Abstract:
:Hyaline droplet formation in the proximal tubular cells of the kidney commonly occurs under different pathological conditions in experimental animals. In rats, intracytoplasmic hyaline droplet formation is predominantly associated with accumulation of the male rat-specific alpha(2u)-globulin, whereas under other (pathological) conditions (eg, histiocytic sarcoma and chronic progressive nephropathy [CPN]) other proteins are involved. Staining methods to visualize hyaline droplets either need plastic embedded material or time-consuming (immuno)histochemical methods. A fast Chromotrope-Aniline-Blue-staining on formalin-fixed paraffin-embedded kidneys taking only 30 minutes is described. Using this method, hyaline droplets consisting of different types of proteins are easily recognized by their bright-red color.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
de Rijk EP,Ravesloot WT,Wijnands Y,van Esch Edoi
10.1080/01926230390213775subject
Has Abstractpub_date
2003-07-01 00:00:00pages
462-4issue
4eissn
0192-6233issn
1533-1601pii
VX2XE18QTDXJ6MMEjournal_volume
31pub_type
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