PTH-PTHrP receptor mRNA is downregulated in chronic renal failure.

abstract：BACKGROUND/AIMS:Advanced glycation end products (AGEs) induce epithelial mesenchymal transition (EMT) in renal proximal tubular epithelial cells (PTECs) by promoting the two EMT regulators, transforming growth factor beta (TGF-β) and connective tissue growth factor (CTGF). However, the exact signaling mechanism remains...

journal_title：American journal of nephrology

authors： Cheng M,Liu H,Zhang D,Liu Y,Wang C,Liu F,Chen J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Growth hormone (GH) resistance in CKD is partly due to increased expression of SOCS2, a GH signaling negative regulator. In SOCS2 absence, body growth is exaggerated. However, GH overexpression in mice causes glomerulosclerosis. Accordingly, we tested whether lack of SOCS2 improves body growth, but accelerat...

journal_title：American journal of nephrology

authors： Landau D,Assadi MH,Abu Hilal R,Chen Y,Rabkin R,Segev Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Recent retrospective studies suggest an association of therapy with erythropoiesis-stimulating agents (ESAs) and increased mortality in renal transplant recipients (RTR). Large artery structure and function are significantly impaired in RTR which contributes to their high cardiovascular morbidity and co...

journal_title：American journal of nephrology

authors： Bartels V,Hillebrand U,Kosch M,Hausberg M,Kisters K,Di Marco GS,Reiermann S,Pavenstaedt H,Lang D

更新日期：2012-01-01 00:00:00

abstract：:Peritoneal sclerosis, a disorder similar to that previously identified in nonuremic patients, is being noted in peritoneal dialysis patients with increasing frequency. The etiology in dialysis patients remains unknown. An association with previous or ongoing peritoneal inflammation or irritation suggests that the inci...

journal_title：American journal of nephrology

authors： Ing TS,Daugirdas JT,Gandhi VC

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Interest in nephrology careers is declining, possibly due to perceptions of the field and/or training aspects. Understanding practices of medical schools successfully instilling nephrology interest could inform efforts to attract leading candidates to the specialty. METHODS:The American Society of Nephrolog...

journal_title：American journal of nephrology

authors： Sozio SM,Pivert KA,Shah HH,Chakkera HA,Asmar AR,Varma MR,Morrow BD,Patel AB,Leight K,Parker MG

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Contemporary prevalence of chronic kidney disease (CKD) and thrombotic cardiovascular (CV) events remains unclear in Veterans enrolled in the Veterans Affairs Health Care System (VA) care. Although oral P2Y12 inhibitors (P2Y12i) are increasingly being prescribed to this patient population, the overall prescr...

journal_title：American journal of nephrology

authors： Singh M,Raghavan D,Williams JS,Martin BC,Hudson TJ,Owen RR,Jain N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Henoch-Schönlein Purpura (HSP) is a common childhood vasculitis with manifestations in numerous organ systems, including glomerulonephritis. Patients with more severe HSP-associated glomerulonephritis may develop chronic renal failure. Currently, no widely accepted treatment protocols exist for patients with...

journal_title：American journal of nephrology

authors： Flynn JT,Smoyer WE,Bunchman TE,Kershaw DB,Sedman AB

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:The susceptibility of patients on maintenance hemodialysis (MHD) to infections is a major cause of mortality and morbidity. Natural resistance-associated macrophage protein 1 (Nramp1) regulates intracellular pathogen proliferation, and its mRNA expression is highest in polymorphonuclear leukocytes (PMNL...

journal_title：American journal of nephrology

authors： Moriguchi R,Otaki Y,Hazeki S,Shimada T,Matsumoto A,Kakita N,Kaibe S,Kuragano T,Nonoguchi H,Masayoshi N,Hasuike Y,Nakanishi T

更新日期：2012-01-01 00:00:00

abstract：AIMS:We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). METHODS:40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-M...

journal_title：American journal of nephrology

authors： Keshtkar-Jahromi M,Argani H,Rahnavardi M,Mirchi E,Atabak S,Tara SA,Gachkar L,Noori-Froothghe A,Mokhtari-Azad T

更新日期：2008-01-01 00:00:00

abstract：:Whole plasma from 6 normolipidemic chronic renal failure (CRF) patients undergoing hemodialysis treatment was passed through the anti-apolipoprotein (Apo) AI immunosorbent column connected to the anti-Apo B immunoaffinity column. Apo AI and B containing particles were analyzed for lipid and Apo contents. The results w...

journal_title：American journal of nephrology

authors： Kandoussi AM,Hugue V,Parra HJ,Dracon M,Fruchart JC,Tacquet A,Cachera C

更新日期：1996-01-01 00:00:00

abstract：:Bicarbonate dialysate is claimed to be superior to acetate for both chronic and acute hemodialysis. We compared acetate and bicarbonate dialysates in 30 acute renal failure patients during 120 dialyses. 4 patients were diabetic and 2 had liver failure. Patients were dialyzed alternating acetate and bicarbonate dialysa...

journal_title：American journal of nephrology

authors： Borges HF,Fryd DS,Rosa AA,Kjellstrand CM

更新日期：1981-01-01 00:00:00

abstract：:Thirty-one renal transplant recipients, submitted to treatment with cyclosporin in association with other immunosuppressive agents, were also treated for 9 months with two hydroxymethylglutaryl coenzyme A reductase inhibitors, simvastatin (10 mg/day) or pravastatin (20 mg/day), for concomitant hypercholesterolemia and...

journal_title：American journal of nephrology

authors： Capone D,Stanziale P,Gentile A,Imperatore P,Pellegrino T,Basile V

更新日期：1999-01-01 00:00:00

abstract：:A renal transplant recipient with a remote history of end-stage renal disease due to postpartum hemolytic-uremic syndrome (HUS) presented with acute renal failure after having stable renal allograft function for 9 years. A diagnosis of thrombotic microangiopathy was made based on clinical and histologic findings at re...

journal_title：American journal of nephrology

authors： Gohh RY,Williams ME,Crosson AW,Federman M,Zambetti FX

更新日期：1997-01-01 00:00:00

abstract：:To elucidate the relationship between the renal regulation of sodium and calcium excretion at extremes of sodium intake, we studied 6 normal men ingesting a fixed, 400 mg/day calcium intake and four levels of sodium intake from 10 to 1,500 mEq/day. Serum ionized calcium was not influenced by sodium intake. Blood press...

journal_title：American journal of nephrology

authors： McCarron DA,Rankin LI,Bennett WM,Krutzik S,McClung MR,Luft FC

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:To promote understanding of immunoglobulin A nephropathy (IgAN) pathophysiology, we tried to elucidate glomerular protein profiles in IgAN, using microsieving that we established recently to isolate glomeruli from renal biopsy samples and proteomic approaches. METHODS:Glomeruli were isolated from renal biop...

journal_title：American journal of nephrology

authors： Kojima S,Koitabashi K,Iizuka N,Okamoto K,Arito M,Sato T,Kurokawa MS,Suematsu N,Shibagaki Y,Yasuda T,Kimura K,Kato T

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoietin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TP...

journal_title：American journal of nephrology

authors： Mansell H,Elmoselhi H,Shoker A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Protein-energy wasting (PEW) is common and associated with poor outcome in hemodialysis patients. In hemodialysis patients, geriatric nutritional risk index (GNRI) and decoy receptor 3 (DcR3) have been shown as the nutritional and inflammatory markers, respectively. The present study aimed to assess the pred...

journal_title：American journal of nephrology

authors： Tsai MT,Hu FH,Lien TJ,Chen PJ,Huang TP,Tarng DC

更新日期：2014-01-01 00:00:00

abstract：:Two patients with a long-standing history of familial Mediterranean fever were found to have both microscopic hematuria and proteinuria during the acute attacks. Kidney biopsies from both patients revealed diffuse mesangial proliferative glomerulonephritis with intense mesangial IgA and C3 deposits and no evidence of ...

journal_title：American journal of nephrology

authors： Said R,Nasrallah N,Hamzah Y,Tarawneh M,al-Khatib M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:There is continued and significant debate regarding the salient etiologies associated with graft loss and racial disparities in kidney transplant recipients. METHODS:This was a longitudinal cohort study of all adult kidney transplant recipients, comparing patients with early graft loss (<5 years) to those w...

journal_title：American journal of nephrology

authors： Taber DJ,Douglass K,Srinivas T,McGillicuddy JW,Bratton CF,Chavin KD,Baliga PK,Egede LE

更新日期：2014-01-01 00:00:00

abstract：:Man-made or massive natural disasters may be followed by 'epidemics' of the muscle crush syndrome. The first descriptions of the crush syndrome were in the German-language literature following the earthquake of Messina in 1909 and World War II. On the threshold of World War II, the English-language literature was stil...

journal_title：American journal of nephrology

authors： Better OS

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:Insulin is synthesised as a pro-hormone with an interconnecting C-peptide, cleaved during post-translational modification. This review discusses growing evidence which indicates that C-peptide is biologically active, benefiting microvascular complications associated with diabetes. METHODS:To explore th...

journal_title：American journal of nephrology

authors： Hills CE,Brunskill NJ,Squires PE

更新日期：2010-01-01 00:00:00

abstract：:A patient with advanced chronic renal failure secondary to polycystic kidney disease suffered an episode of volume contraction during which his urinary sodium concentration fell to less than 5 mEq daily. Urine sodium excretion remained at this level when later in his course he became clinically volume expanded. The pa...

journal_title：American journal of nephrology

authors： Danovitch GM,Jacobson E,Licht A

更新日期：1981-01-01 00:00:00

abstract：:Autopsy reports on 155 successive end-stage renal disease (ESRD) patients and 147 control patients without ESRD, matched for age, race and gender, were collected. Cystic transformation of the kidneys was noted in 58% of the ESRD patients and 13.6% of the control patients. There were 25 ESRD patients with renal adenoma...

journal_title：American journal of nephrology

authors： Miller LR,Soffer O,Nassar VH,Kutner MH

更新日期：1989-01-01 00:00:00

abstract：:The removal of phenytoin by plasmapheresis in a patient with compromised renal function is described. The results indicate that plasma concentrations of total phenytoin increase after plasmapheresis, while unbound phenytoin plasma concentrations and free fraction decrease. The amount of phenytoin removed was 36 mg and...

journal_title：American journal of nephrology

authors： Brown-Molnar CS,Bauer LA,Horn JR

更新日期：1986-01-01 00:00:00

abstract：:Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importan...

journal_title：American journal of nephrology

authors： Piccoli GB,Alrukhaimi M,Liu ZH,Zakharova E,Levin A,World Kidney Day Steering Committee.

更新日期：2018-01-01 00:00:00

abstract：:To evaluate the significance of tubulointerstitial lesions in the cortical area of renal biopsy specimens, clinicopathological studies were performed on 101 cases of IgA nephropathy, 31 cases of IgA-negative (non-IgA) proliferative glomerulonephritis and 75 cases of idiopathic membranous glomerulonephritis. The degree...

journal_title：American journal of nephrology

authors： Abe S,Amagasaki Y,Iyori S,Konishi K,Kato E,Sakaguchi H

更新日期：1989-01-01 00:00:00

abstract：:Although the acute nephrotoxicity of cisplatin has been well documented, long-term follow-up studies are scanty. We have evaluated the renal function in 35 patients who have had completed therapy with cisplatin at least 3 months before the study. All patients had normal serum creatinine levels before chemotherapy. Eva...

journal_title：American journal of nephrology

authors： Brillet G,Deray G,Jacquiaud C,Mignot L,Bunker D,Meillet D,Raymond F,Jacobs C

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Prior studies suggest that certain aspects of the diet related to magnesium intake, such as dietary acid load, protein intake and dietary patterns rich in fruits and vegetables, may impact kidney disease risk. We hypothesized that lower dietary magnesium intake would be prospectively associated with more rap...

journal_title：American journal of nephrology

authors： Rebholz CM,Tin A,Liu Y,Kuczmarski MF,Evans MK,Zonderman AB,Crews DC

更新日期：2016-01-01 00:00:00

abstract：:Radioisotopic methods for the determination of the glomerular filtration rate (GFR) are highly accurate but require the collection of multiple blood and urine samples and are costly to perform due to personnel, material, and analysis costs. Nonradioactive methods of GFR determination have the potential of minimizing p...

journal_title：American journal of nephrology

authors： Rocco MV,Buckalew VM Jr,Moore LC,Shihabi ZK

更新日期：1996-01-01 00:00:00

abstract：:Two patients who developed bilateral renal cortical necrosis as a consequence of Neisseria meningitidis infections are described: 1 patient had meningococcemia and the other had meningococcal meningitis. Both patients developed a Shwartzman-like reaction, disseminated intravascular coagulation and irreversible renal f...

journal_title：American journal of nephrology

authors： Chervu I,Koss M,Campese VM

更新日期：1991-01-01 00:00:00