Abstract:
BACKGROUND:Kidney failure is believed to have a negative impact on cognitive function, and cognitive impairment is common among maintenance hemodialysis (HD) patients. Previous studies have shown a beneficial effect of kidney transplantation in certain cognitive tests but not across all cognitive domains assessed. But, most of these studies performed a cross-sectional analysis, suffered from lack of standardization of adequate dialysis dose, hemoglobin level, and insufficient sensitivity of neuropsychological tests. The aim of this study was to evaluate the effect of successful kidney transplantation on cognitive and psychomotor function in adequately dialyzed HD patients without severe anemia, using sensitive neuropsychological tests. METHODS:Twenty-one medically stable patients (aged 45.1 ± 7.9 years) on maintenance HD (7.6 ± 4.2 years) were investigated before and 20.5 ± 8.5 months after successful kidney transplantation using Complex Reactiometer Drenovac, a battery of computer-generated psychological tests which measure a simple visual discrimination of signal location, short-term memory, simple convergent visual orientation and convergent thinking. RESULTS:Our findings indicated significantly better cognitive and psychomotor performance after transplantation on tests that assess processing speed, attention, short time memory, convergent thinking and executive functioning. Also, significant negative correlation between follow-up time after transplantation and cognitive and psychomotor performance in minimum time of solving test of convergent thinking was found. CONCLUSION:We conclude that cognitive and psychomotor functions are superior after successful kidney transplantation compared with HD, and that early beneficial effects of transplantation are not transient and cognitive and psychomotor performance might be even improved in time following successful transplantation.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Radić J,Ljutić D,Radić M,Kovačić V,Dodig-Ćurković K,Šain Mdoi
10.1159/000330849subject
Has Abstractpub_date
2011-01-01 00:00:00pages
399-406issue
5eissn
0250-8095issn
1421-9670pii
000330849journal_volume
34pub_type
杂志文章abstract::Dialysis patients have increased susceptibility to infection and this is, in part, due to impaired phagocytic and bactericidal activities of polymorphonuclear leukocytes (PMNL). The mechanisms responsible for the reduced phagocytosis are not known. Dialysis patients have elevated blood levels of parathyroid hormone (P...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168284
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abstract::In 1828, Friedrich Wöhler, a German physician and chemist by training, published a paper that describes the formation of urea, known since 1773 to be a major component of mammalian urine, by combining cyanic acid and ammonium in vitro. In these experiments the synthesis of an organic compound from two inorganic molecu...
journal_title:American journal of nephrology
pub_type: 传,历史文章,杂志文章
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,评审
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更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model o...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000242432
更新日期:2009-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000371587
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journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
abstract::Two patients are reported who presented within the first 3 months posttransplantation with acute bone pain where serial magnetic resonance imaging (MRI) allowed differentiation between bone edema, which resolved spontaneously, and avascular necrosis (AVN) requiring core decompression. Case 1 had ill-defined images con...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013305
更新日期:1998-01-01 00:00:00
abstract::Tuberculosis associated with dialysis was studied at the Artificial Kidney Unit (AKU) in Abha, Saudi Arabia. There were 13 tuberculosis patients out of 270 patients on maintenance hemodialysis from August 1986 to July 1993, a prevalence of 4.8%. Ten (77%) were female and 3 (23%) were male, mean age of 51.23 +/- 11.62 ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000169068
更新日期:1997-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000320755
更新日期:2010-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-01-01 00:00:00
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更新日期:2000-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000440685
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journal_title:American journal of nephrology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000013473
更新日期:1999-01-01 00:00:00
abstract::Collapsing glomerulopathy is a pattern of renal injury that is seen in association with human immunodeficiency virus (HIV) infection. Patients with this HIV-associated nephropathy (HIVAN) present nephrotic syndrome and rapid deterioration of the renal function. There is no proven effective therapy for HIVAN, and the m...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000065229
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. METHODS:CsA (15 mg/kg/day) was given to rats for 1 or 4 weeks, and rHuEPO was concurrently admi...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000084275
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journal_title:American journal of nephrology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:American journal of nephrology
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:American journal of nephrology
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更新日期:1993-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013601
更新日期:2000-07-01 00:00:00