Abstract：
:Biomass burning is a major source of indoor air pollution in rural India. The authors investigated in this study whether cumulative exposures to biomass smoke cause activation of the serine/threonine kinase Akt in airway cells and peripheral blood lymphocytes (PBL). For this, the authors enrolled 87 premenopausal (median age 34 years), nonsmoking women who used to cook with biomass (wood, dung, crop wastes) and 85 age-matched control women who cooked with cleaner fuel liquefied petroleum gas. Immunocytochemical and immunoblotting assays revealed significantly higher levels of phosphorylated forms of Akt protein (p-Akt(ser473) and p-Akt(thr308)) in PBL, airway epithelial cells, alveolar macrophages, and neutrophils in sputum of biomass-using women than control. Akt activation in biomass users was associated with marked rise in generation of reactive oxygen species and concomitant depletion of superoxide dismutase. Measurement of particulate matter having a diameter of less than 10 and 2.5 µm in indoor air by real-time aerosol monitor showed 2 to 4 times more particulate pollution in biomass-using households, and Akt activation was positively associated with particulate pollution after controlling potential confounders. The findings suggest that chronic exposure to biomass smoke activates Akt, possibly via generation of oxidative stress.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Mondal NK,Roy A,Mukherjee B,Das D,Ray MRdoi
10.1177/0192623310385139subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1085-98issue
7eissn
0192-6233issn
1533-1601pii
0192623310385139journal_volume
38pub_type
杂志文章abstract：:Peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists such as fenofibrate are used to treat dyslipidemia. Although fenofibrate is considered safe in humans, it is known to cause hepatocarcinogenesis in rodents. To evaluate untargeted metabolic profiling as a tool for gaining insight into the underlying...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309336152
更新日期：2009-06-01 00:00:00
abstract：:To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles journal_title：Toxicologic pathology pub_type： 杂志文章 doi：10.1177/0192623309332994 更新日期：2009-04-01 00:00:00
abstract：:In the present study, beta-catenin localization in hepatocellular neoplasms and hepatoblastomas, induced by oral administration of p-Nitroanisole (pNA) in Crj:BDF1 for 2 years, was evaluated by immunohistochemistry along with genetic alterations in exon 2 of beta-catenin by the polymerase chain reaction-single strand ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230600695474
更新日期：2006-01-01 00:00:00
abstract：:Artemin (ART) signals through the GFR alpha-3/RET receptor complex to support sympathetic neuron development. Here we show that ART also influences autonomic elements in adrenal medulla and enteric and pelvic ganglia. Transgenic mice over-expressing Art throughout development exhibited systemic autonomic neural lesion...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230490431475
更新日期：2004-05-01 00:00:00
abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262338601400103
更新日期：1986-01-01 00:00:00
abstract：:In organs with diverse cell populations, it is not uncommon for one type of cell to respond while others are spared. Even in an organ with common cell types, such as hepatocytes within the liver, the population of cells may respond with different sensitivities for injury or for biochemical responses to toxicants. In t...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230252824789
更新日期：2002-01-01 00:00:00
abstract：:Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide for long-acting delivery. The toxicity of a single intravitreal dose o...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623320969124
更新日期：2020-12-21 00:00:00
abstract：:Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310369343
更新日期：2010-06-01 00:00:00
abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339101900210
更新日期：1991-01-01 00:00:00
abstract：:In standard toxicity studies, the cardiac conduction tissue is not systematically sampled and examined for histopathological changes. Most methods described use serial sectioning perpendicular to the long axis of the sinoauricular node (SAN) and atrioventricular node (AVN). Dozens of slides are needed to allow examina...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300107
更新日期：1995-01-01 00:00:00
abstract：:Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powde...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623312470763
更新日期：2013-08-01 00:00:00
abstract：:Recent advances in immunocytochemical techniques allow the localization of specific antigens in tissue sections. The work reported here attempts to evaluate the application of antibody-labeled, disease-related protein, followed by microscopy and computerized image analysis. Using an experimental anti-tumor, polyclonal...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338701500308
更新日期：1987-01-01 00:00:00
abstract：:Toxicology of the male reproductive system has received increased interest in recent years partly fuelled by the growing reports of falling sperm counts and rising reproductive disorders in the human population. Recently revised regulatory guidelines for the safety assessment of pharmaceuticals and chemicals on reprod...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262339702500201
更新日期：1997-03-01 00:00:00
abstract：:We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300315
更新日期：1995-05-01 00:00:00
abstract：:The 2019 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology's 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This ar...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623319876929
更新日期：2019-12-01 00:00:00
abstract：:We describe 2 cases of a relatively rare tumor diagnosed as pituicytoma in the pars nervosa of rat pituitary. This tumor was spontaneously noted in one 110-week-old female and one 109-week-old male Fischer 344 (F344)/DuCrj rats during 2-year carcinogenicity studies. Although no gross abnormality of the pituitary was d...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262330002800612
更新日期：2000-11-01 00:00:00
abstract：:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338901700109
更新日期：1989-01-01 00:00:00
abstract：:A compendium of carcinogenesis bioassay results organized by target organ is presented for 738 chemicals that are carcinogenic in chronic-exposure, long-term bioassays in at least 1 species. This compendium is based primarily on experiments in rats or mice; results in hamsters, monkeys, and dogs are also reported. The...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/019262301753385979
更新日期：2001-11-01 00:00:00
abstract：:Duplications of the gastrointestinal tract are exceedingly rare in laboratory animals. We report a case of a communicating intestinal duplication in a 17-wk-old Sprague-Dawley (SD) rat. The duplication was present in the mesenteric border of the ileum, and both proximal and distal ends were communicated with the lumen...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600216
更新日期：1998-03-01 00:00:00
abstract：:In tissue slice models, interactions between the heterogeneous cell types comprising the lung parenchyma are maintained thus providing a controlled system for the study of pulmonary toxicology in vitro. However, validation of the model in vitro system must be affirmed. Previous reports, in in vivo systems, have demons...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230390183689
更新日期：2003-03-01 00:00:00
abstract：:The chloracetanilide herbicide alachlor (2-chloro-2',6-diethyl-N-(methoxymethyl)-acetanilide) induces nasal neoplasms in rats following chronic dietary exposure. The present study sought to identify the cellular origin and mechanisms of tumor induction and progression. Male Long-Evans rats were fed alachlor (0 or 126 ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262330002800602
更新日期：2000-11-01 00:00:00
abstract：:Although arsenic exposure causes liver disease and/or hepatoma, little is known about molecular mechanisms of arsenic-induced liver toxicity or carcinogenesis. We investigated the effects of arsenic on expression of cancer-related genes in a rat liver following subchronic exposure to sodium arsenate (1, 10, 100 ppm in...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230490261348
更新日期：2004-01-01 00:00:00
abstract：:Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600517
更新日期：1998-09-01 00:00:00
abstract：:Ocular medical devices (MDs) represent a very wide and promising field of human ophthalmology. In preclinical studies evaluating the safety and/or performance of these ocular MDs, the choice of histologic technique and the focus of the histopathologic evaluation method should take into consideration the following aspe...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623318813533
更新日期：2019-04-01 00:00:00
abstract：:Specific regions in the rodent larynx exhibit cellular changes in response to inhaled xenobiotics. These regions include the base of the epiglottis, ventral pouch, and medial surfaces of the vocal processes of the arytenoid cartilages. There are interspecies differences among laboratory rodents in the microscopic anat...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339302100604
更新日期：1993-11-01 00:00:00
abstract：:Over the past decade, laser capture microdissection (LCM) has grown as a tool for gene expression profiling of small numbers of cells from tumor samples and of specific cell populations in complex tissues. LCM can be used to study toxicant effects on selected cell populations within the testis at different stages of s...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623314526319
更新日期：2014-12-01 00:00:00
abstract：:The role of articular chondrocytes and matrix degrading enzymes such as collagenase and neutral protease in the pathogenesis of quinolone-induced cartilage degeneration was investigated in immature guinea pigs. Articular cartilage from nalidixic acid (NA) treated guinea pigs was examined for the presence of protease a...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339001800209
更新日期：1990-01-01 00:00:00
abstract：:Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cancer bioassays has been due to lack of historical data and diagnostic cr...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311436181
更新日期：2012-06-01 00:00:00
abstract：:A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338601400302
更新日期：1986-01-01 00:00:00
abstract：:Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area and stimulates catecholamine secretion from the adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia and neoplasia. We investigated the possible correlation betwe...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/019262302753559605
更新日期：2002-03-01 00:00:00
