Elevated osteoprotegerin predicts declining renal function in elderly women: a 10-year prospective cohort study.

abstract：BACKGROUND/AIMS:Apoptosis contributes to cyclosporine (CsA)-induced renal cell death. This study tested the effects of CsA-induced endoplasmic reticulum (ER) stress on apoptotic cell death in an experimental model of chronic CsA nephropathy. METHODS:CsA (15 mg/kg per day) was given to rats for 7 or 28 days. The ER str...

journal_title：American journal of nephrology

authors： Han SW,Li C,Ahn KO,Lim SW,Song HG,Jang YS,Cho YM,Jang YM,Ghee JY,Kim JY,Kim SH,Kim J,Kwon OJ,Yang CW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Dietary acid load (DAL) contributes to the risk of CKD and CKD progression. We sought to determine the relation of DAL to racial/ethnic differences in the risk of end-stage renal disease (ESRD) among persons with CKD. METHODS:Among 1,123 non-Hispanic black (NHB) and non-Hispanic white (NHW) National Health ...

journal_title：American journal of nephrology

authors： Crews DC,Banerjee T,Wesson DE,Morgenstern H,Saran R,Burrows NR,Williams DE,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Patients on chronic hemodialysis have a high prevalence of heart disease and poor self-reported physical function. The association between structural heart disease and self-reported physical function in patients on hemodialysis is unknown. METHODS:We studied the association between elevated pulmonary a...

journal_title：American journal of nephrology

authors： Abreo AP,Herzog CA,Kutner NG,Lea J,Johansen KL

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Prior studies suggest that certain aspects of the diet related to magnesium intake, such as dietary acid load, protein intake and dietary patterns rich in fruits and vegetables, may impact kidney disease risk. We hypothesized that lower dietary magnesium intake would be prospectively associated with more rap...

journal_title：American journal of nephrology

authors： Rebholz CM,Tin A,Liu Y,Kuczmarski MF,Evans MK,Zonderman AB,Crews DC

更新日期：2016-01-01 00:00:00

abstract：:Tubulointerstitial disease is an invariant finding in proteinuric renal disease regardless of the underlying disease or the compartment in which the disease originates. Such histologic changes are functionally significant in that scores of such injury rather than glomerular histologic injury correlate with decrements ...

journal_title：American journal of nephrology

authors： Agarwal A,Nath KA

更新日期：1993-01-01 00:00:00

abstract：:A comparative clinicopathological study was retrospectively performed in 61 children and 51 adults with IgA nephropathy. Hematuria and/or proteinuria as a chance finding was the most common initial clinical sign, being observed in 82.0% of the children and in 52.9% of the adults. At renal biopsy, hypertension and seve...

journal_title：American journal of nephrology

authors： Okada K,Funai M,Kawakami K,Kagami S,Yano I,Kuroda Y

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is evidence that hereditary predisposition contributes to the development of diabetic nephropathy and hypertension. Polymorphisms in the genes for bradykinin receptors (B(1)R and B(2)R) were found to be associated with decreased risk of the development of end-stage renal disease. This study examin...

journal_title：American journal of nephrology

authors： Zychma MJ,Gumprecht J,Trautsolt W,Szydlowska I,Grzeszczak W

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetics were enrolled to participate in this prospective observational study. ACE and AGT gene polymorphisms were analyzed by polymerase ...

journal_title：American journal of nephrology

authors： Tien KJ,Hsiao JY,Hsu SC,Liang HT,Lin SR,Chen HC,Hsieh MC

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:The susceptibility of patients on maintenance hemodialysis (MHD) to infections is a major cause of mortality and morbidity. Natural resistance-associated macrophage protein 1 (Nramp1) regulates intracellular pathogen proliferation, and its mRNA expression is highest in polymorphonuclear leukocytes (PMNL...

journal_title：American journal of nephrology

authors： Moriguchi R,Otaki Y,Hazeki S,Shimada T,Matsumoto A,Kakita N,Kaibe S,Kuragano T,Nonoguchi H,Masayoshi N,Hasuike Y,Nakanishi T

更新日期：2012-01-01 00:00:00

abstract：:Tuberculosis associated with dialysis was studied at the Artificial Kidney Unit (AKU) in Abha, Saudi Arabia. There were 13 tuberculosis patients out of 270 patients on maintenance hemodialysis from August 1986 to July 1993, a prevalence of 4.8%. Ten (77%) were female and 3 (23%) were male, mean age of 51.23 +/- 11.62 ...

journal_title：American journal of nephrology

authors： al-Homrany M

更新日期：1997-01-01 00:00:00

abstract：:Dialysis patients have increased susceptibility to infection and this is, in part, due to impaired phagocytic and bactericidal activities of polymorphonuclear leukocytes (PMNL). The mechanisms responsible for the reduced phagocytosis are not known. Dialysis patients have elevated blood levels of parathyroid hormone (P...

journal_title：American journal of nephrology

authors： Alexiewicz JM,Smogorzewski M,Fadda GZ,Massry SG

更新日期：1991-01-01 00:00:00

abstract：:Thirty-one renal transplant recipients, submitted to treatment with cyclosporin in association with other immunosuppressive agents, were also treated for 9 months with two hydroxymethylglutaryl coenzyme A reductase inhibitors, simvastatin (10 mg/day) or pravastatin (20 mg/day), for concomitant hypercholesterolemia and...

journal_title：American journal of nephrology

authors： Capone D,Stanziale P,Gentile A,Imperatore P,Pellegrino T,Basile V

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Although annual influenza vaccination is recommended for kidney transplant recipients, efficacy as reflected by serum antibody titers has not been well studied beyond 1 month in kidney transplant recipients. METHODS:We performed a single-center prospective cohort study of 51 kidney transplant recipient...

journal_title：American journal of nephrology

authors： Birdwell KA,Ikizler MR,Wang L,Byrne DW,Sannella EC,Wright PF,Ikizler TA

更新日期：2012-01-01 00:00:00

abstract：:Percutaneous angioplasty was attempted in 5 patients with acute renal failure due to occlusion of the artery to a solitary functioning kidney. Angioplasty was technically successful in all patients. Renal function was completely restored in 3 and renal perfusion improved in 1 patient. In the fifth patient, renal funct...

journal_title：American journal of nephrology

authors： Kadir S,Watson A,Burrow C

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia is one of the major manifestations of nephrotic syndrome. We have previously shown that nephrotic hypercholesterolemia is associated with and, in part, due to dysregulation of hepatic HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase (ACAT) and cholesterol 7alpha-hydroxylase, as we...

journal_title：American journal of nephrology

authors： Vaziri ND,Liang K

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND/AIMS:Serum phosphorus levels have been associated with adverse long-term outcome in several populations, however, no prior studies evaluated short-term postoperative outcome. The present study evaluated the predictive value of phosphorus levels on 30-day outcome after vascular surgery. METHODS:The study inc...

journal_title：American journal of nephrology

authors： van Kuijk JP,Flu WJ,Chonchol M,Valentijn TM,Verhagen HJ,Bax JJ,Poldermans D

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Studies have shown that kidney injury molecule-1 (KIM-1) is upregulated in damaged renal proximal tubules. In this study, we examined KIM-1 expression in glomerular epithelial cells in diabetic glomerulopathy. METHODS:Renal histology, immunostaining and Western blot for protein level, and real-time PCR...

journal_title：American journal of nephrology

authors： Zhao X,Zhang Y,Li L,Mann D,Imig JD,Emmett N,Gibbons G,Jin LM

更新日期：2011-01-01 00:00:00

abstract：:Shortage of kidney donor is still a major limitation for renal transplantation programs. This review focuses on the emerging practices, adopted to increase transplant activities, of expanding the criteria for donor and recipient selection without exposing the recipient to the drawbacks of a graft with inadequate nephr...

journal_title：American journal of nephrology

authors： Perico N,Ruggenenti P,Scalamogna M,Remuzzi G

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND/AIMS:The mesothelium of patients undergoing peritoneal dialysis (PD) is exposed to glucose in dialysate. Glucose metabolites 3-deoxyglucosone and advanced glycation endproducts (AGEs) in the PD fluid induce peritoneal damage. Circulating factors also affect the peritoneum in the uremic model and predialysis ...

journal_title：American journal of nephrology

authors： Hasuike Y,Moriguchi R,Hata R,Miyagawa K,Kuragano T,Aizawa M,Yamamoto S,Yanase K,Izumi M,Tanimoto T,Nakanishi T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There has been an increasing incidence of hemodialysis (HD) due to old age and comorbid condition such as diabetes. In general, socioeconomic status (SES) is known as one of the most important risk factors for patient mortality and morbidity. Whether low SES is associated with poorer outcome in HD patients i...

journal_title：American journal of nephrology

authors： Park HC,Kwon YE,Choi HY,Oh HJ,Chang TI,Kang EW,Park KS,Yang KH,Won EM,Shin JH,Ryu DR,Lee YK

更新日期：2021-01-13 00:00:00

abstract：:Forty-eight chronic hemodialysis patients were divided comparably into two groups (24 patients in each). Two micrograms of 1 alpha(OH)D3 was administered to one group for 3 months and its placebo to the other group. In the 1 alpha(OH)D3-treated group, serum total calcium increased from 7.82 +/- 0.11 (mean +/- SEM) to ...

journal_title：American journal of nephrology

authors： Shimamatsu K,Onoyama K,Fujimi S,Iseki K,Fujishima M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Growth hormone (GH) resistance in CKD is partly due to increased expression of SOCS2, a GH signaling negative regulator. In SOCS2 absence, body growth is exaggerated. However, GH overexpression in mice causes glomerulosclerosis. Accordingly, we tested whether lack of SOCS2 improves body growth, but accelerat...

journal_title：American journal of nephrology

authors： Landau D,Assadi MH,Abu Hilal R,Chen Y,Rabkin R,Segev Y

更新日期：2020-01-01 00:00:00

abstract：:In order to evaluate the changes in causes and outcome of acute renal failure (ARF) during the years 1975-1989, 710 patients treated in our dialysis center were analyzed. We compared the etiology, the severity and catabolic state of ARF, the techniques of renal replacement therapy, which were employed and the ages and...

journal_title：American journal of nephrology

authors： Biesenbach G,Zazgornik J,Kaiser W,Grafinger P,Stuby U,Necek S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...

journal_title：American journal of nephrology

authors： Jia L,Li X,Gu Y,Cui W

更新日期：2016-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:In the Systolic Blood Pressure Intervention Trial, the possible relationships between acute kidney injury (AKI) and risk of major cardiovascular events and death are not known. STUDY DESIGN:Post hoc analysis of a multicenter, randomized, controlled, open-label clinical trial. SETTING AND PARTI...

journal_title：American journal of nephrology

authors： Dieter BP,Daratha KB,McPherson SM,Short R,Alicic RZ,Tuttle KR

更新日期：2019-01-01 00:00:00

abstract：:We have demonstrated considerable variability in the volumes of different glomeruli in given individuals (individual glomerular volume: IGV) in a stereologic study of kidneys at forensic autopsy performed to investigate sudden or unexpected death in people without manifest kidney disease. We review some important asso...

journal_title：American journal of nephrology

authors： Hoy WE,Hughson MD,Diouf B,Zimanyi M,Samuel T,McNamara BJ,Douglas-Denton RN,Holden L,Mott SA,Bertram JF

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:There is continued and significant debate regarding the salient etiologies associated with graft loss and racial disparities in kidney transplant recipients. METHODS:This was a longitudinal cohort study of all adult kidney transplant recipients, comparing patients with early graft loss (<5 years) to those w...

journal_title：American journal of nephrology

authors： Taber DJ,Douglass K,Srinivas T,McGillicuddy JW,Bratton CF,Chavin KD,Baliga PK,Egede LE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Serum protein profiling patterns can reflect the pathological state of a patient and therefore may be useful for clinical diagnostics. Here, we present results from a pilot study of proteomic expression patterns in hemodialysis patients designed to evaluate the range of serum proteomic alterations in this po...

journal_title：American journal of nephrology

authors： Langlois RG,Trebes JE,Dalmasso EA,Ying Y,Davies RW,Curzi MP,Colston BW Jr,Turteltaub KW,Perkins J,Chromy BA,Choi MW,Murphy GA,Fitch JP,McCutchen-Maloney SL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as ...

journal_title：American journal of nephrology

authors： Tsuji S,Suruda C,Hashiyada M,Kimata T,Yamanouchi S,Kitao T,Kino J,Akane A,Kaneko K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Three million people in the United States are estimated to have chronic kidney disease (CKD). Management of these CKD patients in the outpatient primary care clinic setting has not been well studied. HYPOTHESIS:Primary care management of CKD can be assessed and opportunities for improvement can be identifie...

journal_title：American journal of nephrology

authors： Israni A,Korzelius C,Townsend R,Mesler D

更新日期：2003-01-01 00:00:00