Abstract：
:Seventeen mesotheliomas from 395 untreated male Fischer 344/DuCrj rats were studied by light and electron microscopy to define the morphological characteristics of the tumors. In 16 out of 17 rats, mesotheliomas were observed in the abdominal and/or scrotal sac, and the other one was localized on the pleura. Grossly, tumors were yellow-brown with various-sized multiple modules growing irregularly over the surface of the serosa. Microscopically, they varied from complex papillary to sessile nodular growths. Tumor cells were cuboidal to polygonal with round to oval nuclei, and were sometimes arranged in tubule-like structures. Occasionally, the cells contained Mowry's colloidal iron positive materials, which were negative following prior incubation with hyaluronidase. Furthermore, intracellular keratins were detected using the peroxidase-antiperoxidase method. Ultrastructural features of tumor cells included numerous microvilli, a basement membrane, junctional complexes, abundant cytofilaments, dilated rough surfaced endoplasmic reticulum cisternae, and a well-developed Golgi apparatus. The morphological characteristics of these tumors in Fischer 344 rats were consistent with those in humans and with experimentally induced counterparts in rats. The histogenesis of these tumors and the variability in their incidence following oral administration of chemical carcinogens is discussed.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Tanigawa H,Onodera H,Maekawa Adoi
10.1177/019262338701500205subject
Has Abstractpub_date
1987-01-01 00:00:00pages
157-63issue
2eissn
0192-6233issn
1533-1601journal_volume
15pub_type
杂志文章abstract：:Parenteral administration of recombinant hematopoietic growth factors has been sporadically associated with cutaneous complications, including injection site reactions in humans and nonhuman primates. In this study, subcutaneous injection sites were evaluated from 12 cynomolgus monkeys administered a recombinant human...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339602400401
更新日期：1996-07-01 00:00:00
abstract：:At present (putative) human carcinogens are identified via epidemiological studies and testing using the chronic 2-yr rodent bioassay. Both methods have severe limitations in that they are slow, insensitive, expensive, and are also hampered by many uncertainties. The development of methods to modify specific genes in ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339802600605
更新日期：1998-11-01 00:00:00
abstract：:Livers of male Sprague-Dawley rats were evaluated for foci and nodules 90 days and 16 months after one or two oral doses of 1,2-dibromoethane (DBE). Rats (190 g) were given the following oral treatments. Controls received corn oil (2.5 ml/kg) at 0 and 24 hr. DBE X 1 received corn oil at 0 hr and 75 mg DBE/kg at 24 hr....
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338401200402
更新日期：1984-01-01 00:00:00
abstract：:Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313486316
更新日期：2014-01-01 00:00:00
abstract：:We conducted a retrospective analysis of publicly available preclinical toxicology studies with erythropoiesis-stimulating agents (ESAs) to examine common adverse events in rats, Beagle dogs, and cynomolgus monkeys. Mortality and/or thrombotic events were reported sporadically in a subset of studies and attributed to ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623313486317
更新日期：2014-01-01 00:00:00
abstract：:7,12-Dimethylbenz[a]anthracene (DMBA) presents a pollutant implicated in various toxicological effects. The aim of this experiment was to study the effects of DMBA administration on oxidative stress, histopathological signs, and 18 kDa translocator protein (TSPO) binding characteristics in rat liver. We also studied t...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310379137
更新日期：2010-10-01 00:00:00
abstract：:Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339802600110
更新日期：1998-01-01 00:00:00
abstract：:The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to p...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623316631844
更新日期：2016-06-01 00:00:00
abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...
journal_title：Toxicologic pathology
pub_type： 评论,杂志文章
doi：10.1177/019262339902700503
更新日期：1999-09-01 00:00:00
abstract：:Many antisense oligonucleotides (ASOs) from several classes of molecules are currently in drug development. Despite over 20 years of pharmaceutical research, few ASOs have been marketed due to problems with clinical efficacy or preclinical toxicologic challenges. However, a number of recent developments have renewed i...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623314551840
更新日期：2015-01-01 00:00:00
abstract：:Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological m...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623318767065
更新日期：2018-04-01 00:00:00
abstract：:The 2012 annual National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held in Boston in advance of the Society of Toxicologic Pathology's 31st annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic patholog...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623312467102
更新日期：2013-02-01 00:00:00
abstract：:Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cancer bioassays has been due to lack of historical data and diagnostic cr...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311436181
更新日期：2012-06-01 00:00:00
abstract：:Alanine aminotransferase (ALT) is used as an indicator of hepatocellular injury. Since ALT consists of two isoenzymes, a better understanding of ALT isoenzyme biology in response to compounds that cause metabolic adaptive versus hepatotoxic responses will allow for a more accurate assessment of the significance of an ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623312447550
更新日期：2012-12-01 00:00:00
abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300305
更新日期：1985-01-01 00:00:00
abstract：:Oxidant generation catalyzed by metals has been postulated to account for a lung injury following exposure to air pollution particles. In particles that are predominantly carbonaceous, it is difficult to implicate such an oxidative stress as the responsible mechanism, since concentrations of metals can be extremely lo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262330002800416
更新日期：2000-07-01 00:00:00
abstract：:Selenoprotein P is an abundant extracellular protein that is expressed in liver, brain, and other tissues. Studies in mice with the selenoprotein P gene deleted (Sepp-/- mice) have implicated the protein in maintaining brain selenium. Sepp-/- mice fed a normal or low selenium diet develop severe motor impairment and d...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230500243045
更新日期：2005-01-01 00:00:00
abstract：:Female mammals are born with a finite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopuase in women). Exposure of women to known ovotoxicants, such as contaminants in cigarette smoke, ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/019262301301418892
更新日期：2001-01-01 00:00:00
abstract：:The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230600773941
更新日期：2006-01-01 00:00:00
abstract：:Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of biological functions involved in autoimmune disease pathogenesis. Th...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623316654015
更新日期：2016-10-01 00:00:00
abstract：:Recommendations (best practices) are provided by the Society of Toxicologic Pathology's Adversity Working Group for making consistent interpretations of test article-related effects as "adverse" and assigning a "no observed adverse effect level" (NOAEL) in nonclinical toxicity studies. Adverse is a term indicating "ha...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315623265
更新日期：2016-02-01 00:00:00
abstract：:ISIS 2302 is a phosphorothioate oligodeoxynucleotide with a sequence complementary to the mRNA of human intercellular adhesion molecule 1 (ICAM-1). Hybridization of ISIS 2302 to the mRNA inhibits expression of the ICAM-1 protein in response to inflammatory stimuli. A murine active antisense oligonucleotide, ISIS 3082,...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339902700117
更新日期：1999-01-01 00:00:00
abstract：:The development process of myelination varies between region and species. Fully myelinated fibers are required if mammalian neural circuits are to function normally. Histology samples at staggered time points throughout the study were examined at days 4, 5, 7, 8, 10, 14, 17, 24, 37, and 44. We suggest that the develop...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313503518
更新日期：2014-07-01 00:00:00
abstract：:Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma forma...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230701748164
更新日期：2007-12-01 00:00:00
abstract：:Neurotoxicants with similar structural features or common mechanisms of chemical action frequently produce widely divergent neuropathologic outcomes. Methylmercury (MeHg) produces marked cerebellar dysmorphogenesis during critical periods of development. The pathologic picture is characterized by complete architectura...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262330002800107
更新日期：2000-01-01 00:00:00
abstract：:In standard toxicity studies, the cardiac conduction tissue is not systematically sampled and examined for histopathological changes. Most methods described use serial sectioning perpendicular to the long axis of the sinoauricular node (SAN) and atrioventricular node (AVN). Dozens of slides are needed to allow examina...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300107
更新日期：1995-01-01 00:00:00
abstract：:Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 w...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300602
更新日期：1995-11-01 00:00:00
abstract：:Two-year mouse and rat bioassay studies of 2-methylimidazole (2-MI) conducted by the National Toxicology Program revealed that epididymal sperm granuloma(SG)s occurred only in male B6C3F1 mice in a dose-related manner. The present study characterized 2-MI-induced SGs in these epididymides. Groups of 50 male B6C3F1 mic...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230590922866
更新日期：2005-01-01 00:00:00
abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339202000216
更新日期：1992-01-01 00:00:00
abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315572700
更新日期：2015-08-01 00:00:00
