Efficiency of 1-year treatment with fluvastatin in hyperlipidemic patients with nephrotic syndrome.

Abstract:

:The influence of fluvastatin, a liver-selective, competitive inhibitor of the 3-hydroxymethyl-glutaryl-coenzyme A reductase, on the lipoprotein metabolism was investigated in 9 patients with nephrotic syndrome. All patients had biopsy-proven renal disease as cause of their nephrotic syndrome and exhibited severe hyperlipidemia [baseline: serum cholesterol 358 +/- 46 mg/dl (9.3 mmol/l), low-density lipoprotein cholesterol 236 +/- 18 mg/dl (6.1 mmol/l), triglycerides 333 +/- 28 mg/dl (3.8 mmol/l), and lipoprotein Lp(a) 46 +/- 11 mg/dl]. After 1 year of 40 mg of fluvastatin, significant reductions of total cholesterol by 31% to 242 +/- 26 mg/dl (6.3 mmol/l) and low-density lipoprotein cholesterol by 29% to 162 +/- 12 mg/dl (4.2 mmol/l) were observed. Furthermore, triglyceride values were also lowered significantly by 19% to 268 +/- 21 mg/dl (3.1 mmol/l). Lipoprotein Lp(a) and high-density lipoprotein-cholesterol remained unchanged by fluvastatin. These improvements in lipid profile were maintained during the entire follow-up period of 1 year. There were no adverse events, and the slight increase in serum creatinine observed during the study was considered to be due to the primary renal disease. In conclusion, long- term administration of fluvastatin in patients with nephrotic syndrome appears to be an effective and safe treatment of the hyperlipidemia associated with this disorder.

journal_name

Am J Nephrol

authors

Matzkies FK,Bahner U,Teschner M,Hohage H,Heidland A,Schaefer RM

doi

10.1159/000013504

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

492-4

issue

4

eissn

0250-8095

issn

1421-9670

pii

13504

journal_volume

19

pub_type

临床试验,杂志文章
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:2004-03-01 00:00:00

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    更新日期:2011-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000178816

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    更新日期:2009-01-01 00:00:00

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    更新日期:2017-01-01 00:00:00

  • Dietary Magnesium and Kidney Function Decline: The Healthy Aging in Neighborhoods of Diversity across the Life Span Study.

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    pub_type: 杂志文章,多中心研究,随机对照试验

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