The role of the pathologist in GLP studies.

abstract：:In standard toxicity studies, the cardiac conduction tissue is not systematically sampled and examined for histopathological changes. Most methods described use serial sectioning perpendicular to the long axis of the sinoauricular node (SAN) and atrioventricular node (AVN). Dozens of slides are needed to allow examina...

journal_title：Toxicologic pathology

authors： Palate BM,Denoël SR,Roba JL

更新日期：1995-01-01 00:00:00

abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...

journal_title：Toxicologic pathology

authors： Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito N

更新日期：1993-09-01 00:00:00

abstract：:In the present study, beta-catenin localization in hepatocellular neoplasms and hepatoblastomas, induced by oral administration of p-Nitroanisole (pNA) in Crj:BDF1 for 2 years, was evaluated by immunohistochemistry along with genetic alterations in exon 2 of beta-catenin by the polymerase chain reaction-single strand ...

journal_title：Toxicologic pathology

authors： Kushida M,Aiso S,Morimura K,Wei M,Wanibuchi H,Nagano K,Fukushima S

更新日期：2006-01-01 00:00:00

abstract：:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, ...

journal_title：Toxicologic pathology

authors： Hayes TJ,Roberts GK,Halliwell WH

更新日期：1989-01-01 00:00:00

abstract：:Toxicokinetic (TK) studies are the basis for demonstrating dose-related drug exposure in animals and for ensuring that drug exposure is substantially greater in animals than that expected in humans at therapeutic doses. The usefulness of TK studies can be further enhanced by correlating TK parameters with relevant tox...

journal_title：Toxicologic pathology

authors： Batra VK

更新日期：1995-03-01 00:00:00

abstract：:Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the normal heart histology. It is therefore crucial to understand the normal v...

journal_title：Toxicologic pathology

authors： Chanut F,Kimbrough C,Hailey R,Berridge B,Hughes-Earle A,Davies R,Roland K,Stokes A,Casartelli A,York M,Jordan H,Crivellente F,Cristofori P,Thomas H,Klapwijk J,Adler R

更新日期：2013-01-01 00:00:00

abstract：:Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10, 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above...

journal_title：Toxicologic pathology

authors： Courtney CL,Hawkins KL,Rothwell CE

更新日期：1994-09-01 00:00:00

abstract：:Many goitrogenic xenobiotics that increase the incidence of thyroid tumors in rodents exert a direct effect on the thyroid gland to disrupt one of several possible steps in the biosynthesis, secretion, and metabolism of thyroid hormones. This includes (a) inhibition of the iodine trapping mechanism, (b) blockage of or...

journal_title：Toxicologic pathology

authors： Capen CC

更新日期：1997-01-01 00:00:00

abstract：:Complete evaluation of the toxicity of a new chemical entity requires critical analysis of the pattern of positive and negative findings in all types of toxicity tests, pharmacokinetics and metabolism in the species examined, and correlation of the effects with information about its pharmacodynamic and pharmacological...

journal_title：Toxicologic pathology

authors： Dayan AD

更新日期：1994-03-01 00:00:00

abstract：:Cyclodextrins are oligosaccharides which are used in the pharmaceutical industry and research as vehicles for application of apolar substances such as steroids. The aim of this study was to examine the long-term effects of parenteral administration of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on bone. Sham-operated (SH...

journal_title：Toxicologic pathology

authors： Kantner I,Erben RG

更新日期：2012-07-01 00:00:00

abstract：:This is a survey of the results of recent investigations on gastrointestinal (GI) peptide hormones. In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known. These include vasoactive intestin...

journal_title：Toxicologic pathology

authors： Tansy MF,Kendall FM

更新日期：1988-01-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:A comparative study of histochemical detection of eosinophils in fixed murine tissue is lacking. Five histochemical methods previously reported for eosinophil detection were quantitatively and qualitatively compared in an established murine RSV vaccine-enhanced inflammation model. Nonspecific neutrophil staining was e...

journal_title：Toxicologic pathology

authors： Meyerholz DK,Griffin MA,Castilow EM,Varga SM

更新日期：2009-02-01 00:00:00

abstract：:We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...

journal_title：Toxicologic pathology

authors： Maurer JK,Parker RD,Carr GJ

更新日期：1998-03-01 00:00:00

abstract：:The title of the 2017 Society of Toxicologic Pathology symposium was "Musculoskeletal System." A brief overview of the General Scientific Symposium is presented herein and describes the topics presented by each speaker. Symposium speakers addressed subjects pertinent to musculoskeletal system toxicologic pathology and...

journal_title：Toxicologic pathology

authors： Gropp KE,Boyle MC

更新日期：2017-10-01 00:00:00

abstract：:Selenoprotein P is an abundant extracellular protein that is expressed in liver, brain, and other tissues. Studies in mice with the selenoprotein P gene deleted (Sepp-/- mice) have implicated the protein in maintaining brain selenium. Sepp-/- mice fed a normal or low selenium diet develop severe motor impairment and d...

journal_title：Toxicologic pathology

authors： Valentine WM,Hill KE,Austin LM,Valentine HL,Goldowitz D,Burk RF

更新日期：2005-01-01 00:00:00

abstract：:A spontaneous multicystic peritoneal mesothelioma was detected in a 108-wk-old male Fischer-344/DuCrj rat. Grossly, a tumor containing numerous, semi-transparent, variously sized, thin-walled cysts was found on the splenic serosal surface. Microscopically, each cyst was surrounded by variable amounts of loose connecti...

journal_title：Toxicologic pathology

authors： Shibuya K,Tajima M,Yamate J

更新日期：1993-01-01 00:00:00

abstract：:Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...

journal_title：Toxicologic pathology

authors： Latendresse JR,Pereira MA

更新日期：1997-09-01 00:00:00

abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...

journal_title：Toxicologic pathology

authors： Harris DL,Washington MK,Hood DB,Roberts LJ 2nd,Ramesh A

更新日期：2009-12-01 00:00:00

abstract：:The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP...

journal_title：Toxicologic pathology

authors： Palazzi X,Burkhardt JE,Caplain H,Dellarco V,Fant P,Foster JR,Francke S,Germann P,Gröters S,Harada T,Harleman J,Inui K,Kaufmann W,Lenz B,Nagai H,Pohlmeyer-Esch G,Schulte A,Skydsgaard M,Tomlinson L,Wood CE,Yoshida M

更新日期：2016-08-01 00:00:00

abstract：:This report describes the findings of preclinical testing of SCH 351591, a selective phosphodiesterase 4 inhibitor, in CD-1 mice over a wide range of doses, in which the heart and reproductive organs of both sexes demonstrated toxic effects. Repeat-dose toxicity studies assessed 5, 15, 50, 100, 200, 400, and 800 mg/kg...

journal_title：Toxicologic pathology

authors： Losco PE,Poulet FM,Kaminska-McNamara GZ,Klein MF

更新日期：2010-06-01 00:00:00

abstract：:Ribonucleic acid (RNA) interference (RNAi) is a recently discovered phenomenon whereby the introduction of double stranded (ds) RNA into the cytoplasm of the cell results in the specific and efficient degradation of complementary messenger (m) RNA and, therefore, reduced protein production. It was discovered by chance...

journal_title：Toxicologic pathology

authors： Martineau HM,Pyrah IT

更新日期：2007-04-01 00:00:00

abstract：:The cochlea is one of the more common targets for toxic effects, yet current toxicologic screening in animals does not routinely evaluate the cochlea as a potential target organ. Although histopathologic sections are routinely taken from the eye and the optic nerve and tract and most studies include at least 1 section...

journal_title：Toxicologic pathology

authors： Mattsson JL

更新日期：2000-01-01 00:00:00

abstract：:B6.A.D. (Ahr(d)/Nat(s)) mice were utilized to investigate the short-term pulmonary response to JP-8 jet fuel (JP-8) aerosol inhalation. Mice were nose-only exposed to atmospheres of 0 to 118 mg/m3 for 1 h/d over a period of 7 days to further test the hypothesis that JP-8 concentrations below the permissible exposure l...

journal_title：Toxicologic pathology

authors： Robledo RF,Young RS,Lantz RC,Witten ML

更新日期：2000-09-01 00:00:00

abstract：:In a 13-week feeding toxicity study of grape skin extract (GSE) performed previously, 5.0% GSE showed diffuse hypertrophy and basophilia in rat parotid glands. To clarify whether the change in the parotid glands was an adverse effect of GSE, 6-week-old male F344 rats were fed a diet containing 5.0% GSE or were adminis...

journal_title：Toxicologic pathology

authors： Inoue K,Morikawa T,Matsuo S,Tamura K,Takahashi M,Yoshida M

更新日期：2014-08-01 00:00:00

abstract：:The dose dependence of L-ascorbic acid (AsA) copromotion of urinary bladder carcinogenesis with continuous concomitant administration of NaHCO3 was investigated. In the first experiment, 83 male F344 rats were all given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 wk and then divided into 5 groups, which re...

journal_title：Toxicologic pathology

authors： Iwata H,Yamamoto S,Yano Y,Ohtani S,Fukushima S

更新日期：1997-05-01 00:00:00

abstract：:Apoptosis is a highly regulated mechanism of cell death. Although apoptosis has a functional role in normal development and tissue homeostasis, aberrant triggering of the process by toxicants may lead to abnormal function or disease. Low level exposures to toxicants that induce apoptosis in kidney may therefore create...

journal_title：Toxicologic pathology

authors： Davis MA,Ryan DH

更新日期：1998-11-01 00:00:00

abstract：:This article provides a synopsis of the first two presentations from the second scientific session of the 37th Annual Symposium of the Society of Toxicologic Pathology in Indianapolis, Indiana, on June 18, 2018; the session focused on acute kidney injury. The first presentation, given by Dr. Kevin McDorman, focused on...

journal_title：Toxicologic pathology

authors： Crabbs TA,McDorman KS

更新日期：2018-12-01 00:00:00

abstract：:Helicobacter hepaticus infection induces sustained inflammation and carcinoma of the liver in A/JCr mice, and serves as a model of human cancers associated with viral hepatitis and H. pylorichronic gastritis. Here we describe the pathogenesis of premalignant disease in A/JCr mice infected with H. hepaticus. We inocula...

journal_title：Toxicologic pathology

authors： Rogers AB,Boutin SR,Whary MT,Sundina N,Ge Z,Cormier K,Fox JG

更新日期：2004-11-01 00:00:00

abstract：:Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 w...

journal_title：Toxicologic pathology

authors： Gray RH,Adam-Rodwell GA,Maris D,Haskins JR,Stoner GD

更新日期：1995-11-01 00:00:00