Transplantation of preneoplastic rat hepatocytes by intraportal injection.

abstract：:The fate of inspired mercury vapour (Hg0) is critical in the central nervous system (CNS) where it can circumvent the blood-brain barrier (BBB) at the neuromuscular junction (NMJ) and accumulate indefinitely in motor neurons by retrograde transport. The detoxification of systemic Hg0 by lung and liver requires investi...

journal_title：Toxicologic pathology

authors： Stankovic RK,Lee V,Kekic M,Harper C

更新日期：2003-09-01 00:00:00

abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...

journal_title：Toxicologic pathology

authors： Kemp DR,Percy DH,Hayes MA

更新日期：1991-01-01 00:00:00

abstract：:A variety of phenotypic cellular changes emerge in the liver of different species prior to the appearance of hepatocellular adenomas and carcinomas induced by carcinogenic agents (chemicals, radiation, hepadna viruses) or develop "spontaneously." Foci of altered hepatocytes have been studied most extensively in rats t...

journal_title：Toxicologic pathology

authors： Bannasch P,Enzmann H,Klimek F,Weber E,Zerban H

更新日期：1989-01-01 00:00:00

abstract：:Chronic ingestion of arsenic is associated with increased incidence of respiratory and cardiovascular diseases. To investigate the role of arsenic in early events in vascular pathology, C57BL/6 mice ingested drinking water with or without 50 ppb sodium arsenite (AsIII) for four, five, or eight weeks. At five and eight...

journal_title：Toxicologic pathology

authors： Hays AM,Lantz RC,Rodgers LS,Sollome JJ,Vaillancourt RR,Andrew AS,Hamilton JW,Camenisch TD

更新日期：2008-10-01 00:00:00

abstract：:In the Federal Register of January 10, 2000 (65 FR 1399), FDA published a draft guidance entitled "Photosafety Testing." The notice gave interested persons an opportunity to submit comments. As a result of the comments, certain sections of the guidance were reworded to improve clarity. A final guidance was published i...

journal_title：Toxicologic pathology

authors： Jacobs AC,Brown PC,Chen C,Ellis A,Farrelly J,Osterberg R

更新日期：2004-07-01 00:00:00

abstract：:Sections of thymus from New Zealand white rabbits used as controls in 28-day and 91-day percutaneous toxicity studies conducted at different laboratories were morphometrically assessed. Measurements of total thymic area, medullary area, and cortical area were greater for 28-day vs 91-day studies conducted at a given l...

journal_title：Toxicologic pathology

authors： Maurer JK,Gibbons BA,Bruce RD

更新日期：1990-01-01 00:00:00

abstract：:A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...

journal_title：Toxicologic pathology

authors： Frith CH,Ayres PH,Shinohara Y,West R

更新日期：1986-01-01 00:00:00

abstract：:This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks. A total of 120 chicks were divided equally into 4 groups and were fed poultry mash without ...

journal_title：Toxicologic pathology

authors： Garg UK,Pal AK,Jha GJ,Jadhao SB

更新日期：2004-05-01 00:00:00

abstract：:Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological m...

journal_title：Toxicologic pathology

authors： Ureshino RP,Costa AJ,Erustes AG,Pereira GJDS,Sinigaglia-Coimbra R,Smaili SS

更新日期：2018-04-01 00:00:00

abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...

journal_title：Toxicologic pathology

authors： Schmidt F,Wolf R,Baumann L,Braunbeck T

更新日期：2017-07-01 00:00:00

abstract：:Pepsinogens are acid protease enzymes of pepsin usually found in gastric mucosa. In the present study, we demonstrated the presence of pepsinogen isozymes in male Syrian golden hamster lung tissues by a combined immunohistochemical and biochemical approach. Immunohistochemically, using rat pepsinogen 1 antibody, pepsi...

journal_title：Toxicologic pathology

authors： Imaida K,Furihata C,Tatematsu M,Yoon CH,Furukawa F,Uneyama C,Takahashi M,Ito N,Hayashi Y

更新日期：1991-01-01 00:00:00

abstract：:Necropsies conducted to support medical device development may be conducted in facilities that do not have the infrastructure in place to support Good Laboratory Practice for Nonclinical Laboratory Studies (GLP) studies and for a variety of reasons they may be conducted without a pathologist present at necropsy. Howev...

journal_title：Toxicologic pathology

authors： Nikula KJ,Funk K

更新日期：2016-01-01 00:00:00

abstract：:Helicobacter hepaticus infection induces sustained inflammation and carcinoma of the liver in A/JCr mice, and serves as a model of human cancers associated with viral hepatitis and H. pylorichronic gastritis. Here we describe the pathogenesis of premalignant disease in A/JCr mice infected with H. hepaticus. We inocula...

journal_title：Toxicologic pathology

authors： Rogers AB,Boutin SR,Whary MT,Sundina N,Ge Z,Cormier K,Fox JG

更新日期：2004-11-01 00:00:00

abstract：:A significant correlation exists between average daily food consumption and 2-yr survival in control ad libitum (AL)-fed Sprague-Dawley (SD) rats. SD rats were fed Purina Rodent Chow 5002 or a modified chow, 5002-9, with lower protein, fat, metabolizable energy and increased fiber AL or by dietary restriction (DR) to ...

journal_title：Toxicologic pathology

authors： Keenan KP,Smith PF,Hertzog P,Soper K,Ballam GC,Clark RL

更新日期：1994-05-01 00:00:00

abstract：:Progressive renal interstitial fibrosis occurs following tissue injury, resulting in chronic renal failure. In the fibrogenesis, macrophages are speculated to induce myofibroblasts producing matrix protein. The kinetics of these cells in renal fibrosis induced in rats by repeated injection of cisplatin (CDDP) (2 mg/kg...

journal_title：Toxicologic pathology

authors： Yamate J,Ishida A,Tsujino K,Tatsumi M,Nakatsuji S,Kuwamura M,Kotani T,Sakuma S

更新日期：1996-03-01 00:00:00

abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...

journal_title：Toxicologic pathology

authors： Shupe JL,Bruner RH,Seymour JL,Alden CL

更新日期：1992-01-01 00:00:00

abstract：:I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic Pathology Symposium "Toxicologic Pathology and the Immune System." I had the opportunity to reminisce about events in the 1970s that set the stage for the birth and subsequent growth of the field of immunotoxicology and to summarize my r...

journal_title：Toxicologic pathology

authors： Kerkvliet NI

更新日期：2012-01-01 00:00:00

abstract：:During the conduct of in vivo toxicology studies, in-life, clinical pathology, and anatomic pathology parameters are collected and interpreted. These sets of parameters are evaluated in an integrative manner to determine the overall toxicity of a test article. For clinical pathology parameters, the inherent variabilit...

journal_title：Toxicologic pathology

authors： Everds NE

更新日期：2015-01-01 00:00:00

abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...

journal_title：Toxicologic pathology

authors： Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito N

更新日期：1993-09-01 00:00:00

abstract：:Highly standardized and controlled inhalation studies are required for hazard identification to make test results reproducible and comparable and to fulfill general regulatory requirements for the registration of new drugs, pesticides, or chemicals. Despite significant efforts, the results of inhalation studies have t...

journal_title：Toxicologic pathology

authors： Pauluhn J,Mohr U

更新日期：2000-09-01 00:00:00

abstract：:This study aimed to evaluate the carcinogenic potential of the herbicide Diuron in a two-stage rat medium-term mammary carcinogenesis model initiated by 7,12-dimethylbenz(a)anthracene (DMBA). Female seven-week-old Sprague-Dawley (SD) rats were allocated to six groups: groups G1 to G4 received intragastrically (i.g.) a...

journal_title：Toxicologic pathology

authors： Grassi TF,Rodrigues MA,de Camargo JL,Barbisan LF

更新日期：2011-04-01 00:00:00

abstract：:The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This...

journal_title：Toxicologic pathology

authors： Zühlke U,Weinbauer G

更新日期：2003-01-01 00:00:00

abstract：:The beagle is a monoestric, nonseasonal breeder with a long estrous cycle. Owing to lengthy stages in individual phases of the estrous cycle, limited group size, and typical group assignment focused on homogenized body weight, dogs in the same stage of the cycle can be inadvertently assigned to one treatment group in ...

journal_title：Toxicologic pathology

authors： Chandra SA,Adler RR

更新日期：2008-12-01 00:00:00

abstract：:Novel urinary protein biomarkers for the detection of acute renal damage, recently accepted by the U.S. Food and Drug Administration, European Medicines Agency, and Pharmaceuticals and Medical Devices Agency (Japan), now have to be validated in practice. Limited data regarding the performance of these acute markers af...

journal_title：Toxicologic pathology

authors： Fuchs TC,Frick K,Emde B,Czasch S,von Landenberg F,Hewitt P

更新日期：2012-10-01 00:00:00

abstract：:The carcinogenic potential of misoprostol, a synthetic prostaglandin E1 analogue with anti-ulcer potential, was evaluated in CD Sprague-Dawley rats. The compound was given daily by gavage at 24, 240, and 2,400 micrograms/kg, up to 150 times the daily human dose for 2 years. Necropsies were done on all animals and the ...

journal_title：Toxicologic pathology

authors： Dodd DC,Port CD,Deslex P,Regnier B,Sanders P,Indacochea-Redmond N

更新日期：1987-01-01 00:00:00

abstract：:Lung cancer is the most common cause of cancer-related deaths in humans worldwide. There is strong evidence that the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play an important role in carcinogenesis caused ...

journal_title：Toxicologic pathology

authors： Kovi RC,Johnson CS,Balbo S,Hecht SS,O'Sullivan MG

更新日期：2018-02-01 00:00:00

abstract：:Enzyme histochemistry was assessed in semi-thin glycolmethacrylate sections after 100 mg/kg 2-bromoethanamine (BEA) hydrobromide had been given ip to male Wistar rats to induce renal papillary necrosis. Changes in the proximal tubular marker enzymes alkaline phosphatase (Alk Phos), gamma-glutamytranspeptidase (GGT) an...

journal_title：Toxicologic pathology

authors： Gregg NJ,Courtauld EA,Bach PH

更新日期：1990-01-01 00:00:00

abstract：:Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have investigated the potential of furan to induce oxidative stress and DNA damage associated with inflammatory and regenerative responses in rat liver. Furan was ad...

journal_title：Toxicologic pathology

authors： Hickling KC,Hitchcock JM,Oreffo V,Mally A,Hammond TG,Evans JG,Chipman JK

更新日期：2010-02-01 00:00:00

abstract：:Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide for long-acting delivery. The toxicity of a single intravitreal dose o...

journal_title：Toxicologic pathology

authors： Laing ST,Tassew N,Tesar D,Wang Y,Crowell SR,Gray J,Kwong M,Loyet KM,Andaya R,Kusi A,Kelley RF

更新日期：2020-12-21 00:00:00

abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...

journal_title：Toxicologic pathology

authors： Payne SR,Kemp CJ

更新日期：2003-07-01 00:00:00