Abstract：
BACKGROUND:Protein-energy wasting (PEW) is common and associated with poor outcome in hemodialysis patients. In hemodialysis patients, geriatric nutritional risk index (GNRI) and decoy receptor 3 (DcR3) have been shown as the nutritional and inflammatory markers, respectively. The present study aimed to assess the predictive ability of GNRI and DcR3 for PEW status and long-term outcomes in chronic hemodialysis patients. METHODS:A prospective cohort of 318 hemodialysis patients was conducted with a median follow-up of 54 months. Malnutrition-inflammation score (MIS) was used as the reference standard for the presence of PEW. Endpoints were cardiovascular and all-cause mortality. RESULTS:Baseline GNRI had a strong negative correlation with DcR3 and MIS score. For patients with age < or ≥60, high DcR3 and low GNRI were independent predictors for the presence of PEW at baseline. At the end of the study, 81 patients died (27 cardiovascular deaths). The adjusted hazard ratios (95% confidence intervals) of low GNRI and high DcR3 were 1.93 (1.1-4.8) and 2.53 (1.2-5.5) for cardiovascular mortality and 1.85 (1.1-3.2) and 2.37 (1.5-3.7) for all-cause mortality, respectively. While integrated into a model of conventional risk factors, GNRI together with DcR3 further significantly improved the predictability for overall mortality (c statistic, 0.823). CONCLUSIONS:Low GNRI and high DcR3 were the alternatives for identifying hemodialysis patients at risk of PEW and overall mortality. Further studies are needed to verify whether timely recognition of hemodialysis patients with a high malnutrition-inflammation risk could reduce their mortality by appropriate interventional strategies.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Tsai MT,Hu FH,Lien TJ,Chen PJ,Huang TP,Tarng DCdoi
10.1159/000366457subject
Has Abstractpub_date
2014-01-01 00:00:00pages
191-9issue
3eissn
0250-8095issn
1421-9670pii
000366457journal_volume
40pub_type
杂志文章abstract：:Therapeutic use of D-penicillamine has been associated with a range of adverse effects. We present a patient with scleroderma, treated with D-penicillamine for 5 years, who developed severe renal failure due to rapidly progressive glomerulonephritis with both crescents and subepithelial immune deposits on renal biopsy...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000169183
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000492623
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:A poor nutritional state is associated with an increased risk of cardiovascular events in end-stage renal disease. It is unclear whether malnutrition itself can induce cardiovascular disease (CVD). We examined the impact of nutritional status on patients' arterial stiffness in peritoneal dialysis (PD) patien...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000206697
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND/AIMS:A recent study suggests that inflammation and malnutrition are strongly associated with cardiovascular disease in dialysis patients. Endothelial lipase (EL) is a newly cloned physiological regulator of high-density lipoprotein cholesterol (HDL), which is associated with the progression of atherosclerosi...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000144025
更新日期：2008-01-01 00:00:00
abstract：:Peritoneal sclerosis, a disorder similar to that previously identified in nonuremic patients, is being noted in peritoneal dialysis patients with increasing frequency. The etiology in dialysis patients remains unknown. An association with previous or ongoing peritoneal inflammation or irritation suggests that the inci...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166799
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND/AIMS:We examined the correlations between renal biopsy findings in Wegener's granulomatosis and renal function at baseline and 1 year in 22 patients who presented between 1988 and 1999. METHODS:Renal histology was independently reviewed by 2 pathologists who were masked to the clinical data. The primary out...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000065283
更新日期：2002-09-01 00:00:00
abstract：INTRODUCTION:Evidence using real-world data is sparse regarding the effects of oral anticoagulants (OACs) among patients with kidney disease. The aim of this study was to investigate the effects of kidney disease on ischemic stroke (IS) or systemic embolism (SE) among patients taking OAC, using large-scale real-world d...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000509567
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND/AIMS:Post-renal transplant recurrent glomerulonephritis (GN) contributes to allograft loss. Rituximab treatment has been used in a multidose strategy with variable efficacy and toxicity. We investigated a novel single-dose approach. METHODS:A single center, retrospective, cohort study was conducted between ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000371587
更新日期：2015-01-01 00:00:00
abstract：:To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168357
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Interest in nephrology careers is declining, possibly due to perceptions of the field and/or training aspects. Understanding practices of medical schools successfully instilling nephrology interest could inform efforts to attract leading candidates to the specialty. METHODS:The American Society of Nephrolog...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000501058
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND/AIMS:Patients with chronic renal failure (CRF) secondary to diabetes mellitus show a high incidence of atherosclerosis with its thrombotic complications. Both CRF and type 2 diabetes mellitus (DM2) results in fibrinolysis defects causally related to atherogenesis and thrombogenesis. It is not well known whet...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000065270
更新日期：2002-09-01 00:00:00
abstract：:To determine the prevalence and type of glomerulonephritis (GN) associated with hepatitis C virus (HCV) cirrhosis, we prospectively evaluated 28 consecutive Saudi patients with HCV cirrhosis for liver transplantation. Six patients (21%) underwent kidney biopsies for proteinuria, unexplained elevated serum creatinine o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168874
更新日期：1995-01-01 00:00:00
abstract：:The substitution of recombinant human erythropoietin (rhEPO) in chronic hemodialysis patients is often associated with the development of severe hypertension. In the present study, a systematical echocardiographic analysis was performed in 25 patients on maintenance hemodialysis during rhEPO therapy for at least 4 mon...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168273
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Medullary sponge kidney (MSK) is characterized by malformation of the terminal collecting ducts and is associated with an increased risk of nephrolithiasis, nephrocalcinosis, urinary tract infections, renal acidification defects, and reduced bone density. It has been historically diagnosed with intravenous p...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000358496
更新日期：2014-01-01 00:00:00
abstract：:Proteinuria is characteristic of many glomerular conditions, and often exceeds 2-3 g/24 h. There are several possible routes by which such profuse proteinuria might contribute to progression of the underlying pathology, whatever its type. First, proteinuria leads to a transit of protein through glomerular structures, ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168199
更新日期：1990-01-01 00:00:00
abstract：:John Bostock has a reasonable claim to being one of the first chemical pathologists. Most of his work was done before that of William Prout, with whom both he and Bright were in contact. Bostock's work was done about the same time as that of his friends and colleagues Marcet and Wollaston. Although other, notably Crui...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000168749
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND/AIMS:We previously reported that patients with chronic kidney disease (CKD) receiving warfarin therapy and whose international normalized ratio increases to >3.0 may develop acute kidney injury (AKI) as a result of glomerular hemorrhage and formation of obstructive red blood cell (RBC) casts. We named this c...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000337918
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000450838
更新日期：2016-01-01 00:00:00
abstract：:A meeting on the History of Nephrology is an opportunity to discuss the links between science and faith which were split until the 6th century. However, this was changed by Cassiodorus and monasticism. From the times of Abbot Bertario (died 883 AD) in Montecassino, medicine was regarded as an art and a science. Codex ...
journal_title：American journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.1159/000168769
更新日期：1994-01-01 00:00:00
abstract：:Whole plasma from 6 normolipidemic chronic renal failure (CRF) patients undergoing hemodialysis treatment was passed through the anti-apolipoprotein (Apo) AI immunosorbent column connected to the anti-Apo B immunoaffinity column. Apo AI and B containing particles were analyzed for lipid and Apo contents. The results w...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169011
更新日期：1996-01-01 00:00:00
abstract：:Skin ulceration is a well-characterized thrombotic complication of the heparin-induced thrombocytopenia (HIT) syndrome. We present the case of a 73-year-old diabetic woman nearing end-stage renal failure who developed extensive upper thigh, abdominal and buttock ulceration following initiation of subcutaneous heparin ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000046263
更新日期：2001-07-01 00:00:00
abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166918
更新日期：1985-01-01 00:00:00
abstract：:In order to evaluate the changes in causes and outcome of acute renal failure (ARF) during the years 1975-1989, 710 patients treated in our dialysis center were analyzed. We compared the etiology, the severity and catabolic state of ARF, the techniques of renal replacement therapy, which were employed and the ages and...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168466
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Most studies evaluating predictors of renal replacement therapy (RRT) following cardiac surgery use arbitrary defined limits of preoperative serum creatinine. The aim of this study was to evaluate the effect of preoperative renal function using either estimated-glomerular filtration rate (eGFR) derived using...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000492182
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000455390
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Patients with chronic kidney disease (CKD) have a high prevalence of periodontal disease that may predispose to tooth loss and inflammation. The goal of this study was to test the hypotheses that a genetic rat model of progressive CKD would exhibit altered oral bone properties and that treatment with ei...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000356335
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Published reports examining the efficacy and safety of glucocorticoids for preserving renal function in immunoglobulin A nephropathy (IgAN) have yielded conflicting results. To systematically evaluate the efficacy and safety of glucocorticoids agents for IgAN, we conducted a meta-analysis of the published ra...
journal_title：American journal of nephrology
pub_type： 杂志文章,meta分析,评审
doi：10.1159/000226129
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, and a strong correlation between MIS and morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there is no cut-off value of MIS to ca...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000137684
更新日期：2008-01-01 00:00:00
abstract：:Accelerated atherosclerosis is both a cause and a consequence of chronic renal failure. Vascular smooth muscle cells (VSMCs) are an important component of atherosclerotic plaques, responsible for promoting plaque stability in advanced lesions. In contrast, VSMC apoptosis has been implicated in a number of deleterious ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000097815
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Home dialysis patients may be at an increased risk of adverse events after transitional states. The home dialysis virtual ward (HDVW) trial was conducted in Canadian dialysis centers and aimed to evaluate potential care gaps and patient satisfaction during the HDVW. METHODS:The HDVW was a multicenter single...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1159/000503439
更新日期：2019-01-01 00:00:00
