Abstract:
:This study was designed to evaluate beta-adrenergic responsiveness as assessed by the generation of cyclic AMP after the subcutaneous administration of epinephrine in 31 subjects: normal controls, patients with chronic renal insufficiency, hemodynamically stable patients on chronic acetate dialysis and hemodynamically unstable patients with acetate intolerance on chronic bicarbonate dialysis. As compared with controls, only unstable patients on bicarbonate dialysis presented impaired beta-responsiveness, which, in turn, was acutely reduced only after acetate but not bicarbonate dialysis. Our results show that acetate dialysis impairs the beta-adrenergic responsiveness and that the observed beta-hyporesponsiveness in unstable patients with acetate intolerance may represent part of a broader spectrum of autonomic dysfunction which may develop in some patients on chronic hemodialysis.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Fuiano G,Dal Canton A,Maj M,Testa A,Memoli B,Conte G,Ariano MG,Guarriello L,Russo D,Andreucci VEdoi
10.1159/000167985subject
Has Abstractpub_date
1989-01-01 00:00:00pages
303-8issue
4eissn
0250-8095issn
1421-9670journal_volume
9pub_type
杂志文章abstract::Pasteurella multocida has been reported only once previously as a cause of peritonitis in a patient undergoing chronic peritoneal dialysis. The present report describes findings associated with a case of P. multocida peritonitis in a human immunodeficiency virus (HIV)-positive patient in which renal replacement therap...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168274
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000070864
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Renal insufficiency is a well-described risk factor for perioperative morbidity and shortened survival after major vascular procedures. Due to the potential inaccuracy of serum creatinine levels alone in measuring kidney function, our aim was to determine whether estimated creatinine clearance more consisten...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000098150
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Home dialysis patients may be at an increased risk of adverse events after transitional states. The home dialysis virtual ward (HDVW) trial was conducted in Canadian dialysis centers and aimed to evaluate potential care gaps and patient satisfaction during the HDVW. METHODS:The HDVW was a multicenter single...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000503439
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiate...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000441804
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Aldosterone plays an important role in fibrosis. Recent studies showed that Na(+)-H(+) exchanger isoform 1 (NHE1) is involved in mineralocorticoid-induced organ fibrosis. In this study, we examined the role of NHE1 in aldosterone-induced fibronectin accumulation in rat mesangial cells and the signaling pathw...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000256665
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000088279
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND/AIMS:Apoptosis contributes to cyclosporine (CsA)-induced renal cell death. This study tested the effects of CsA-induced endoplasmic reticulum (ER) stress on apoptotic cell death in an experimental model of chronic CsA nephropathy. METHODS:CsA (15 mg/kg per day) was given to rats for 7 or 28 days. The ER str...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000127432
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:African Americans (AAs) suffer the widest gaps in chronic kidney disease (CKD) outcomes compared to Caucasian Americans (CAs) and this is because of the disparities that exist in both health and healthcare. In fact, the prevalence of CKD is 3.5 times higher in AAs compared to CAs. The disparities exist at al...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000479481
更新日期:2017-01-01 00:00:00
abstract::45 bone biopsies from patients with chronic uremia were reviewed to define which noninvasive investigations were of value in predicting the histological diagnosis and to quantify the spectrum of uremic bone disease at a center that has consistently used an aluminum-free dialysis bath. 17 biopsies were taken postmortem...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167465
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Tacrolimus has been reported to be effective in refractory nephrotic syndrome, such as focal segmental glomerulosclerosis and membranous nephropathy. Some IgA nephropathy (IgAN) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000337175
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The proinflammatory cytokine S100A12 (also known as EN-RAGE) is associated with cardiovascular morbidity and mortality in hemodialysis patients. In the current study, we tested the hypothesis that S100A12 expressed in vascular smooth muscle in nonatherosclerosis-prone C57BL/6J mice on normal rodent chow diet...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000324693
更新日期:2011-01-01 00:00:00
abstract::The pathogenesis of calciphylaxis, a potentially life-threatening condition, is not well understood. Several factors such as end-stage renal disease (azotemia), hyperparathyroidism, hyperphosphatemia, hypercalcemia, a high calcium-phosphate product, and the use of steroids and cytotoxic drugs after kidney transplantat...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000169021
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced est...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000487198
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Older adults with advanced non-dialysis-dependent chronic kidney disease (NDD-CKD) face a high risk of hospitalization and related adverse events. METHODS:This prospective cohort study followed nephrology clinic patients ≥60 years old with NDD-CKD stages 4-5. After an eligible patient's office visit, study ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000509046
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and tr...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000487857
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Kidney failure is believed to have a negative impact on cognitive function, and cognitive impairment is common among maintenance hemodialysis (HD) patients. Previous studies have shown a beneficial effect of kidney transplantation in certain cognitive tests but not across all cognitive domains assessed. But,...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000330849
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Although there is a very high mortality rate (>50%) with acute renal failure (ARF) in the intensive care unit (ICU), there is no general consensus on the best dialysis treatment for this condition. METHODS:We surveyed by mail questionnaire, all adult academic and community registered Canadian nephrology cen...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000046671
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Hemodialysis treatment requires a well-functioning vascular access. Access patency is limited by the development of venous intimal hyperplasia, which predisposes to fistula stenosis and subsequent thrombosis. In animal models, the renin-angiotensin system has a major role in the development of intimal h...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000080464
更新日期:2004-07-01 00:00:00
abstract::The objective was to evaluate the effect of high-flux hemodialysis on quality of life, intra- and interdialytic symptoms and neuropsychological function. The study was double-blind single cross-over with random allocation to order of treatment. The patients were stable adult hospital hemodialysis patients. Both the co...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000168491
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Obesity is an independent risk factor for morbidity and mortality in cardiovascular diseases not only in the general population, but also in hemodialysis (HD) patients. We previously reported that an increased visceral fat area (VFA) determined using computed tomography (CT) scans was associated with atheros...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000358335
更新日期:2014-01-01 00:00:00
abstract::In this paper, we analyze the collection of ancient Greek treatises ascribed to Hippocrates (460; between 371 and 350 BC), in order to determine whether or not edema can be traced. As a result of reading these works on the Greek text, we recognize some symptoms of edema in those called oidêma (swelling) and udrôps (dr...
journal_title:American journal of nephrology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000013442
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:Evaluation of the risk factors, and phenotype-genotype correlation of familial Mediterranean fever (FMF) gene (MEFV) and serum amyloid A1 (SAA1) gene polymorphisms in renal amyloidosis. METHODS:We investigated MEFV and SAA1 genotypes (alpha, beta, and gamma isoforms) in 50 FMF patients and 50 healthy c...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000087824
更新日期:2005-09-01 00:00:00
abstract::Skin ulceration is a well-characterized thrombotic complication of the heparin-induced thrombocytopenia (HIT) syndrome. We present the case of a 73-year-old diabetic woman nearing end-stage renal failure who developed extensive upper thigh, abdominal and buttock ulceration following initiation of subcutaneous heparin ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000046263
更新日期:2001-07-01 00:00:00
abstract::Forty-eight chronic hemodialysis patients were divided comparably into two groups (24 patients in each). Two micrograms of 1 alpha(OH)D3 was administered to one group for 3 months and its placebo to the other group. In the 1 alpha(OH)D3-treated group, serum total calcium increased from 7.82 +/- 0.11 (mean +/- SEM) to ...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
doi:10.1159/000167658
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIMS:The association between chronic kidney disease (CKD) awareness and healthy behaviors is unknown. We examined whether CKD self-recognition is associated with healthy behaviors and achieving risk-reduction targets known to decrease risk of cardiovascular morbidity and CKD progression. METHODS:CKD awarene...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000346712
更新日期:2013-01-01 00:00:00
abstract::Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechani...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000151277
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS:This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from t...
journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000455388
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. METHODS:CsA (15 mg/kg/day) was given to rats for 1 or 4 weeks, and rHuEPO was concurrently admi...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000084275
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:Current status of primary hyperoxaluria (PH) has not been surveyed in Japan. METHODS:Japanese patients with PH were reviewed in the published literature. RESULTS:Fifty-nine patients were diagnosed as PH from 1962 to 2003. The median ages both at diagnosis and at the onset of initial symptoms were 17 (...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000086361
更新日期:2005-05-01 00:00:00