Deciphering Sources of Variability in Clinical Pathology.

abstract：:A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular d...

journal_title：Toxicologic pathology

authors： Swartley OM,Foley JF,Livingston DP 3rd,Cullen JM,Elmore SA

更新日期：2016-07-01 00:00:00

abstract：:Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluo...

journal_title：Toxicologic pathology

authors： Shupe JL,Bruner RH,Seymour JL,Alden CL

更新日期：1992-01-01 00:00:00

abstract：:Livers of male Sprague-Dawley rats were evaluated for foci and nodules 90 days and 16 months after one or two oral doses of 1,2-dibromoethane (DBE). Rats (190 g) were given the following oral treatments. Controls received corn oil (2.5 ml/kg) at 0 and 24 hr. DBE X 1 received corn oil at 0 hr and 75 mg DBE/kg at 24 hr....

journal_title：Toxicologic pathology

authors： Moslen MT

更新日期：1984-01-01 00:00:00

abstract：:Changes in the mRNA and protein expression of renin-secreting cells in the juxtaglomerular apparatus (JGA) were examined in the rat following administration of ZENECA ZD8731, an angiotensin II receptor antagonist. Doses of 0 or 90 mg/kg were administered daily by gavage for 26 wk. JGA hypertrophy was apparent in histo...

journal_title：Toxicologic pathology

authors： Doughty SE,Ferrier RK,Hillan KJ,Jackson DG

更新日期：1995-05-01 00:00:00

abstract：:A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...

journal_title：Toxicologic pathology

authors： Butt MT

更新日期：2011-01-01 00:00:00

abstract：:In a three-week oral gavage toxicity study in rats, a high incidence of respiratory symptoms and high mortality was noted in compound-dosed rats only. Because of audible respiration, an effect in the upper respiratory tract was suspected and the nasal cavity was included for examination. Histology revealed extensive n...

journal_title：Toxicologic pathology

authors： Damsch S,Eichenbaum G,Looszova A,Lammens L,Feyen B,Van den Bulck K,Knight E,Kelley M,Tonelli A

更新日期：2011-02-01 00:00:00

abstract：:We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...

journal_title：Toxicologic pathology

authors： Maurer JK,Parker RD,Carr GJ

更新日期：1998-03-01 00:00:00

abstract：:Cancer affects approximately 1 in 3 individuals. An individual's susceptibility to cancer is partly determined by environmental exposures and by the combination of inherited cancer susceptibility and resistance genes. Initial mapping of these low penetrance cancer susceptibility genes has been done in the mouse becaus...

journal_title：Toxicologic pathology

authors： Ewart-Toland A,Balmain A

更新日期：2004-03-01 00:00:00

abstract：:Determining the carcinogenic potential of materials to which humans have significant exposures is an important, complex, and imperfect exercise. Not only are the methods for such determinations protracted and expensive and use large numbers of animals, extrapolation of data from such studies to human risk is imprecise...

journal_title：Toxicologic pathology

authors： Jacobson-Kram D

更新日期：2010-01-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:Carbonyl sulfide (COS) is an odorless gas that produces highly reproducible lesions in the central nervous system. In the present study, the time course for the development of the neurotoxicological lesions was defined and the gene expression changes occurring in the posterior colliculus upon exposure to COS were char...

journal_title：Toxicologic pathology

authors： Morrison JP,Ton TV,Collins JB,Switzer RC,Little PB,Morgan DL,Sills RC

更新日期：2009-06-01 00:00:00

abstract：:Over the past decade, laser capture microdissection (LCM) has grown as a tool for gene expression profiling of small numbers of cells from tumor samples and of specific cell populations in complex tissues. LCM can be used to study toxicant effects on selected cell populations within the testis at different stages of s...

journal_title：Toxicologic pathology

authors： Catlin NR,Huse SM,Boekelheide K

更新日期：2014-12-01 00:00:00

abstract：:Previous work in our laboratory revealed that the pubertal period of reproductive development in the male rat was particularly vulnerable to gossypol exposure, with a higher frequency of round structures in the lumen of the cauda epididymidis in the treated rats. Herein, we utilized hemicastration and electron microsc...

journal_title：Toxicologic pathology

authors： de Andrade SF,Oliva SU,Klinefelter GR,De Grava Kempinas W

更新日期：2006-01-01 00:00:00

abstract：:Hepatic microsomal enzymes play an important role in thyroid hormone homeostasis. Glucuronidation of thyroxine is the rate limiting step in the biliary excretion of thyroxine in the rat; the monodeiodinases are important in the conversion of T4 to T3 and reverse T3 and subsequent deiodinations. Phenobarbital is known ...

journal_title：Toxicologic pathology

authors： McClain RM

更新日期：1989-01-01 00:00:00

abstract：:Specific regions in the rodent larynx exhibit cellular changes in response to inhaled xenobiotics. These regions include the base of the epiglottis, ventral pouch, and medial surfaces of the vocal processes of the arytenoid cartilages. There are interspecies differences among laboratory rodents in the microscopic anat...

journal_title：Toxicologic pathology

authors： Renne RA,Sagartz JW,Burger GT

更新日期：1993-11-01 00:00:00

abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...

journal_title：Toxicologic pathology

authors： Treumann S,Buesen R,Gröters S,Eichler JO,van Ravenzwaay B

更新日期：2015-08-01 00:00:00

abstract：:S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced nephrotoxicity in vivo was investigated in New Zealand White rabbits. A primary emphasis in these studies was further characterization of DCVC-induced nephrotoxicity using a variety of serum and urinary analytes, including sodium dodecyl sulfate-polyacrylamide gel electr...

journal_title：Toxicologic pathology

authors： Davis JW,Blakeman DP,Jolly RA,Packwood WH,Kolaja GJ,Petry TW

更新日期：1995-07-01 00:00:00

abstract：:Alloxan-induced diabetic rats frequently exhibit proliferative lesions of squamous hyperplasia accompanied by chronic inflammation and Candida albicans infection in the forestomach, and some lesions progress to squamous cell carcinoma (SCC). Candida infection causes not only hyperplastic changes with inflammation but ...

journal_title：Toxicologic pathology

authors： Sano T,Ozaki K,Kodama Y,Matsuura T,Narama I

更新日期：2009-10-01 00:00:00

abstract：:In the context of human hematopathology, the terms myelodysplasia and Myelodysplastic Syndromes (MDS) are applied to disorders of hematopoiesis that are clonal, neoplastic, and, in most forms, manifested as ineffective hematopoiesis with characteristic morphologic abnormalities in multiple cell lines. Studies of human...

journal_title：Toxicologic pathology

authors： Blue JT

更新日期：2003-01-01 00:00:00

abstract：:Cardiac troponin (cTn) is a sensitive and specific biomarker for assessing cardiac damage and should be utilized in drug safety assessment. Lactate dehydrogenase and creatine kinase isoenzyme analyses have historically been used in pre-clinical toxicity testing to assess cardiac injury, but since these assays are less...

journal_title：Toxicologic pathology

authors： Reagan WJ

更新日期：2010-12-01 00:00:00

abstract：:The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP...

journal_title：Toxicologic pathology

authors： Palazzi X,Burkhardt JE,Caplain H,Dellarco V,Fant P,Foster JR,Francke S,Germann P,Gröters S,Harada T,Harleman J,Inui K,Kaufmann W,Lenz B,Nagai H,Pohlmeyer-Esch G,Schulte A,Skydsgaard M,Tomlinson L,Wood CE,Yoshida M

更新日期：2016-08-01 00:00:00

abstract：:Duplications of the gastrointestinal tract are exceedingly rare in laboratory animals. We report a case of a communicating intestinal duplication in a 17-wk-old Sprague-Dawley (SD) rat. The duplication was present in the mesenteric border of the ileum, and both proximal and distal ends were communicated with the lumen...

journal_title：Toxicologic pathology

authors： Elangbam CS,Clevidence KJ,Jackson CB,Holson JF

更新日期：1998-03-01 00:00:00

abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...

journal_title：Toxicologic pathology

authors： Schmidt F,Wolf R,Baumann L,Braunbeck T

更新日期：2017-07-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a chemical used in the production of fluoropolymers. Its persistence in the environment and presence in humans and wildlife has raised health concerns. Liver tumor induction by PFOA is thought to be mediated in rodents by PPAR-alpha. A recent US EPA scientific advisory board questioned...

journal_title：Toxicologic pathology

authors： Wolf DC,Moore T,Abbott BD,Rosen MB,Das KP,Zehr RD,Lindstrom AB,Strynar MJ,Lau C

更新日期：2008-06-01 00:00:00

abstract：:A nondopaminergic antipsychotic agent, 5-ethyl-1,3,8-trimethyl-1H-imidazo]1,2-c]pyrazolo[3,4-e]pyrimidine (TIPP; PD 112488), has been tested for potential toxicity in rats. As part of a preclinical safety evaluation, 10 Wistar rats per sex were administered TIPP as a dietary admixture, receiving doses of 0, 5, 10, 20,...

journal_title：Toxicologic pathology

authors： Macallum GE,Albassam MA

更新日期：1994-01-01 00:00:00

abstract：:The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascu...

journal_title：Toxicologic pathology

authors： Morton D,Reed L,Huang W,Marcek JM,Austin-LaFrance R,Northcott CA,Schelling SH,Enerson BE,Tomlinson L

更新日期：2015-06-01 00:00:00

abstract：:The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic act...

journal_title：Toxicologic pathology

authors： Caspritz G,Hadden J

更新日期：1987-01-01 00:00:00

abstract：:Weber, K. (2017). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. J Toxicol Pathol45, 64-75. (Original DOI: 10.1177/0192623316672075) In the January 2017 issue of Toxicologic Pathology, a number of in text Table citations were incorrectly labeled. The following are the sentences ...

journal_title：Toxicologic pathology

authors：

更新日期：2017-04-01 00:00:00

abstract：:Morphologic lesions have received only limited attention as in vitro endpoints of toxicity. In the present work, "tissue" and cell morphology of control and toxicant-treated primary dissociated cerebrocortical cell cultures from fetal mice were examined using phase-contrast and bright-field microscopy. In untreated co...

journal_title：Toxicologic pathology

authors： Bolon B,Dorman DC,Bonnefoi MS,Randall HW,Morgan KT

更新日期：1993-09-01 00:00:00