New findings concerning eosinophilic substance deposition in mouse nasal septum: sex difference and no increase in seniles.

abstract：:I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic Pathology Symposium "Toxicologic Pathology and the Immune System." I had the opportunity to reminisce about events in the 1970s that set the stage for the birth and subsequent growth of the field of immunotoxicology and to summarize my r...

journal_title：Toxicologic pathology

authors： Kerkvliet NI

更新日期：2012-01-01 00:00:00

abstract：:Chronic prostatitis characterized on light microscopic examination by moderate, multifocal, predominantly lymphocytic inflammation associated with epithelial atypia and intranuclear and cytoplasmic inclusion-like material was identified in the prostate gland of 2 Wistar Han rats administered an immunomodulatory test a...

journal_title：Toxicologic pathology

authors： Masek-Hammerman K,Brown TP,Bobrowski WF,Tomlinson L,Debrue M,Whiteley L,Radi Z

更新日期：2017-07-01 00:00:00

abstract：:During preclinical investigations into the safety of drugs and chemicals, many are found to interfere with reproductive function in the female rat. This interference is commonly expressed as a change in normal morphology of the reproductive tract or a disturbance in the duration of particular phases of the estrous cyc...

journal_title：Toxicologic pathology

authors： Westwood FR

更新日期：2008-04-01 00:00:00

abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...

journal_title：Toxicologic pathology

authors： Stoll RE,Holden HE,Barthel CH,Blanchard KT

更新日期：1999-09-01 00:00:00

abstract：:Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are associated with a mobilization of iron and catalysis of an oxi...

journal_title：Toxicologic pathology

authors： Ghio AJ,Funkhouser W,Pugh CB,Winters S,Stonehuerner JG,Mahar AM,Roggli VL

更新日期：2006-01-01 00:00:00

abstract：:Single doses of aspirin induce scattered foci of necrosis of proximal tubules in some strains of rats, whereas acute or sub-acute administration of phenylbutazone causes renal papillary necrosis. Initially, using Sprague-Dawley rats of CFY and CD strains, it became clear that these rats were not as susceptible to thes...

journal_title：Toxicologic pathology

authors： Owen RA,Heywood R

更新日期：1986-01-01 00:00:00

abstract：:Biomass burning is a major source of indoor air pollution in rural India. The authors investigated in this study whether cumulative exposures to biomass smoke cause activation of the serine/threonine kinase Akt in airway cells and peripheral blood lymphocytes (PBL). For this, the authors enrolled 87 premenopausal (med...

journal_title：Toxicologic pathology

authors： Mondal NK,Roy A,Mukherjee B,Das D,Ray MR

更新日期：2010-12-01 00:00:00

abstract：:Oltipraz, developed as an antischistosomal agent, protects against the hepatotoxicity of many xenobiotics and is known to be an effective inhibitor of experimental carcinogenesis in rodents. In the present study, we investigated its effects on the development of lesions in LEC rats, established as a mutant strain char...

journal_title：Toxicologic pathology

authors： Nakamura H,Nishikawa A,Furukawa F,Kasahara K,Miyauchi M,Okazaki K,Imazawa T,Uchida K,Hirose M

更新日期：2002-03-01 00:00:00

abstract：:One of the biggest challenges in drug development is interpretation of findings suggestive of immunostimulation, particularly when the findings are unexpected based on the known mechanism of action of the drug. Findings suggestive of immunostimulation do not necessarily preclude development of the drug. By understandi...

journal_title：Toxicologic pathology

authors： Evans EW

更新日期：2014-10-01 00:00:00

abstract：:A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of bone alkaline phosphatase (BALP) with wheat germ lectin and differential inhibition with levamisole for determination of intestinal alkaline phosphatase (IALP). Th...

journal_title：Toxicologic pathology

authors： Hoffmann WE,Everds N,Pignatello M,Solter PF

更新日期：1994-11-01 00:00:00

abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...

journal_title：Toxicologic pathology

authors： Kemp DR,Percy DH,Hayes MA

更新日期：1991-01-01 00:00:00

abstract：:The dose dependence of L-ascorbic acid (AsA) copromotion of urinary bladder carcinogenesis with continuous concomitant administration of NaHCO3 was investigated. In the first experiment, 83 male F344 rats were all given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 wk and then divided into 5 groups, which re...

journal_title：Toxicologic pathology

authors： Iwata H,Yamamoto S,Yano Y,Ohtani S,Fukushima S

更新日期：1997-05-01 00:00:00

abstract：:Vaginal exfoliative cytology is commonly used in biomedical and toxicological research to classify the stages of the rodent estrous cycle. However, mouse vaginal exfoliative cytology is commonly used as a stand-alone tool and has not been evaluated in reference to vaginal histology and serum sex hormone levels. In thi...

journal_title：Toxicologic pathology

authors： Gal A,Lin PC,Barger AM,MacNeill AL,Ko C

更新日期：2014-12-01 00:00:00

abstract：:The nonnucleoside inhibitor (NNI) of HIV-1 reverse transcriptase, PHI-346 (N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea), is a dual-function spermicidal agent with potent anti-HIV activity against drug-sensitive as well as drug-resistant HIV-1 strains with genotypic and phenotypic NNI resistance. PHI-3...

journal_title：Toxicologic pathology

authors： D'Cruz OJ,Waurzyniak B,Uckun FM

更新日期：2002-11-01 00:00:00

abstract：:We examined the localization and expression of the nuclear oncoprotein c-myc and the cytoplasmic membrane-associated oncoprotein c-ras in rainbow trout cell lines derived from both normal and tumor tissue in order to question whether c-myc and ras oncoprotein immunostaining was increased in cells derived from tumors c...

journal_title：Toxicologic pathology

authors： Carter CA,Ellington WW,Van Beneden RJ

更新日期：1996-05-01 00:00:00

abstract：:Glucokinase activators (GKAs) are being developed for the treatment of type 2 diabetes. The toxicity of 4 GKAs (PF-04279405, PF-04651887, piragliatin, and PF-04937319) was assessed in mice, rats, dogs, and/or monkeys. GKAs were administered for 2 to 8 weeks. Standard endpoints, glucose, and insulin were assessed. All ...

journal_title：Toxicologic pathology

authors： Pettersen JC,Litchfield J,Neef N,Schmidt SP,Shirai N,Walters KM,Enerson BE,Chatman LA,Pfefferkorn JA

更新日期：2014-06-01 00:00:00

abstract：:The cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem cells represent an appea...

journal_title：Toxicologic pathology

authors： Cheng L,Ramesh AV,Flesken-Nikitin A,Choi J,Nikitin AY

更新日期：2010-01-01 00:00:00

abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...

journal_title：Toxicologic pathology

authors： Gill S,Veinot J,Kavanagh M,Pulido O

更新日期：2007-04-01 00:00:00

abstract：:The effects of oral contraceptives have been studied in the beagle bitch for periods up to 7 yr. High doses of these potent estrogen: progestogen (E:P) combinations have been shown to promote tumors in the mammary glands, smooth muscle of the tubular genitalia, and occasionally in the transitional epithelium of the ne...

journal_title：Toxicologic pathology

authors： Johnson AN

更新日期：1989-01-01 00:00:00

abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...

journal_title：Toxicologic pathology

authors： Bulger RE

更新日期：1986-01-01 00:00:00

abstract：:The histologic effect of 400 mg/M2/day of hydrocortisone, given alternatively from day 7 to day 19 after birth, was studied on the spleen of the immunologically immature rat. Two days after the cessation of treatment, the periarteriolar lymphatic sheaths were found to be largely depleted of small lymphocytes. Immunope...

journal_title：Toxicologic pathology

authors： el Fouhil AF,Iskander FA,Turkall RM

更新日期：1993-01-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:The mechanisms underlying the development of gastrointestinal (GI) damage by the NSAIDs differ considerably from drug to drug. Aside from environmental or intersubject influence (e.g., concurrent disease, physical or sociopsychologic stress, dietary and genetic status), the intrinsic pharmacokinetic and physicochemica...

journal_title：Toxicologic pathology

authors： Rainsford KD

更新日期：1988-01-01 00:00:00

abstract：:Conazoles are a class of azole based fungicides used in agriculture and as pharmaceutical products. They have a common mode of antifungal action through inhibition of ergosterol biosynthesis. Some members of this class have been shown to be hepatotoxic and will induce mouse hepatocellular tumors and/or rat thyroid fol...

journal_title：Toxicologic pathology

authors： Wolf DC,Allen JW,George MH,Hester SD,Sun G,Moore T,Thai SF,Delker D,Winkfield E,Leavitt S,Nelson G,Roop BC,Jones C,Thibodeaux J,Nesnow S

更新日期：2006-01-01 00:00:00

abstract：:Hepatic microsomal enzymes play an important role in thyroid hormone homeostasis. Glucuronidation of thyroxine is the rate limiting step in the biliary excretion of thyroxine in the rat; the monodeiodinases are important in the conversion of T4 to T3 and reverse T3 and subsequent deiodinations. Phenobarbital is known ...

journal_title：Toxicologic pathology

authors： McClain RM

更新日期：1989-01-01 00:00:00

abstract：:To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles

journal_title：Toxicologic pathology

authors： Akinaga LM,Lichtenfels AJ,Carvalho-Oliveira R,Caldini EG,Dolhnikoff M,Silva LF,Bueno HM,Pereira LA,Saldiva PH,Garcia ML

更新日期：2009-04-01 00:00:00

abstract：:The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This...

journal_title：Toxicologic pathology

authors： Zühlke U,Weinbauer G

更新日期：2003-01-01 00:00:00

abstract：:Transgenic mouse strains offer the prospect of significant benefits in the in vivo assessment of carcinogenic potential. The European Regulatory Authorities have been supportive of their inclusion as one of the second-test options in the International Conference on Harmonization of Technical Requirements for the Regis...

journal_title：Toxicologic pathology

authors： van der Laan J,Lima BS,Snodin D

更新日期：2002-01-01 00:00:00

abstract：:Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in...

journal_title：Toxicologic pathology

authors： Bach PH,Nguyen TK

更新日期：1998-01-01 00:00:00

abstract：:Novel urinary protein biomarkers for the detection of acute renal damage, recently accepted by the U.S. Food and Drug Administration, European Medicines Agency, and Pharmaceuticals and Medical Devices Agency (Japan), now have to be validated in practice. Limited data regarding the performance of these acute markers af...

journal_title：Toxicologic pathology

authors： Fuchs TC,Frick K,Emde B,Czasch S,von Landenberg F,Hewitt P

更新日期：2012-10-01 00:00:00