Evidence of oxidative stress and associated DNA damage, increased proliferative drive, and altered gene expression in rat liver produced by the cholangiocarcinogenic agent furan.

abstract：:Novel urinary protein biomarkers for the detection of acute renal damage, recently accepted by the U.S. Food and Drug Administration, European Medicines Agency, and Pharmaceuticals and Medical Devices Agency (Japan), now have to be validated in practice. Limited data regarding the performance of these acute markers af...

journal_title：Toxicologic pathology

authors： Fuchs TC,Frick K,Emde B,Czasch S,von Landenberg F,Hewitt P

更新日期：2012-10-01 00:00:00

abstract：:A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...

journal_title：Toxicologic pathology

authors： Butt MT

更新日期：2011-01-01 00:00:00

abstract：:In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...

journal_title：Toxicologic pathology

authors： Ozaki M,Ozaki K,Watanabe T,Uwagawa S,Okuno Y,Shirai T

更新日期：2005-01-01 00:00:00

abstract：:The new Appendix A of the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, which gives guidelines for accommodation and care of animals and was approved on June 15, 2006, was the main reason the authors decided to investigate the origins of the regulatio...

journal_title：Toxicologic pathology

authors： Atalić B,Fatović-Ferencić S

更新日期：2009-10-01 00:00:00

abstract：:Cancer affects approximately 1 in 3 individuals. An individual's susceptibility to cancer is partly determined by environmental exposures and by the combination of inherited cancer susceptibility and resistance genes. Initial mapping of these low penetrance cancer susceptibility genes has been done in the mouse becaus...

journal_title：Toxicologic pathology

authors： Ewart-Toland A,Balmain A

更新日期：2004-03-01 00:00:00

abstract：:The development process of myelination varies between region and species. Fully myelinated fibers are required if mammalian neural circuits are to function normally. Histology samples at staggered time points throughout the study were examined at days 4, 5, 7, 8, 10, 14, 17, 24, 37, and 44. We suggest that the develop...

journal_title：Toxicologic pathology

authors： Downes N,Mullins P

更新日期：2014-07-01 00:00:00

abstract：:The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcinogenicity of chemicals with a high degree of concordance (LeBoeuf et al [1996]. Mutat Res 356: 85-127). The SHE assay models the earliest identifiable stage in carcinogenicity, morphologi...

journal_title：Toxicologic pathology

authors： Mauthe RJ,Gibson DP,Bunch RT,Custer L

更新日期：2001-01-01 00:00:00

abstract：:There is increased interest to use minipigs in ocular toxicology studies due to their anatomical similarities with human eyes and as a substitute for nonhuman primates. This requires adaptation of enhanced optical coherence tomography (OCT) techniques and of ocular relevant immunohistochemistry (IHC) or in situ hybrid...

journal_title：Toxicologic pathology

authors： Atzpodien EA,Jacobsen B,Funk J,Altmann B,Silva Munoz MA,Singer T,Gyger C,Hasler P,Maloca P

更新日期：2016-04-01 00:00:00

abstract：:This is a survey of the results of recent investigations on gastrointestinal (GI) peptide hormones. In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known. These include vasoactive intestin...

journal_title：Toxicologic pathology

authors： Tansy MF,Kendall FM

更新日期：1988-01-01 00:00:00

abstract：:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...

journal_title：Toxicologic pathology

authors： Zwicker GM,Killinger JM,McConnel RF

更新日期：1985-01-01 00:00:00

abstract：:The expression of specific cytokeratin (CK) polypeptide patterns is a sensitive marker of the cytoskeletal differentiation of epithelial cells. We developed an immunohistochemical method to assess CK expression patterns in the rat respiratory tract using serial paraffin-embedded sections from the nasal cavity, trachea...

journal_title：Toxicologic pathology

authors： Schlage WK,Bülles H,Friedrichs D,Kuhn M,Teredesai A,Terpstra PM

更新日期：1998-05-01 00:00:00

abstract：:The 2019 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology's 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This ar...

journal_title：Toxicologic pathology

authors： Elmore SA,Cesta MF,Crabbs TA,Janardhan KS,Krane GA,Mahapatra D,Quist EM,Rinke M,Schaaf GW,Travlos GS,Wang H,Willson CJ,Wolf JC

更新日期：2019-12-01 00:00:00

abstract：:The relatively high incidence and variety of lesions induced in the upper respiratory tract of rodents by inhalation of xenobiotics has resulted in considerable attention given to the microscopic anatomy of this area. Specific areas of the rodent laryngeal mucosa appear to be more sensitive to inhaled materials and mo...

journal_title：Toxicologic pathology

authors： Renne RA,Gideon KM,Miller RA,Mellick PW,Grumbein SL

更新日期：1992-01-01 00:00:00

abstract：:Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of biological functions involved in autoimmune disease pathogenesis. Th...

journal_title：Toxicologic pathology

authors： Long AJ,Sampson E,McCarthy RW,Harris CM,Barnard M,Shi D,Conlon D,Caldwell R,Honor D,Wishart N,Hoemann M,Duggan L,Fritz D,Stedman C,O'Connor E,Mikaelian I,Schwartz A

更新日期：2016-10-01 00:00:00

abstract：:A number of novel urinary biomarkers have been identified and partially qualified for use as markers for renal injury in rats. We used two multiplex assays for these novel biomarkers to quantify biomarker concentration in serial urine collections from rats of both sexes administered varying concentrations of cisplatin...

journal_title：Toxicologic pathology

authors： Pinches MD,Betts CJ,Bickerton SJ,Beattie L,Burdett LD,Thomas HT,Derbyshire NA,Moores M,Price SA

更新日期：2012-04-01 00:00:00

abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...

journal_title：Toxicologic pathology

authors： Treumann S,Buesen R,Gröters S,Eichler JO,van Ravenzwaay B

更新日期：2015-08-01 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI3Ks) regulate intracellular signaling events for multiple cell surface receptors. Phosphatidylinositol 3-kinase δ, 1 of 4 class I PI3K isoforms, is primarily found in leukocytes and regulates immune cell functions. Here, we report changes in the immune and digestive systems that were ...

journal_title：Toxicologic pathology

authors： Werner JA,Ishida K,Wisler J,Karbowski C,Kalanzi J,Bussiere J,Monticello TM

更新日期：2020-12-01 00:00:00

abstract：:Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...

journal_title：Toxicologic pathology

authors： Rogers-Cotrone T,Burgess MP,Hancock SH,Hinckley J,Lowe K,Ehrich MF,Jortner BS

更新日期：2010-06-01 00:00:00

abstract：:This report demonstrates the advantages of using a noninvasive soft tissue imaging technique--magnetic resonance imaging (MRI)--to monitor liver regeneration after 70% partial hepatectomy in the rat in a longitudinal manner. Six animals were scanned prior to and on 6 subsequent occasions up to 9 days after surgical re...

journal_title：Toxicologic pathology

authors： Hockings PD,Roberts T,Campbell SP,Reid DG,Greenhill RW,Polley SR,Nelson P,Bertram TA,Kramer K

更新日期：2002-09-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak that started in Wuhan, China, in 2019 resulted in a pandemic not seen for a century, and there is an urgent need to develop safe and efficacious vaccines. The scientific community has made tremendous efforts to understand the disease, and unpara...

journal_title：Toxicologic pathology

authors： Bennet BM,Wolf J,Laureano R,Sellers RS

更新日期：2020-10-01 00:00:00

abstract：:Groups of C57BL6 mice of each sex were assigned to one of 2 dietary regimens, ad libitum (AL) or dietary restriction (DR), to study effects of food restriction on body weight, survival, and neoplasia. The AL and DR groups were subdivided into a scheduled sacrifice group for examination at 6-mo intervals, and a lifetim...

journal_title：Toxicologic pathology

authors： Blackwell BN,Bucci TJ,Hart RW,Turturro A

更新日期：1995-09-01 00:00:00

abstract：:In the constantly evolving field of toxicologic pathology, a pathologist's career is often characterized by multiple career transitions. However, these transitions can be challenging and/or overwhelming and may require a shift in focus, strategic approach, and acquisition of new skills and expertise. In order to provi...

journal_title：Toxicologic pathology

authors： Choudhary S,Osborne T,Adler RR,McDorman KS,Dillberger JE,Ochoa R

更新日期：2017-10-01 00:00:00

abstract：:The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...

journal_title：Toxicologic pathology

authors： Radi ZA,Khan NK

更新日期：2006-01-01 00:00:00

abstract：:The definition of diagnostic thresholds is an important aspect of identification and recording of histopathologic lesions in toxicology studies. Although the primary goal of the pathology examination is to identify and interpret lesions associated with the administration of the test article, the toxicologic pathologis...

journal_title：Toxicologic pathology

authors： Long GG,Hardisty JF

更新日期：2012-10-01 00:00:00

abstract：:The cochlea is one of the more common targets for toxic effects, yet current toxicologic screening in animals does not routinely evaluate the cochlea as a potential target organ. Although histopathologic sections are routinely taken from the eye and the optic nerve and tract and most studies include at least 1 section...

journal_title：Toxicologic pathology

authors： Mattsson JL

更新日期：2000-01-01 00:00:00

abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...

journal_title：Toxicologic pathology

authors： Harris DL,Washington MK,Hood DB,Roberts LJ 2nd,Ramesh A

更新日期：2009-12-01 00:00:00

abstract：:A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...

journal_title：Toxicologic pathology

authors： Frith CH,Ayres PH,Shinohara Y,West R

更新日期：1986-01-01 00:00:00

abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...

journal_title：Toxicologic pathology

authors： Gill S,Veinot J,Kavanagh M,Pulido O

更新日期：2007-04-01 00:00:00

abstract：:Some developmental dual-acting PPARalpha/gamma agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats orally dosed with ragaglitazar, using a newly developed flow c...

journal_title：Toxicologic pathology

authors： Oleksiewicz MB,Thorup I,Nielsen HS,Andersen HV,Hegelund AC,Iversen L,Guldberg TS,Brinck PR,Sjogren I,Thinggaard UK,Jørgensen L,Jensen MB

更新日期：2005-01-01 00:00:00

abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...

journal_title：Toxicologic pathology

authors： Stoll RE,Holden HE,Barthel CH,Blanchard KT

更新日期：1999-09-01 00:00:00