Morphological and ultrastructural study of the histogenesis of meningeal granular cell tumors in rats.

abstract：:In vitro techniques for the culture of hemopoietic stem cells and committed hemopoietic progenitor cells in rat bone marrow have not been adequately described in the literature. In the present investigations, and using commercially available hemopoietic cytokines and growth factors, the conditions required to perform ...

journal_title：Toxicologic pathology

authors： Molyneux G,Rizzo S,Turton J,Phul P,Gibson F

更新日期：2009-02-01 00:00:00

abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...

journal_title：Toxicologic pathology

authors： Stoll RE,Holden HE,Barthel CH,Blanchard KT

更新日期：1999-09-01 00:00:00

abstract：:The literature evidencing the role of iron in promoting a range of neoplasms in humans and animals prompted us to search for a possible association between chemically induced hemosiderosis and hemangiosarcomas in the liver of mice in selected studies conducted by the National Toxicology Program (NTP). Its historical c...

journal_title：Toxicologic pathology

authors： Nyska A,Haseman JK,Kohen R,Maronpot RR

更新日期：2004-03-01 00:00:00

abstract：:Hepatic microsomal enzymes play an important role in thyroid hormone homeostasis. Glucuronidation of thyroxine is the rate limiting step in the biliary excretion of thyroxine in the rat; the monodeiodinases are important in the conversion of T4 to T3 and reverse T3 and subsequent deiodinations. Phenobarbital is known ...

journal_title：Toxicologic pathology

authors： McClain RM

更新日期：1989-01-01 00:00:00

abstract：:Laser scanning cytometry (LSC) is a powerful tool for qualitative and quantitative analysis of tissue sections in preclinical drug development. LSC combines the strengths of flow cytometry with tissue architecture retention. This technology has been used predominantly with immunofluorescent techniques on cell culture ...

journal_title：Toxicologic pathology

authors： Peterson RA,Krull DL,Butler L

更新日期：2008-01-01 00:00:00

abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...

journal_title：Toxicologic pathology

authors： Treumann S,Buesen R,Gröters S,Eichler JO,van Ravenzwaay B

更新日期：2015-08-01 00:00:00

abstract：:Whole mount enzyme histochemistry to localize lacZ-bearing transgenes (lacZ-WMH) also detects endogenous beta-galactosidases. The experiments reported here evaluated lacZ-WMH as a potential tool for transgene expression analysis during high-throughput rodent necropsies. A lacZ-WMH survey of organs from adult, wild-typ...

journal_title：Toxicologic pathology

authors： Bolon B

更新日期：2008-02-01 00:00:00

abstract：:High-resolution digitalizing of histology slides facilitates the development of computational alternatives to manual quantitation of features of interest. We developed a MATLAB-based quantitative histological analysis tool (QuHAnT) for the high-throughput assessment of distinguishable histological features. QuHAnT val...

journal_title：Toxicologic pathology

authors： Nault R,Colbry D,Brandenberger C,Harkema JR,Zacharewski TR

更新日期：2015-04-01 00:00:00

abstract：:Progressive renal interstitial fibrosis occurs following tissue injury, resulting in chronic renal failure. In the fibrogenesis, macrophages are speculated to induce myofibroblasts producing matrix protein. The kinetics of these cells in renal fibrosis induced in rats by repeated injection of cisplatin (CDDP) (2 mg/kg...

journal_title：Toxicologic pathology

authors： Yamate J,Ishida A,Tsujino K,Tatsumi M,Nakatsuji S,Kuwamura M,Kotani T,Sakuma S

更新日期：1996-03-01 00:00:00

abstract：:In carcinogenicity studies with PPAR gamma and alpha/gamma agonists, urinary bladder tumors have been reported in Harlan Sprague-Dawley (HSD) and Charles River Sprague-Dawley (SD) but not Wistar (WI) rats, with urolithiasis purported to be the inciting event. In two 3-month studies, the authors investigated strain-rel...

journal_title：Toxicologic pathology

authors： Tannehill-Gregg SH,Dominick MA,Reisinger AJ,Moehlenkamp JD,Waites CR,Stock DA,Sanderson TP,Cohen SM,Arnold LL,Schilling BE

更新日期：2009-04-01 00:00:00

abstract：:Studies were carried out on microsomes isolated from the highly differentiated (slow-growing) Morris hepatoma 9618A, on microsomes and plasma membranes from the poorly differentiated (fast-growing) Morris hepatoma 3924A, and rat liver used as control. The lipid composition (phospholipid and cholesterol content, degree...

journal_title：Toxicologic pathology

authors： Galeotti T,Borrello S,Minotti G,Palombini G,Masotti L,Sartor G,Cavatorta P,Arcioni A,Zannoni C

更新日期：1984-01-01 00:00:00

abstract：:Transgenic Tg.AC mice carry a v-Ha-ras coding region flanked by a zeta-globin promoter and an SV40 polyadenylation signal sequence. These mice respond to carcinogens by developing epidermal papillomas. In some cases, malignancies develop at the sites of these papillomas. Various patterns of squamous cell differentiati...

journal_title：Toxicologic pathology

authors： Asano S,Trempus CS,Spalding JW,Tennant RW,Battalora MS

更新日期：1998-07-01 00:00:00

abstract：:The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...

journal_title：Toxicologic pathology

authors： Radi ZA,Khan NK

更新日期：2006-01-01 00:00:00

abstract：:The administration of mesenchymal stromal cells (MSCs) provides an exciting emerging therapeutic modality for the treatment of peripheral arterial disease, a condition that is associated with critical limb ischemia as its end stage. Placental-derived MSCs, termed PLX-PAD cells, are stable adhesive stromal cells isolat...

journal_title：Toxicologic pathology

authors： Ramot Y,Meiron M,Toren A,Steiner M,Nyska A

更新日期：2009-08-01 00:00:00

abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...

journal_title：Toxicologic pathology

authors： Schmidt F,Wolf R,Baumann L,Braunbeck T

更新日期：2017-07-01 00:00:00

abstract：:Macrophages appearing in lesions are polarized toward M1 (for inflammation) and M2 (for anti-inflammation/fibrosis) types. We analyzed immunophenotypes of macrophages appearing in myocardial lesion in rats injected once with isoproterenol (10 mg/kg body weight). Inflammation following myocardial necrosis on day 1 was ...

journal_title：Toxicologic pathology

authors： Koga M,Karim MR,Kuramochi M,Izawa T,Kuwamura M,Yamate J

更新日期：2021-01-05 00:00:00

abstract：:Repeated intraperitoneal injections of crocidolite asbestos fibers induced diffuse malignant mesotheliomas in mice. A series of mesothelial cell lines was isolated from mice at different stages in the development of these tumors. The cell lines isolated from mice with mesotheliomas recapitulated their growth pattern i...

journal_title：Toxicologic pathology

authors： Goodglick LA,Vaslet CA,Messier NJ,Kane AB

更新日期：1997-11-01 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:High doses of insulin and the insulin analog AspB10 have been reported to increase mammary tumor incidence in female rats likely via receptor-mediated mechanisms, possibly involving enhanced IGF-1 receptor activation. However, insulin and IGF-1 receptor functionality and intracellular signaling in the rat mammary glan...

journal_title：Toxicologic pathology

authors： Hvid H,Fels JJ,Kirk RK,Thorup I,Jensen HE,Hansen BF,Oleksiewicz MB

更新日期：2011-06-01 00:00:00

abstract：:Two-year toxicity studies were conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. With goldenseal root powder, the primary finding was an increase in liver tumors in rats and mice, and with milk thistle extract, a decrease in spontaneous backgroun...

journal_title：Toxicologic pathology

authors： Dunnick JK,Singh B,Nyska A,Peckham J,Kissling GE,Sanders JM

更新日期：2011-02-01 00:00:00

abstract：:Conazoles are a class of azole based fungicides used in agriculture and as pharmaceutical products. They have a common mode of antifungal action through inhibition of ergosterol biosynthesis. Some members of this class have been shown to be hepatotoxic and will induce mouse hepatocellular tumors and/or rat thyroid fol...

journal_title：Toxicologic pathology

authors： Wolf DC,Allen JW,George MH,Hester SD,Sun G,Moore T,Thai SF,Delker D,Winkfield E,Leavitt S,Nelson G,Roop BC,Jones C,Thibodeaux J,Nesnow S

更新日期：2006-01-01 00:00:00

abstract：:There has been a substantial increase in the number and efficacy of laboratory biomarkers for the evaluation of human cardiac injury over the last decade. The advantages of these over traditional laboratory tests have encouraged adoption of comparable markers in nonclinical studies for cardiac injury assessment. Of pa...

journal_title：Toxicologic pathology

authors： Walker DB

更新日期：2006-01-01 00:00:00

abstract：:The development process of myelination varies between region and species. Fully myelinated fibers are required if mammalian neural circuits are to function normally. Histology samples at staggered time points throughout the study were examined at days 4, 5, 7, 8, 10, 14, 17, 24, 37, and 44. We suggest that the develop...

journal_title：Toxicologic pathology

authors： Downes N,Mullins P

更新日期：2014-07-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:Nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. Our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. We nebulized nedocromil sodium into beagle dogs (n = 10, mean +/- SEM ages: 149 +/- 13 days) before and after in...

journal_title：Toxicologic pathology

authors： Anderson KA,Lemen RJ,Weger NS,Chen H,Bowers MC,Witten ML,Lantz RC,Bice DE,Muggenburg BA

更新日期：2000-03-01 00:00:00

abstract：:Cardiac troponin (cTn) is a sensitive and specific biomarker for assessing cardiac damage and should be utilized in drug safety assessment. Lactate dehydrogenase and creatine kinase isoenzyme analyses have historically been used in pre-clinical toxicity testing to assess cardiac injury, but since these assays are less...

journal_title：Toxicologic pathology

authors： Reagan WJ

更新日期：2010-12-01 00:00:00

abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...

journal_title：Toxicologic pathology

authors： Payne SR,Kemp CJ

更新日期：2003-07-01 00:00:00

abstract：:Pepsinogens are acid protease enzymes of pepsin usually found in gastric mucosa. In the present study, we demonstrated the presence of pepsinogen isozymes in male Syrian golden hamster lung tissues by a combined immunohistochemical and biochemical approach. Immunohistochemically, using rat pepsinogen 1 antibody, pepsi...

journal_title：Toxicologic pathology

authors： Imaida K,Furihata C,Tatematsu M,Yoon CH,Furukawa F,Uneyama C,Takahashi M,Ito N,Hayashi Y

更新日期：1991-01-01 00:00:00

abstract：:Toxicology of the male reproductive system has received increased interest in recent years partly fuelled by the growing reports of falling sperm counts and rising reproductive disorders in the human population. Recently revised regulatory guidelines for the safety assessment of pharmaceuticals and chemicals on reprod...

journal_title：Toxicologic pathology

authors： Creasy DM

更新日期：1997-03-01 00:00:00

abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...

journal_title：Toxicologic pathology

authors： Sayama A,Okado K,Nakamura K,Kawaguchi T,Iguchi T,Makino T,Yabe K,Kai K,Mori K

更新日期：2018-02-01 00:00:00