Abstract：
:The objective was to evaluate the effect of high-flux hemodialysis on quality of life, intra- and interdialytic symptoms and neuropsychological function. The study was double-blind single cross-over with random allocation to order of treatment. The patients were stable adult hospital hemodialysis patients. Both the conventional and high-flux membranes were cellulose acetate, the dialysate was bicarbonate, and dialysate sodium was held constant. The high-flux membrane had an ultrafiltration rate of 15 ml/h/mm Hg transmembrane pressure, a B12 clearance of 88 ml/min and a beta 2-microglobulin clearance of 11.4 ml/min. The values of the conventional membrane were 3.5-5.0, 34-45 and negligible. Each treatment period was 4 months. Twenty-two patients completed both phases of the cross-over. The KT/V value was higher during high-flux than conventional treatment; 1.42 versus 1.27(p < 0.05). There were no differences between high-flux and conventional treatment with respect to quality of life. Symptoms during dialysis were less severe during high-flux than conventional treatment for 12/14 items. Only 3 items reached statistical significance (0.05 > p > 0.01) and none were clinically significant. Symptoms between dialyses were less severe during high-flux than conventional treatment for 18/20 items. No single item had a statistically significant improvement but 3 had clinically important improvement. Among the 23 neuropsychological variables, none demonstrated statistically significant changes.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Churchill DN,Bird DR,Taylor DW,Beecroft ML,Gorman J,Wallace JEdoi
10.1159/000168491subject
Has Abstractpub_date
1992-01-01 00:00:00pages
412-8issue
6eissn
0250-8095issn
1421-9670journal_volume
12pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these v...
journal_title：American journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000445443
更新日期：2016-01-01 00:00:00
abstract：:We have compared the renal effects of ioxitalamate, ioxaglate, and iopamidol in patients with chronic renal failure. Sixty consecutive patients with an estimated creatinine clearance (ECRCl) less than 60 ml/min were randomly assigned to receive either ioxitalamate, iopamidol, or ioxaglate. All patients received 500 cm...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000168328
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Tacrolimus (FK) is currently widely used in transplant immunosuppression and the treatment of autoimmune diseases. However, FK induces nephrotoxicity which is characterized by functional and structural renal injury. The ubiquitous protein annexin A1 (ANXA1) has potent anti-inflammatory effects and protects a...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000309756
更新日期：2010-01-01 00:00:00
abstract：:We report on a Mycobacterium marinum infection in a diabetic woman 8 years after undergoing a combined pancreas-kidney transplantation. This is, to our knowledge, the first case report on an isolated skin infection with atypical mycobacteria after simultaneous pancreas-kidney transplantation. A genetic probe categoriz...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000065271
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:There has been an increasing incidence of hemodialysis (HD) due to old age and comorbid condition such as diabetes. In general, socioeconomic status (SES) is known as one of the most important risk factors for patient mortality and morbidity. Whether low SES is associated with poorer outcome in HD patients i...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000512855
更新日期：2021-01-13 00:00:00
abstract：:The effects of cisplatin (5 mg/kg BW given intraperitoneally) on renal concentration mechanism were evaluated initially by clearance studies in rats 5-7 days after cisplatin administration and compared to normal rats. During hypotonic saline infusion, cisplatin rats showed a lower inulin clearance (0.56 +/- 0.07 vs. 1...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167938
更新日期：1989-01-01 00:00:00
abstract：:Bacterial endocarditis, particularly involving the left side, has been shown to occur in patients in regular hemodialysis. We report a case of right-sided endocarditis characterized by a very torpid evolution. Although the diagnosis was suspected early in the course, confirmation was obtained 2 months after the onset....
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168806
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Previous studies on end-of-life (EOL) care among patients with chronic kidney disease (CKD) have been largely limited to White hemodialysis patients. In this study, we sought to explore racial variability in EOL communication, care preferences and advance care planning (ACP) among patients with advanced CKD ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000447097
更新日期：2016-01-01 00:00:00
abstract：:The prejunctional beta-adrenoceptors present in the isolated perfused kidney of normotensive rats (NR) and spontaneously hypertensive rats (SHR) were compared and the effects of tertatolol on these receptors were investigated. Kidneys of NR (Wistar + Wistar-Kyoto [WKY]) and SHR, were continuously perfused with Tyrode ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167330
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is a prevalent condition; however, little is known about healthcare resource utilization (HRU) by CKD patients. METHODS:This analysis included NHANES participants aged > or =18 years, with serum creatinine, urine protein, and hemoglobin measurements. We assessed the association ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000178816
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Since low-density lipoprotein (LDL) S-homocysteinylation has been recently reported to enhance atherogenicity of lipoprotein, we have investigated the levels of homocysteine (Hcy) linked to LDL in chronic proteinuric patients in which lipid abnormalities highly contribute to the excess of morbidity and morta...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000319012
更新日期：2010-01-01 00:00:00
abstract：:Dialysis patients have increased susceptibility to infection and this is, in part, due to impaired phagocytic and bactericidal activities of polymorphonuclear leukocytes (PMNL). The mechanisms responsible for the reduced phagocytosis are not known. Dialysis patients have elevated blood levels of parathyroid hormone (P...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168284
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Three million people in the United States are estimated to have chronic kidney disease (CKD). Management of these CKD patients in the outpatient primary care clinic setting has not been well studied. HYPOTHESIS:Primary care management of CKD can be assessed and opportunities for improvement can be identifie...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000066296
更新日期：2003-01-01 00:00:00
abstract：:The treatment of the bleeding diathesis of renal failure remains unsatisfactory. 1-Deamino-8-D-arginine vasopressin (DDAVP) has recently been shown to shorten the prolonged bleeding time of renal failure and may as a result diminish the risk of clinical hemorrhage. We describe 2 cases where DDAVP was used successfully...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166773
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND/AIMS:Patients on chronic hemodialysis have a high prevalence of heart disease and poor self-reported physical function. The association between structural heart disease and self-reported physical function in patients on hemodialysis is unknown. METHODS:We studied the association between elevated pulmonary a...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000431334
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. METHODS:This...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000357787
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Hypertension often accompanies chronic kidney disease (CKD), and diuretics are widely prescribed to reduce blood pressure (BP). Chlorthalidone (CTD) is a thiazide-like diuretic and an effective antihypertensive drug, yet little data exist to support its use in treating hypertension in individuals with advanc...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000508700
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000088279
更新日期：2005-09-01 00:00:00
abstract：:The influence of fluvastatin, a liver-selective, competitive inhibitor of the 3-hydroxymethyl-glutaryl-coenzyme A reductase, on the lipoprotein metabolism was investigated in 9 patients with nephrotic syndrome. All patients had biopsy-proven renal disease as cause of their nephrotic syndrome and exhibited severe hyper...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000013504
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Treatment of metabolic acidosis to target the higher serum bicarbonate level than guideline recommendation may downregulate muscle protein degradation and improve renal function among chronic kidney disease (CKD) patients. We conducted a study to test the effects of increased serum bicarbonate level on muscl...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000504557
更新日期：2020-01-01 00:00:00
abstract：:The great Spanish military and orthopedic surgeon J. Trueta gained his field and clinical experience in the Spanish civil war (1936-1939) and in Britain during World War II. As part of his major contribution to traumatology, he searched for the causes of the characteristic oliguria of combat casualties. For this purpo...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000013473
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited. METH...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.1159/000494840
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The outcome-predictability of baseline and instantaneously changing serum calcium in hemodialysis patients has been examined. We investigated the mortality-predictability of time-averaged calcium values to reflect the 'cumulative' effect of calcium burden over time. METHODS:We employed a Cox model using up-...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000319861
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000101191
更新日期：2007-01-01 00:00:00
abstract：:Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this persp...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000368563
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/AIMS:Although the effect of exercise on health is well established, nephrologists seldom consider physical activity in the treatment of chronic kidney disease (CKD) or CKD in the presence of diabetes mellitus (DM/CKD). The aim of the present study was to analyze the benefits of leisure-time physical activity...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000357133
更新日期：2013-01-01 00:00:00
abstract：AIM:The relation of ambient temperature (AMT) and relative humidity to systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight (BW), and body weight gain between dialysis sessions (DeltaBW) was examined in hemodialysis patients by Fourier analysis. METHODS AND RESULTS:The authors recruited 144 dialy...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013538
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS:This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from t...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1159/000455388
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Conditionally immortalized podocytes are valuable research tools but are difficult to efficiently transfect and do not provide graded transgene expression. METHODS:Conditionally immortalized mouse podocyte cell lines were established employing a tetracycline-inducible system. Glomerular cells, isolated from...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000151770
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000487557
更新日期：2018-01-01 00:00:00
