Abstract：
:Vaginal exfoliative cytology is commonly used in biomedical and toxicological research to classify the stages of the rodent estrous cycle. However, mouse vaginal exfoliative cytology is commonly used as a stand-alone tool and has not been evaluated in reference to vaginal histology and serum sex hormone levels. In this study, the direct and Giemsa-stained methods of vaginal exfoliative cytology were compared in reference to vaginal fold histology and serum sex hormone levels. Both methods predicted the estrous stages similarly with mean discordance rates of 55%, 77%, 46%, and 31%, for diestrus, proestrus, estrus, and metestrus, respectively. From these results, we conclude that vaginal exfoliative cytology may be used as a general guide to determine the desired estrous stage end point and that a definitive confirmation of the estrous stage should be obtained from evaluation of vaginal fold histology. Confirmation of the stage of the estrous cycle by vaginal fold histology will decrease the variability otherwise introduced by misclassification of estrous cycle stages with vaginal exfoliative cytology.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Gal A,Lin PC,Barger AM,MacNeill AL,Ko Cdoi
10.1177/0192623314526321subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1212-20issue
8eissn
0192-6233issn
1533-1601pii
0192623314526321journal_volume
42pub_type
杂志文章abstract：:Groups of 5 male beagle dogs were treated orally with hydralazine tablets in gelatin capsules at a dose of 12 or 24 mg/kg twice a day (6 hours apart) for 2 consecutive days. Five male dogs treated with empty gelatin capsules served as untreated controls. Clinical findings and heart rate changes during treatment and te...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338701500404
更新日期：1987-01-01 00:00:00
abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309351722
更新日期：2009-12-01 00:00:00
abstract：:Oltipraz, developed as an antischistosomal agent, protects against the hepatotoxicity of many xenobiotics and is known to be an effective inhibitor of experimental carcinogenesis in rodents. In the present study, we investigated its effects on the development of lesions in LEC rats, established as a mutant strain char...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/019262302753559506
更新日期：2002-03-01 00:00:00
abstract：:Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have investigated the potential of furan to induce oxidative stress and DNA damage associated with inflammatory and regenerative responses in rat liver. Furan was ad...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309357946
更新日期：2010-02-01 00:00:00
abstract：:Seventeen mesotheliomas from 395 untreated male Fischer 344/DuCrj rats were studied by light and electron microscopy to define the morphological characteristics of the tumors. In 16 out of 17 rats, mesotheliomas were observed in the abdominal and/or scrotal sac, and the other one was localized on the pleura. Grossly, ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338701500205
更新日期：1987-01-01 00:00:00
abstract：:Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are associated with a mobilization of iron and catalysis of an oxi...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230600932448
更新日期：2006-01-01 00:00:00
abstract：:The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to p...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623316631844
更新日期：2016-06-01 00:00:00
abstract：:This continuing education course presented at the Society of Toxicologic Pathology's 31st Annual Symposium explored and defined the many roles that toxicologic pathologists serve Good Laboratory Practice (GLP)-conducted toxicology and carcinogenicity studies. ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313506521
更新日期：2014-01-01 00:00:00
abstract：:Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339702500501
更新日期：1997-09-01 00:00:00
abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339202000216
更新日期：1992-01-01 00:00:00
abstract：:Neurotoxicants with similar structural features or common mechanisms of chemical action frequently produce widely divergent neuropathologic outcomes. Methylmercury (MeHg) produces marked cerebellar dysmorphogenesis during critical periods of development. The pathologic picture is characterized by complete architectura...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262330002800107
更新日期：2000-01-01 00:00:00
abstract：:Phosphatidylinositol 3-kinases (PI3Ks) regulate intracellular signaling events for multiple cell surface receptors. Phosphatidylinositol 3-kinase δ, 1 of 4 class I PI3K isoforms, is primarily found in leukocytes and regulates immune cell functions. Here, we report changes in the immune and digestive systems that were ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623320966238
更新日期：2020-12-01 00:00:00
abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317721748
更新日期：2017-07-01 00:00:00
abstract：:Histopathologic examination of the testis from juvenile rats is often necessary to characterize the safety of new drugs for pediatric use and is a required end point in male pubertal development and thyroid function assays. To aid in evaluation and interpretation of the immature testis, the characteristic histologic f...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623314547279
更新日期：2015-04-01 00:00:00
abstract：:Dogs treated with AR-H047108, an imidazopyridine potassium competitive acid blocker (P-CAB), developed clinical signs of hepatic dysfunction as well as morphologically manifest hepatotoxicity in repeat-dose toxicity studies. An investigative one-month study was performed, with interim euthanasia after one and two week...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623308320802
更新日期：2008-07-01 00:00:00
abstract：:Aminoglycoside antibiotics are ototoxic in mammals and birds, including recently hatched chicks, but chicken embryos are insensitive to the ototoxicity of gentamicin, kanamycin, and streptomycin. To determine whether or not the insensitivity is due to a lack of antibiotic distribution to the avian cochlea, the distrib...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339402200103
更新日期：1994-01-01 00:00:00
abstract：:The use of biodegradable materials is gaining popularity in medicine, especially in orthopedic applications. However, preclinical evaluation of biodegradable materials can be challenging, since they are located in close contact with host tissues and might be implanted for a long period of time. Evaluation of these com...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315600275
更新日期：2015-12-01 00:00:00
abstract：:Direct tissue profiling and imaging mass spectrometry (MS) allow for detailed mapping of the complex protein pattern across a tissue sample. Utilization of these tools provides spatial information across a tissue section for target protein expression and can be used to correlate changes in expression levels with speci...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230590881862
更新日期：2005-01-01 00:00:00
abstract：:Sensitive kidney safety assessment is important for successful drug development in both preclinical and clinical stages. The Food and Drug Administration recently qualified a composite measure of 6 urine creatinine-normalized biomarkers, such as clusterin, cystatin C, kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glu...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623320964391
更新日期：2020-12-01 00:00:00
abstract：:The B6C3F1 strain of mice is prone to develop liver nodules as animals grow older. This spontaneous tumor development is enhanced by dietary lipotrope deficiency. The present studies were performed to evaluate the liver of the B6C3F1 mice in early periods of lipotrope deficiency and before the nodules appear. Mice wer...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300103
更新日期：1985-01-01 00:00:00
abstract：:We have previously indicated that the ideal animal tumor model should mimic the human disease. This means that the investigator should be able to ascertain the influence of host factors on the initiation of tumorigenesis, mimic the susceptibility of tumor response based on age and reproductive history, and determine t...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623314532036
更新日期：2015-02-01 00:00:00
abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315572700
更新日期：2015-08-01 00:00:00
abstract：:7,12-Dimethylbenz[a]anthracene (DMBA) presents a pollutant implicated in various toxicological effects. The aim of this experiment was to study the effects of DMBA administration on oxidative stress, histopathological signs, and 18 kDa translocator protein (TSPO) binding characteristics in rat liver. We also studied t...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310379137
更新日期：2010-10-01 00:00:00
abstract：:Phentolamine is a reversible competitive alpha-adrenergic antagonist with similar affinities for alphal and alpha2 receptors. It has a long history of safe clinical use, and was developed as a potential therapy for male erectile dysfunction because of its capacity to increase the arteriolar blood flow to the corpora c...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230490505086
更新日期：2004-09-01 00:00:00
abstract：:In vitro techniques for the culture of hemopoietic stem cells and committed hemopoietic progenitor cells in rat bone marrow have not been adequately described in the literature. In the present investigations, and using commercially available hemopoietic cytokines and growth factors, the conditions required to perform ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623308328133
更新日期：2009-02-01 00:00:00
abstract：:Apoptosis is a highly regulated mechanism of cell death. Although apoptosis has a functional role in normal development and tissue homeostasis, aberrant triggering of the process by toxicants may lead to abnormal function or disease. Low level exposures to toxicants that induce apoptosis in kidney may therefore create...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339802600615
更新日期：1998-11-01 00:00:00
abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339101900403
更新日期：1991-01-01 00:00:00
abstract：:The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identi...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623318823150
更新日期：2019-02-01 00:00:00
abstract：:The title of the 2017 Society of Toxicologic Pathology symposium was "Musculoskeletal System." A brief overview of the General Scientific Symposium is presented herein and describes the topics presented by each speaker. Symposium speakers addressed subjects pertinent to musculoskeletal system toxicologic pathology and...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623317738211
更新日期：2017-10-01 00:00:00
abstract：:To investigate pathogenesis of post-bile duct (BD) injury fibrosis, interlobular BD epithelial injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 mg/kg body weight) and rats were observed for 12 days. On days 1 to 2, cholangiocytes were injured and desquamated. On days 3 to 5...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311413790
更新日期：2011-08-01 00:00:00
