3,4,3',4'-tetrachlorobiphenyl-induced effects in the rat liver. I. Serum and hepatic retinoid reduction and morphologic changes.

abstract：:Osteogenic Protein-1 (OP-1) is a bone morphogen involved in tissue repair and development. We have shown that OP-1 is downregulated during acute ischemic renal injury. Here we report the use of the rat remnant kidney model (RRKM) to evaluate changes in kidney OP-1 expression during chronic injury, and determine if tre...

journal_title：Toxicologic pathology

authors： Dube PH,Almanzar MM,Frazier KS,Jones WK,Charette MF,Paredes A

更新日期：2004-07-01 00:00:00

abstract：:Toxicologists and pathologists worldwide will benefit from a new, website-based, and completely searchable Nonneoplastic Lesion Atlas just released by the U.S. National Toxicology Program (NTP). The atlas is a much-needed resource with thousands of high-quality, zoomable images and diagnostic guidelines for each roden...

journal_title：Toxicologic pathology

authors： Cesta MF,Malarkey DE,Herbert RA,Brix A,Hamlin MH 2nd,Singletary E,Sills RC,Bucher JR,Birnbaum LS

更新日期：2014-01-01 00:00:00

abstract：:The toxicities of 2'-fluorouridine (2'-FU) and 2'-fluorocytidine-HCl (2'-FC) were separately evaluated in 2 species, male Fischer 344 (F334) rats and woodchucks. Particular attention was focused on the ability of these nucleosides to induce toxicities similar to those induced by the antiviral drug fialuridine (FIAU). ...

journal_title：Toxicologic pathology

authors： Richardson FC,Tennant BC,Meyer DJ,Richardson KA,Mann PC,McGinty GR,Wolf JL,Zack PM,Bendele RA

更新日期：1999-11-01 00:00:00

abstract：:Expression of antigens in cells and tissues can be readily studied immunohistochemically with the use of antibodies. A panel of antibodies to cell-specific markers can be used to diagnose lesions, including tumors, in the hematopoietic and lymphoid systems. This review discusses the use of readily available antibodies...

journal_title：Toxicologic pathology

authors： Rehg JE,Bush D,Ward JM

更新日期：2012-01-01 00:00:00

abstract：:This study aimed to evaluate the carcinogenic potential of the herbicide Diuron in a two-stage rat medium-term mammary carcinogenesis model initiated by 7,12-dimethylbenz(a)anthracene (DMBA). Female seven-week-old Sprague-Dawley (SD) rats were allocated to six groups: groups G1 to G4 received intragastrically (i.g.) a...

journal_title：Toxicologic pathology

authors： Grassi TF,Rodrigues MA,de Camargo JL,Barbisan LF

更新日期：2011-04-01 00:00:00

abstract：:Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powde...

journal_title：Toxicologic pathology

authors： Wahlström E,Ollerstam A,Sundius L,Zhang H

更新日期：2013-08-01 00:00:00

abstract：:A significant correlation exists between average daily food consumption and 2-yr survival in control ad libitum (AL)-fed Sprague-Dawley (SD) rats. SD rats were fed Purina Rodent Chow 5002 or a modified chow, 5002-9, with lower protein, fat, metabolizable energy and increased fiber AL or by dietary restriction (DR) to ...

journal_title：Toxicologic pathology

authors： Keenan KP,Smith PF,Hertzog P,Soper K,Ballam GC,Clark RL

更新日期：1994-05-01 00:00:00

abstract：:This report documents the histological changes in nude mouse skin and in human skin xenografts on nude mice following exposure to phenyldichloroarsine (PDA), a vesicant arsenical. Under light microscopy, we observed in PDA-treated human skin grafts: 1) degeneration of epidermal cell nuclei (apparent by 2 hr after expo...

journal_title：Toxicologic pathology

authors： McGown EL,van Ravenswaay T,Dumlao CR

更新日期：1987-01-01 00:00:00

abstract：:With the increasing use of animal-based biomaterials for regenerative medical applications, the need for their safety assessment is paramount. A porcine cholecyst-derived scaffold (CDS), intended as a muscle repair graft, prepared by a nondetergent/enzymatic method was engrafted in a rat abdominal wall defect model. H...

journal_title：Toxicologic pathology

authors： Balakrishnan-Nair DK,Nair ND,Venugopal SK,Das VN,George S,Abraham MJ,Eassow S,Alison MR,Sainulabdeen A,Anilkumar TV

更新日期：2018-02-01 00:00:00

abstract：:7,12-Dimethylbenz[a]anthracene (DMBA) presents a pollutant implicated in various toxicological effects. The aim of this experiment was to study the effects of DMBA administration on oxidative stress, histopathological signs, and 18 kDa translocator protein (TSPO) binding characteristics in rat liver. We also studied t...

journal_title：Toxicologic pathology

authors： Dimitrova-Shumkovska J,Veenman L,Ristoski T,Leschiner S,Gavish M

更新日期：2010-10-01 00:00:00

abstract：:To characterize genetic alterations occurring in renal tumorigenesis, EHEN-induced renal cell tumors were examined using restriction landmark genomic scanning (RLGS) analysis, an electrophoretic separation technique that detects gene amplifications and deletions. Comparison of DNAs from tumor against those from corres...

journal_title：Toxicologic pathology

authors： Konishi N,Nakamura M,Ishida E,Kawada Y,Nishimine M,Nagai H,Emi M

更新日期：2001-03-01 00:00:00

abstract：:We have previously indicated that the ideal animal tumor model should mimic the human disease. This means that the investigator should be able to ascertain the influence of host factors on the initiation of tumorigenesis, mimic the susceptibility of tumor response based on age and reproductive history, and determine t...

journal_title：Toxicologic pathology

authors： Russo J

更新日期：2015-02-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:Hepatocyte suspensions prepared from inbred male Wistar-Kyoto rats were transplanted to the livers of syngeneic recipients by injection into the portal venous system immediately after partial hepatectomy. Donor cells were labelled with 51Cr in vitro before transplantation. Animals were sacrificed 1 hr, 10 hr, 48 hr, o...

journal_title：Toxicologic pathology

authors： Saeter G,Schwarze PE,Nesland JM,Seglen PO

更新日期：1987-01-01 00:00:00

abstract：:Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...

journal_title：Toxicologic pathology

authors： Trotta Mde R,Cajaiba DM,Parra OM,Dagli ML,Hernandez-Blazquez FJ

更新日期：2014-01-01 00:00:00

abstract：:A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular d...

journal_title：Toxicologic pathology

authors： Swartley OM,Foley JF,Livingston DP 3rd,Cullen JM,Elmore SA

更新日期：2016-07-01 00:00:00

abstract：:The nonnucleoside inhibitor (NNI) of HIV-1 reverse transcriptase, PHI-346 (N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea), is a dual-function spermicidal agent with potent anti-HIV activity against drug-sensitive as well as drug-resistant HIV-1 strains with genotypic and phenotypic NNI resistance. PHI-3...

journal_title：Toxicologic pathology

authors： D'Cruz OJ,Waurzyniak B,Uckun FM

更新日期：2002-11-01 00:00:00

abstract：:This continuing education course presented at the Society of Toxicologic Pathology's 31st Annual Symposium explored and defined the many roles that toxicologic pathologists serve Good Laboratory Practice (GLP)-conducted toxicology and carcinogenicity studies. ...

journal_title：Toxicologic pathology

authors： Weber K,Hailey JR,Mann PC,Seaton M,Funk KA

更新日期：2014-01-01 00:00:00

abstract：:Duplications of the gastrointestinal tract are exceedingly rare in laboratory animals. We report a case of a communicating intestinal duplication in a 17-wk-old Sprague-Dawley (SD) rat. The duplication was present in the mesenteric border of the ileum, and both proximal and distal ends were communicated with the lumen...

journal_title：Toxicologic pathology

authors： Elangbam CS,Clevidence KJ,Jackson CB,Holson JF

更新日期：1998-03-01 00:00:00

abstract：:Monocrotaline pyrrole (MCTP) is a highly reactive pneumotoxic metabolite of the pyrrolizidine alkaloid plant toxin monocrotaline. When administered to rats, it causes a delayed and progressive lung injury, vascular remodeling, and pulmonary hypertension. Structural remodeling consists of endothelial cell swelling foll...

journal_title：Toxicologic pathology

authors： Lappin PB,Roth RA

更新日期：1997-07-01 00:00:00

abstract：:Substantial progress in understanding nongenotoxic or secondary mechanisms of tumorigenesis has been made over the past decade. However, the methods used in regulated studies for assessment of carcinogenic potential in chemicals in development have not evolved significantly. Based on the experience of over 30 yr of te...

journal_title：Toxicologic pathology

authors： Alden CL,Smith PF,Piper CE,Brej L

更新日期：1996-11-01 00:00:00

abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...

journal_title：Toxicologic pathology

authors： Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito N

更新日期：1993-09-01 00:00:00

abstract：:Laser scanning cytometry (LSC) is a powerful tool for qualitative and quantitative analysis of tissue sections in preclinical drug development. LSC combines the strengths of flow cytometry with tissue architecture retention. This technology has been used predominantly with immunofluorescent techniques on cell culture ...

journal_title：Toxicologic pathology

authors： Peterson RA,Krull DL,Butler L

更新日期：2008-01-01 00:00:00

abstract：:A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...

journal_title：Toxicologic pathology

authors： Frith CH,Ayres PH,Shinohara Y,West R

更新日期：1986-01-01 00:00:00

abstract：:The relatively high incidence and variety of lesions induced in the upper respiratory tract of rodents by inhalation of xenobiotics has resulted in considerable attention given to the microscopic anatomy of this area. Specific areas of the rodent laryngeal mucosa appear to be more sensitive to inhaled materials and mo...

journal_title：Toxicologic pathology

authors： Renne RA,Gideon KM,Miller RA,Mellick PW,Grumbein SL

更新日期：1992-01-01 00:00:00

abstract：:Groups of C57BL6 mice of each sex were assigned to one of 2 dietary regimens, ad libitum (AL) or dietary restriction (DR), to study effects of food restriction on body weight, survival, and neoplasia. The AL and DR groups were subdivided into a scheduled sacrifice group for examination at 6-mo intervals, and a lifetim...

journal_title：Toxicologic pathology

authors： Blackwell BN,Bucci TJ,Hart RW,Turturro A

更新日期：1995-09-01 00:00:00

abstract：:A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...

journal_title：Toxicologic pathology

authors： Butt MT

更新日期：2011-01-01 00:00:00

abstract：:Chronic ingestion of arsenic is associated with increased incidence of respiratory and cardiovascular diseases. To investigate the role of arsenic in early events in vascular pathology, C57BL/6 mice ingested drinking water with or without 50 ppb sodium arsenite (AsIII) for four, five, or eight weeks. At five and eight...

journal_title：Toxicologic pathology

authors： Hays AM,Lantz RC,Rodgers LS,Sollome JJ,Vaillancourt RR,Andrew AS,Hamilton JW,Camenisch TD

更新日期：2008-10-01 00:00:00

abstract：:The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP...

journal_title：Toxicologic pathology

authors： Palazzi X,Burkhardt JE,Caplain H,Dellarco V,Fant P,Foster JR,Francke S,Germann P,Gröters S,Harada T,Harleman J,Inui K,Kaufmann W,Lenz B,Nagai H,Pohlmeyer-Esch G,Schulte A,Skydsgaard M,Tomlinson L,Wood CE,Yoshida M

更新日期：2016-08-01 00:00:00

abstract：:The mouse liver is the primary target site for carcinogenesis of more than 200 chemicals (including pesticides, food additives, pharmaceuticals, and industrial intermediates) tested in long-term toxicity safety assessment assays. Mouse liver tumors develop through defined morphological stages (similar to those found i...

journal_title：Toxicologic pathology

authors： Ward JM,Shibata MA,Devor DE

更新日期：1996-01-01 00:00:00