The PPARα agonists fenofibrate and CP-778875 cause increased β-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat.

abstract：:In order to investigate the role of the stimulation of cell division for the initiation (and possibly promotion) of liver tumors by chemical carcinogens, the incorporation of radiolabelled thymidine into liver DNA was determined in male rats. Single doses of various levels of aflatoxin B1, benzidine and carbon tetrach...

journal_title：Toxicologic pathology

authors： Lutz WK,Büsser MT,Sagelsdorff P

更新日期：1984-01-01 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI3Ks) regulate intracellular signaling events for multiple cell surface receptors. Phosphatidylinositol 3-kinase δ, 1 of 4 class I PI3K isoforms, is primarily found in leukocytes and regulates immune cell functions. Here, we report changes in the immune and digestive systems that were ...

journal_title：Toxicologic pathology

authors： Werner JA,Ishida K,Wisler J,Karbowski C,Kalanzi J,Bussiere J,Monticello TM

更新日期：2020-12-01 00:00:00

abstract：:Chronic (24-month) inhalation exposure to 5 or 10 ppm allyl glycidyl ether (AGE) induced nasal lesions in Osborne-Mendel rats and B6C3F1 mice. Inflammation, degeneration, regeneration, metaplasia, hyperplasia, and neoplasia were observed in the nasal mucosa. Squamous metaplasia and hyperplasia of the respiratory epith...

journal_title：Toxicologic pathology

authors： Renne RA,Brown HR,Jokinen MP

更新日期：1992-01-01 00:00:00

abstract：:The distribution of 3,4,3',4'-tetrachlorobiphenyl (TCB), its effects on serum and hepatic retinoid, content and liver morphology were investigated in adult female WAG/Rij rats. Animals received a single intraperitoneal injection of either a corn oil vehicle, 15 or 200 mg TCB/kg body weight and were killed at 1, 3, 7, ...

journal_title：Toxicologic pathology

authors： Durham SK,Brouwer A

更新日期：1989-01-01 00:00:00

abstract：:This report describes the findings of preclinical testing of SCH 351591, a selective phosphodiesterase 4 inhibitor, in CD-1 mice over a wide range of doses, in which the heart and reproductive organs of both sexes demonstrated toxic effects. Repeat-dose toxicity studies assessed 5, 15, 50, 100, 200, 400, and 800 mg/kg...

journal_title：Toxicologic pathology

authors： Losco PE,Poulet FM,Kaminska-McNamara GZ,Klein MF

更新日期：2010-06-01 00:00:00

abstract：:Congenital intrahepatic arteriovenous fistulae, a rare hepatic vascular anomaly, in an 8-mo-old female beagle dog was investigated. The animal showed anorexia, repeated vomiting, hemorrhagic diarrhea, and jaundice for approximately 2 wk. There was mild to severe increase of serum alkaline phosphatase, glutamic-oxalace...

journal_title：Toxicologic pathology

authors： Yoshizawa K,Oishi Y,Matsumoto M,Fukuhara Y,Makino N,Noto T,Fujii T

更新日期：1997-09-01 00:00:00

abstract：:The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascu...

journal_title：Toxicologic pathology

authors： Morton D,Reed L,Huang W,Marcek JM,Austin-LaFrance R,Northcott CA,Schelling SH,Enerson BE,Tomlinson L

更新日期：2015-06-01 00:00:00

abstract：:A rat liver foci bioassay (RLFB) based on an initiation-promotion protocol employing preneoplastic foci of altered hepatocytes (FAH) as an endpoint, was prevalidated in 5 different laboratories. FAH were identified by immunohistochemical demonstration of glutathione-S-transferase (placental form, GSTP) and by staining...

journal_title：Toxicologic pathology

authors： Ittrich C,Deml E,Oesterle D,Küttler K,Mellert W,Brendler-Schwaab S,Enzmann H,Schladt L,Bannasch P,Haertel T,Mönnikes O,Schwarz M,Kopp-Schneider A

更新日期：2003-01-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:Two-year toxicity studies were conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. With goldenseal root powder, the primary finding was an increase in liver tumors in rats and mice, and with milk thistle extract, a decrease in spontaneous backgroun...

journal_title：Toxicologic pathology

authors： Dunnick JK,Singh B,Nyska A,Peckham J,Kissling GE,Sanders JM

更新日期：2011-02-01 00:00:00

abstract：:In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...

journal_title：Toxicologic pathology

authors： Ozaki M,Ozaki K,Watanabe T,Uwagawa S,Okuno Y,Shirai T

更新日期：2005-01-01 00:00:00

abstract：:Interrelationships among induction of cytochrome P-450 (CYP) 1A1/2, decrease in connexin 32 (Cx32), and liver tumor-promoting activity by beta-naphthoflavone (BNF) in the promotion stage were examined in a 2-stage liver carcinogenesis model. A total of 20 male Fischer 344 rats were initiated with a single intraperiton...

journal_title：Toxicologic pathology

authors： Shoda T,Mitsumori K,Onodera H,Toyoda K,Uneyama C,Takada K,Hirose M

更新日期：2000-07-01 00:00:00

abstract：:Ocular medical devices (MDs) represent a very wide and promising field of human ophthalmology. In preclinical studies evaluating the safety and/or performance of these ocular MDs, the choice of histologic technique and the focus of the histopathologic evaluation method should take into consideration the following aspe...

journal_title：Toxicologic pathology

authors： Drevon-Gaillot E

更新日期：2019-04-01 00:00:00

abstract：:To clarify the cell of origin of granular cell tumors in the rat brain, light and/or electron microscopic examinations were performed on 40 cases of spontaneous meningeal tumors in Wistar (Jcl: Wistar) rats. The meningeal tumors were histologically subclassified into 3 types: meningothelial meningiomas (MMs), 3 cases;...

journal_title：Toxicologic pathology

authors： Yoshida T,Mitsumori K,Harada T,Maita K

更新日期：1997-03-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a chemical used in the production of fluoropolymers. Its persistence in the environment and presence in humans and wildlife has raised health concerns. Liver tumor induction by PFOA is thought to be mediated in rodents by PPAR-alpha. A recent US EPA scientific advisory board questioned...

journal_title：Toxicologic pathology

authors： Wolf DC,Moore T,Abbott BD,Rosen MB,Das KP,Zehr RD,Lindstrom AB,Strynar MJ,Lau C

更新日期：2008-06-01 00:00:00

abstract：:Enzyme histochemistry was assessed in semi-thin glycolmethacrylate sections after 100 mg/kg 2-bromoethanamine (BEA) hydrobromide had been given ip to male Wistar rats to induce renal papillary necrosis. Changes in the proximal tubular marker enzymes alkaline phosphatase (Alk Phos), gamma-glutamytranspeptidase (GGT) an...

journal_title：Toxicologic pathology

authors： Gregg NJ,Courtauld EA,Bach PH

更新日期：1990-01-01 00:00:00

abstract：:A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular d...

journal_title：Toxicologic pathology

authors： Swartley OM,Foley JF,Livingston DP 3rd,Cullen JM,Elmore SA

更新日期：2016-07-01 00:00:00

abstract：:We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...

journal_title：Toxicologic pathology

authors： Maurer JK,Parker RD,Carr GJ

更新日期：1998-03-01 00:00:00

abstract：:Direct tissue profiling and imaging mass spectrometry (MS) allow for detailed mapping of the complex protein pattern across a tissue sample. Utilization of these tools provides spatial information across a tissue section for target protein expression and can be used to correlate changes in expression levels with speci...

journal_title：Toxicologic pathology

authors： Chaurand P,Schwartz SA,Reyzer ML,Caprioli RM

更新日期：2005-01-01 00:00:00

abstract：:This report demonstrates the advantages of using a noninvasive soft tissue imaging technique--magnetic resonance imaging (MRI)--to monitor liver regeneration after 70% partial hepatectomy in the rat in a longitudinal manner. Six animals were scanned prior to and on 6 subsequent occasions up to 9 days after surgical re...

journal_title：Toxicologic pathology

authors： Hockings PD,Roberts T,Campbell SP,Reid DG,Greenhill RW,Polley SR,Nelson P,Bertram TA,Kramer K

更新日期：2002-09-01 00:00:00

abstract：:The usefulness of isolated adult cardiac myocytes, both in suspension and in culture, as a model system for measuring cardiotoxicity is evaluated. It has been suggested that isolated adult myocytes should preferably be cultured for such experimentation, as this restores the cells to a physiological preference for fatt...

journal_title：Toxicologic pathology

authors： Haworth RA,Goknur AB,Cook MG,Decker RS

更新日期：1990-01-01 00:00:00

abstract：:Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...

journal_title：Toxicologic pathology

authors： Trotta Mde R,Cajaiba DM,Parra OM,Dagli ML,Hernandez-Blazquez FJ

更新日期：2014-01-01 00:00:00

abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...

journal_title：Toxicologic pathology

authors： Shupe JL,Bruner RH,Seymour JL,Alden CL

更新日期：1992-01-01 00:00:00

abstract：:We describe 2 cases of a relatively rare tumor diagnosed as pituicytoma in the pars nervosa of rat pituitary. This tumor was spontaneously noted in one 110-week-old female and one 109-week-old male Fischer 344 (F344)/DuCrj rats during 2-year carcinogenicity studies. Although no gross abnormality of the pituitary was d...

journal_title：Toxicologic pathology

authors： Satoh H,Iwata H,Furuhama K,Enomoto M

更新日期：2000-11-01 00:00:00

abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...

journal_title：Toxicologic pathology

authors： Sayama A,Okado K,Nakamura K,Kawaguchi T,Iguchi T,Makino T,Yabe K,Kai K,Mori K

更新日期：2018-02-01 00:00:00

abstract：:The toxicities of 2'-fluorouridine (2'-FU) and 2'-fluorocytidine-HCl (2'-FC) were separately evaluated in 2 species, male Fischer 344 (F334) rats and woodchucks. Particular attention was focused on the ability of these nucleosides to induce toxicities similar to those induced by the antiviral drug fialuridine (FIAU). ...

journal_title：Toxicologic pathology

authors： Richardson FC,Tennant BC,Meyer DJ,Richardson KA,Mann PC,McGinty GR,Wolf JL,Zack PM,Bendele RA

更新日期：1999-11-01 00:00:00

abstract：:Effective wound healing leads to restoration of tissue integrity and occurs through a highly organized multistage process involving various cell types. Currently, methods for wound healing assessment lack a structured system for analysis of quantitative parameters. We have established a unique quantitative assessment ...

journal_title：Toxicologic pathology

authors： Braiman-Wiksman L,Solomonik I,Spira R,Tennenbaum T

更新日期：2007-10-01 00:00:00

abstract：:The handling-induced dark neuron is a histological artifact observed in brain samples handled before fixation with aldehydes. To explore associations between dark neurons and immunohistochemical alterations in mouse brains, we examined protein products encoded by Cav3 (neuronal perikarya/neurites), Rbbp4 (neuronal nuc...

journal_title：Toxicologic pathology

authors： Soontornniyomkij V,Chang RC,Soontornniyomkij B,Schilling JM,Patel HH,Jeste DV

更新日期：2020-04-01 00:00:00

abstract：:A spontaneous multicystic peritoneal mesothelioma was detected in a 108-wk-old male Fischer-344/DuCrj rat. Grossly, a tumor containing numerous, semi-transparent, variously sized, thin-walled cysts was found on the splenic serosal surface. Microscopically, each cyst was surrounded by variable amounts of loose connecti...

journal_title：Toxicologic pathology

authors： Shibuya K,Tajima M,Yamate J

更新日期：1993-01-01 00:00:00

abstract：:Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine have been used extensively in biomedical research, there is a paucity of information in the...

journal_title：Toxicologic pathology

authors： Helke KL,Nelson KN,Sargeant AM,Jacob B,McKeag S,Haruna J,Vemireddi V,Greeley M,Brocksmith D,Navratil N,Stricker-Krongrad A,Hollinger C

更新日期：2016-04-01 00:00:00