Abstract:
:Blood platelets play a fundamental role in hemostasis and thrombosis. The physiological role of platelets is to preserve the integrity of the cardiovascular system such that upon injury platelets are activated and serve to interrupt a potentially deleterious situation (i.e., hemorrhage). However, platelets are also involved in the pathophysiology of thrombosis in which the normal repair process is grossly exacerbated, resulting in interruption of blood flow to vital tissues. Thus, a critical balance exists between the normal function of blood platelets to preserve tissue function and a pathophysiological function in which tissue is damaged due to thrombosis and subsequent ischemia. Numerous anti-platelet agents have been developed in an attempt to interrupt the thrombotic process without severely compromising the hemostatic state of patients. This article will be devoted to a discussion of a commonly utilized anti-thrombotic agent, aspirin, as well as a class of newer, possibly more effective anti-thrombotic agents referred to collectively as fibrinogen receptor antagonists.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Shebuski RJdoi
10.1177/019262339302100210subject
Has Abstractpub_date
1993-01-01 00:00:00pages
180-9issue
2eissn
0192-6233issn
1533-1601journal_volume
21pub_type
杂志文章abstract::The distribution of 3,4,3',4'-tetrachlorobiphenyl (TCB), its effects on serum and hepatic retinoid, content and liver morphology were investigated in adult female WAG/Rij rats. Animals received a single intraperitoneal injection of either a corn oil vehicle, 15 or 200 mg TCB/kg body weight and were killed at 1, 3, 7, ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338901700308
更新日期:1989-01-01 00:00:00
abstract::Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide for long-acting delivery. The toxicity of a single intravitreal dose o...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623320969124
更新日期:2020-12-21 00:00:00
abstract::Lung cancer is the most common cause of cancer-related deaths in humans worldwide. There is strong evidence that the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play an important role in carcinogenesis caused ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623317751573
更新日期:2018-02-01 00:00:00
abstract::The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascu...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623314559103
更新日期:2015-06-01 00:00:00
abstract::An annular, reddened lesion with mild serosal hemorrhage and no tumorous mass formation was detected in the right uterine horn of a 37-week-old female Sprague-Dawley rat that had postpubertal vaginal bleeding. Histological examination revealed prominent proliferation of the endometrium, which occupied the uterine lume...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623313476575
更新日期:2013-01-01 00:00:00
abstract::The 2012 annual National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held in Boston in advance of the Society of Toxicologic Pathology's 31st annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic patholog...
journal_title:Toxicologic pathology
pub_type:
doi:10.1177/0192623312467102
更新日期:2013-02-01 00:00:00
abstract::We investigated, morphologically and immunohistochemically, 74 medullary adrenal tumors, including 64 pheochromocytomas (14 malignant and 50 benign), 9 ganglioneuromas, and 1 malignant schwannoma. The tumors were detected in 2-year-old Wistar and Sprague-Dawley rats from carcinogenicity studies. Morphologically, benig...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230290105668
更新日期:2002-07-01 00:00:00
abstract::Monocrotaline pyrrole (MCTP) is a highly reactive pneumotoxic metabolite of the pyrrolizidine alkaloid plant toxin monocrotaline. When administered to rats, it causes a delayed and progressive lung injury, vascular remodeling, and pulmonary hypertension. Structural remodeling consists of endothelial cell swelling foll...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339702500405
更新日期:1997-07-01 00:00:00
abstract::Recently, considerable attention has been focused on certain environmental contaminants--"endocrine disruptors"--of industrial origin that may mimic the action of sex hormones. Natural compounds and their effects on other types of hormonal activity (eg, on adrenal or thyroid function) have for some reason not provoked...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262330002800311
更新日期:2000-05-01 00:00:00
abstract::Macrophages appearing in lesions are polarized toward M1 (for inflammation) and M2 (for anti-inflammation/fibrosis) types. We analyzed immunophenotypes of macrophages appearing in myocardial lesion in rats injected once with isoproterenol (10 mg/kg body weight). Inflammation following myocardial necrosis on day 1 was ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623320982526
更新日期:2021-01-05 00:00:00
abstract::A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623310391679
更新日期:2011-01-01 00:00:00
abstract::In tissue slice models, interactions between the heterogeneous cell types comprising the lung parenchyma are maintained thus providing a controlled system for the study of pulmonary toxicology in vitro. However, validation of the model in vitro system must be affirmed. Previous reports, in in vivo systems, have demons...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230390183689
更新日期:2003-03-01 00:00:00
abstract::Alloxan-induced diabetic rats frequently exhibit proliferative lesions of squamous hyperplasia accompanied by chronic inflammation and Candida albicans infection in the forestomach, and some lesions progress to squamous cell carcinoma (SCC). Candida infection causes not only hyperplastic changes with inflammation but ...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623309344204
更新日期:2009-10-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists such as fenofibrate are used to treat dyslipidemia. Although fenofibrate is considered safe in humans, it is known to cause hepatocarcinogenesis in rodents. To evaluate untargeted metabolic profiling as a tool for gaining insight into the underlying...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623309336152
更新日期:2009-06-01 00:00:00
abstract::One of the major roles for the toxicologic pathologists now and into the future will be to determine the biologic significance of chemically induced biochemical and molecular alterations detected in whole tissue homogenates or cell cultures. The biologically significant effects will then require further analysis to de...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/019262301301418973
更新日期:2001-01-01 00:00:00
abstract::Nephrotoxic renal injury, and especially drug nephrotoxicity is now a common cause of acute renal failure. The most common patterns of renal injury produced by nephrotoxins, tubular damage, and interstitial nephritis, are discussed here. Toxic agents which are primarily tubular toxins include certain antibiotics, cisp...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338601400106
更新日期:1986-01-01 00:00:00
abstract::Qualitative histopathology has been the gold standard for evaluation of morphological tissue changes in all organ systems, including the peripheral nervous system. However, the human eye is not sensitive enough to detect small changes in quantity or size. Peripheral nervous system toxicity can manifest as subtle chang...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623319854746
更新日期:2020-01-01 00:00:00
abstract::Oxidant generation catalyzed by metals has been postulated to account for a lung injury following exposure to air pollution particles. In particles that are predominantly carbonaceous, it is difficult to implicate such an oxidative stress as the responsible mechanism, since concentrations of metals can be extremely lo...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262330002800416
更新日期:2000-07-01 00:00:00
abstract::Histopathologic examination of the testis from juvenile rats is often necessary to characterize the safety of new drugs for pediatric use and is a required end point in male pubertal development and thyroid function assays. To aid in evaluation and interpretation of the immature testis, the characteristic histologic f...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623314547279
更新日期:2015-04-01 00:00:00
abstract::Direct tissue profiling and imaging mass spectrometry (MS) allow for detailed mapping of the complex protein pattern across a tissue sample. Utilization of these tools provides spatial information across a tissue section for target protein expression and can be used to correlate changes in expression levels with speci...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/01926230590881862
更新日期:2005-01-01 00:00:00
abstract::A total of 75 BALB/cStCrlfC3H/Nctr male weanling mice were administered either 0 or 250 ppm of 4 ethylsulfonylnaphthalene-1-sulfonamide (ENS) in the diet for periods up to 14 days to evaluate the early morphological changes of the transitional epithelium of the urinary bladder with scanning (SEM) and transmission (TEM...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338601400302
更新日期:1986-01-01 00:00:00
abstract::Some developmental dual-acting PPARalpha/gamma agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after months-years of dosing. We examined early (precancerous) changes in the bladder urothelium of rats orally dosed with ragaglitazar, using a newly developed flow c...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230500214657
更新日期:2005-01-01 00:00:00
abstract::Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339702500501
更新日期:1997-09-01 00:00:00
abstract::Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338501300309
更新日期:1985-01-01 00:00:00
abstract::Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10, 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339402200506
更新日期:1994-09-01 00:00:00
abstract::The title of the 2017 Society of Toxicologic Pathology symposium was "Musculoskeletal System." A brief overview of the General Scientific Symposium is presented herein and describes the topics presented by each speaker. Symposium speakers addressed subjects pertinent to musculoskeletal system toxicologic pathology and...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623317738211
更新日期:2017-10-01 00:00:00
abstract::Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/01926230390175002
更新日期:2003-01-01 00:00:00
abstract::Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339101900403
更新日期:1991-01-01 00:00:00
abstract::Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338501300305
更新日期:1985-01-01 00:00:00