Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial.

Abstract:

AIMS:We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). METHODS:40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006-2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. >or=1:40), the serological response (i.e. >or=4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated. RESULTS:KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination. CONCLUSIONS:Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs.

journal_name

Am J Nephrol

authors

Keshtkar-Jahromi M,Argani H,Rahnavardi M,Mirchi E,Atabak S,Tara SA,Gachkar L,Noori-Froothghe A,Mokhtari-Azad T

doi

10.1159/000119742

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

654-60

issue

4

eissn

0250-8095

issn

1421-9670

pii

000119742

journal_volume

28

pub_type

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