Abstract:
:Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are associated with a mobilization of iron and catalysis of an oxidative stress. We describe 2 patients with ILD associated with exposure to synthetic textile fibers who demonstrated carbon-based ferruginous bodies suggesting an in vivo accumulation of iron by synthetic fibers after deposition in the lung. These iron-laden bodies varied from perfectly linear fibers to almost particulate matter. Linear structures were irregularly interrupted by deposition of iron-abundant material. The capacity of these synthetic fibers to complex iron and generate an oxidative stress is confirmed in vitro.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Ghio AJ,Funkhouser W,Pugh CB,Winters S,Stonehuerner JG,Mahar AM,Roggli VLdoi
10.1080/01926230600932448subject
Has Abstractpub_date
2006-01-01 00:00:00pages
723-9issue
6eissn
0192-6233issn
1533-1601pii
V3H5177404782774journal_volume
34pub_type
杂志文章abstract::We conducted a retrospective analysis of publicly available preclinical toxicology studies with erythropoiesis-stimulating agents (ESAs) to examine common adverse events in rats, Beagle dogs, and cynomolgus monkeys. Mortality and/or thrombotic events were reported sporadically in a subset of studies and attributed to ...
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