Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features.

abstract：:Cancer affects approximately 1 in 3 individuals. An individual's susceptibility to cancer is partly determined by environmental exposures and by the combination of inherited cancer susceptibility and resistance genes. Initial mapping of these low penetrance cancer susceptibility genes has been done in the mouse becaus...

journal_title：Toxicologic pathology

authors： Ewart-Toland A,Balmain A

更新日期：2004-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...

journal_title：Toxicologic pathology

authors： Kakiuchi-Kiyota S,Arnold LL,Yokohira M,Koza-Taylor P,Suzuki S,Varney M,Pennington KL,Cohen SM

更新日期：2011-12-01 00:00:00

abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...

journal_title：Toxicologic pathology

authors： Harris DL,Washington MK,Hood DB,Roberts LJ 2nd,Ramesh A

更新日期：2009-12-01 00:00:00

abstract：:Astrocytes assume multiple roles in maintaining an optimally suited milieu for neuronal function. Select astrocytic functions include the maintenance of redox potential, the production of trophic factors, the regulation of neurotransmitter and ion concentrations, and the removal of toxins and debris from the cerebrosp...

journal_title：Toxicologic pathology

authors： Sidoryk-Wegrzynowicz M,Wegrzynowicz M,Lee E,Bowman AB,Aschner M

更新日期：2011-01-01 00:00:00

abstract：:A factor limiting widespread use of the transgenic rasH2 mouse model for carcinogenicity testing of pharmaceuticals is the paucity of published data on actual drug candidates in rasH2 mice. This report addresses this gap by highlighting rasH2 mouse study data for 10 pharmaceutical candidates. These results were compar...

journal_title：Toxicologic pathology

authors： Nambiar PR,Morton D

更新日期：2013-01-01 00:00:00

abstract：:Sections of thymus from New Zealand white rabbits used as controls in 28-day and 91-day percutaneous toxicity studies conducted at different laboratories were morphometrically assessed. Measurements of total thymic area, medullary area, and cortical area were greater for 28-day vs 91-day studies conducted at a given l...

journal_title：Toxicologic pathology

authors： Maurer JK,Gibbons BA,Bruce RD

更新日期：1990-01-01 00:00:00

abstract：:This brief review summarizes our current understanding of vasculitis mediated by phlogistic immune complexes. The Arthus reaction and serum sickness both represent experimental models for immune complex disease. Immune complex phenomena occur in conjunction with C3 deficiency of dogs during canine distemper virus infe...

journal_title：Toxicologic pathology

authors： Krakowka S

更新日期：1989-01-01 00:00:00

abstract：:A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular d...

journal_title：Toxicologic pathology

authors： Swartley OM,Foley JF,Livingston DP 3rd,Cullen JM,Elmore SA

更新日期：2016-07-01 00:00:00

abstract：:This is a survey of the results of recent investigations on gastrointestinal (GI) peptide hormones. In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known. These include vasoactive intestin...

journal_title：Toxicologic pathology

authors： Tansy MF,Kendall FM

更新日期：1988-01-01 00:00:00

abstract：:Slc:Wistar male rats treated with human natural tumor necrosis factor alpha (hn TNF-alpha, 3 X 10(5) Japan reference units/kg intravenously) for 3 months showed histologic vacuolation of basophils in the anterior pituitary, hyperplasia of the thyroidal follicular epithelium, and hyperplasia of the testicular interstit...

journal_title：Toxicologic pathology

authors： Kakinuma C,Hamada Y,Futamura Y,Kuwayama C,Shimoi A,Shibutani Y

更新日期：1999-07-01 00:00:00

abstract：:Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...

journal_title：Toxicologic pathology

authors： Rogers-Cotrone T,Burgess MP,Hancock SH,Hinckley J,Lowe K,Ehrich MF,Jortner BS

更新日期：2010-06-01 00:00:00

abstract：:Cysteamine is the first chemical identified that induces acute and chronic duodenal ulcers in rodents. Structure-activity studies with cysteamine, propionitrile and their derivatives, as well as with analogues of toluene, revealed numerous alkyl and aryl duodenal ulcerogens. Among these, one of the most interesting fr...

journal_title：Toxicologic pathology

authors： Szabo S,Cho CH

更新日期：1988-01-01 00:00:00

abstract：:Regulatory guidelines for nonclinical neurotoxicity testing require spinal cord evaluation but do not specify a trimming scheme. The Society of Toxicologic Pathology (STP) "best practices" for nervous system sampling during nonclinical general toxicity studies recommend that spinal cord be assessed in both longitudina...

journal_title：Toxicologic pathology

authors： Bolon B

更新日期：2017-07-01 00:00:00

abstract：:The title of the 2017 Society of Toxicologic Pathology symposium was "Musculoskeletal System." A brief overview of the General Scientific Symposium is presented herein and describes the topics presented by each speaker. Symposium speakers addressed subjects pertinent to musculoskeletal system toxicologic pathology and...

journal_title：Toxicologic pathology

authors： Gropp KE,Boyle MC

更新日期：2017-10-01 00:00:00

abstract：:Many common inflammatory disorders are characterized by the infiltration of neutrophils across epithelial lined (mucosal) surfaces resulting in disruption of critical barrier function that protects from microbes and noxious agents. In such conditions, disease symptoms are complex but directly related to leukocyte effe...

journal_title：Toxicologic pathology

authors： Matthews JD,Weight CM,Parkos CA

更新日期：2014-01-01 00:00:00

abstract：:Exposed to a diverse array of potentially noxious agents, the respiratory tract is protected by a highly developed innate defense system. Physiologically regulated epithelial ion and water transport coordinated with mucin secretion, beating cilia, and cough results in continuous flow of fluid and mucus over airway sur...

journal_title：Toxicologic pathology

authors： Livraghi A,Randell SH

更新日期：2007-01-01 00:00:00

abstract：:In the Federal Register of January 10, 2000 (65 FR 1399), FDA published a draft guidance entitled "Photosafety Testing." The notice gave interested persons an opportunity to submit comments. As a result of the comments, certain sections of the guidance were reworded to improve clarity. A final guidance was published i...

journal_title：Toxicologic pathology

authors： Jacobs AC,Brown PC,Chen C,Ellis A,Farrelly J,Osterberg R

更新日期：2004-07-01 00:00:00

abstract：:Spontaneous neoplasm rates were determined for control Fischer 344 (F344) rats and B6C3F1 mice from 2-yr rodent carcinogenicity studies carried out by the National Toxicology Program (NTP). The most frequently occurring neoplasms in untreated male F344 rats were testicular adenoma (89.1%), mononuclear cell leukemia (5...

journal_title：Toxicologic pathology

authors： Haseman JK,Hailey JR,Morris RW

更新日期：1998-05-01 00:00:00

abstract：:In tissue slice models, interactions between the heterogeneous cell types comprising the lung parenchyma are maintained thus providing a controlled system for the study of pulmonary toxicology in vitro. However, validation of the model in vitro system must be affirmed. Previous reports, in in vivo systems, have demons...

journal_title：Toxicologic pathology

authors： Hays AM,Lantz RC,Witten ML

更新日期：2003-03-01 00:00:00

abstract：:The nonnucleoside inhibitor (NNI) of HIV-1 reverse transcriptase, PHI-346 (N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea), is a dual-function spermicidal agent with potent anti-HIV activity against drug-sensitive as well as drug-resistant HIV-1 strains with genotypic and phenotypic NNI resistance. PHI-3...

journal_title：Toxicologic pathology

authors： D'Cruz OJ,Waurzyniak B,Uckun FM

更新日期：2002-11-01 00:00:00

abstract：:Toxicogenomics using a reference database can provide a better understanding and prediction of toxicity, largely by creating biomarkers that tie gene expression to actual pathology events. During the course of building a toxicogenomic database, an observation was made that a number of non-steroidal anti-inflammatory c...

journal_title：Toxicologic pathology

authors： Tugendreich S,Pearson CI,Sagartz J,Jarnagin K,Kolaja K

更新日期：2006-01-01 00:00:00

abstract：:During preclinical investigations into the safety of drugs and chemicals, many are found to interfere with reproductive function in the female rat. This interference is commonly expressed as a change in normal morphology of the reproductive tract or a disturbance in the duration of particular phases of the estrous cyc...

journal_title：Toxicologic pathology

authors： Westwood FR

更新日期：2008-04-01 00:00:00

abstract：:Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in...

journal_title：Toxicologic pathology

authors： Bach PH,Nguyen TK

更新日期：1998-01-01 00:00:00

abstract：:Ocular medical devices (MDs) represent a very wide and promising field of human ophthalmology. In preclinical studies evaluating the safety and/or performance of these ocular MDs, the choice of histologic technique and the focus of the histopathologic evaluation method should take into consideration the following aspe...

journal_title：Toxicologic pathology

authors： Drevon-Gaillot E

更新日期：2019-04-01 00:00:00

abstract：:The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment. Male Balb/c mice received a single intraperitoneal injection of DENA (0, 2.5, 10.0, 25.0 or 50.0 micrograms/gbw) in saline on day 15 of age. N...

journal_title：Toxicologic pathology

authors： Klaunig JE,Pereira MA,Ruch RJ,Weghorst CM

更新日期：1988-01-01 00:00:00

abstract：:The usefulness of isolated adult cardiac myocytes, both in suspension and in culture, as a model system for measuring cardiotoxicity is evaluated. It has been suggested that isolated adult myocytes should preferably be cultured for such experimentation, as this restores the cells to a physiological preference for fatt...

journal_title：Toxicologic pathology

authors： Haworth RA,Goknur AB,Cook MG,Decker RS

更新日期：1990-01-01 00:00:00

abstract：:Congenital anomalies of the alimentary tract are rare lesions in laboratory animals. We describe a congenital cyst attached to the greater curvature of the forestomach in a B6C3F1 mouse. The inner surface of the cyst was mostly covered with cuboidal or pseudostratified ciliated epithelium and was focally covered with ...

journal_title：Toxicologic pathology

authors： Miyajima R,Kihara T,Hosoi M,Yamamoto S,Mikami S,Yamakawa S,Iwata H,Enomoto M

更新日期：1999-09-01 00:00:00

abstract：:Bioabsorbable implants can be advantageous for certain surgical tissue bioengineering applications and implant-assisted tissue repair. They offer the obvious benefits of nonpermanence and eventual restoration of the native tissue's biomechanical and immunological properties, while providing a structural scaffold for h...

journal_title：Toxicologic pathology

authors： Rousselle SD,Ramot Y,Nyska A,Jackson ND

更新日期：2019-04-01 00:00:00

abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...

journal_title：Toxicologic pathology

authors： Sayama A,Okado K,Nakamura K,Kawaguchi T,Iguchi T,Makino T,Yabe K,Kai K,Mori K

更新日期：2018-02-01 00:00:00

abstract：:Helicobacter hepaticus infection induces sustained inflammation and carcinoma of the liver in A/JCr mice, and serves as a model of human cancers associated with viral hepatitis and H. pylorichronic gastritis. Here we describe the pathogenesis of premalignant disease in A/JCr mice infected with H. hepaticus. We inocula...

journal_title：Toxicologic pathology

authors： Rogers AB,Boutin SR,Whary MT,Sundina N,Ge Z,Cormier K,Fox JG

更新日期：2004-11-01 00:00:00