Abstract:
:Benzene is of particular concern because of recent research indicating that benzene exposure can result in toxicity. The hematotoxic effect of benzene is mentioned. However, there is little knowledge about the correlation between the biomarker of benzene exposure and changes in red blood cell parameters. Here, the correlation between the urine trans, trans-muconic acid (ttMA) level and red blood cell parameters were studied in 30 Thai subjects at risk. The regression analysis shows no significant correlation between urine ttMA and any studied red cell parameters (Hb, MCV or MCH). Based on our hematologic data, we proposed that only investigation for the urine ttMA might be not sufficient in detection of alteration in red blood cell parameters in the exposed population. Combinations between biomarker and hematological test are recommended.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Wiwanitkit V,Soogarun S,Suwansaksri Jdoi
10.1080/01926230601156278subject
Has Abstractpub_date
2007-02-01 00:00:00pages
268-9issue
2eissn
0192-6233issn
1533-1601pii
772662957journal_volume
35pub_type
杂志文章abstract::The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...
journal_title:Toxicologic pathology
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