Abstract：
:The fate of inspired mercury vapour (Hg0) is critical in the central nervous system (CNS) where it can circumvent the blood-brain barrier (BBB) at the neuromuscular junction (NMJ) and accumulate indefinitely in motor neurons by retrograde transport. The detoxification of systemic Hg0 by lung and liver requires investigation. We exposed 129/Sv wild-type (Wt) and 129/Sv MT-I, II double knockout (KO) mice to 500 microg Hg0/m3 for 4 hours to investigate the expression of MT in the lung, liver, and spinal cord following Hg0 exposure using unexposed groups as controls. There were congestive changes in liver and lung of both Wt and MT-KO groups of Hg0-treated mice; these changes appeared more pronounced in the MT-KO group. Motor neurons in the spinal cord did not show any pathological changes. Based on expression of MT, liver appears to have a major role in trapping and stabilising mercury. In the spinal cord, MT was expressed in all white matter astrocytes and in some grey matter astrocytes. Notably, motor neurons did not express MT, and the presence of MT could not be demonstrated in the axons of the ventral root. The absence of MT expression in motor neurons and their axons suggests the dependence of the motor system on the detoxifying capacity of liver MTs.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Stankovic RK,Lee V,Kekic M,Harper Cdoi
10.1080/01926230390226069subject
Has Abstractpub_date
2003-09-01 00:00:00pages
514-23issue
5eissn
0192-6233issn
1533-1601journal_volume
31pub_type
杂志文章abstract：:Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area and stimulates catecholamine secretion from the adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia and neoplasia. We investigated the possible correlation betwe...
journal_title：Toxicologic pathology
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abstract：:Kozlowski, C., Brumm, J., and Cain, G. (2018). An Automated Image Analysis Method to Quantify Veterinary Bone Marrow Cellularity on H&E Sections. Tox Path46, 324-335. (Original DOI: 10.1177/0192623318766457). Kozlowski, C., Fullerton, A., Cain, G., Katavolos, P., Bravo, J., and Tarrant, J. M. (2018). Proof of Concept ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,已发布勘误
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abstract：:A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...
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abstract：:The chloracetanilide herbicide alachlor (2-chloro-2',6-diethyl-N-(methoxymethyl)-acetanilide) induces nasal neoplasms in rats following chronic dietary exposure. The present study sought to identify the cellular origin and mechanisms of tumor induction and progression. Male Long-Evans rats were fed alachlor (0 or 126 ...
journal_title：Toxicologic pathology
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journal_title：Toxicologic pathology
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journal_title：Toxicologic pathology
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abstract：:Most available data on the involvement of p53 in rodent carcinogenesis are based on results of the end point of chemically or virally induced carcinogenesis, i.e., tumors. To investigate the role of altered p53 expression in early stages of rodent hepatocarcinogenesis in a systematic way, we treated male Wistar rats f...
journal_title：Toxicologic pathology
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abstract：:Alloxan-induced diabetic rats frequently exhibit proliferative lesions of squamous hyperplasia accompanied by chronic inflammation and Candida albicans infection in the forestomach, and some lesions progress to squamous cell carcinoma (SCC). Candida infection causes not only hyperplastic changes with inflammation but ...
journal_title：Toxicologic pathology
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abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...
journal_title：Toxicologic pathology
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更新日期：2003-07-01 00:00:00
abstract：:A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular d...
journal_title：Toxicologic pathology
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更新日期：2016-07-01 00:00:00
abstract：:In order to investigate the role of the stimulation of cell division for the initiation (and possibly promotion) of liver tumors by chemical carcinogens, the incorporation of radiolabelled thymidine into liver DNA was determined in male rats. Single doses of various levels of aflatoxin B1, benzidine and carbon tetrach...
journal_title：Toxicologic pathology
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更新日期：1984-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：1984-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2013-08-01 00:00:00
abstract：:Documentation of Chinese materia medica (CMM) dates back to around 1,100 BC when only dozens of drugs were first described. By the end of the 16th century, the number of drugs documented had reached close to 1,900. And by the end of the last century, published records of CMM have reached 12,800 drugs. The recorded tra...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Toxicologic pathology
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doi：
更新日期：1996-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2006-01-01 00:00:00
abstract：:A factor limiting widespread use of the transgenic rasH2 mouse model for carcinogenicity testing of pharmaceuticals is the paucity of published data on actual drug candidates in rasH2 mice. This report addresses this gap by highlighting rasH2 mouse study data for 10 pharmaceutical candidates. These results were compar...
journal_title：Toxicologic pathology
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更新日期：2013-01-01 00:00:00
abstract：:Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of biological functions involved in autoimmune disease pathogenesis. Th...
journal_title：Toxicologic pathology
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更新日期：2016-10-01 00:00:00
abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...
journal_title：Toxicologic pathology
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更新日期：1991-01-01 00:00:00
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journal_title：Toxicologic pathology
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journal_title：Toxicologic pathology
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更新日期：1991-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2005-01-01 00:00:00
abstract：:GJA1 gene (Connexin43, also known as Cx43) is the most abundant gap junction protein isoform in animal cells and is associated with bone development in embryos. The objective of the present work was to evaluate in vivo osteal development in GJA1-deficient fetal mice through determination of the histological and molecu...
journal_title：Toxicologic pathology
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更新日期：2011-12-01 00:00:00
abstract：:Congenital anomalies of the alimentary tract are rare lesions in laboratory animals. We describe a congenital cyst attached to the greater curvature of the forestomach in a B6C3F1 mouse. The inner surface of the cyst was mostly covered with cuboidal or pseudostratified ciliated epithelium and was focally covered with ...
journal_title：Toxicologic pathology
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更新日期：1999-09-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：1989-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2020-12-31 00:00:00
abstract：:S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced nephrotoxicity in vivo was investigated in New Zealand White rabbits. A primary emphasis in these studies was further characterization of DCVC-induced nephrotoxicity using a variety of serum and urinary analytes, including sodium dodecyl sulfate-polyacrylamide gel electr...
journal_title：Toxicologic pathology
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journal_title：Toxicologic pathology
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更新日期：2017-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2014-12-01 00:00:00
abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...
journal_title：Toxicologic pathology
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更新日期：1997-11-01 00:00:00
