：2020-04-01 00:00:00

abstract：:Astrocytes assume multiple roles in maintaining an optimally suited milieu for neuronal function. Select astrocytic functions include the maintenance of redox potential, the production of trophic factors, the regulation of neurotransmitter and ion concentrations, and the removal of toxins and debris from the cerebrosp...

journal_title：Toxicologic pathology

authors： Sidoryk-Wegrzynowicz M,Wegrzynowicz M,Lee E,Bowman AB,Aschner M

更新日期：2011-01-01 00:00:00

abstract：:Minoxidil, a long-acting vasodilating antihypertensive agent, reduces arterial blood pressure by a direct action on arteriolar smooth muscle. The present studies examined the gross anatomic, histologic and ultrastructural myocardial alterations produced by 2 daily doses of minoxidil in beagle dogs (0.5, 1, or 3 mg/kg)...

journal_title：Toxicologic pathology

authors： Herman EH,Ferrans VJ,Young RS,Balazs T

更新日期：1989-01-01 00:00:00

abstract：:Hyaline droplet formation in the proximal tubular cells of the kidney commonly occurs under different pathological conditions in experimental animals. In rats, intracytoplasmic hyaline droplet formation is predominantly associated with accumulation of the male rat-specific alpha(2u)-globulin, whereas under other (path...

journal_title：Toxicologic pathology

authors： de Rijk EP,Ravesloot WT,Wijnands Y,van Esch E

更新日期：2003-07-01 00:00:00

abstract：:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...

journal_title：Toxicologic pathology

authors： Zwicker GM,Killinger JM,McConnel RF

更新日期：1985-01-01 00:00:00

abstract：:The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and biochemistry of minipigs are similar enough to humans to consider them as ...

journal_title：Toxicologic pathology

authors： Colleton C,Brewster D,Chester A,Clarke DO,Heining P,Olaharski A,Graziano M

更新日期：2016-04-01 00:00:00

abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...

journal_title：Toxicologic pathology

authors： Payne SR,Kemp CJ

更新日期：2003-07-01 00:00:00

abstract：:We investigated, morphologically and immunohistochemically, 74 medullary adrenal tumors, including 64 pheochromocytomas (14 malignant and 50 benign), 9 ganglioneuromas, and 1 malignant schwannoma. The tumors were detected in 2-year-old Wistar and Sprague-Dawley rats from carcinogenicity studies. Morphologically, benig...

journal_title：Toxicologic pathology

authors： Pace V,Perentes E,Germann PG

更新日期：2002-07-01 00:00:00

abstract：:This report documents the histological changes in nude mouse skin and in human skin xenografts on nude mice following exposure to phenyldichloroarsine (PDA), a vesicant arsenical. Under light microscopy, we observed in PDA-treated human skin grafts: 1) degeneration of epidermal cell nuclei (apparent by 2 hr after expo...

journal_title：Toxicologic pathology

authors： McGown EL,van Ravenswaay T,Dumlao CR

更新日期：1987-01-01 00:00:00

abstract：:Recent clinical evidence suggests that hylan, a modified hyaluronan, and related products potentially elicit foreign body granulomatous inflammation in human soft tissue. We investigated the biocompatibility of hylan G-F 20 (Synvisc) for up to 28 days after intradermal injection in guinea pigs and intramuscular inject...

journal_title：Toxicologic pathology

authors： Sasaki M,Miyazaki Y,Takahashi T

更新日期：2003-05-01 00:00:00

abstract：:Groups of 5 male beagle dogs were treated orally with hydralazine tablets in gelatin capsules at a dose of 12 or 24 mg/kg twice a day (6 hours apart) for 2 consecutive days. Five male dogs treated with empty gelatin capsules served as untreated controls. Clinical findings and heart rate changes during treatment and te...

journal_title：Toxicologic pathology

authors： Mesfin GM,Shawaryn GG,Higgins MJ

更新日期：1987-01-01 00:00:00

abstract：:The administration of mesenchymal stromal cells (MSCs) provides an exciting emerging therapeutic modality for the treatment of peripheral arterial disease, a condition that is associated with critical limb ischemia as its end stage. Placental-derived MSCs, termed PLX-PAD cells, are stable adhesive stromal cells isolat...

journal_title：Toxicologic pathology

authors： Ramot Y,Meiron M,Toren A,Steiner M,Nyska A

更新日期：2009-08-01 00:00:00

abstract：:Chronic (24-month) inhalation exposure to 5 or 10 ppm allyl glycidyl ether (AGE) induced nasal lesions in Osborne-Mendel rats and B6C3F1 mice. Inflammation, degeneration, regeneration, metaplasia, hyperplasia, and neoplasia were observed in the nasal mucosa. Squamous metaplasia and hyperplasia of the respiratory epith...

journal_title：Toxicologic pathology

authors： Renne RA,Brown HR,Jokinen MP

更新日期：1992-01-01 00:00:00

abstract：:Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of biological functions involved in autoimmune disease pathogenesis. Th...

journal_title：Toxicologic pathology

authors： Long AJ,Sampson E,McCarthy RW,Harris CM,Barnard M,Shi D,Conlon D,Caldwell R,Honor D,Wishart N,Hoemann M,Duggan L,Fritz D,Stedman C,O'Connor E,Mikaelian I,Schwartz A

更新日期：2016-10-01 00:00:00

abstract：:In tissue slice models, interactions between the heterogeneous cell types comprising the lung parenchyma are maintained thus providing a controlled system for the study of pulmonary toxicology in vitro. However, validation of the model in vitro system must be affirmed. Previous reports, in in vivo systems, have demons...

journal_title：Toxicologic pathology

authors： Hays AM,Lantz RC,Witten ML

更新日期：2003-03-01 00:00:00

abstract：:This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible me...

journal_title：Toxicologic pathology

authors： Getz GS

更新日期：1990-01-01 00:00:00