Prevention of myelinolysis in rats by dexamethasone or colchicine.

Abstract:

:The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatremia was induced in rats with Pitressin and water. After 4 days hyponatremic rats received hypertonic saline alone or hypertonic saline plus dexamethasone or colchicine. All of the 9 rats that received only 5% NaCl developed demyelinating disease, while 3 of 6 rats treated with dexamethasone and 5 of 15 rats treated with colchicine showed no CNS abnormality. The results of our investigation might help understand the pathogenetic mechanism of central pontine myelinolysis in humans, a disease attributed to rapid correction of hyponatremia.

journal_name

Am J Nephrol

authors

Oh MS,Choi KC,Uribarri J,Sher J,Rao C,Carroll HJ

doi

10.1159/000168071

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

158-61

issue

2

eissn

0250-8095

issn

1421-9670

journal_volume

10

pub_type

杂志文章
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    doi:10.1159/000167485

    authors: Kopolovic J,Shvil Y,Pomeranz A,Ron N,Rubinger D,Oren R

    更新日期:1987-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Churchill DN,Bird DR,Taylor DW,Beecroft ML,Gorman J,Wallace JE

    更新日期:1992-01-01 00:00:00

  • Increasing Medical Student Interest in Nephrology.

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    authors: Sozio SM,Pivert KA,Shah HH,Chakkera HA,Asmar AR,Varma MR,Morrow BD,Patel AB,Leight K,Parker MG

    更新日期:2019-01-01 00:00:00

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    authors: Karpinski J,Jothy S,Radoux V,Levy M,Baran D

    更新日期:1997-01-01 00:00:00

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    authors: Matzkies FK,Bahner U,Teschner M,Hohage H,Heidland A,Schaefer RM

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    authors: Choudhury D,Ahmed Z,Girgis HI,Kronfli S

    更新日期:1999-01-01 00:00:00

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    doi:10.1159/000377641

    authors: Mansell H,Elmoselhi H,Shoker A

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    doi:10.1159/000013365

    authors: Auguet T,Lorenzo A,Colomer E,Zamora A,García C,Martínez-Vea A,Richart C,Oliver JA

    更新日期:1998-01-01 00:00:00

  • Detection of cardiac calcinosis in hemodialysis patients by whole-body scintigraphy with 99m-technetium methylene diphosphonate.

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    journal_title:American journal of nephrology

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    doi:10.1159/000013601

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    更新日期:2000-07-01 00:00:00

  • Effect of nutrition on arterial stiffness in peritoneal dialysis patients.

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    更新日期:2008-01-01 00:00:00

  • Right ventricular dysfunction in patients with end-stage renal disease.

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    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000320755

    authors: Paneni F,Gregori M,Ciavarella GM,Sciarretta S,De Biase L,Marino L,Tocci G,Principe F,Domenici A,Luciani R,Punzo G,Menè P,Volpe M

    更新日期:2010-01-01 00:00:00

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    pub_type: 历史文章,杂志文章

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    更新日期:2013-01-01 00:00:00

  • Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes.

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    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000151770

    authors: Kajiyama H,Titus S,Austin CP,Chiotos K,Matsumoto T,Sakairi T,Kopp JB

    更新日期:2009-01-01 00:00:00

  • Impact of Poverty and Health Care Insurance on Arteriovenous Fistula Use among Incident Hemodialysis Patients.

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    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000441804

    authors: Nee R,Moon DS,Jindal RM,Hurst FP,Yuan CM,Agodoa LY,Abbott KC

    更新日期:2015-01-01 00:00:00

  • IgA nephropathy in Japanese children and adults: a comparative study of clinicopathological features.

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    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168080

    authors: Okada K,Funai M,Kawakami K,Kagami S,Yano I,Kuroda Y

    更新日期:1990-01-01 00:00:00

  • The role of physical activity in chronic kidney disease in the presence of diabetes mellitus: a prospective cohort study.

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    journal_title:American journal of nephrology

    pub_type: 杂志文章

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    更新日期:2013-01-01 00:00:00

  • Elevated preoperative phosphorus levels are an independent risk factor for cardiovascular mortality.

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    pub_type: 杂志文章

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  • Thymoglobulin and its use in renal transplantation: a review.

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    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000351643

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    更新日期:2013-01-01 00:00:00

  • High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus.

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    pub_type: 杂志文章

    doi:10.1159/000381965

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    pub_type: 杂志文章

    doi:10.1159/000077409

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    更新日期:2004-03-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1159/000166914

    authors: Dische FE,Weston MJ,Parsons V

    更新日期:1985-01-01 00:00:00

  • Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against cisplatin-induced acute kidney injury in rats.

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  • Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial.

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