Abstract:
:Changes in the mRNA and protein expression of renin-secreting cells in the juxtaglomerular apparatus (JGA) were examined in the rat following administration of ZENECA ZD8731, an angiotensin II receptor antagonist. Doses of 0 or 90 mg/kg were administered daily by gavage for 26 wk. JGA hypertrophy was apparent in histological sections. Immunohistochemistry demonstrated an increase in the number of renin-containing cells in both the afferent arterioles and the interlobular arteries. Similarly, renin mRNA expression, demonstrated by in situ hybridization, had extended to more proximal segments of the afferent arterioles and was also present in efferent arterioles and interlobular arteries. In conclusion, JGA hypertrophy occurred as a result of antagonism of the angiotensin II receptor. Associated with JGA hypertrophy was increased expression of both renin and renin mRNA, indicative of stimulated renin synthesis caused by an exaggerated pharmacological response of renin-secreting cells to the loss of feedback inhibition by angiotensin II.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Doughty SE,Ferrier RK,Hillan KJ,Jackson DGdoi
10.1177/019262339502300303subject
Has Abstractpub_date
1995-05-01 00:00:00pages
256-61issue
3eissn
0192-6233issn
1533-1601journal_volume
23pub_type
杂志文章abstract::Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623315572700
更新日期:2015-08-01 00:00:00
abstract::Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cancer bioassays has been due to lack of historical data and diagnostic cr...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623311436181
更新日期:2012-06-01 00:00:00
abstract::The definition of diagnostic thresholds is an important aspect of identification and recording of histopathologic lesions in toxicology studies. Although the primary goal of the pathology examination is to identify and interpret lesions associated with the administration of the test article, the toxicologic pathologis...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623312443322
更新日期:2012-10-01 00:00:00
abstract::We have developed a guinea pig model of iron overload toxicity. Animals were administered intraperitoneal iron dextran 3 times a week to achieve total body iron load of 0.25, 0.5, 1.0, 1.5, and 2.0 g Fe/kg body weight in less than 30 days. Quantitation of tissue iron levels with atomic absorption indicated increased i...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339302100307
更新日期:1993-01-01 00:00:00
abstract::Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate. Fontana-Masson stain demonstrated decr...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338901700310
更新日期:1989-01-01 00:00:00
abstract::Cells have to double their protein mass in order to divide. Whether this is achieved through increased synthesis (PS), decreased degradation (PD), or a combination of both is still debated. Likewise open are other basic questions: whether, beyond differences relating to growth phase (GP) or rate, reduced PD rates are ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338401200312
更新日期:1984-01-01 00:00:00
abstract::A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of bone alkaline phosphatase (BALP) with wheat germ lectin and differential inhibition with levamisole for determination of intestinal alkaline phosphatase (IALP). Th...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339402200607
更新日期:1994-11-01 00:00:00
abstract::The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identi...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623318823150
更新日期:2019-02-01 00:00:00
abstract::The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230600773941
更新日期:2006-01-01 00:00:00
abstract::The evaluation of neurotoxic damage involves a unique set of challenges. Vulnerable structures, such as neocortex, hippocampus, spinal cord, and peripheral nerve are complex and sharply differentiated; deficits can result from insults to one or more element(s) in the system (e.g., myelin, axon, soma, synapse, or glia)...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623310390231
更新日期:2011-01-01 00:00:00
abstract::Toxic injury occurs in the liver more often than any other organ. This can be attributed to the fact that virtually all ingested substances that are absorbed are first presented to the liver and that the liver is responsible for the metabolism and elimination of many substances. Drug-induced liver injury has become a ...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/01926230590522428
更新日期:2005-01-01 00:00:00
abstract::During the conduct of in vivo toxicology studies, in-life, clinical pathology, and anatomic pathology parameters are collected and interpreted. These sets of parameters are evaluated in an integrative manner to determine the overall toxicity of a test article. For clinical pathology parameters, the inherent variabilit...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623314555340
更新日期:2015-01-01 00:00:00
abstract::Results of early nonclinical "General Toxicology" studies are used to set a safe starting dose for first-in-human (FIH) clinical trials. In FIH trials, the research subjects are typically healthy volunteers who have little to gain but much to lose if a trial goes wrong. With that in mind, good laboratory practice regu...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623313506878
更新日期:2014-01-01 00:00:00
abstract::Nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. Our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. We nebulized nedocromil sodium into beagle dogs (n = 10, mean +/- SEM ages: 149 +/- 13 days) before and after in...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262330002800212
更新日期:2000-03-01 00:00:00
abstract::The B6C3F1 strain of mice is prone to develop liver nodules as animals grow older. This spontaneous tumor development is enhanced by dietary lipotrope deficiency. The present studies were performed to evaluate the liver of the B6C3F1 mice in early periods of lipotrope deficiency and before the nodules appear. Mice wer...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338501300103
更新日期:1985-01-01 00:00:00
abstract::A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623310391679
更新日期:2011-01-01 00:00:00
abstract::The outcome of cardiac ischemic events depends not only on the extent and duration of the ischemic stimulus but also on the myocardial intrinsic tolerance to ischemic injury. Cardiac ischemic tolerance reflects myocardial functional reserves that are not always used when the tissue is appropriately oxygenated. Ischemi...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623309339503
更新日期:2009-08-01 00:00:00
abstract::The nonnucleoside inhibitor (NNI) of HIV-1 reverse transcriptase, PHI-346 (N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea), is a dual-function spermicidal agent with potent anti-HIV activity against drug-sensitive as well as drug-resistant HIV-1 strains with genotypic and phenotypic NNI resistance. PHI-3...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230290168551
更新日期:2002-11-01 00:00:00
abstract::In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230590908231
更新日期:2005-01-01 00:00:00
abstract::Blood platelets play a fundamental role in hemostasis and thrombosis. The physiological role of platelets is to preserve the integrity of the cardiovascular system such that upon injury platelets are activated and serve to interrupt a potentially deleterious situation (i.e., hemorrhage). However, platelets are also in...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339302100210
更新日期:1993-01-01 00:00:00
abstract::Gadolinium is used as a contrast media for magnetic resonance imaging and, experimentally, to block Kupffer cell phagocytosis. In this study, we utilize electron probe microanalysis to determine the subcellular localization of gadolinium chloride (GdCl3) administered to mice in a short-term toxicology study. Male CD-1...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339602400508
更新日期:1996-09-01 00:00:00
abstract::The usefulness of isolated adult cardiac myocytes, both in suspension and in culture, as a model system for measuring cardiotoxicity is evaluated. It has been suggested that isolated adult myocytes should preferably be cultured for such experimentation, as this restores the cells to a physiological preference for fatt...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Highly standardized and controlled inhalation studies are required for hazard identification to make test results reproducible and comparable and to fulfill general regulatory requirements for the registration of new drugs, pesticides, or chemicals. Despite significant efforts, the results of inhalation studies have t...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262330002800514
更新日期:2000-09-01 00:00:00
abstract::The coronavirus disease 2019 pandemic has affected business on numerous fronts in unprecedented and abrupt ways. From site closures and local "stay-at-home orders" to travel advisories and restrictions, the day-to-day practice of toxicologic pathology has been impacted dramatically and rapidly. A critical function of ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623320964087
更新日期:2020-12-01 00:00:00
abstract::Livers of male Sprague-Dawley rats were evaluated for foci and nodules 90 days and 16 months after one or two oral doses of 1,2-dibromoethane (DBE). Rats (190 g) were given the following oral treatments. Controls received corn oil (2.5 ml/kg) at 0 and 24 hr. DBE X 1 received corn oil at 0 hr and 75 mg DBE/kg at 24 hr....
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338401200402
更新日期:1984-01-01 00:00:00
abstract::Ocular medical devices (MDs) represent a very wide and promising field of human ophthalmology. In preclinical studies evaluating the safety and/or performance of these ocular MDs, the choice of histologic technique and the focus of the histopathologic evaluation method should take into consideration the following aspe...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623318813533
更新日期:2019-04-01 00:00:00
abstract::Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological m...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623318767065
更新日期:2018-04-01 00:00:00
abstract::The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/01926230390175002
更新日期:2003-01-01 00:00:00
abstract::Direct tissue profiling and imaging mass spectrometry (MS) allow for detailed mapping of the complex protein pattern across a tissue sample. Utilization of these tools provides spatial information across a tissue section for target protein expression and can be used to correlate changes in expression levels with speci...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/01926230590881862
更新日期:2005-01-01 00:00:00
abstract::We have previously indicated that the ideal animal tumor model should mimic the human disease. This means that the investigator should be able to ascertain the influence of host factors on the initiation of tumorigenesis, mimic the susceptibility of tumor response based on age and reproductive history, and determine t...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623314532036
更新日期:2015-02-01 00:00:00