Abstract：
:The B6C3F1 strain of mice is prone to develop liver nodules as animals grow older. This spontaneous tumor development is enhanced by dietary lipotrope deficiency. The present studies were performed to evaluate the liver of the B6C3F1 mice in early periods of lipotrope deficiency and before the nodules appear. Mice were fed high levels of dietary fat (cotton seed oil or beef fat) without choline or vitamin B12. The livers of these mice were compared with those of mice subjected to partial hepatectomy or dietary phenobarbital both of which enhance liver nodule formation. The ability of putative preneoplastic hepatocytes to exclude parenteral-administered iron was used to detect this eventual phenotype. A lipotrope-deficient condition was established which typically exhibited fatty liver and increased cell proliferation, the latter measured by autoradiography. In the time periods evaluated the lipotrope-devoid diets were not sufficient to induce nodular or putative preneoplastic lesions. An excessively high activity of p-nitroanisole-O-demethylase and a single small fatty nodule were obtained when phenobarbital was added to the lipotrope-deficient diet. Scattered eosinophilic hepatocytes were seen in every experimental group when the histologic slides were stained for iron pigments, but their biologic significance in the present experiments could not be established. Under the conditions of this study, the liver of the B6C3F1 strain of mouse exhibited only minor indications of future tumor development.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
de Camargo JL,Punyarit P,Newberne PMdoi
10.1177/019262338501300103subject
Has Abstractpub_date
1985-01-01 00:00:00pages
10-7issue
1eissn
0192-6233issn
1533-1601journal_volume
13pub_type
杂志文章abstract：:Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310369343
更新日期：2010-06-01 00:00:00
abstract：:The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. Framing testable hypotheses for experimental a...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623316672073
更新日期：2017-01-01 00:00:00
abstract：:We conducted a retrospective analysis of publicly available preclinical toxicology studies with erythropoiesis-stimulating agents (ESAs) to examine common adverse events in rats, Beagle dogs, and cynomolgus monkeys. Mortality and/or thrombotic events were reported sporadically in a subset of studies and attributed to ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623313486317
更新日期：2014-01-01 00:00:00
abstract：:Hepatic microsomal enzymes play an important role in thyroid hormone homeostasis. Glucuronidation of thyroxine is the rate limiting step in the biliary excretion of thyroxine in the rat; the monodeiodinases are important in the conversion of T4 to T3 and reverse T3 and subsequent deiodinations. Phenobarbital is known ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262338901700206
更新日期：1989-01-01 00:00:00
abstract：:We have developed a guinea pig model of iron overload toxicity. Animals were administered intraperitoneal iron dextran 3 times a week to achieve total body iron load of 0.25, 0.5, 1.0, 1.5, and 2.0 g Fe/kg body weight in less than 30 days. Quantitation of tissue iron levels with atomic absorption indicated increased i...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339302100307
更新日期：1993-01-01 00:00:00
abstract：:d-galactosamine (d-GalN) is a well-known hepatotoxic agent that causes liver injury. Conversely, hepatic macrophages play a crucial role in maintaining liver tissue integrity. Macrophage functions were investigated in hepatic lesions induced by a single intraperitoneal injection of d-GalN (800 mg/kg body weight [BW]) ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623318801574
更新日期：2018-10-01 00:00:00
abstract：:A comparative study of histochemical detection of eosinophils in fixed murine tissue is lacking. Five histochemical methods previously reported for eosinophil detection were quantitatively and qualitatively compared in an established murine RSV vaccine-enhanced inflammation model. Nonspecific neutrophil staining was e...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623308329342
更新日期：2009-02-01 00:00:00
abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300305
更新日期：1985-01-01 00:00:00
abstract：:Partial hepatectomy (PH) and neonatal rat short-term liver focus models were used to examine the effects of selected chemicals that had been previously tested in the National Toxicology Program (NTP) 2-yr carcinogenicity studies. C.I. Solvent Yellow 14, monuron, chlorendic acid, and 4-hydroxyacetanilide were tested fo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623389017004110
更新日期：1989-01-01 00:00:00
abstract：:Most available data on the involvement of p53 in rodent carcinogenesis are based on results of the end point of chemically or virally induced carcinogenesis, i.e., tumors. To investigate the role of altered p53 expression in early stages of rodent hepatocarcinogenesis in a systematic way, we treated male Wistar rats f...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600507
更新日期：1998-09-01 00:00:00
abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315572700
更新日期：2015-08-01 00:00:00
abstract：:This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks. A total of 120 chicks were divided equally into 4 groups and were fed poultry mash without ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230490431745
更新日期：2004-05-01 00:00:00
abstract：:A nondopaminergic antipsychotic agent, 5-ethyl-1,3,8-trimethyl-1H-imidazo]1,2-c]pyrazolo[3,4-e]pyrimidine (TIPP; PD 112488), has been tested for potential toxicity in rats. As part of a preclinical safety evaluation, 10 Wistar rats per sex were administered TIPP as a dietary admixture, receiving doses of 0, 5, 10, 20,...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339402200106
更新日期：1994-01-01 00:00:00
abstract：:This continuing education course presented at the Society of Toxicologic Pathology's 31st Annual Symposium explored and defined the many roles that toxicologic pathologists serve Good Laboratory Practice (GLP)-conducted toxicology and carcinogenicity studies. ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313506521
更新日期：2014-01-01 00:00:00
abstract：:The performance of the p53-/- transgenic (knockout) mouse model was evaluated through review of the data from 31 short-term carcinogenicity studies with 21 compounds tested as part of the International Life Sciences Institute's (ILSI) Alternatives to Carcinogenicity Testing (ACT) project, together with data from other...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262338601400103
更新日期：1986-01-01 00:00:00
abstract：:The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and biochemistry of minipigs are similar enough to humans to consider them as ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315617562
更新日期：2016-04-01 00:00:00
abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317721748
更新日期：2017-07-01 00:00:00
abstract：:Many goitrogenic xenobiotics that increase the incidence of thyroid tumors in rodents exert a direct effect on the thyroid gland to disrupt one of several possible steps in the biosynthesis, secretion, and metabolism of thyroid hormones. This includes (a) inhibition of the iodine trapping mechanism, (b) blockage of or...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339702500109
更新日期：1997-01-01 00:00:00
abstract：:More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues. Formulating these compounds as pure drug nanoparticles is one ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
abstract：:The definition of diagnostic thresholds is an important aspect of identification and recording of histopathologic lesions in toxicology studies. Although the primary goal of the pathology examination is to identify and interpret lesions associated with the administration of the test article, the toxicologic pathologis...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623312443322
更新日期：2012-10-01 00:00:00
abstract：:This report documents the histological changes in nude mouse skin and in human skin xenografts on nude mice following exposure to phenyldichloroarsine (PDA), a vesicant arsenical. Under light microscopy, we observed in PDA-treated human skin grafts: 1) degeneration of epidermal cell nuclei (apparent by 2 hr after expo...
journal_title：Toxicologic pathology
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doi：10.1177/019262338701500204
更新日期：1987-01-01 00:00:00
abstract：:Astrocytes assume multiple roles in maintaining an optimally suited milieu for neuronal function. Select astrocytic functions include the maintenance of redox potential, the production of trophic factors, the regulation of neurotransmitter and ion concentrations, and the removal of toxins and debris from the cerebrosp...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623310385254
更新日期：2011-01-01 00:00:00
abstract：:Direct tissue profiling and imaging mass spectrometry (MS) allow for detailed mapping of the complex protein pattern across a tissue sample. Utilization of these tools provides spatial information across a tissue section for target protein expression and can be used to correlate changes in expression levels with speci...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230590881862
更新日期：2005-01-01 00:00:00
abstract：:In order to investigate the role of the stimulation of cell division for the initiation (and possibly promotion) of liver tumors by chemical carcinogens, the incorporation of radiolabelled thymidine into liver DNA was determined in male rats. Single doses of various levels of aflatoxin B1, benzidine and carbon tetrach...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338401200118
更新日期：1984-01-01 00:00:00
abstract：:In a simulated fire-related smoke exposure protocol, New Zealand white rabbits were utilized to investigate the potential effects of the 21-aminosteroid (lazaroid) analog U75412E on the early events of acute lung injury. Inhalation of a total of 1.6 mg/kg U75412E aerosolized at a rate of 1.53 mg/min at 0.5 hr after sm...
journal_title：Toxicologic pathology
pub_type： 杂志文章
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更新日期：1999-05-01 00:00:00
abstract：:The expression of specific cytokeratin (CK) polypeptide patterns is a sensitive marker of the cytoskeletal differentiation of epithelial cells. We developed an immunohistochemical method to assess CK expression patterns in the rat respiratory tract using serial paraffin-embedded sections from the nasal cavity, trachea...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600308
更新日期：1998-05-01 00:00:00
abstract：:Toxicologists and pathologists worldwide will benefit from a new, website-based, and completely searchable Nonneoplastic Lesion Atlas just released by the U.S. National Toxicology Program (NTP). The atlas is a much-needed resource with thousands of high-quality, zoomable images and diagnostic guidelines for each roden...
journal_title：Toxicologic pathology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...
journal_title：Toxicologic pathology
pub_type： 评论,杂志文章
doi：10.1177/019262339902700503
更新日期：1999-09-01 00:00:00
abstract：:Many common inflammatory disorders are characterized by the infiltration of neutrophils across epithelial lined (mucosal) surfaces resulting in disruption of critical barrier function that protects from microbes and noxious agents. In such conditions, disease symptoms are complex but directly related to leukocyte effe...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623313511336
更新日期：2014-01-01 00:00:00
