The genetics of cancer susceptibility: from mouse to man.

Abstract:

:Cancer affects approximately 1 in 3 individuals. An individual's susceptibility to cancer is partly determined by environmental exposures and by the combination of inherited cancer susceptibility and resistance genes. Initial mapping of these low penetrance cancer susceptibility genes has been done in the mouse because human low penetrance genes are extremely difficult to find using traditional methods due to heterogeneity and interacting factors. Also, the choice of candidate genes for human association studies can miss the unknown or unexpected. Mouse models also have limitations; it can be difficult to identify causal polymorphisms in the mouse because linkage disequilibrium often extends across several genes. To exploit the strengths of both systems, we outline a cross-species strategy to identify human variants associated with increased cancer risk. This approach uses linkage analysis and haplotyping, allelic imbalance in tumors, and gene expression studies in the mouse, combined with association studies and tumor imbalance studies in humans to identify causal cancer susceptibility variants. Allelic variants in both mouse and human can then be used to better understand the mechanisms behind cancer risk and as targets for intervention.

journal_name

Toxicol Pathol

journal_title

Toxicologic pathology

authors

Ewart-Toland A,Balmain A

doi

10.1080/01926230490424716

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

26-30

eissn

0192-6233

issn

1533-1601

journal_volume

32 Suppl 1

pub_type

杂志文章,评审
  • Spontaneous cardiomyopathy in young Sprague-Dawley rats: evaluation of biological and environmental variability.

    abstract::Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the normal heart histology. It is therefore crucial to understand the normal v...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623313478692

    authors: Chanut F,Kimbrough C,Hailey R,Berridge B,Hughes-Earle A,Davies R,Roland K,Stokes A,Casartelli A,York M,Jordan H,Crivellente F,Cristofori P,Thomas H,Klapwijk J,Adler R

    更新日期:2013-01-01 00:00:00

  • Subchronic toxicity of pentostatin in Wistar rats.

    abstract::Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10, 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339402200506

    authors: Courtney CL,Hawkins KL,Rothwell CE

    更新日期:1994-09-01 00:00:00

  • The common marmoset (Callithrix jacchus) as a model in toxicology.

    abstract::The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1080/01926230390175002

    authors: Zühlke U,Weinbauer G

    更新日期:2003-01-01 00:00:00

  • Complementarity between two rat liver tumor promoters.

    abstract::A delay in the exposure of initiated rats to orotic acid (OA) beyond a specific time frame results in a progressive loss of promotional effect in liver carcinogenesis. The current study was designed to ascertain whether the loss of promotional effect could be counteracted by pre-exposing the initiated animals to other...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338701500212

    authors: Laconi E,Vasudevan S,Rao PM,Rajalakshmi S,Sarma DS

    更新日期:1987-01-01 00:00:00

  • Longitudinal magnetic resonance imaging quantitation of rat liver regeneration after partial hepatectomy.

    abstract::This report demonstrates the advantages of using a noninvasive soft tissue imaging technique--magnetic resonance imaging (MRI)--to monitor liver regeneration after 70% partial hepatectomy in the rat in a longitudinal manner. Six animals were scanned prior to and on 6 subsequent occasions up to 9 days after surgical re...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230290105811

    authors: Hockings PD,Roberts T,Campbell SP,Reid DG,Greenhill RW,Polley SR,Nelson P,Bertram TA,Kramer K

    更新日期:2002-09-01 00:00:00

  • Renal papillary necrosis--40 years on.

    abstract::Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1177/019262339802600110

    authors: Bach PH,Nguyen TK

    更新日期:1998-01-01 00:00:00

  • Evaluation of novel urinary renal biomarkers: biological variation and reference change values.

    abstract::A number of novel urinary biomarkers have been identified and partially qualified for use as markers for renal injury in rats. We used two multiplex assays for these novel biomarkers to quantify biomarker concentration in serial urine collections from rats of both sexes administered varying concentrations of cisplatin...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623311432436

    authors: Pinches MD,Betts CJ,Bickerton SJ,Beattie L,Burdett LD,Thomas HT,Derbyshire NA,Moores M,Price SA

    更新日期:2012-04-01 00:00:00

  • Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media.

    abstract::Contrast-induced nephropathy (CIN) refers to a decline in renal function following exposure to iodinated contrast media (CM). The present study was initiated to explore the role of known human risk factors (spontaneous hypertension, diabetes, protein-losing nephropathy) on CIN development in rodent models and to deter...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623312464122

    authors: Rouse RL,Stewart SR,Thompson KL,Zhang J

    更新日期:2013-01-01 00:00:00

  • A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity.

    abstract::One application of genomics in drug safety assessment is the identification of biomarkers to predict compound toxicity before it is detected using traditional approaches, such as histopathology. However, many genomic approaches have failed to demonstrate superiority to traditional methods, have not been appropriately ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230500321213

    authors: Fielden MR,Eynon BP,Natsoulis G,Jarnagin K,Banas D,Kolaja KL

    更新日期:2005-01-01 00:00:00

  • Vacuolation of sensory ganglion neuron cytoplasm in rats with long-term exposure to organophosphates.

    abstract::Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623310369343

    authors: Rogers-Cotrone T,Burgess MP,Hancock SH,Hinckley J,Lowe K,Ehrich MF,Jortner BS

    更新日期:2010-06-01 00:00:00

  • Erratum.

    abstract::Weber, K. (2017). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. J Toxicol Pathol45, 64-75. (Original DOI: 10.1177/0192623316672075) In the January 2017 issue of Toxicologic Pathology, a number of in text Table citations were incorrectly labeled. The following are the sentences ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,已发布勘误

    doi:10.1177/0192623317702643

    authors:

    更新日期:2017-04-01 00:00:00

  • Twenty-six-Week carcinogenicity study of chloroform in CB6F1 rasH2-transgenic mice.

    abstract::The carcinogenic potential of chloroform was evaluated in a short-term carcinogenicity testing system using CB6F1 rasH2-Tg (rasH2-Tg) mice. Chloroform was administered to rasH2-Tg males at doses of 28, 90, or 140 mg/kg and rasH2-Tg females at 24, 90, or 240 mg/kg by oral gavage for 26 weeks. Wild-type (non-Tg) male an...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230252929909

    authors: Sehata S,Maejima T,Watanabe M,Ogata S,Makino T,Tanaka K,Manabe S,Takaoka M

    更新日期:2002-05-01 00:00:00

  • Toxicokinetic and mechanistic considerations in the interpretation of the rodent bioassay.

    abstract::When chemicals that are nongenotoxic in conventional assays produce increases in tumor incidence in rodents in chronic bioassays, the determination of the significance of these data for human safety is a challenging task. An important first step in this process is consideration of available data on the mechanism of ac...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1177/019262339402200206

    authors: MacDonald JS,Lankas GR,Morrissey RE

    更新日期:1994-03-01 00:00:00

  • The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies.

    abstract::Glucokinase activators (GKAs) are being developed for the treatment of type 2 diabetes. The toxicity of 4 GKAs (PF-04279405, PF-04651887, piragliatin, and PF-04937319) was assessed in mice, rats, dogs, and/or monkeys. GKAs were administered for 2 to 8 weeks. Standard endpoints, glucose, and insulin were assessed. All ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623314526006

    authors: Pettersen JC,Litchfield J,Neef N,Schmidt SP,Shirai N,Walters KM,Enerson BE,Chatman LA,Pfefferkorn JA

    更新日期:2014-06-01 00:00:00

  • Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet.

    abstract::Groups of C57BL6 mice of each sex were assigned to one of 2 dietary regimens, ad libitum (AL) or dietary restriction (DR), to study effects of food restriction on body weight, survival, and neoplasia. The AL and DR groups were subdivided into a scheduled sacrifice group for examination at 6-mo intervals, and a lifetim...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339502300503

    authors: Blackwell BN,Bucci TJ,Hart RW,Turturro A

    更新日期:1995-09-01 00:00:00

  • Regulatory Forum Opinion Piece*: An Experienced Pathologist Should Be Present at Necropsy for Novel Medical Device Studies.

    abstract::Necropsies conducted to support medical device development may be conducted in facilities that do not have the infrastructure in place to support Good Laboratory Practice for Nonclinical Laboratory Studies (GLP) studies and for a variety of reasons they may be conducted without a pathologist present at necropsy. Howev...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623315617035

    authors: Nikula KJ,Funk K

    更新日期:2016-01-01 00:00:00

  • Dissimilar characteristics of N-methyl-N-nitrosourea-initiated foci and tumors promoted by dichloroacetic acid or trichloroacetic acid in the liver of female B6C3F1 mice.

    abstract::Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339702500501

    authors: Latendresse JR,Pereira MA

    更新日期:1997-09-01 00:00:00

  • Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats.

    abstract::The renal toxicity of harman and norharman, administered for 2 or 4 weeks at dietary levels of 1,000, 500, or 0 parts per million (ppm), was investigated in 6-week-old male F344/DuCrj rats. Although rats fed 1,000 ppm harman or norharman, but not the 500 ppm level, demonstrated marked body weight retardation from 1 we...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339202000206

    authors: Hagiwara A,Asakawa E,Kurata Y,Sano M,Hirose M,Ito N

    更新日期:1992-01-01 00:00:00

  • Enzymic pattern of preneoplastic and neoplastic lesions induced in the kidney of CBA mice by 1,2-dimethylhydrazine.

    abstract::Mouse renal cell tumors (RCTs) were induced in male CBA mice by 5 subcutaneous injections of 8 mg 1,2-dimethylhydrazine (DMH)/kg body weight once a week. After a lag period of 2 yr kidneys were removed, and serial cryostat sections of the kidneys were histochemically analyzed for the following parameters: glycogen con...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339402200407

    authors: Ahn YS,Chemeris GY,Turusov VS,Bannasch P

    更新日期:1994-07-01 00:00:00

  • Statistical support of the proposed National Toxicology Program protocol.

    abstract::Statistical issues related to the design, analysis and interpretation of carcinogenicity studies are considered. A proposed modification of the "standard" National Cancer Institute (NCI) design of carcinogenicity studies in rodents is discussed. The primary objective was to obtain a design that maintained the power of...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338301100113

    authors: Haseman JK

    更新日期:1983-01-01 00:00:00

  • Troponin as a biomarker of cardiac toxicity: past, present, and future.

    abstract::Cardiac troponin (cTn) is a sensitive and specific biomarker for assessing cardiac damage and should be utilized in drug safety assessment. Lactate dehydrogenase and creatine kinase isoenzyme analyses have historically been used in pre-clinical toxicity testing to assess cardiac injury, but since these assays are less...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623310382438

    authors: Reagan WJ

    更新日期:2010-12-01 00:00:00

  • Use of isolated adult myocytes to evaluate cardiotoxicity. I. Sugar uptake and protein synthesis.

    abstract::The usefulness of isolated adult cardiac myocytes, both in suspension and in culture, as a model system for measuring cardiotoxicity is evaluated. It has been suggested that isolated adult myocytes should preferably be cultured for such experimentation, as this restores the cells to a physiological preference for fatt...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:

    authors: Haworth RA,Goknur AB,Cook MG,Decker RS

    更新日期:1990-01-01 00:00:00

  • Osteogenic Protein-1: gene expression and treatment in rat remnant kidney model.

    abstract::Osteogenic Protein-1 (OP-1) is a bone morphogen involved in tissue repair and development. We have shown that OP-1 is downregulated during acute ischemic renal injury. Here we report the use of the rat remnant kidney model (RRKM) to evaluate changes in kidney OP-1 expression during chronic injury, and determine if tre...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230490440925

    authors: Dube PH,Almanzar MM,Frazier KS,Jones WK,Charette MF,Paredes A

    更新日期:2004-07-01 00:00:00

  • Interruption of thrombosis and hemostasis by anti-platelet agents.

    abstract::Blood platelets play a fundamental role in hemostasis and thrombosis. The physiological role of platelets is to preserve the integrity of the cardiovascular system such that upon injury platelets are activated and serve to interrupt a potentially deleterious situation (i.e., hemorrhage). However, platelets are also in...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339302100210

    authors: Shebuski RJ

    更新日期:1993-01-01 00:00:00

  • Background Pathological Changes in Minipigs: A Comparison of the Incidence and Nature among Different Breeds and Populations of Minipigs.

    abstract::Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine have been used extensively in biomedical research, there is a paucity of information in the...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623315611762

    authors: Helke KL,Nelson KN,Sargeant AM,Jacob B,McKeag S,Haruna J,Vemireddi V,Greeley M,Brocksmith D,Navratil N,Stricker-Krongrad A,Hollinger C

    更新日期:2016-04-01 00:00:00

  • Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine.

    abstract::To characterize genetic alterations occurring in renal tumorigenesis, EHEN-induced renal cell tumors were examined using restriction landmark genomic scanning (RLGS) analysis, an electrophoretic separation technique that detects gene amplifications and deletions. Comparison of DNAs from tumor against those from corres...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/019262301317052503

    authors: Konishi N,Nakamura M,Ishida E,Kawada Y,Nishimine M,Nagai H,Emi M

    更新日期:2001-03-01 00:00:00

  • Generalized cellular hypertrophy is induced by a dual-acting PPAR agonist in rat urinary bladder urothelium in vivo.

    abstract::Some developmental dual-acting PPARalpha/gamma agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats orally dosed with ragaglitazar, using a newly developed flow c...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230500214657

    authors: Oleksiewicz MB,Thorup I,Nielsen HS,Andersen HV,Hegelund AC,Iversen L,Guldberg TS,Brinck PR,Sjogren I,Thinggaard UK,Jørgensen L,Jensen MB

    更新日期:2005-01-01 00:00:00

  • Altered p53 expression in early stages of chemically induced rodent hepatocarcinogenesis.

    abstract::Most available data on the involvement of p53 in rodent carcinogenesis are based on results of the end point of chemically or virally induced carcinogenesis, i.e., tumors. To investigate the role of altered p53 expression in early stages of rodent hepatocarcinogenesis in a systematic way, we treated male Wistar rats f...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339802600507

    authors: Wirnitzer U,Töpfer R,Rosenbruch M

    更新日期:1998-09-01 00:00:00

  • Renal toxicity of a nondopaminergic antipsychotic agent, trimethyl imidazopyrazolopyrimidine, in rats.

    abstract::A nondopaminergic antipsychotic agent, 5-ethyl-1,3,8-trimethyl-1H-imidazo]1,2-c]pyrazolo[3,4-e]pyrimidine (TIPP; PD 112488), has been tested for potential toxicity in rats. As part of a preclinical safety evaluation, 10 Wistar rats per sex were administered TIPP as a dietary admixture, receiving doses of 0, 5, 10, 20,...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339402200106

    authors: Macallum GE,Albassam MA

    更新日期:1994-01-01 00:00:00

  • Hylan G-F 20 induces delayed foreign body inflammation in Guinea pigs and rabbits.

    abstract::Recent clinical evidence suggests that hylan, a modified hyaluronan, and related products potentially elicit foreign body granulomatous inflammation in human soft tissue. We investigated the biocompatibility of hylan G-F 20 (Synvisc) for up to 28 days after intradermal injection in guinea pigs and intramuscular inject...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230390204360

    authors: Sasaki M,Miyazaki Y,Takahashi T

    更新日期:2003-05-01 00:00:00