Abstract:
:Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10, 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above the therapeutic dose in humans). Lymphoplasmacytic thyroiditis was present in 20% of females given 25 mg/kg and in 20 and 47% of males and females given 50 mg/kg, respectively. Thyroiditis was still present 4 wk following drug withdrawal. Thyroiditis was characterized by glandular enlargement, follicular epithelial hyperplasia and degeneration, colloid depletion, and interstitial infiltrates of lymphocytes and plasma cells. Drug-related changes in other tissues included lymphoid depletion of T-cell regions of thymus, spleen, and lymph nodes; bronchiolization of alveolar ducts with accumulation of mucus and foamy macrophages; testicular atrophy with sperm granulomas; dermoepidermal lymphocytic infiltrates with ulceration and alopecia; and hepatocytomegaly.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Courtney CL,Hawkins KL,Rothwell CEdoi
10.1177/019262339402200506subject
Has Abstractpub_date
1994-09-01 00:00:00pages
519-23issue
5eissn
0192-6233issn
1533-1601journal_volume
22pub_type
杂志文章abstract::GJA1 gene (Connexin43, also known as Cx43) is the most abundant gap junction protein isoform in animal cells and is associated with bone development in embryos. The objective of the present work was to evaluate in vivo osteal development in GJA1-deficient fetal mice through determination of the histological and molecu...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623311422075
更新日期:2011-12-01 00:00:00
abstract::Statistical issues related to the design, analysis and interpretation of carcinogenicity studies are considered. A proposed modification of the "standard" National Cancer Institute (NCI) design of carcinogenicity studies in rodents is discussed. The primary objective was to obtain a design that maintained the power of...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338301100113
更新日期:1983-01-01 00:00:00
abstract::Female mammals are born with a finite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopuase in women). Exposure of women to known ovotoxicants, such as contaminants in cigarette smoke, ...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/019262301301418892
更新日期:2001-01-01 00:00:00
abstract::Hyaline droplet formation in the proximal tubular cells of the kidney commonly occurs under different pathological conditions in experimental animals. In rats, intracytoplasmic hyaline droplet formation is predominantly associated with accumulation of the male rat-specific alpha(2u)-globulin, whereas under other (path...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230390213775
更新日期:2003-07-01 00:00:00
abstract::The title of the 2017 Society of Toxicologic Pathology symposium was "Musculoskeletal System." A brief overview of the General Scientific Symposium is presented herein and describes the topics presented by each speaker. Symposium speakers addressed subjects pertinent to musculoskeletal system toxicologic pathology and...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623317738211
更新日期:2017-10-01 00:00:00
abstract::The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolati...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623316675765
更新日期:2017-01-01 00:00:00
abstract::In the Federal Register of January 10, 2000 (65 FR 1399), FDA published a draft guidance entitled "Photosafety Testing." The notice gave interested persons an opportunity to submit comments. As a result of the comments, certain sections of the guidance were reworded to improve clarity. A final guidance was published i...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230490463821
更新日期:2004-07-01 00:00:00
abstract::Necropsies conducted to support medical device development may be conducted in facilities that do not have the infrastructure in place to support Good Laboratory Practice for Nonclinical Laboratory Studies (GLP) studies and for a variety of reasons they may be conducted without a pathologist present at necropsy. Howev...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623315617035
更新日期:2016-01-01 00:00:00
abstract::Enzyme histochemistry was assessed in semi-thin glycolmethacrylate sections after 100 mg/kg 2-bromoethanamine (BEA) hydrobromide had been given ip to male Wistar rats to induce renal papillary necrosis. Changes in the proximal tubular marker enzymes alkaline phosphatase (Alk Phos), gamma-glutamytranspeptidase (GGT) an...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339001800106
更新日期:1990-01-01 00:00:00
abstract::Clinically, girls appear to be more sensitive than boys to the cardiotoxic effects of doxorubicin, whereas the opposite may be true for adults. To identify and characterize potential sex-related differences, adult male and female spontaneously hypertensive rats (SHR; some ovariectomized [OVX]) received 1 mg/kg of doxo...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623313482778
更新日期:2014-01-01 00:00:00
abstract::Absorbable metallic implants have been under investigation for more than a century. Animal and human studies have shown that magnesium (Mg) alloys can be safely used in bioresorbable scaffolds. Several cardiovascular and orthopedic biodegradable metallic devices have recently been approved for use in humans. Bioresorb...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623318816936
更新日期:2019-04-01 00:00:00
abstract::In a 13-week feeding toxicity study of grape skin extract (GSE) performed previously, 5.0% GSE showed diffuse hypertrophy and basophilia in rat parotid glands. To clarify whether the change in the parotid glands was an adverse effect of GSE, 6-week-old male F344 rats were fed a diet containing 5.0% GSE or were adminis...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623313512429
更新日期:2014-08-01 00:00:00
abstract::We describe 2 cases of a relatively rare tumor diagnosed as pituicytoma in the pars nervosa of rat pituitary. This tumor was spontaneously noted in one 110-week-old female and one 109-week-old male Fischer 344 (F344)/DuCrj rats during 2-year carcinogenicity studies. Although no gross abnormality of the pituitary was d...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262330002800612
更新日期:2000-11-01 00:00:00
abstract::Transgenic Tg.AC mice carry a v-Ha-ras coding region flanked by a zeta-globin promoter and an SV40 polyadenylation signal sequence. These mice respond to carcinogens by developing epidermal papillomas. In some cases, malignancies develop at the sites of these papillomas. Various patterns of squamous cell differentiati...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339802600407
更新日期:1998-07-01 00:00:00
abstract::Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262339802600110
更新日期:1998-01-01 00:00:00
abstract::Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339802600517
更新日期:1998-09-01 00:00:00
abstract::The beagle is a monoestric, nonseasonal breeder with a long estrous cycle. Owing to lengthy stages in individual phases of the estrous cycle, limited group size, and typical group assignment focused on homogenized body weight, dogs in the same stage of the cycle can be inadvertently assigned to one treatment group in ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623308326150
更新日期:2008-12-01 00:00:00
abstract::A rat liver foci bioassay (RLFB) based on an initiation-promotion protocol employing preneoplastic foci of altered hepatocytes (FAH) as an endpoint, was prevalidated in 5 different laboratories. FAH were identified by immunohistochemical demonstration of glutathione-S-transferase (placental form, GSTP) and by staining...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230390173888
更新日期:2003-01-01 00:00:00
abstract::The objective was to determine the respiratory toxicity of MAP0004, orally inhaled dihydroergotamine (DHE), via inhalation for six months. Forty beagle dogs (twenty females, twenty males) were treated by nose-only inhalation for 182 days. Groups 2 through 5 received MAP0004 (mean doses: 0.045, 0.154, 0.44, 0.825 mg/kg...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623311399786
更新日期:2011-04-01 00:00:00
abstract::Standard histology trimming practices for toxicity studies in dogs include preparation of a section of the papillary muscle associated with the left ventricular free wall-the anteriolateral or anterior muscle. In contrast, the posteromedial or posterior papillary muscle, associated with the interventricular septum, is...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623320963020
更新日期:2020-10-01 00:00:00
abstract::The carcinogenic potential of chloroform was evaluated in a short-term carcinogenicity testing system using CB6F1 rasH2-Tg (rasH2-Tg) mice. Chloroform was administered to rasH2-Tg males at doses of 28, 90, or 140 mg/kg and rasH2-Tg females at 24, 90, or 240 mg/kg by oral gavage for 26 weeks. Wild-type (non-Tg) male an...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230252929909
更新日期:2002-05-01 00:00:00
abstract::Zibotentan, an endothelin-A receptor antagonist, has been used in the treatment of various cardiovascular disorders and neoplasia. Castrated athymic nude mice receiving zibotentan for a preclinical xenograft efficacy study experienced weight loss, gastrointestinal bloat, and the presence of an audible respiratory clic...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623318816295
更新日期:2019-02-01 00:00:00
abstract::A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338601400302
更新日期:1986-01-01 00:00:00
abstract::Recent advances in immunocytochemical techniques allow the localization of specific antigens in tissue sections. The work reported here attempts to evaluate the application of antibody-labeled, disease-related protein, followed by microscopy and computerized image analysis. Using an experimental anti-tumor, polyclonal...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338701500308
更新日期:1987-01-01 00:00:00
abstract::Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...
journal_title:Toxicologic pathology
pub_type: 评论,杂志文章
doi:10.1177/019262339902700503
更新日期:1999-09-01 00:00:00
abstract::The dose dependence of L-ascorbic acid (AsA) copromotion of urinary bladder carcinogenesis with continuous concomitant administration of NaHCO3 was investigated. In the first experiment, 83 male F344 rats were all given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 wk and then divided into 5 groups, which re...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339702500306
更新日期:1997-05-01 00:00:00
abstract::We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339502300315
更新日期:1995-05-01 00:00:00
abstract::Determining the carcinogenic potential of materials to which humans have significant exposures is an important, complex, and imperfect exercise. Not only are the methods for such determinations protracted and expensive and use large numbers of animals, extrapolation of data from such studies to human risk is imprecise...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623309351892
更新日期:2010-01-01 00:00:00
abstract::Osteogenic Protein-1 (OP-1) is a bone morphogen involved in tissue repair and development. We have shown that OP-1 is downregulated during acute ischemic renal injury. Here we report the use of the rat remnant kidney model (RRKM) to evaluate changes in kidney OP-1 expression during chronic injury, and determine if tre...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230490440925
更新日期:2004-07-01 00:00:00
abstract::The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic act...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262338701500310
更新日期:1987-01-01 00:00:00