Gastrointestinal damage from nonsteroidal anti-inflammatory drugs.

abstract：:Contrast-induced nephropathy (CIN) refers to a decline in renal function following exposure to iodinated contrast media (CM). The present study was initiated to explore the role of known human risk factors (spontaneous hypertension, diabetes, protein-losing nephropathy) on CIN development in rodent models and to deter...

journal_title：Toxicologic pathology

authors： Rouse RL,Stewart SR,Thompson KL,Zhang J

更新日期：2013-01-01 00:00:00

abstract：:Hepatocyte suspensions prepared from inbred male Wistar-Kyoto rats were transplanted to the livers of syngeneic recipients by injection into the portal venous system immediately after partial hepatectomy. Donor cells were labelled with 51Cr in vitro before transplantation. Animals were sacrificed 1 hr, 10 hr, 48 hr, o...

journal_title：Toxicologic pathology

authors： Saeter G,Schwarze PE,Nesland JM,Seglen PO

更新日期：1987-01-01 00:00:00

abstract：:Morphologic lesions have received only limited attention as in vitro endpoints of toxicity. In the present work, "tissue" and cell morphology of control and toxicant-treated primary dissociated cerebrocortical cell cultures from fetal mice were examined using phase-contrast and bright-field microscopy. In untreated co...

journal_title：Toxicologic pathology

authors： Bolon B,Dorman DC,Bonnefoi MS,Randall HW,Morgan KT

更新日期：1993-09-01 00:00:00

abstract：:Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...

journal_title：Toxicologic pathology

authors： Latendresse JR,Pereira MA

更新日期：1997-09-01 00:00:00

abstract：:Whole mount enzyme histochemistry to localize lacZ-bearing transgenes (lacZ-WMH) also detects endogenous beta-galactosidases. The experiments reported here evaluated lacZ-WMH as a potential tool for transgene expression analysis during high-throughput rodent necropsies. A lacZ-WMH survey of organs from adult, wild-typ...

journal_title：Toxicologic pathology

authors： Bolon B

更新日期：2008-02-01 00:00:00

abstract：:Standard histology trimming practices for toxicity studies in dogs include preparation of a section of the papillary muscle associated with the left ventricular free wall-the anteriolateral or anterior muscle. In contrast, the posteromedial or posterior papillary muscle, associated with the interventricular septum, is...

journal_title：Toxicologic pathology

authors： Kohnken R,Weber A

更新日期：2020-10-01 00:00:00

abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...

journal_title：Toxicologic pathology

authors： Payne SR,Kemp CJ

更新日期：2003-07-01 00:00:00

abstract：:This study aimed to evaluate the carcinogenic potential of the herbicide Diuron in a two-stage rat medium-term mammary carcinogenesis model initiated by 7,12-dimethylbenz(a)anthracene (DMBA). Female seven-week-old Sprague-Dawley (SD) rats were allocated to six groups: groups G1 to G4 received intragastrically (i.g.) a...

journal_title：Toxicologic pathology

authors： Grassi TF,Rodrigues MA,de Camargo JL,Barbisan LF

更新日期：2011-04-01 00:00:00

abstract：:Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...

journal_title：Toxicologic pathology

authors： Yamate J,Iwaki M,Nakatsuji S,Kuwamura M,Kotani T,Sakuma S

更新日期：1998-09-01 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...

journal_title：Toxicologic pathology

authors： Maurer JK,Parker RD,Carr GJ

更新日期：1998-03-01 00:00:00

abstract：:The B6C3F1 strain of mice is prone to develop liver nodules as animals grow older. This spontaneous tumor development is enhanced by dietary lipotrope deficiency. The present studies were performed to evaluate the liver of the B6C3F1 mice in early periods of lipotrope deficiency and before the nodules appear. Mice wer...

journal_title：Toxicologic pathology

authors： de Camargo JL,Punyarit P,Newberne PM

更新日期：1985-01-01 00:00:00

abstract：:Slc:Wistar male rats treated with human natural tumor necrosis factor alpha (hn TNF-alpha, 3 X 10(5) Japan reference units/kg intravenously) for 3 months showed histologic vacuolation of basophils in the anterior pituitary, hyperplasia of the thyroidal follicular epithelium, and hyperplasia of the testicular interstit...

journal_title：Toxicologic pathology

authors： Kakinuma C,Hamada Y,Futamura Y,Kuwayama C,Shimoi A,Shibutani Y

更新日期：1999-07-01 00:00:00

abstract：:BMS-645737, an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1, has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. This article characterizes the BMS-645737-induced clinical, gross, and histologic lesions of i...

journal_title：Toxicologic pathology

authors： Fletcher AM,Bregman CL,Woicke J,Salcedo TW,Zidell RH,Janke HE,Fang H,Janusz WJ,Schulze GE,Mense MG

更新日期：2010-02-01 00:00:00

abstract：:Oltipraz, developed as an antischistosomal agent, protects against the hepatotoxicity of many xenobiotics and is known to be an effective inhibitor of experimental carcinogenesis in rodents. In the present study, we investigated its effects on the development of lesions in LEC rats, established as a mutant strain char...

journal_title：Toxicologic pathology

authors： Nakamura H,Nishikawa A,Furukawa F,Kasahara K,Miyauchi M,Okazaki K,Imazawa T,Uchida K,Hirose M

更新日期：2002-03-01 00:00:00

abstract：:The fate of inspired mercury vapour (Hg0) is critical in the central nervous system (CNS) where it can circumvent the blood-brain barrier (BBB) at the neuromuscular junction (NMJ) and accumulate indefinitely in motor neurons by retrograde transport. The detoxification of systemic Hg0 by lung and liver requires investi...

journal_title：Toxicologic pathology

authors： Stankovic RK,Lee V,Kekic M,Harper C

更新日期：2003-09-01 00:00:00

abstract：:Parenteral administration of recombinant hematopoietic growth factors has been sporadically associated with cutaneous complications, including injection site reactions in humans and nonhuman primates. In this study, subcutaneous injection sites were evaluated from 12 cynomolgus monkeys administered a recombinant human...

journal_title：Toxicologic pathology

authors： Khan KN,Kats AA,Fouant MM,Snook SS,Mckearn JP,Alden CL,Smith PF

更新日期：1996-07-01 00:00:00

abstract：:In non-rodent toxicity studies supporting pharmaceutical or chemical product registration, the value of histopathology evaluation of all tissues from all animals from all dose groups is an ongoing discussion topic among pathologists. This manuscript documents an examination of this topic through a retrospective review...

journal_title：Toxicologic pathology

authors： Weddle DL,Mahrt CR,Schmidt SP

更新日期：2012-07-01 00:00:00

abstract：:Congenital intrahepatic arteriovenous fistulae, a rare hepatic vascular anomaly, in an 8-mo-old female beagle dog was investigated. The animal showed anorexia, repeated vomiting, hemorrhagic diarrhea, and jaundice for approximately 2 wk. There was mild to severe increase of serum alkaline phosphatase, glutamic-oxalace...

journal_title：Toxicologic pathology

authors： Yoshizawa K,Oishi Y,Matsumoto M,Fukuhara Y,Makino N,Noto T,Fujii T

更新日期：1997-09-01 00:00:00

abstract：:A delay in the exposure of initiated rats to orotic acid (OA) beyond a specific time frame results in a progressive loss of promotional effect in liver carcinogenesis. The current study was designed to ascertain whether the loss of promotional effect could be counteracted by pre-exposing the initiated animals to other...

journal_title：Toxicologic pathology

authors： Laconi E,Vasudevan S,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1987-01-01 00:00:00

abstract：:This brief review summarizes our current understanding of vasculitis mediated by phlogistic immune complexes. The Arthus reaction and serum sickness both represent experimental models for immune complex disease. Immune complex phenomena occur in conjunction with C3 deficiency of dogs during canine distemper virus infe...

journal_title：Toxicologic pathology

authors： Krakowka S

更新日期：1989-01-01 00:00:00

abstract：:Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as...

journal_title：Toxicologic pathology

authors： Parkinson A

更新日期：1996-01-01 00:00:00

abstract：:Recent clinical evidence suggests that hylan, a modified hyaluronan, and related products potentially elicit foreign body granulomatous inflammation in human soft tissue. We investigated the biocompatibility of hylan G-F 20 (Synvisc) for up to 28 days after intradermal injection in guinea pigs and intramuscular inject...

journal_title：Toxicologic pathology

authors： Sasaki M,Miyazaki Y,Takahashi T

更新日期：2003-05-01 00:00:00

abstract：:Mouse renal cell tumors (RCTs) were induced in male CBA mice by 5 subcutaneous injections of 8 mg 1,2-dimethylhydrazine (DMH)/kg body weight once a week. After a lag period of 2 yr kidneys were removed, and serial cryostat sections of the kidneys were histochemically analyzed for the following parameters: glycogen con...

journal_title：Toxicologic pathology

authors： Ahn YS,Chemeris GY,Turusov VS,Bannasch P

更新日期：1994-07-01 00:00:00

abstract：:Novel urinary protein biomarkers for the detection of acute renal damage, recently accepted by the U.S. Food and Drug Administration, European Medicines Agency, and Pharmaceuticals and Medical Devices Agency (Japan), now have to be validated in practice. Limited data regarding the performance of these acute markers af...

journal_title：Toxicologic pathology

authors： Fuchs TC,Frick K,Emde B,Czasch S,von Landenberg F,Hewitt P

更新日期：2012-10-01 00:00:00

abstract：:Focal spontaneously occurring eosinophilic hypertrophic cells, histomorphologically resembling oncocytes and hepatocytes, were observed in the pancreas from 11 (0.3%) of 4,177 Sprague-Dawley rats, 3 to 26 months old. The age of these eleven rats ranged from 13 to 25 months. The incidence was not different between sexe...

journal_title：Toxicologic pathology

authors： Chiu T

更新日期：1987-01-01 00:00:00

abstract：:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...

journal_title：Toxicologic pathology

authors： Zwicker GM,Killinger JM,McConnel RF

更新日期：1985-01-01 00:00:00

abstract：:Reticulum cell hyperplasia (RCH) was a term used for many years by the National Toxicology Program (NTP) to describe a certain non-neoplastic bone marrow lesion of rats. Retrospective microscopic evaluation of RCH lesions and immunohistochemistry analyses were performed to reassess and further characterize these lesio...

journal_title：Toxicologic pathology

authors： Cora MC,Janardhan KS,Jensen H,Clayton N,Travlos GS

更新日期：2020-02-01 00:00:00

abstract：:Nephrotoxic renal injury, and especially drug nephrotoxicity is now a common cause of acute renal failure. The most common patterns of renal injury produced by nephrotoxins, tubular damage, and interstitial nephritis, are discussed here. Toxic agents which are primarily tubular toxins include certain antibiotics, cisp...

journal_title：Toxicologic pathology

authors： Racusen LC,Solez K

更新日期：1986-01-01 00:00:00

abstract：:The objective was to determine the respiratory toxicity of MAP0004, orally inhaled dihydroergotamine (DHE), via inhalation for six months. Forty beagle dogs (twenty females, twenty males) were treated by nose-only inhalation for 182 days. Groups 2 through 5 received MAP0004 (mean doses: 0.045, 0.154, 0.44, 0.825 mg/kg...

journal_title：Toxicologic pathology

authors： Armer TA,Lynch M,Moutvic R,Singer A

更新日期：2011-04-01 00:00:00