Evolution of alachlor-induced nasal neoplasms in the Long-Evans rat.

abstract：:An eosinophilic substance (ES) is usually observed in the mouse nasal septum. In contrast to textbooks and one report describing ES as amyloid, a previous study by the authors revealed that ES is not amyloid but consists of collagen and an amorphous material. Furthermore, it was suggested that the amorphous material w...

journal_title：Toxicologic pathology

authors： Doi T,Kokoshima H,Kanno T,Sato J,Wako Y,Tsuchitani M,Matsui T

更新日期：2010-06-01 00:00:00

abstract：:Chronic ingestion of arsenic is associated with increased incidence of respiratory and cardiovascular diseases. To investigate the role of arsenic in early events in vascular pathology, C57BL/6 mice ingested drinking water with or without 50 ppb sodium arsenite (AsIII) for four, five, or eight weeks. At five and eight...

journal_title：Toxicologic pathology

authors： Hays AM,Lantz RC,Rodgers LS,Sollome JJ,Vaillancourt RR,Andrew AS,Hamilton JW,Camenisch TD

更新日期：2008-10-01 00:00:00

abstract：:With the increasing use of animal-based biomaterials for regenerative medical applications, the need for their safety assessment is paramount. A porcine cholecyst-derived scaffold (CDS), intended as a muscle repair graft, prepared by a nondetergent/enzymatic method was engrafted in a rat abdominal wall defect model. H...

journal_title：Toxicologic pathology

authors： Balakrishnan-Nair DK,Nair ND,Venugopal SK,Das VN,George S,Abraham MJ,Eassow S,Alison MR,Sainulabdeen A,Anilkumar TV

更新日期：2018-02-01 00:00:00

abstract：:This is a survey of the results of recent investigations on gastrointestinal (GI) peptide hormones. In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known. These include vasoactive intestin...

journal_title：Toxicologic pathology

authors： Tansy MF,Kendall FM

更新日期：1988-01-01 00:00:00

abstract：:Minoxidil, a long-acting vasodilating antihypertensive agent, reduces arterial blood pressure by a direct action on arteriolar smooth muscle. The present studies examined the gross anatomic, histologic and ultrastructural myocardial alterations produced by 2 daily doses of minoxidil in beagle dogs (0.5, 1, or 3 mg/kg)...

journal_title：Toxicologic pathology

authors： Herman EH,Ferrans VJ,Young RS,Balazs T

更新日期：1989-01-01 00:00:00

abstract：:Benzene is of particular concern because of recent research indicating that benzene exposure can result in toxicity. The hematotoxic effect of benzene is mentioned. However, there is little knowledge about the correlation between the biomarker of benzene exposure and changes in red blood cell parameters. Here, the cor...

journal_title：Toxicologic pathology

authors： Wiwanitkit V,Soogarun S,Suwansaksri J

更新日期：2007-02-01 00:00:00

abstract：:This report describes the findings of preclinical testing of SCH 351591, a selective phosphodiesterase 4 inhibitor, in CD-1 mice over a wide range of doses, in which the heart and reproductive organs of both sexes demonstrated toxic effects. Repeat-dose toxicity studies assessed 5, 15, 50, 100, 200, 400, and 800 mg/kg...

journal_title：Toxicologic pathology

authors： Losco PE,Poulet FM,Kaminska-McNamara GZ,Klein MF

更新日期：2010-06-01 00:00:00

abstract：:Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological m...

journal_title：Toxicologic pathology

authors： Ureshino RP,Costa AJ,Erustes AG,Pereira GJDS,Sinigaglia-Coimbra R,Smaili SS

更新日期：2018-04-01 00:00:00

abstract：:The use of biodegradable materials is gaining popularity in medicine, especially in orthopedic applications. However, preclinical evaluation of biodegradable materials can be challenging, since they are located in close contact with host tissues and might be implanted for a long period of time. Evaluation of these com...

journal_title：Toxicologic pathology

authors： Ramot Y,Nyska A,Markovitz E,Dekel A,Klaiman G,Zada MH,Domb AJ,Maronpot RR

更新日期：2015-12-01 00:00:00

abstract：:To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles

journal_title：Toxicologic pathology

authors： Akinaga LM,Lichtenfels AJ,Carvalho-Oliveira R,Caldini EG,Dolhnikoff M,Silva LF,Bueno HM,Pereira LA,Saldiva PH,Garcia ML

更新日期：2009-04-01 00:00:00

abstract：:Toxicogenomics using a reference database can provide a better understanding and prediction of toxicity, largely by creating biomarkers that tie gene expression to actual pathology events. During the course of building a toxicogenomic database, an observation was made that a number of non-steroidal anti-inflammatory c...

journal_title：Toxicologic pathology

authors： Tugendreich S,Pearson CI,Sagartz J,Jarnagin K,Kolaja K

更新日期：2006-01-01 00:00:00

abstract：:Kozlowski, C., Brumm, J., and Cain, G. (2018). An Automated Image Analysis Method to Quantify Veterinary Bone Marrow Cellularity on H&E Sections. Tox Path46, 324-335. (Original DOI: 10.1177/0192623318766457). Kozlowski, C., Fullerton, A., Cain, G., Katavolos, P., Bravo, J., and Tarrant, J. M. (2018). Proof of Concept ...

journal_title：Toxicologic pathology

authors：

更新日期：2018-08-01 00:00:00

abstract：:Groups of 5 male beagle dogs were treated orally with hydralazine tablets in gelatin capsules at a dose of 12 or 24 mg/kg twice a day (6 hours apart) for 2 consecutive days. Five male dogs treated with empty gelatin capsules served as untreated controls. Clinical findings and heart rate changes during treatment and te...

journal_title：Toxicologic pathology

authors： Mesfin GM,Shawaryn GG,Higgins MJ

更新日期：1987-01-01 00:00:00

abstract：:This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible me...

journal_title：Toxicologic pathology

authors： Getz GS

更新日期：1990-01-01 00:00:00

abstract：:The carcinogenic potential of misoprostol, a synthetic prostaglandin E1 analogue with anti-ulcer potential, was evaluated in CD Sprague-Dawley rats. The compound was given daily by gavage at 24, 240, and 2,400 micrograms/kg, up to 150 times the daily human dose for 2 years. Necropsies were done on all animals and the ...

journal_title：Toxicologic pathology

authors： Dodd DC,Port CD,Deslex P,Regnier B,Sanders P,Indacochea-Redmond N

更新日期：1987-01-01 00:00:00

abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...

journal_title：Toxicologic pathology

authors： Kashida Y,Kato M

更新日期：1997-11-01 00:00:00

abstract：:Nephrotoxic renal injury, and especially drug nephrotoxicity is now a common cause of acute renal failure. The most common patterns of renal injury produced by nephrotoxins, tubular damage, and interstitial nephritis, are discussed here. Toxic agents which are primarily tubular toxins include certain antibiotics, cisp...

journal_title：Toxicologic pathology

authors： Racusen LC,Solez K

更新日期：1986-01-01 00:00:00

abstract：:Partial hepatectomy (PH) and neonatal rat short-term liver focus models were used to examine the effects of selected chemicals that had been previously tested in the National Toxicology Program (NTP) 2-yr carcinogenicity studies. C.I. Solvent Yellow 14, monuron, chlorendic acid, and 4-hydroxyacetanilide were tested fo...

journal_title：Toxicologic pathology

authors： Maronpot RR,Pitot HC,Peraino C

更新日期：1989-01-01 00:00:00

abstract：:Cardiac troponin (cTn) is a sensitive and specific biomarker for assessing cardiac damage and should be utilized in drug safety assessment. Lactate dehydrogenase and creatine kinase isoenzyme analyses have historically been used in pre-clinical toxicity testing to assess cardiac injury, but since these assays are less...

journal_title：Toxicologic pathology

authors： Reagan WJ

更新日期：2010-12-01 00:00:00

abstract：:The preclinical safety of RPR 106541, a novel 17-thiosteroid, was evaluated in young adult and mature dogs by inhalation exposure for 26 weeks and 52 weeks, respectively. A dry powder formulation of RPR 106541 in lactose was administered to young adult dogs (approximately 6 months of age at initiation) at doses of 0 (...

journal_title：Toxicologic pathology

authors： Miller GK,Valerio MG,Pino MV,Larson JL,Viau A,Hamelin N,Labbé R,Banks CM

更新日期：2000-03-01 00:00:00

abstract：:Weak peroxisome proliferator-activated receptor (PPAR) α agonists (fibrates) are used to treat dyslipidemia. This study compared the effects of the potent and selective PPARα agonist CP-778875 on peroxisomal β-oxidation and cardiac and/or skeletal muscle injury with those of the weak PPARα agonist fenofibrate. We hypo...

journal_title：Toxicologic pathology

authors： Pettersen JC,Pruimboom-Brees I,Francone OL,Amacher DE,Boldt SE,Kerlin RL,Ballinger WE

更新日期：2012-04-01 00:00:00

abstract：:In the Federal Register of January 10, 2000 (65 FR 1399), FDA published a draft guidance entitled "Photosafety Testing." The notice gave interested persons an opportunity to submit comments. As a result of the comments, certain sections of the guidance were reworded to improve clarity. A final guidance was published i...

journal_title：Toxicologic pathology

authors： Jacobs AC,Brown PC,Chen C,Ellis A,Farrelly J,Osterberg R

更新日期：2004-07-01 00:00:00

abstract：:In preclinical safety studies, drug-induced vascular injury can negatively impact candidate-drug selection because there are no obvious diagnostic markers for monitoring this pathology preclinically or clinically. Furthermore, our current understanding of the pathogenesis of this lesion is limited. While vasodilatatio...

journal_title：Toxicologic pathology

authors： Louden C,Brott D,Katein A,Kelly T,Gould S,Jones H,Betton G,Valetin JP,Richardson RJ

更新日期：2006-01-01 00:00:00

abstract：:To characterize the hepatic lesions in Fischer 344 (F344) rats afflicted with large granular lymphocyte (LGL) leukemia, the livers of rats with LGL leukemia at various stages were examined histopathologically and immunohistochemically. The morphologic features in the livers of rats afflicted with LGL leukemia were dif...

journal_title：Toxicologic pathology

authors： Shiga A,Narama I

更新日期：2015-08-01 00:00:00

abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...

journal_title：Toxicologic pathology

authors： Payne SR,Kemp CJ

更新日期：2003-07-01 00:00:00

abstract：:The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. Framing testable hypotheses for experimental a...

journal_title：Toxicologic pathology

authors： Silbergeld EK

更新日期：2017-01-01 00:00:00

abstract：:Selenoprotein P is an abundant extracellular protein that is expressed in liver, brain, and other tissues. Studies in mice with the selenoprotein P gene deleted (Sepp-/- mice) have implicated the protein in maintaining brain selenium. Sepp-/- mice fed a normal or low selenium diet develop severe motor impairment and d...

journal_title：Toxicologic pathology

authors： Valentine WM,Hill KE,Austin LM,Valentine HL,Goldowitz D,Burk RF

更新日期：2005-01-01 00:00:00

abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...

journal_title：Toxicologic pathology

authors： Bulger RE

更新日期：1986-01-01 00:00:00

abstract：:We conducted a retrospective analysis of publicly available preclinical toxicology studies with erythropoiesis-stimulating agents (ESAs) to examine common adverse events in rats, Beagle dogs, and cynomolgus monkeys. Mortality and/or thrombotic events were reported sporadically in a subset of studies and attributed to ...

journal_title：Toxicologic pathology

authors： Andrews DA,Pyrah IT,Boren BM,Tannehill-Gregg SH,Lightfoot-Dunn RM

更新日期：2014-01-01 00:00:00

abstract：:The Tg.AC mouse is being evaluated for use in short-term carcinogenicity bioassays. Because the dermal test protocol necessitates dissolving test agents we determined the effects of several solvents on responsiveness of hemizygous mice to dermal applications of the classical skin tumor promoter. phorbol 12-myristate 1...

journal_title：Toxicologic pathology

authors： Stoll RE,Furst SM,Stoltz JH,Lilly PD,Mennear JH

更新日期：2001-09-01 00:00:00