The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity.

abstract：:In hypoaldosteronemic patients with chronic renal insufficiency, administration of a mineralocorticoid steroid such as fludrocortisone can ameliorate hyperkalemia and metabolic acidosis, but this therapy is not always safe owing to the deleterious consequences of extracellular fluid volume expansion resulting from min...

journal_title：American journal of nephrology

authors： Sebastian A,Schambelan M,Sutton JM

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce. METHODS:We used data from a multicenter, prospective, randomized trial among 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) and its observational follow-up study. The associatio...

journal_title：American journal of nephrology

authors： Triebswetter S,Gutjahr-Lengsfeld LJ,Schmidt KR,Drechsler C,Wanner C,Krane V

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the correlations between renal biopsy findings in Wegener's granulomatosis and renal function at baseline and 1 year in 22 patients who presented between 1988 and 1999. METHODS:Renal histology was independently reviewed by 2 pathologists who were masked to the clinical data. The primary out...

journal_title：American journal of nephrology

authors： Haroun MK,Stone JH,Nair R,Racusen L,Hellmann DB,Eustace JA

更新日期：2002-09-01 00:00:00

abstract：:Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importan...

journal_title：American journal of nephrology

authors： Piccoli GB,Alrukhaimi M,Liu ZH,Zakharova E,Levin A,World Kidney Day Steering Committee.

更新日期：2018-01-01 00:00:00

abstract：:The administration of calcium-blocking drugs exerts a natriuretic response. Acute studies in isolated perfused kidneys and in experimental animals, as well as in man, consistently demonstrate diuresis, natriuresis, calciuresis, and generally kaliuresis, even in the face of arterial blood pressure reduction. Clearance ...

journal_title：American journal of nephrology

authors： Luft FC

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Apoptosis contributes to cyclosporine (CsA)-induced renal cell death. This study tested the effects of CsA-induced endoplasmic reticulum (ER) stress on apoptotic cell death in an experimental model of chronic CsA nephropathy. METHODS:CsA (15 mg/kg per day) was given to rats for 7 or 28 days. The ER str...

journal_title：American journal of nephrology

authors： Han SW,Li C,Ahn KO,Lim SW,Song HG,Jang YS,Cho YM,Jang YM,Ghee JY,Kim JY,Kim SH,Kim J,Kwon OJ,Yang CW

更新日期：2008-01-01 00:00:00

abstract：:To evaluate the therapeutic effect of recombinant human alpha-interferon (alpha-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of proteinuria, the hepatitis B viral markers and urinary protein were monitored during alpha...

journal_title：American journal of nephrology

authors： Chung DR,Yang WS,Kim SB,Yu E,Chung YH,Lee Y,Park JS

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIM:Nephropathy after ingestion of Chinese herbs is known as a rapidly progressive form of interstitial renal fibrosis after a slimming regimen containing aristolochic acid that was identified first in Belgium. Intake of traditional Chinese herbal medicines is very popular in Taiwan. So we looked for similar...

journal_title：American journal of nephrology

authors： Chang CH,Wang YM,Yang AH,Chiang SS

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced est...

journal_title：American journal of nephrology

authors： Bitker L,Sens F,Payet C,Turquier S,Duclos A,Cottin V,Juillard L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Predicting the mortality risk of patients un-dergoing hemodialysis (HD) is challenging. Cell-free DNA (cfDNA) is released into circulation from dying cells, and its elevation is predictive of unfavorable outcome. In a pilot study, we found post-HD cfDNA level to be a predictor of all-cause mortality. Thus, t...

journal_title：American journal of nephrology

authors： Einbinder Y,Shnaider A,Ghanayem K,Basok A,Rogachev B,Lior Y,Haviv YS,Cohen-Hagai K,Nacasch N,Rozenberg I,Benchetrit S,Zitman-Gal T,Douvdevani A

更新日期：2020-01-01 00:00:00

abstract：UNLABELLED:Although it is anticipated that most patients with renal insufficiency will progress towards end-stage renal disease (ESRD) there have been few population-based studies to validate this assumption. We examined serial creatinines from 3,874 anonymous patients at an urban VA medical center who had a baseline c...

journal_title：American journal of nephrology

authors： Fink JC,Salmanullah M,Blahut SA,Weir MR,Sawyer R,Henrich WL,Hise MK

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hemodialysis (HD) patients are more inactive, leading to poor functional capacity and quality of life; this may be reversed with intradialytic exercise training. To systematically evaluate the efficacy and safety of intradialytic exercise for HD patients, we conducted a meta-analysis of the pub...

journal_title：American journal of nephrology

authors： Sheng K,Zhang P,Chen L,Cheng J,Wu C,Chen J

更新日期：2014-01-01 00:00:00

abstract：:Resistance to the action of PTH is encountered in chronic renal failure (CRF). This was attributed to downregulation of PTH receptor due to the state of secondary hyperparathyroidism of CRF. The present study examined whether the amount of PTH-PTH-related peptide (PTH-PTHrP) mRNA in a traditional (kidney) and a nontra...

journal_title：American journal of nephrology

authors： Tian J,Smogorzewski M,Kedes L,Massry SG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and is associated with poor prognosis. Treatment with interferon and ribavirin is poorly tolerated, and few data are available on the impact of new direct-acting antivirals (DAAs). This study was intended to analyze the...

journal_title：American journal of nephrology

authors： Abad S,Vega A,Hernández E,Mérida E,de Sequera P,Albalate M,Macías N,Milla M,López-Gómez JM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Intravenous (IV) iron preparations are widely used in the management of anemia in ESRD populations. Recent changes in reimbursement policy have dramatically increased the use of IV iron to lower the use of costly erythropoiesis-stimulating agents. These preparations are frequently administered with insu...

journal_title：American journal of nephrology

authors： Kamanna VS,Ganji SH,Shelkovnikov S,Norris K,Vaziri ND

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:A recent study suggests that inflammation and malnutrition are strongly associated with cardiovascular disease in dialysis patients. Endothelial lipase (EL) is a newly cloned physiological regulator of high-density lipoprotein cholesterol (HDL), which is associated with the progression of atherosclerosi...

journal_title：American journal of nephrology

authors： Fujii H,Fukuda A,Tanaka M,Kojima Y,Ishida T,Hirata K,Fukagawa M

更新日期：2008-01-01 00:00:00

abstract：:The relationship between abnormalities in nocturnal penile tumescence (NPT) and autonomic function, measured by the Valsalva maneuver, was evaluated in 25 uremic patients and 22 normal subjects. NPT in uremic patients (45 +/- 6.8 min/night) was lower (p less than 0.01) than in normals (85 +/- 10.4 min/night). Valsalva...

journal_title：American journal of nephrology

authors： Campese VM,Procci WR,Levitan D,Romoff MS,Goldstein DA,Massry SG

更新日期：1982-01-01 00:00:00

abstract：:The removal of phenytoin by plasmapheresis in a patient with compromised renal function is described. The results indicate that plasma concentrations of total phenytoin increase after plasmapheresis, while unbound phenytoin plasma concentrations and free fraction decrease. The amount of phenytoin removed was 36 mg and...

journal_title：American journal of nephrology

authors： Brown-Molnar CS,Bauer LA,Horn JR

更新日期：1986-01-01 00:00:00

abstract：:Skin ulceration is a well-characterized thrombotic complication of the heparin-induced thrombocytopenia (HIT) syndrome. We present the case of a 73-year-old diabetic woman nearing end-stage renal failure who developed extensive upper thigh, abdominal and buttock ulceration following initiation of subcutaneous heparin ...

journal_title：American journal of nephrology

authors： Denton MD,Mauiyyedi S,Bazari H

更新日期：2001-07-01 00:00:00

abstract：:Alcaligenes xylosoxidans is an uncommon cause of peritonitis in patients on maintenance continuous ambulatory peritoneal dialysis (CAPD). Peritonitis caused by A. xylosoxidans usually carries a poor prognosis because of the pathogen's virulence and its universal resistance to most antimicrobial agents. Even after earl...

journal_title：American journal of nephrology

authors： Tang S,Cheng CC,Tse KC,Li FK,Choy BY,Chan TM,Lai KN

更新日期：2001-11-01 00:00:00

abstract：:The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatr...

journal_title：American journal of nephrology

authors： Oh MS,Choi KC,Uribarri J,Sher J,Rao C,Carroll HJ

更新日期：1990-01-01 00:00:00

abstract：:We report the case of a 42-year-old woman with autosomal dominant polycystic kidney disease complicated by primary aldosteronism. She had a history of hypertension for 12 years and was found to have hypokalemia and polycystic renal and hepatic disease. Endocrinological tests revealed hyporeninemia and hyperaldosterone...

journal_title：American journal of nephrology

authors： Gejyo F,Ishida K,Arakawa M

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The optimal level of serum ferritin (s-ft) for anemia control and good survival in hemodialysis (HD) patients remains unclear. A 10-year survey was performed to clarify the appropriate quantities of s-ft and investigate the relationships among s-ft, transferrin saturation (TSAT), and mortality in HD patients...

journal_title：American journal of nephrology

authors： Ogawa C,Tsuchiya K,Kanda F,Maeda T

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D repl...

journal_title：American journal of nephrology

authors： Sprague SM,Silva AL,Al-Saghir F,Damle R,Tabash SP,Petkovich M,Messner EJ,White JA,Melnick JZ,Bishop CW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Medullary sponge kidney (MSK) is characterized by malformation of the terminal collecting ducts and is associated with an increased risk of nephrolithiasis, nephrocalcinosis, urinary tract infections, renal acidification defects, and reduced bone density. It has been historically diagnosed with intravenous p...

journal_title：American journal of nephrology

authors： Koraishy FM,Ngo TT,Israel GM,Dahl NK

更新日期：2014-01-01 00:00:00

abstract：AIM:To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS:A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 su...

journal_title：American journal of nephrology

authors： Bae KT,Sun H,Lee JG,Bae K,Wang J,Tao C,Chapman AB,Torres VE,Grantham JJ,Mrug M,Bennett WM,Flessner MF,Landsittel DP,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiate...

journal_title：American journal of nephrology

authors： Nee R,Moon DS,Jindal RM,Hurst FP,Yuan CM,Agodoa LY,Abbott KC

更新日期：2015-01-01 00:00:00

abstract：:Fifty-four patients with noninsulin-dependent diabetes mellitus, who had established nephropathy, were examined to evaluate the risk factors for the progression of diabetic nephropathy. Time-averaged values of blood pressure, serum total cholesterol and fasting plasma glucose concentrations, and the degree of proteinu...

journal_title：American journal of nephrology

authors： Yokota C,Kimura G,Inenaga T,Kawano Y,Matsuoka H,Omae T

更新日期：1995-01-01 00:00:00

abstract：:Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, with just two previous descriptions of 4 cases in the literature. We describe a 5th case. The reaction may be mediated by the presence of antibodies reactive against platelets in the presence of quinine. Treatment has included use o...

journal_title：American journal of nephrology

authors： Hagley MT,Hosney IA,Hulisz DT,Davis HH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hemodialysis treatment requires a well-functioning vascular access. Access patency is limited by the development of venous intimal hyperplasia, which predisposes to fistula stenosis and subsequent thrombosis. In animal models, the renin-angiotensin system has a major role in the development of intimal h...

journal_title：American journal of nephrology

authors： Heine GH,Ulrich C,Köhler H,Girndt M

更新日期：2004-07-01 00:00:00