Effects of uremia, acetate and bicarbonate dialysis on beta-adrenergic responsiveness as assessed by epinephrine-stimulated adenylate cyclase.

Abstract:

:This study was designed to evaluate beta-adrenergic responsiveness as assessed by the generation of cyclic AMP after the subcutaneous administration of epinephrine in 31 subjects: normal controls, patients with chronic renal insufficiency, hemodynamically stable patients on chronic acetate dialysis and hemodynamically unstable patients with acetate intolerance on chronic bicarbonate dialysis. As compared with controls, only unstable patients on bicarbonate dialysis presented impaired beta-responsiveness, which, in turn, was acutely reduced only after acetate but not bicarbonate dialysis. Our results show that acetate dialysis impairs the beta-adrenergic responsiveness and that the observed beta-hyporesponsiveness in unstable patients with acetate intolerance may represent part of a broader spectrum of autonomic dysfunction which may develop in some patients on chronic hemodialysis.

journal_name

Am J Nephrol

authors

Fuiano G,Dal Canton A,Maj M,Testa A,Memoli B,Conte G,Ariano MG,Guarriello L,Russo D,Andreucci VE

doi

10.1159/000167985

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

303-8

issue

4

eissn

0250-8095

issn

1421-9670

journal_volume

9

pub_type

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