Long-term Local and Systemic Safety of Poly(L-lactide-co-epsilon-caprolactone) after Subcutaneous and Intra-articular Implantation in Rats.

abstract：:A comparative study of histochemical detection of eosinophils in fixed murine tissue is lacking. Five histochemical methods previously reported for eosinophil detection were quantitatively and qualitatively compared in an established murine RSV vaccine-enhanced inflammation model. Nonspecific neutrophil staining was e...

journal_title：Toxicologic pathology

authors： Meyerholz DK,Griffin MA,Castilow EM,Varga SM

更新日期：2009-02-01 00:00:00

abstract：:Bioabsorbable implants can be advantageous for certain surgical tissue bioengineering applications and implant-assisted tissue repair. They offer the obvious benefits of nonpermanence and eventual restoration of the native tissue's biomechanical and immunological properties, while providing a structural scaffold for h...

journal_title：Toxicologic pathology

authors： Rousselle SD,Ramot Y,Nyska A,Jackson ND

更新日期：2019-04-01 00:00:00

abstract：:(+/-)-trans-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-diol) and 9-hydroxybenzo(a)pyrene (9-OH-BP) were metabolized by rat liver microsomes in the presence of calf thymus DNA, resulting in preferential DNA binding of fluorescent (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) and 9-OH-BP-4,5-epoxide, respectively. When the ...

journal_title：Toxicologic pathology

authors： Gräslund A,Jernström B,Undeman O,Dock L,Ehrenberg A,Astlind T

更新日期：1984-01-01 00:00:00

abstract：:Two-year toxicity studies were conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. With goldenseal root powder, the primary finding was an increase in liver tumors in rats and mice, and with milk thistle extract, a decrease in spontaneous backgroun...

journal_title：Toxicologic pathology

authors： Dunnick JK,Singh B,Nyska A,Peckham J,Kissling GE,Sanders JM

更新日期：2011-02-01 00:00:00

abstract：:Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cancer bioassays has been due to lack of historical data and diagnostic cr...

journal_title：Toxicologic pathology

authors： Nambiar PR,Turnquist SE,Morton D

更新日期：2012-06-01 00:00:00

abstract：:The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. Framing testable hypotheses for experimental a...

journal_title：Toxicologic pathology

authors： Silbergeld EK

更新日期：2017-01-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:The B6C3F1 strain of mice is prone to develop liver nodules as animals grow older. This spontaneous tumor development is enhanced by dietary lipotrope deficiency. The present studies were performed to evaluate the liver of the B6C3F1 mice in early periods of lipotrope deficiency and before the nodules appear. Mice wer...

journal_title：Toxicologic pathology

authors： de Camargo JL,Punyarit P,Newberne PM

更新日期：1985-01-01 00:00:00

abstract：:B6.A.D. (Ahr(d)/Nat(s)) mice were utilized to investigate the short-term pulmonary response to JP-8 jet fuel (JP-8) aerosol inhalation. Mice were nose-only exposed to atmospheres of 0 to 118 mg/m3 for 1 h/d over a period of 7 days to further test the hypothesis that JP-8 concentrations below the permissible exposure l...

journal_title：Toxicologic pathology

authors： Robledo RF,Young RS,Lantz RC,Witten ML

更新日期：2000-09-01 00:00:00

abstract：:The chloracetanilide herbicide alachlor (2-chloro-2',6-diethyl-N-(methoxymethyl)-acetanilide) induces nasal neoplasms in rats following chronic dietary exposure. The present study sought to identify the cellular origin and mechanisms of tumor induction and progression. Male Long-Evans rats were fed alachlor (0 or 126 ...

journal_title：Toxicologic pathology

authors： Genter MB,Burman DM,Dingeldein MW,Clough I,Bolon B

更新日期：2000-11-01 00:00:00

abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...

journal_title：Toxicologic pathology

authors： Kemp DR,Percy DH,Hayes MA

更新日期：1991-01-01 00:00:00

abstract：:Slc:Wistar male rats treated with human natural tumor necrosis factor alpha (hn TNF-alpha, 3 X 10(5) Japan reference units/kg intravenously) for 3 months showed histologic vacuolation of basophils in the anterior pituitary, hyperplasia of the thyroidal follicular epithelium, and hyperplasia of the testicular interstit...

journal_title：Toxicologic pathology

authors： Kakinuma C,Hamada Y,Futamura Y,Kuwayama C,Shimoi A,Shibutani Y

更新日期：1999-07-01 00:00:00

abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...

journal_title：Toxicologic pathology

authors： Hottendorf GH

更新日期：1985-01-01 00:00:00

abstract：:The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment. Male Balb/c mice received a single intraperitoneal injection of DENA (0, 2.5, 10.0, 25.0 or 50.0 micrograms/gbw) in saline on day 15 of age. N...

journal_title：Toxicologic pathology

authors： Klaunig JE,Pereira MA,Ruch RJ,Weghorst CM

更新日期：1988-01-01 00:00:00

abstract：:Monocrotaline pyrrole (MCTP) is a highly reactive pneumotoxic metabolite of the pyrrolizidine alkaloid plant toxin monocrotaline. When administered to rats, it causes a delayed and progressive lung injury, vascular remodeling, and pulmonary hypertension. Structural remodeling consists of endothelial cell swelling foll...

journal_title：Toxicologic pathology

authors： Lappin PB,Roth RA

更新日期：1997-07-01 00:00:00

abstract：:The role of articular chondrocytes and matrix degrading enzymes such as collagenase and neutral protease in the pathogenesis of quinolone-induced cartilage degeneration was investigated in immature guinea pigs. Articular cartilage from nalidixic acid (NA) treated guinea pigs was examined for the presence of protease a...

journal_title：Toxicologic pathology

authors： Bendele AM,Hulman JF,Harvey AK,Hrubey PS,Chandrasekhar S

更新日期：1990-01-01 00:00:00

abstract：:A compendium of carcinogenesis bioassay results organized by target organ is presented for 738 chemicals that are carcinogenic in chronic-exposure, long-term bioassays in at least 1 species. This compendium is based primarily on experiments in rats or mice; results in hamsters, monkeys, and dogs are also reported. The...

journal_title：Toxicologic pathology

authors： Gold LS,Manley NB,Slone TH,Ward JM

更新日期：2001-11-01 00:00:00

abstract：:Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...

journal_title：Toxicologic pathology

authors： Yamate J,Iwaki M,Nakatsuji S,Kuwamura M,Kotani T,Sakuma S

更新日期：1998-09-01 00:00:00

abstract：:Existing liver perfusion models are largely limited by high degrees of ischemic and reperfusion injury and the lack of standardization. To establish a highly standardized perfusion model and minimize reperfusion injury, a porcine liver perfusion model was developed using an artificial heart pump (Buecherl Artificial H...

journal_title：Toxicologic pathology

authors： Nagel S,Hegemann O,Groneberg DA,Grosse-Siestrup C

更新日期：2005-01-01 00:00:00

abstract：:Macrophages appearing in lesions are polarized toward M1 (for inflammation) and M2 (for anti-inflammation/fibrosis) types. We analyzed immunophenotypes of macrophages appearing in myocardial lesion in rats injected once with isoproterenol (10 mg/kg body weight). Inflammation following myocardial necrosis on day 1 was ...

journal_title：Toxicologic pathology

authors： Koga M,Karim MR,Kuramochi M,Izawa T,Kuwamura M,Yamate J

更新日期：2021-01-05 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:Dogs treated with AR-H047108, an imidazopyridine potassium competitive acid blocker (P-CAB), developed clinical signs of hepatic dysfunction as well as morphologically manifest hepatotoxicity in repeat-dose toxicity studies. An investigative one-month study was performed, with interim euthanasia after one and two week...

journal_title：Toxicologic pathology

authors： Berg AL,Böttcher G,Andersson K,Carlsson E,Lindström AK,Huby R,Håkansson H,Skånberg-Wilhelmsson I,Hellmold H

更新日期：2008-07-01 00:00:00

abstract：:Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma forma...

journal_title：Toxicologic pathology

authors： Li Y,Wheeler DL,Ananthaswamy HN,Verma AK,Oberley TD

更新日期：2007-12-01 00:00:00

abstract：:Hepatocyte suspensions prepared from inbred male Wistar-Kyoto rats were transplanted to the livers of syngeneic recipients by injection into the portal venous system immediately after partial hepatectomy. Donor cells were labelled with 51Cr in vitro before transplantation. Animals were sacrificed 1 hr, 10 hr, 48 hr, o...

journal_title：Toxicologic pathology

authors： Saeter G,Schwarze PE,Nesland JM,Seglen PO

更新日期：1987-01-01 00:00:00

abstract：:In vitro techniques for the culture of hemopoietic stem cells and committed hemopoietic progenitor cells in rat bone marrow have not been adequately described in the literature. In the present investigations, and using commercially available hemopoietic cytokines and growth factors, the conditions required to perform ...

journal_title：Toxicologic pathology

authors： Molyneux G,Rizzo S,Turton J,Phul P,Gibson F

更新日期：2009-02-01 00:00:00

abstract：:Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area and stimulates catecholamine secretion from the adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia and neoplasia. We investigated the possible correlation betwe...

journal_title：Toxicologic pathology

authors： Ozaki K,Haseman JK,Hailey JR,Maronpot RR,Nyska A

更新日期：2002-03-01 00:00:00

abstract：:Recent clinical evidence suggests that hylan, a modified hyaluronan, and related products potentially elicit foreign body granulomatous inflammation in human soft tissue. We investigated the biocompatibility of hylan G-F 20 (Synvisc) for up to 28 days after intradermal injection in guinea pigs and intramuscular inject...

journal_title：Toxicologic pathology

authors： Sasaki M,Miyazaki Y,Takahashi T

更新日期：2003-05-01 00:00:00

abstract：:In a 13-week feeding toxicity study of grape skin extract (GSE) performed previously, 5.0% GSE showed diffuse hypertrophy and basophilia in rat parotid glands. To clarify whether the change in the parotid glands was an adverse effect of GSE, 6-week-old male F344 rats were fed a diet containing 5.0% GSE or were adminis...

journal_title：Toxicologic pathology

authors： Inoue K,Morikawa T,Matsuo S,Tamura K,Takahashi M,Yoshida M

更新日期：2014-08-01 00:00:00

abstract：:Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological m...

journal_title：Toxicologic pathology

authors： Ureshino RP,Costa AJ,Erustes AG,Pereira GJDS,Sinigaglia-Coimbra R,Smaili SS

更新日期：2018-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...

journal_title：Toxicologic pathology

authors： Kakiuchi-Kiyota S,Arnold LL,Yokohira M,Koza-Taylor P,Suzuki S,Varney M,Pennington KL,Cohen SM

更新日期：2011-12-01 00:00:00