p27(Kip1) (Cdkn1b)-deficient mice are susceptible to chemical carcinogenesis and may be a useful model for carcinogen screening.

abstract：:Changes in the mRNA and protein expression of renin-secreting cells in the juxtaglomerular apparatus (JGA) were examined in the rat following administration of ZENECA ZD8731, an angiotensin II receptor antagonist. Doses of 0 or 90 mg/kg were administered daily by gavage for 26 wk. JGA hypertrophy was apparent in histo...

journal_title：Toxicologic pathology

authors： Doughty SE,Ferrier RK,Hillan KJ,Jackson DG

更新日期：1995-05-01 00:00:00

abstract：:Toxicogenomics using a reference database can provide a better understanding and prediction of toxicity, largely by creating biomarkers that tie gene expression to actual pathology events. During the course of building a toxicogenomic database, an observation was made that a number of non-steroidal anti-inflammatory c...

journal_title：Toxicologic pathology

authors： Tugendreich S,Pearson CI,Sagartz J,Jarnagin K,Kolaja K

更新日期：2006-01-01 00:00:00

abstract：:Successful development and use of biomarkers will improve the productivity of oncology drug development. Recognition of the importance of biomarkers for speeding drug development is reflected in the precise definitions and concepts proposed by an NIH Working Group to standardize terminology and promote a more coherent...

journal_title：Toxicologic pathology

authors： Floyd E,McShane TM

更新日期：2004-03-01 00:00:00

abstract：:Some developmental dual-acting PPARalpha/gamma agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats orally dosed with ragaglitazar, using a newly developed flow c...

journal_title：Toxicologic pathology

authors： Oleksiewicz MB,Thorup I,Nielsen HS,Andersen HV,Hegelund AC,Iversen L,Guldberg TS,Brinck PR,Sjogren I,Thinggaard UK,Jørgensen L,Jensen MB

更新日期：2005-01-01 00:00:00

abstract：:In carcinogenicity studies with PPAR gamma and alpha/gamma agonists, urinary bladder tumors have been reported in Harlan Sprague-Dawley (HSD) and Charles River Sprague-Dawley (SD) but not Wistar (WI) rats, with urolithiasis purported to be the inciting event. In two 3-month studies, the authors investigated strain-rel...

journal_title：Toxicologic pathology

authors： Tannehill-Gregg SH,Dominick MA,Reisinger AJ,Moehlenkamp JD,Waites CR,Stock DA,Sanderson TP,Cohen SM,Arnold LL,Schilling BE

更新日期：2009-04-01 00:00:00

abstract：:Livers of male Sprague-Dawley rats were evaluated for foci and nodules 90 days and 16 months after one or two oral doses of 1,2-dibromoethane (DBE). Rats (190 g) were given the following oral treatments. Controls received corn oil (2.5 ml/kg) at 0 and 24 hr. DBE X 1 received corn oil at 0 hr and 75 mg DBE/kg at 24 hr....

journal_title：Toxicologic pathology

authors： Moslen MT

更新日期：1984-01-01 00:00:00

abstract：:Transgenic Tg.AC mice carry a v-Ha-ras coding region flanked by a zeta-globin promoter and an SV40 polyadenylation signal sequence. These mice respond to carcinogens by developing epidermal papillomas. In some cases, malignancies develop at the sites of these papillomas. Various patterns of squamous cell differentiati...

journal_title：Toxicologic pathology

authors： Asano S,Trempus CS,Spalding JW,Tennant RW,Battalora MS

更新日期：1998-07-01 00:00:00

abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...

journal_title：Toxicologic pathology

authors： Gill S,Veinot J,Kavanagh M,Pulido O

更新日期：2007-04-01 00:00:00

abstract：:Pepsinogens are acid protease enzymes of pepsin usually found in gastric mucosa. In the present study, we demonstrated the presence of pepsinogen isozymes in male Syrian golden hamster lung tissues by a combined immunohistochemical and biochemical approach. Immunohistochemically, using rat pepsinogen 1 antibody, pepsi...

journal_title：Toxicologic pathology

authors： Imaida K,Furihata C,Tatematsu M,Yoon CH,Furukawa F,Uneyama C,Takahashi M,Ito N,Hayashi Y

更新日期：1991-01-01 00:00:00

abstract：:The distribution of 3,4,3',4'-tetrachlorobiphenyl (TCB), its effects on serum and hepatic retinoid, content and liver morphology were investigated in adult female WAG/Rij rats. Animals received a single intraperitoneal injection of either a corn oil vehicle, 15 or 200 mg TCB/kg body weight and were killed at 1, 3, 7, ...

journal_title：Toxicologic pathology

authors： Durham SK,Brouwer A

更新日期：1989-01-01 00:00:00

abstract：:This article provides a synopsis of the first two presentations from the second scientific session of the 37th Annual Symposium of the Society of Toxicologic Pathology in Indianapolis, Indiana, on June 18, 2018; the session focused on acute kidney injury. The first presentation, given by Dr. Kevin McDorman, focused on...

journal_title：Toxicologic pathology

authors： Crabbs TA,McDorman KS

更新日期：2018-12-01 00:00:00

abstract：:There is increased interest to use minipigs in ocular toxicology studies due to their anatomical similarities with human eyes and as a substitute for nonhuman primates. This requires adaptation of enhanced optical coherence tomography (OCT) techniques and of ocular relevant immunohistochemistry (IHC) or in situ hybrid...

journal_title：Toxicologic pathology

authors： Atzpodien EA,Jacobsen B,Funk J,Altmann B,Silva Munoz MA,Singer T,Gyger C,Hasler P,Maloca P

更新日期：2016-04-01 00:00:00

abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...

journal_title：Toxicologic pathology

authors： Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito N

更新日期：1993-09-01 00:00:00

abstract：:Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powde...

journal_title：Toxicologic pathology

authors： Wahlström E,Ollerstam A,Sundius L,Zhang H

更新日期：2013-08-01 00:00:00

abstract：:The toxicities of 2'-fluorouridine (2'-FU) and 2'-fluorocytidine-HCl (2'-FC) were separately evaluated in 2 species, male Fischer 344 (F334) rats and woodchucks. Particular attention was focused on the ability of these nucleosides to induce toxicities similar to those induced by the antiviral drug fialuridine (FIAU). ...

journal_title：Toxicologic pathology

authors： Richardson FC,Tennant BC,Meyer DJ,Richardson KA,Mann PC,McGinty GR,Wolf JL,Zack PM,Bendele RA

更新日期：1999-11-01 00:00:00

abstract：:Sensitive kidney safety assessment is important for successful drug development in both preclinical and clinical stages. The Food and Drug Administration recently qualified a composite measure of 6 urine creatinine-normalized biomarkers, such as clusterin, cystatin C, kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glu...

journal_title：Toxicologic pathology

authors： Sandelius Å,Basak J,Hölttä M,Sultana S,Hyberg G,Wilson A,Andersson P,Söderberg M

更新日期：2020-12-01 00:00:00

abstract：:We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...

journal_title：Toxicologic pathology

authors： Kato M,Takada S,Kashida Y,Nomura M

更新日期：1995-05-01 00:00:00

abstract：:Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...

journal_title：Toxicologic pathology

authors： Trotta Mde R,Cajaiba DM,Parra OM,Dagli ML,Hernandez-Blazquez FJ

更新日期：2014-01-01 00:00:00

abstract：:This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible me...

journal_title：Toxicologic pathology

authors： Getz GS

更新日期：1990-01-01 00:00:00

abstract：:In organs with diverse cell populations, it is not uncommon for one type of cell to respond while others are spared. Even in an organ with common cell types, such as hepatocytes within the liver, the population of cells may respond with different sensitivities for injury or for biochemical responses to toxicants. In t...

journal_title：Toxicologic pathology

authors： Andersen ME

更新日期：2002-01-01 00:00:00

abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...

journal_title：Toxicologic pathology

authors： Bulger RE

更新日期：1986-01-01 00:00:00

abstract：:The expression of specific cytokeratin (CK) polypeptide patterns is a sensitive marker of the cytoskeletal differentiation of epithelial cells. We developed an immunohistochemical method to assess CK expression patterns in the rat respiratory tract using serial paraffin-embedded sections from the nasal cavity, trachea...

journal_title：Toxicologic pathology

authors： Schlage WK,Bülles H,Friedrichs D,Kuhn M,Teredesai A,Terpstra PM

更新日期：1998-05-01 00:00:00

abstract：:This is a survey of the results of recent investigations on gastrointestinal (GI) peptide hormones. In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known. These include vasoactive intestin...

journal_title：Toxicologic pathology

authors： Tansy MF,Kendall FM

更新日期：1988-01-01 00:00:00

abstract：:B6.A.D. (Ahr(d)/Nat(s)) mice were utilized to investigate the short-term pulmonary response to JP-8 jet fuel (JP-8) aerosol inhalation. Mice were nose-only exposed to atmospheres of 0 to 118 mg/m3 for 1 h/d over a period of 7 days to further test the hypothesis that JP-8 concentrations below the permissible exposure l...

journal_title：Toxicologic pathology

authors： Robledo RF,Young RS,Lantz RC,Witten ML

更新日期：2000-09-01 00:00:00

abstract：:Direct tissue profiling and imaging mass spectrometry (MS) allow for detailed mapping of the complex protein pattern across a tissue sample. Utilization of these tools provides spatial information across a tissue section for target protein expression and can be used to correlate changes in expression levels with speci...

journal_title：Toxicologic pathology

authors： Chaurand P,Schwartz SA,Reyzer ML,Caprioli RM

更新日期：2005-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...

journal_title：Toxicologic pathology

authors： Kakiuchi-Kiyota S,Arnold LL,Yokohira M,Koza-Taylor P,Suzuki S,Varney M,Pennington KL,Cohen SM

更新日期：2011-12-01 00:00:00

abstract：:A review of the data obtained from various studies on carcinogenicity of vinyl chloride (VC) in rodents, particularly on the effect of dose, age, duration of exposure and potential reversibility of lesions, revealed that vinyl chloride-induced carcinogenicity in rodents was dose and time related; no recovery occurred ...

journal_title：Toxicologic pathology

authors： Bhandari JC

更新日期：1983-01-01 00:00:00

abstract：:The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcinogenicity of chemicals with a high degree of concordance (LeBoeuf et al [1996]. Mutat Res 356: 85-127). The SHE assay models the earliest identifiable stage in carcinogenicity, morphologi...

journal_title：Toxicologic pathology

authors： Mauthe RJ,Gibson DP,Bunch RT,Custer L

更新日期：2001-01-01 00:00:00

abstract：:We investigated, morphologically and immunohistochemically, 74 medullary adrenal tumors, including 64 pheochromocytomas (14 malignant and 50 benign), 9 ganglioneuromas, and 1 malignant schwannoma. The tumors were detected in 2-year-old Wistar and Sprague-Dawley rats from carcinogenicity studies. Morphologically, benig...

journal_title：Toxicologic pathology

authors： Pace V,Perentes E,Germann PG

更新日期：2002-07-01 00:00:00

abstract：:Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in...

journal_title：Toxicologic pathology

authors： Bach PH,Nguyen TK

更新日期：1998-01-01 00:00:00