Appearance of Heterogeneous Macrophages During Development of Isoproterenol-Induced Rat Myocardial Fibrosis.

abstract：:This is a survey of the results of recent investigations on gastrointestinal (GI) peptide hormones. In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known. These include vasoactive intestin...

journal_title：Toxicologic pathology

authors： Tansy MF,Kendall FM

更新日期：1988-01-01 00:00:00

abstract：:We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...

journal_title：Toxicologic pathology

authors： Maurer JK,Parker RD,Carr GJ

更新日期：1998-03-01 00:00:00

abstract：:Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...

journal_title：Toxicologic pathology

authors： Yamate J,Iwaki M,Nakatsuji S,Kuwamura M,Kotani T,Sakuma S

更新日期：1998-09-01 00:00:00

abstract：:Ocular medical devices (MDs) represent a very wide and promising field of human ophthalmology. In preclinical studies evaluating the safety and/or performance of these ocular MDs, the choice of histologic technique and the focus of the histopathologic evaluation method should take into consideration the following aspe...

journal_title：Toxicologic pathology

authors： Drevon-Gaillot E

更新日期：2019-04-01 00:00:00

abstract：:In the present study, beta-catenin localization in hepatocellular neoplasms and hepatoblastomas, induced by oral administration of p-Nitroanisole (pNA) in Crj:BDF1 for 2 years, was evaluated by immunohistochemistry along with genetic alterations in exon 2 of beta-catenin by the polymerase chain reaction-single strand ...

journal_title：Toxicologic pathology

authors： Kushida M,Aiso S,Morimura K,Wei M,Wanibuchi H,Nagano K,Fukushima S

更新日期：2006-01-01 00:00:00

abstract：:An eosinophilic substance (ES) is usually observed in the mouse nasal septum. In contrast to textbooks and one report describing ES as amyloid, a previous study by the authors revealed that ES is not amyloid but consists of collagen and an amorphous material. Furthermore, it was suggested that the amorphous material w...

journal_title：Toxicologic pathology

authors： Doi T,Kokoshima H,Kanno T,Sato J,Wako Y,Tsuchitani M,Matsui T

更新日期：2010-06-01 00:00:00

abstract：:Microminipigs have become an attractive animal model for toxicology and pharmacology studies and for human disease models, owing to their manageable size. Although there are numerous reports of spontaneous age-related lesions in mice, rats, dogs, and monkeys, those in minipigs are scarce. In the present study, spontan...

journal_title：Toxicologic pathology

authors： Kangawa A,Nishimura T,Nishimura T,Otake M,Enya S,Yoshida T,Shibata M

更新日期：2019-10-01 00:00:00

abstract：:Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...

journal_title：Toxicologic pathology

authors： Latendresse JR,Pereira MA

更新日期：1997-09-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:To investigate pathogenesis of post-bile duct (BD) injury fibrosis, interlobular BD epithelial injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 mg/kg body weight) and rats were observed for 12 days. On days 1 to 2, cholangiocytes were injured and desquamated. On days 3 to 5...

journal_title：Toxicologic pathology

authors： Golbar HM,Izawa T,Yano R,Ichikawa C,Sawamoto O,Kuwamura M,Lamarre J,Yamate J

更新日期：2011-08-01 00:00:00

abstract：:Mixed-function oxidase (MFO) induction in the mouse liver results in a rapid and sustained centrilobular hypertrophy associated with a hyperplastic response. In many studies, the long-term sequela of prolonged exposure is an increased incidence of lesions considered to be adenomas. Studies have shown in aged control m...

journal_title：Toxicologic pathology

authors： Butler WH

更新日期：1996-07-01 00:00:00

abstract：:In a three-week oral gavage toxicity study in rats, a high incidence of respiratory symptoms and high mortality was noted in compound-dosed rats only. Because of audible respiration, an effect in the upper respiratory tract was suspected and the nasal cavity was included for examination. Histology revealed extensive n...

journal_title：Toxicologic pathology

authors： Damsch S,Eichenbaum G,Looszova A,Lammens L,Feyen B,Van den Bulck K,Knight E,Kelley M,Tonelli A

更新日期：2011-02-01 00:00:00

abstract：:Cyclodextrins are oligosaccharides which are used in the pharmaceutical industry and research as vehicles for application of apolar substances such as steroids. The aim of this study was to examine the long-term effects of parenteral administration of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on bone. Sham-operated (SH...

journal_title：Toxicologic pathology

authors： Kantner I,Erben RG

更新日期：2012-07-01 00:00:00

abstract：:Standard histology trimming practices for toxicity studies in dogs include preparation of a section of the papillary muscle associated with the left ventricular free wall-the anteriolateral or anterior muscle. In contrast, the posteromedial or posterior papillary muscle, associated with the interventricular septum, is...

journal_title：Toxicologic pathology

authors： Kohnken R,Weber A

更新日期：2020-10-01 00:00:00

abstract：:The nonnucleoside inhibitor (NNI) of HIV-1 reverse transcriptase, PHI-346 (N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea), is a dual-function spermicidal agent with potent anti-HIV activity against drug-sensitive as well as drug-resistant HIV-1 strains with genotypic and phenotypic NNI resistance. PHI-3...

journal_title：Toxicologic pathology

authors： D'Cruz OJ,Waurzyniak B,Uckun FM

更新日期：2002-11-01 00:00:00

abstract：:Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubulog...

journal_title：Toxicologic pathology

authors： Wang J,Zhong J,Yang HC,Fogo AB

更新日期：2018-12-01 00:00:00

abstract：:Neurotoxicants with similar structural features or common mechanisms of chemical action frequently produce widely divergent neuropathologic outcomes. Methylmercury (MeHg) produces marked cerebellar dysmorphogenesis during critical periods of development. The pathologic picture is characterized by complete architectura...

journal_title：Toxicologic pathology

authors： Philbert MA,Billingsley ML,Reuhl KR

更新日期：2000-01-01 00:00:00

abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...

journal_title：Toxicologic pathology

authors： Gill S,Veinot J,Kavanagh M,Pulido O

更新日期：2007-04-01 00:00:00

abstract：:Congenital anomalies of the alimentary tract are rare lesions in laboratory animals. We describe a congenital cyst attached to the greater curvature of the forestomach in a B6C3F1 mouse. The inner surface of the cyst was mostly covered with cuboidal or pseudostratified ciliated epithelium and was focally covered with ...

journal_title：Toxicologic pathology

authors： Miyajima R,Kihara T,Hosoi M,Yamamoto S,Mikami S,Yamakawa S,Iwata H,Enomoto M

更新日期：1999-09-01 00:00:00

abstract：:Parenteral administration of recombinant hematopoietic growth factors has been sporadically associated with cutaneous complications, including injection site reactions in humans and nonhuman primates. In this study, subcutaneous injection sites were evaluated from 12 cynomolgus monkeys administered a recombinant human...

journal_title：Toxicologic pathology

authors： Khan KN,Kats AA,Fouant MM,Snook SS,Mckearn JP,Alden CL,Smith PF

更新日期：1996-07-01 00:00:00

abstract：:Aminoglycoside antibiotics are ototoxic in mammals and birds, including recently hatched chicks, but chicken embryos are insensitive to the ototoxicity of gentamicin, kanamycin, and streptomycin. To determine whether or not the insensitivity is due to a lack of antibiotic distribution to the avian cochlea, the distrib...

journal_title：Toxicologic pathology

authors： Fikes JD,Render JA,Reed WM,Bursian S,Poppenga RH,Sleight SD,Yoshioka T

更新日期：1994-01-01 00:00:00

abstract：:The lung is a target organ for the toxic effects of several chemical agents, including natural products, industrial chemicals, pesticides, environmental agents, and occasionally, drugs. Factors that establish the lung as a target organ include selective tissue exposure, high tissue oxygenation, and the presence of bio...

journal_title：Toxicologic pathology

authors： Smith BR,Brian WR

更新日期：1991-01-01 00:00:00

abstract：:Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate. Fontana-Masson stain demonstrated decr...

journal_title：Toxicologic pathology

authors： Walsh KM,Gough AW

更新日期：1989-01-01 00:00:00

abstract：:A spontaneous multicystic peritoneal mesothelioma was detected in a 108-wk-old male Fischer-344/DuCrj rat. Grossly, a tumor containing numerous, semi-transparent, variously sized, thin-walled cysts was found on the splenic serosal surface. Microscopically, each cyst was surrounded by variable amounts of loose connecti...

journal_title：Toxicologic pathology

authors： Shibuya K,Tajima M,Yamate J

更新日期：1993-01-01 00:00:00

abstract：:The renal toxicity of harman and norharman, administered for 2 or 4 weeks at dietary levels of 1,000, 500, or 0 parts per million (ppm), was investigated in 6-week-old male F344/DuCrj rats. Although rats fed 1,000 ppm harman or norharman, but not the 500 ppm level, demonstrated marked body weight retardation from 1 we...

journal_title：Toxicologic pathology

authors： Hagiwara A,Asakawa E,Kurata Y,Sano M,Hirose M,Ito N

更新日期：1992-01-01 00:00:00

abstract：:The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identi...

journal_title：Toxicologic pathology

authors： Pinkney AE,Harshbarger JC,Rutter MA,Sakaris PC

更新日期：2019-02-01 00:00:00

abstract：:Substantial progress in understanding nongenotoxic or secondary mechanisms of tumorigenesis has been made over the past decade. However, the methods used in regulated studies for assessment of carcinogenic potential in chemicals in development have not evolved significantly. Based on the experience of over 30 yr of te...

journal_title：Toxicologic pathology

authors： Alden CL,Smith PF,Piper CE,Brej L

更新日期：1996-11-01 00:00:00

abstract：:Recently, considerable attention has been focused on certain environmental contaminants--"endocrine disruptors"--of industrial origin that may mimic the action of sex hormones. Natural compounds and their effects on other types of hormonal activity (eg, on adrenal or thyroid function) have for some reason not provoked...

journal_title：Toxicologic pathology

authors： Nilsson R

更新日期：2000-05-01 00:00:00

abstract：:Cardiac troponin (cTn) is a sensitive and specific biomarker for assessing cardiac damage and should be utilized in drug safety assessment. Lactate dehydrogenase and creatine kinase isoenzyme analyses have historically been used in pre-clinical toxicity testing to assess cardiac injury, but since these assays are less...

journal_title：Toxicologic pathology

authors： Reagan WJ

更新日期：2010-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...

journal_title：Toxicologic pathology

authors： Kakiuchi-Kiyota S,Arnold LL,Yokohira M,Koza-Taylor P,Suzuki S,Varney M,Pennington KL,Cohen SM

更新日期：2011-12-01 00:00:00