Abstract:
:Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Gender differences continue to exist around the world in access to education, medical care, and participation in clinical studies. Pregnancy is a unique state for women, offering an opportunity for diagnosis of kidney disease, but also a state where acute and chronic kidney diseases may manifest, and which may impact future generations with respect to kidney health. There are various autoimmune and other conditions that are more likely to have an impact on women, with profound consequences for child bearing, and on the fetus. Women have different complications on dialysis than men, and are more likely to be donors than recipients of kidney transplants. In this editorial, we focus on what we do and do not know about women, kidney health, and kidney disease, and what we might learn in the future to improve outcomes worldwide.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Piccoli GB,Alrukhaimi M,Liu ZH,Zakharova E,Levin A,World Kidney Day Steering Committee.doi
10.1159/000486408subject
Has Abstractpub_date
2018-01-01 00:00:00pages
103-114issue
2eissn
0250-8095issn
1421-9670pii
000486408journal_volume
47pub_type
社论abstract:BACKGROUND/AIMS:We examined the correlations between renal biopsy findings in Wegener's granulomatosis and renal function at baseline and 1 year in 22 patients who presented between 1988 and 1999. METHODS:Renal histology was independently reviewed by 2 pathologists who were masked to the clinical data. The primary out...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000065283
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:To determine the association of vancomycin with acute kidney injury (AKI) in relation to its serum concentration value and to examine the risk of AKI in patients treated with vancomycin when compared with a matched cohort of patients receiving non-glycopeptide antibiotics (linezolid/daptomycin). METHODS:Fro...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000496484
更新日期:2019-01-01 00:00:00
abstract::We report a 29-year-old female with recurrent focal glomerulosclerosis (FGS) presenting as heavy proteinuria immediately following renal transplantation. From day 13 after transplantation, daily plasma exchange was performed 6 times. Proteinuria decreased from 13 to 0.2 g/day after plasma exchange and remained to be l...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000168637
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Dietary acid load (DAL) contributes to the risk of CKD and CKD progression. We sought to determine the relation of DAL to racial/ethnic differences in the risk of end-stage renal disease (ESRD) among persons with CKD. METHODS:Among 1,123 non-Hispanic black (NHB) and non-Hispanic white (NHW) National Health ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000487715
更新日期:2018-01-01 00:00:00
abstract::Therapeutic use of D-penicillamine has been associated with a range of adverse effects. We present a patient with scleroderma, treated with D-penicillamine for 5 years, who developed severe renal failure due to rapidly progressive glomerulonephritis with both crescents and subepithelial immune deposits on renal biopsy...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000169183
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:While chronic dialysis treatment has been suggested to increase pulmonary pressure values, right ventricular dysfunction (RVD) is a major cause of death in patients with end-stage renal disease. We investigated the impact of different dialysis treatments on right ventricular function. METHODS:We examined 22...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000320755
更新日期:2010-01-01 00:00:00
abstract::The administration of calcium-blocking drugs exerts a natriuretic response. Acute studies in isolated perfused kidneys and in experimental animals, as well as in man, consistently demonstrate diuresis, natriuresis, calciuresis, and generally kaliuresis, even in the face of arterial blood pressure reduction. Clearance ...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000167541
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Detection of chronic kidney disease (CKD) with urine albumin-to-creatinine ratio (UACR) among patients with hypertension (HTN) provides an opportunity for early treatment, potentially mitigating risk of CKD progression and cardiovascular complications. Differences in UACR testing patterns among racial/ethnic...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000500706
更新日期:2019-01-01 00:00:00
abstract::The present study evaluated thyroid hormone indices of patients with acute renal failure without other systemic illnesses (n = 12), as compared to patients with critical illnesses in the presence (n = 16) and absence (n = 6) of acute renal failure. Abnormalities in the group with acute renal failure alone included dec...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166531
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Protein-energy wasting (PEW) is common and associated with poor outcome in hemodialysis patients. In hemodialysis patients, geriatric nutritional risk index (GNRI) and decoy receptor 3 (DcR3) have been shown as the nutritional and inflammatory markers, respectively. The present study aimed to assess the pred...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000366457
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseli...
journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000446122
更新日期:2016-01-01 00:00:00
abstract::A patient with unilateral gross hematuria was found to have mesangial proliferation and IgM deposition on renal biopsy, consistent with the entity of primary renal hematuria. This case refutes previous assumptions that renal biopsy is normal in patients with unilateral hematuria. Glomerular lesions may be more common ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167127
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000450838
更新日期:2016-01-01 00:00:00
abstract::We studied plasma, dialysate, and muscle carnitine levels in patients with stable chronic renal failure on hemodialysis, and intermittent peritoneal, or continuous ambulatory peritoneal dialysis (CAPD). In patients on hemodialysis, plasma carnitine levels fell from 46.2 +/- 4.5 mumol/l (mean +/- SEM) to 18.8 +/- 2.7 m...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166711
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND/AIMS:The mesothelium of patients undergoing peritoneal dialysis (PD) is exposed to glucose in dialysate. Glucose metabolites 3-deoxyglucosone and advanced glycation endproducts (AGEs) in the PD fluid induce peritoneal damage. Circulating factors also affect the peritoneum in the uremic model and predialysis ...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
doi:10.1159/000108358
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:There is evidence that hereditary predisposition contributes to the development of diabetic nephropathy and hypertension. Polymorphisms in the genes for bradykinin receptors (B(1)R and B(2)R) were found to be associated with decreased risk of the development of end-stage renal disease. This study examin...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000068035
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:In autosomal dominant polycystic kidney disease, renoprotective treatment with a vasopressin V2 receptor antagonist (V2RA) is given in a fixed dose (FD). Disease progression and drug habituation could diminish treatment efficacy. We investigated whether the renoprotective effect of the V2RA can be improved b...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000448693
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:We determined the familial aggregation of end-stage renal disease (ESRD) in a large, population-based sample of incident ESRD cases to assess the feasibility of developing a targeted screening and prevention program directed at members of families at high risk for kidney disease. METHODS:Between January 1, ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000088491
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in pe...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000494665
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The identification of nephrin and CD2AP, podocyte proteins which modulate the properties of glomerular barrier selectivity, has made it possible to unravel the mechanisms undergoing foot process effacement and proteinuria. Here we explored the role of nephrin and CD2AP together with the integrity of the slit...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000072281
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Since low-density lipoprotein (LDL) S-homocysteinylation has been recently reported to enhance atherogenicity of lipoprotein, we have investigated the levels of homocysteine (Hcy) linked to LDL in chronic proteinuric patients in which lipid abnormalities highly contribute to the excess of morbidity and morta...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000319012
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000455390
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Henoch-Schönlein Purpura (HSP) is a common childhood vasculitis with manifestations in numerous organ systems, including glomerulonephritis. Patients with more severe HSP-associated glomerulonephritis may develop chronic renal failure. Currently, no widely accepted treatment protocols exist for patients with...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
doi:10.1159/000046235
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND/AIMS:In chronic hemodialysis patients, we evaluated determinants of repetitive ventricular tachyarrhythmias which included late potentials and heart rate variability. METHODS:We compared the presence of late potentials and heart rate variability obtained by ambulatory electrocardiogram (ECG), findings of ec...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013351
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:The long-term renal outcomes of patients with IgA nephropathy (IgAN) who present with recurrent macroscopic hematuria (RMH) have not been described in previous studies. METHODS:Patients with biopsy-proven primary IgAN in Jinling Hospital were divided into three groups according to different patterns of...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000364954
更新日期:2014-01-01 00:00:00
abstract::The terminal complement-inhibitor eculizumab has dramatically changed the management of patients with atypical hemolytic uremic syndrome (aHUS), and has also shown promise for treating certain forms of secondary HUS (sHUS), including that caused by drugs and solid-organ/hematopoietic stem cell transplant. While effect...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000492033
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) and serious mental illness (SMI) are both associated with an increased risk for repeated hospitalization. The objective of this study was to determine if co-occurring SMI exacerbates the risk for subsequent hospitalization, particularly through the emergency department (ED),...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000360095
更新日期:2014-01-01 00:00:00
abstract::Obese Zucker rats spontaneously develop lipoprotein abnormalities, proteinuria, mesangial expansion and glomerulosclerosis. Previous studies have implicated these lipoprotein abnormalities in the pathogenesis of the progressive renal injury which these rats develop. The present study was designed to examine the chrono...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168588
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000101191
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000070864
更新日期:2003-05-01 00:00:00