Apoptosis in the kidney.

abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...

journal_title：Toxicologic pathology

authors： Kashida Y,Kato M

更新日期：1997-11-01 00:00:00

abstract：:Spontaneous neoplasm rates were determined for control Fischer 344 (F344) rats and B6C3F1 mice from 2-yr rodent carcinogenicity studies carried out by the National Toxicology Program (NTP). The most frequently occurring neoplasms in untreated male F344 rats were testicular adenoma (89.1%), mononuclear cell leukemia (5...

journal_title：Toxicologic pathology

authors： Haseman JK,Hailey JR,Morris RW

更新日期：1998-05-01 00:00:00

abstract：:B6.A.D. (Ahr(d)/Nat(s)) mice were utilized to investigate the short-term pulmonary response to JP-8 jet fuel (JP-8) aerosol inhalation. Mice were nose-only exposed to atmospheres of 0 to 118 mg/m3 for 1 h/d over a period of 7 days to further test the hypothesis that JP-8 concentrations below the permissible exposure l...

journal_title：Toxicologic pathology

authors： Robledo RF,Young RS,Lantz RC,Witten ML

更新日期：2000-09-01 00:00:00

abstract：:Documentation of Chinese materia medica (CMM) dates back to around 1,100 BC when only dozens of drugs were first described. By the end of the 16th century, the number of drugs documented had reached close to 1,900. And by the end of the last century, published records of CMM have reached 12,800 drugs. The recorded tra...

journal_title：Toxicologic pathology

authors： Leung AY

更新日期：2006-01-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:Focal spontaneously occurring eosinophilic hypertrophic cells, histomorphologically resembling oncocytes and hepatocytes, were observed in the pancreas from 11 (0.3%) of 4,177 Sprague-Dawley rats, 3 to 26 months old. The age of these eleven rats ranged from 13 to 25 months. The incidence was not different between sexe...

journal_title：Toxicologic pathology

authors： Chiu T

更新日期：1987-01-01 00:00:00

abstract：:Clinically, girls appear to be more sensitive than boys to the cardiotoxic effects of doxorubicin, whereas the opposite may be true for adults. To identify and characterize potential sex-related differences, adult male and female spontaneously hypertensive rats (SHR; some ovariectomized [OVX]) received 1 mg/kg of doxo...

journal_title：Toxicologic pathology

authors： Zhang J,Knapton A,Lipshultz SE,Cochran TR,Hiraragi H,Herman EH

更新日期：2014-01-01 00:00:00

abstract：:The histologic effect of 400 mg/M2/day of hydrocortisone, given alternatively from day 7 to day 19 after birth, was studied on the spleen of the immunologically immature rat. Two days after the cessation of treatment, the periarteriolar lymphatic sheaths were found to be largely depleted of small lymphocytes. Immunope...

journal_title：Toxicologic pathology

authors： el Fouhil AF,Iskander FA,Turkall RM

更新日期：1993-01-01 00:00:00

abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...

journal_title：Toxicologic pathology

authors： Shupe JL,Bruner RH,Seymour JL,Alden CL

更新日期：1992-01-01 00:00:00

abstract：:Substantial progress in understanding nongenotoxic or secondary mechanisms of tumorigenesis has been made over the past decade. However, the methods used in regulated studies for assessment of carcinogenic potential in chemicals in development have not evolved significantly. Based on the experience of over 30 yr of te...

journal_title：Toxicologic pathology

authors： Alden CL,Smith PF,Piper CE,Brej L

更新日期：1996-11-01 00:00:00

abstract：:The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. Framing testable hypotheses for experimental a...

journal_title：Toxicologic pathology

authors： Silbergeld EK

更新日期：2017-01-01 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:The definition of diagnostic thresholds is an important aspect of identification and recording of histopathologic lesions in toxicology studies. Although the primary goal of the pathology examination is to identify and interpret lesions associated with the administration of the test article, the toxicologic pathologis...

journal_title：Toxicologic pathology

authors： Long GG,Hardisty JF

更新日期：2012-10-01 00:00:00

abstract：:Biomass burning is a major source of indoor air pollution in rural India. The authors investigated in this study whether cumulative exposures to biomass smoke cause activation of the serine/threonine kinase Akt in airway cells and peripheral blood lymphocytes (PBL). For this, the authors enrolled 87 premenopausal (med...

journal_title：Toxicologic pathology

authors： Mondal NK,Roy A,Mukherjee B,Das D,Ray MR

更新日期：2010-12-01 00:00:00

abstract：:The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic act...

journal_title：Toxicologic pathology

authors： Caspritz G,Hadden J

更新日期：1987-01-01 00:00:00

abstract：:The mouse liver is the primary target site for carcinogenesis of more than 200 chemicals (including pesticides, food additives, pharmaceuticals, and industrial intermediates) tested in long-term toxicity safety assessment assays. Mouse liver tumors develop through defined morphological stages (similar to those found i...

journal_title：Toxicologic pathology

authors： Ward JM,Shibata MA,Devor DE

更新日期：1996-01-01 00:00:00

abstract：:Specific regions in the rodent larynx exhibit cellular changes in response to inhaled xenobiotics. These regions include the base of the epiglottis, ventral pouch, and medial surfaces of the vocal processes of the arytenoid cartilages. There are interspecies differences among laboratory rodents in the microscopic anat...

journal_title：Toxicologic pathology

authors： Renne RA,Sagartz JW,Burger GT

更新日期：1993-11-01 00:00:00

abstract：:Repeated intraperitoneal injections of crocidolite asbestos fibers induced diffuse malignant mesotheliomas in mice. A series of mesothelial cell lines was isolated from mice at different stages in the development of these tumors. The cell lines isolated from mice with mesotheliomas recapitulated their growth pattern i...

journal_title：Toxicologic pathology

authors： Goodglick LA,Vaslet CA,Messier NJ,Kane AB

更新日期：1997-11-01 00:00:00

abstract：:Aroclor 1254, at a dose level of 280 micrograms/kg body weight equivalent to 200 micrograms/kg/day, was given 5 days per week to rhesus monkeys over a 27 to 28 month period. Terminal clinical signs of varying severity included fingernail detachment, exuberant nail beds, weight loss, stomatitis and normocytic anemia. A...

journal_title：Toxicologic pathology

authors： Tryphonas L,Arnold DL,Zawidzka Z,Mes J,Charbonneau S,Wong J

更新日期：1986-01-01 00:00:00

abstract：:Vaginal exfoliative cytology is commonly used in biomedical and toxicological research to classify the stages of the rodent estrous cycle. However, mouse vaginal exfoliative cytology is commonly used as a stand-alone tool and has not been evaluated in reference to vaginal histology and serum sex hormone levels. In thi...

journal_title：Toxicologic pathology

authors： Gal A,Lin PC,Barger AM,MacNeill AL,Ko C

更新日期：2014-12-01 00:00:00

abstract：:Weber, K. (2017). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. J Toxicol Pathol45, 64-75. (Original DOI: 10.1177/0192623316672075) In the January 2017 issue of Toxicologic Pathology, a number of in text Table citations were incorrectly labeled. The following are the sentences ...

journal_title：Toxicologic pathology

authors：

更新日期：2017-04-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:Kozlowski, C., Brumm, J., and Cain, G. (2018). An Automated Image Analysis Method to Quantify Veterinary Bone Marrow Cellularity on H&E Sections. Tox Path46, 324-335. (Original DOI: 10.1177/0192623318766457). Kozlowski, C., Fullerton, A., Cain, G., Katavolos, P., Bravo, J., and Tarrant, J. M. (2018). Proof of Concept ...

journal_title：Toxicologic pathology

authors：

更新日期：2018-08-01 00:00:00

abstract：:Minoxidil, a long-acting vasodilating antihypertensive agent, reduces arterial blood pressure by a direct action on arteriolar smooth muscle. The present studies examined the gross anatomic, histologic and ultrastructural myocardial alterations produced by 2 daily doses of minoxidil in beagle dogs (0.5, 1, or 3 mg/kg)...

journal_title：Toxicologic pathology

authors： Herman EH,Ferrans VJ,Young RS,Balazs T

更新日期：1989-01-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) refers to a decline in renal function following exposure to iodinated contrast media (CM). The present study was initiated to explore the role of known human risk factors (spontaneous hypertension, diabetes, protein-losing nephropathy) on CIN development in rodent models and to deter...

journal_title：Toxicologic pathology

authors： Rouse RL,Stewart SR,Thompson KL,Zhang J

更新日期：2013-01-01 00:00:00

abstract：:Dysfunction of the visual system remains a leading cause of human disability worldwide. Preclinical studies are a key component of efforts to develop drugs and devices to ameliorate visual impairment. Although new opportunities for the delivery of targeted ocular therapeutics have been created, clinical success has be...

journal_title：Toxicologic pathology

authors： Ramos MF,Schafer KA,Sorden SD

更新日期：2021-01-05 00:00:00

abstract：:This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible me...

journal_title：Toxicologic pathology

authors： Getz GS

更新日期：1990-01-01 00:00:00

abstract：:Congenital intrahepatic arteriovenous fistulae, a rare hepatic vascular anomaly, in an 8-mo-old female beagle dog was investigated. The animal showed anorexia, repeated vomiting, hemorrhagic diarrhea, and jaundice for approximately 2 wk. There was mild to severe increase of serum alkaline phosphatase, glutamic-oxalace...

journal_title：Toxicologic pathology

authors： Yoshizawa K,Oishi Y,Matsumoto M,Fukuhara Y,Makino N,Noto T,Fujii T

更新日期：1997-09-01 00:00:00

abstract：:The coronavirus disease 2019 pandemic has affected business on numerous fronts in unprecedented and abrupt ways. From site closures and local "stay-at-home orders" to travel advisories and restrictions, the day-to-day practice of toxicologic pathology has been impacted dramatically and rapidly. A critical function of ...

journal_title：Toxicologic pathology

authors： Hukkanen RR,Irizarry A,Fikes JD,Schafer KA,Boyle MH

更新日期：2020-12-01 00:00:00

abstract：:Recently, considerable attention has been focused on certain environmental contaminants--"endocrine disruptors"--of industrial origin that may mimic the action of sex hormones. Natural compounds and their effects on other types of hormonal activity (eg, on adrenal or thyroid function) have for some reason not provoked...

journal_title：Toxicologic pathology

authors： Nilsson R

更新日期：2000-05-01 00:00:00