Light microscopic sciatic nerve changes in control beagle dogs from toxicity studies.

abstract：:Sprague-Dawley CD rats received daily oral doses (45 mg/kg) of the cationic amphiphilic tricyclic antidepressant imipramine HCl (Tofranil) for up to two years. Representative specimens of liver, lung, spleen, mesenteric lymph node, retina and dorsal root ganglion were examined for myeloid bodies (MB). The extent that ...

journal_title：Toxicologic pathology

authors： Spaet RH,Sullivan DJ,Diener RM

更新日期：1983-01-01 00:00:00

abstract：:The title of the 2017 Society of Toxicologic Pathology symposium was "Musculoskeletal System." A brief overview of the General Scientific Symposium is presented herein and describes the topics presented by each speaker. Symposium speakers addressed subjects pertinent to musculoskeletal system toxicologic pathology and...

journal_title：Toxicologic pathology

authors： Gropp KE,Boyle MC

更新日期：2017-10-01 00:00:00

abstract：:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, ...

journal_title：Toxicologic pathology

authors： Hayes TJ,Roberts GK,Halliwell WH

更新日期：1989-01-01 00:00:00

abstract：:Successful development and use of biomarkers will improve the productivity of oncology drug development. Recognition of the importance of biomarkers for speeding drug development is reflected in the precise definitions and concepts proposed by an NIH Working Group to standardize terminology and promote a more coherent...

journal_title：Toxicologic pathology

authors： Floyd E,McShane TM

更新日期：2004-03-01 00:00:00

abstract：:The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolati...

journal_title：Toxicologic pathology

authors： Irizarry AR,Gropp KE,Dixon D

更新日期：2017-01-01 00:00:00

abstract：:The objectives of this session were to explore causes of variability in clinical pathology data due to preanalytical and analytical variables as well as study design and other procedures that occur in toxicity testing studies. The presenters highlighted challenges associated with such variability in differentiating te...

journal_title：Toxicologic pathology

authors： Tripathi NK,Everds NE,Schultze AE,Irizarry AR,Hall RL,Provencher A,Aulbach A

更新日期：2017-01-01 00:00:00

abstract：:Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...

journal_title：Toxicologic pathology

authors： Rogers-Cotrone T,Burgess MP,Hancock SH,Hinckley J,Lowe K,Ehrich MF,Jortner BS

更新日期：2010-06-01 00:00:00

abstract：:The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. Framing testable hypotheses for experimental a...

journal_title：Toxicologic pathology

authors： Silbergeld EK

更新日期：2017-01-01 00:00:00

abstract：:Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate. Fontana-Masson stain demonstrated decr...

journal_title：Toxicologic pathology

authors： Walsh KM,Gough AW

更新日期：1989-01-01 00:00:00

abstract：:We have previously indicated that the ideal animal tumor model should mimic the human disease. This means that the investigator should be able to ascertain the influence of host factors on the initiation of tumorigenesis, mimic the susceptibility of tumor response based on age and reproductive history, and determine t...

journal_title：Toxicologic pathology

authors： Russo J

更新日期：2015-02-01 00:00:00

abstract：:Livers of male Sprague-Dawley rats were evaluated for foci and nodules 90 days and 16 months after one or two oral doses of 1,2-dibromoethane (DBE). Rats (190 g) were given the following oral treatments. Controls received corn oil (2.5 ml/kg) at 0 and 24 hr. DBE X 1 received corn oil at 0 hr and 75 mg DBE/kg at 24 hr....

journal_title：Toxicologic pathology

authors： Moslen MT

更新日期：1984-01-01 00:00:00

abstract：:Female mammals are born with a finite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopuase in women). Exposure of women to known ovotoxicants, such as contaminants in cigarette smoke, ...

journal_title：Toxicologic pathology

authors： Hoyer PB,Devine PJ,Hu X,Thompson KE,Sipes IG

更新日期：2001-01-01 00:00:00

abstract：:This report describes the findings of preclinical testing of SCH 351591, a selective phosphodiesterase 4 inhibitor, in CD-1 mice over a wide range of doses, in which the heart and reproductive organs of both sexes demonstrated toxic effects. Repeat-dose toxicity studies assessed 5, 15, 50, 100, 200, 400, and 800 mg/kg...

journal_title：Toxicologic pathology

authors： Losco PE,Poulet FM,Kaminska-McNamara GZ,Klein MF

更新日期：2010-06-01 00:00:00

abstract：:In the constantly evolving field of toxicologic pathology, a pathologist's career is often characterized by multiple career transitions. However, these transitions can be challenging and/or overwhelming and may require a shift in focus, strategic approach, and acquisition of new skills and expertise. In order to provi...

journal_title：Toxicologic pathology

authors： Choudhary S,Osborne T,Adler RR,McDorman KS,Dillberger JE,Ochoa R

更新日期：2017-10-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a chemical used in the production of fluoropolymers. Its persistence in the environment and presence in humans and wildlife has raised health concerns. Liver tumor induction by PFOA is thought to be mediated in rodents by PPAR-alpha. A recent US EPA scientific advisory board questioned...

journal_title：Toxicologic pathology

authors： Wolf DC,Moore T,Abbott BD,Rosen MB,Das KP,Zehr RD,Lindstrom AB,Strynar MJ,Lau C

更新日期：2008-06-01 00:00:00

abstract：:The spleen is the largest secondary lymphoid organ, is considered the draining site for compounds that are administered intravenously, and is therefore considered an important organ to evaluate for treatment-related lesions. Due to the presence of B and T lymphocytes, the immunotoxic effects of xenobiotics or their me...

journal_title：Toxicologic pathology

authors： Elmore SA

更新日期：2006-01-01 00:00:00

abstract：:Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are metabolites of the industrial solvent and environmental contaminant trichloroethylene (TCE), as well as contaminants of chlorinated drinking water. Human exposure to these chemicals is of concern as all three have been shown to increase liver tumor incidence...

journal_title：Toxicologic pathology

authors： Latendresse JR,Pereira MA

更新日期：1997-09-01 00:00:00

abstract：:In vitro techniques for the culture of hemopoietic stem cells and committed hemopoietic progenitor cells in rat bone marrow have not been adequately described in the literature. In the present investigations, and using commercially available hemopoietic cytokines and growth factors, the conditions required to perform ...

journal_title：Toxicologic pathology

authors： Molyneux G,Rizzo S,Turton J,Phul P,Gibson F

更新日期：2009-02-01 00:00:00

abstract：:High doses of insulin and the insulin analog AspB10 have been reported to increase mammary tumor incidence in female rats likely via receptor-mediated mechanisms, possibly involving enhanced IGF-1 receptor activation. However, insulin and IGF-1 receptor functionality and intracellular signaling in the rat mammary glan...

journal_title：Toxicologic pathology

authors： Hvid H,Fels JJ,Kirk RK,Thorup I,Jensen HE,Hansen BF,Oleksiewicz MB

更新日期：2011-06-01 00:00:00

abstract：:(+/-)-trans-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-diol) and 9-hydroxybenzo(a)pyrene (9-OH-BP) were metabolized by rat liver microsomes in the presence of calf thymus DNA, resulting in preferential DNA binding of fluorescent (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) and 9-OH-BP-4,5-epoxide, respectively. When the ...

journal_title：Toxicologic pathology

authors： Gräslund A,Jernström B,Undeman O,Dock L,Ehrenberg A,Astlind T

更新日期：1984-01-01 00:00:00

abstract：:This article provides a synopsis of the first two presentations from the second scientific session of the 37th Annual Symposium of the Society of Toxicologic Pathology in Indianapolis, Indiana, on June 18, 2018; the session focused on acute kidney injury. The first presentation, given by Dr. Kevin McDorman, focused on...

journal_title：Toxicologic pathology

authors： Crabbs TA,McDorman KS

更新日期：2018-12-01 00:00:00

abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...

journal_title：Toxicologic pathology

authors： Shupe JL,Bruner RH,Seymour JL,Alden CL

更新日期：1992-01-01 00:00:00

abstract：:Overexpression of c-myc and transforming growth factor-alpha (TGF-alpha) has been frequently observed in human hepatocellular carcinoma (HCC),suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant transformation, we...

journal_title：Toxicologic pathology

authors： Calvisi DF,Thorgeirsson SS

更新日期：2005-01-01 00:00:00

abstract：:A number of factors related to study design have the potential to impact clinical pathology test results during the conduct of nonclinical safety studies. A thorough understanding of these factors is paramount in drawing accurate conclusions from clinical pathology data generated during such studies, particularly when...

journal_title：Toxicologic pathology

authors： Aulbach A,Provencher A,Tripathi N

更新日期：2017-02-01 00:00:00

abstract：:This brief review summarizes our current understanding of vasculitis mediated by phlogistic immune complexes. The Arthus reaction and serum sickness both represent experimental models for immune complex disease. Immune complex phenomena occur in conjunction with C3 deficiency of dogs during canine distemper virus infe...

journal_title：Toxicologic pathology

authors： Krakowka S

更新日期：1989-01-01 00:00:00

abstract：:In the present study, beta-catenin localization in hepatocellular neoplasms and hepatoblastomas, induced by oral administration of p-Nitroanisole (pNA) in Crj:BDF1 for 2 years, was evaluated by immunohistochemistry along with genetic alterations in exon 2 of beta-catenin by the polymerase chain reaction-single strand ...

journal_title：Toxicologic pathology

authors： Kushida M,Aiso S,Morimura K,Wei M,Wanibuchi H,Nagano K,Fukushima S

更新日期：2006-01-01 00:00:00

abstract：:An annular, reddened lesion with mild serosal hemorrhage and no tumorous mass formation was detected in the right uterine horn of a 37-week-old female Sprague-Dawley rat that had postpubertal vaginal bleeding. Histological examination revealed prominent proliferation of the endometrium, which occupied the uterine lume...

journal_title：Toxicologic pathology

authors： Shirota M,Kawashima J,Nakamura T,Ogawa Y,Kamiie J,Shirota K

更新日期：2013-01-01 00:00:00

abstract：:Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10, 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above...

journal_title：Toxicologic pathology

authors： Courtney CL,Hawkins KL,Rothwell CE

更新日期：1994-09-01 00:00:00

abstract：:The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identi...

journal_title：Toxicologic pathology

authors： Pinkney AE,Harshbarger JC,Rutter MA,Sakaris PC

更新日期：2019-02-01 00:00:00

abstract：:Phentolamine is a reversible competitive alpha-adrenergic antagonist with similar affinities for alphal and alpha2 receptors. It has a long history of safe clinical use, and was developed as a potential therapy for male erectile dysfunction because of its capacity to increase the arteriolar blood flow to the corpora c...

journal_title：Toxicologic pathology

authors： Poulet FM,Berardi MR,Halliwell W,Hartman B,Auletta C,Bolte H

更新日期：2004-09-01 00:00:00