Abstract:
BACKGROUND/AIMS:Patients with chronic kidney disease (CKD) have a high prevalence of periodontal disease that may predispose to tooth loss and inflammation. The goal of this study was to test the hypotheses that a genetic rat model of progressive CKD would exhibit altered oral bone properties and that treatment with either bisphosphonates or calcium could attenuate these adverse changes. METHODS:At 25 weeks of age, rats were treated with zoledronate (ZOL), calcium gluconate, or their combination for 5 or 10 weeks. Mandible bone properties were assessed using micro-computed tomography to determine bone volume (BV/TV) and cementum-enamel junction to alveolar crest distance (CEJ-AC). RESULTS:Untreated CKD animals had significantly lower BV/TV at both 30 (-5%) and 35 (-14%) weeks of age and higher CEJ-AC (+27 and 29%) compared to normal animals. CKD animals had a significantly higher parathyroid hormone (PTH) compared to normal animals, yet similar levels of C-reactive protein (CRP). ZOL treatment normalized BV/TV over the first 5 weeks but this benefit was lost by 10 weeks. Calcium treatment, alone or in combination with ZOL, was effective in normalizing BV/TV at both time points. Neither ZOL nor calcium was able to correct the higher CEJ-AC caused by CKD. Calcium, but not ZOL, significantly reduced serum PTH, while neither treatment affected CRP. CONCLUSIONS:(i) This progressive animal model of CKD shows a clear mandibular skeletal phenotype consistent with periodontitis, (ii) the periodontitis is not associated with systemic inflammation as measured by CRP, and (iii) reducing PTH has positive effects on the mandible phenotype.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Allen MR,Chen NX,Gattone VH 2nd,Moe SMdoi
10.1159/000356335subject
Has Abstractpub_date
2013-01-01 00:00:00pages
458-64issue
6eissn
0250-8095issn
1421-9670pii
000356335journal_volume
38pub_type
杂志文章abstract::A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166918
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A(1) receptors (A1Rs). We studied the effect of the orally active, A1R antagonist tonapofylline (BG9928) on biochemical measures of re...
journal_title:American journal of nephrology
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
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journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000168476
更新日期:1992-01-01 00:00:00
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journal_title:American journal of nephrology
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更新日期:1984-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 传,历史文章,杂志文章
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000169011
更新日期:1996-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000168491
更新日期:1992-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013627
更新日期:2000-09-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167570
更新日期:1988-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIM:Nephropathy after ingestion of Chinese herbs is known as a rapidly progressive form of interstitial renal fibrosis after a slimming regimen containing aristolochic acid that was identified first in Belgium. Intake of traditional Chinese herbal medicines is very popular in Taiwan. So we looked for similar...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000046647
更新日期:2001-11-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000168199
更新日期:1990-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000496276
更新日期:2019-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000094403
更新日期:2006-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000492623
更新日期:2018-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013391
更新日期:1998-01-01 00:00:00
abstract::This study was carried out to find out whether Ramadan fasting would affect the renal function in kidney transplant recipients with normal or impaired graft function. Twenty-three transplant recipients, 17 with a normal function and 6 with an impaired but stable function with plasma creatinine levels not exceeding 300...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013316
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journal_title:American journal of nephrology
pub_type: 杂志文章,评审
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journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000503439
更新日期:2019-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168020
更新日期:1989-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000510771
更新日期:2020-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 历史文章,杂志文章
doi:10.1159/000168759
更新日期:1994-01-01 00:00:00
abstract::The review focuses on biochemical metabolisms of conventional buffers and emphasizes advantages of sodium pyruvate (Pyr) in the correction of intracellular acidosis. Exogenous lactate (Lac) as an alternative of natural buffer, bicarbonate, consumes intracellular protons on an equimolar basis, regenerating bicarbonate ...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000084141
更新日期:2005-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000455390
更新日期:2017-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000505145
更新日期:2020-01-01 00:00:00
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journal_title:American journal of nephrology
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更新日期:2015-01-01 00:00:00