Association of post-renal transplant erythrocytosis and microalbuminuria: response to angiotensin-converting enzyme inhibition.

Abstract:

:Angiotensin-converting enzyme (ACE) inhibitor therapy has recently been shown to be effective in the treatment of post-renal transplant erythrocytosis (PTE). In an attempt to assess the effect of drug treatment on serum erythropoietin level, glomerular filtration rate, and urinary protein excretion, we prospectively evaluated 8 consecutive cadaveric renal transplant recipients with PTE treated with ACE inhibitor therapy for 3 months. In response to ACE inhibition, the mean hematocrit (HCT) value decreased from 53.7 +/- 0.6% before treatment to 42.7 +/- 2.2% at the conclusion of the study (p = 0.03). However, 1 patient failed to respond to ACE inhibition (HCT > 50%), and 2 patients with PTE developed anemia (HCT < 35%) while maintained on drug treatment. Although the mean serum erythropoietin level decreased during ACE inhibition (from 22.8 +/- 8.4 to 9.4 +/- 5.3 mU/ml; p = 0.06), a consistent change in individual erythropoietin levels was not identified. At the conclusion of the study, the serum erythropoietin levels were undetectable in 4 patients, decreased in 1, unchanged in 2, and increased in the only patient with PTE who failed to respond to drug treatment. All patients tolerated the ACE inhibitor therapy without developing cough or hyperkalemia. In addition, serum creatinine levels, 125I-iothalamate clearances, and mean arterial blood pressures were unchanged throughout the study. Microalbuminuria (spot urinary albumin/creatinine ratio between 30 and 200 mg/g) developed in 5 patients with PTE and coincided with the onset of erythrocytosis (25.2 +/- 7 mg/g before PTE and 76.3 +/- 36.7 mg/g at the time of PTE detection).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Am J Nephrol

authors

Mulhern JG,Lipkowitz GS,Braden GL,Madden RL,O'Shea MH,Harvilchuck H,Guarnera JM,Germain MJ

doi

10.1159/000168856

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

318-22

issue

4

eissn

0250-8095

issn

1421-9670

journal_volume

15

pub_type

杂志文章
  • Aldosterone promotes fibronectin synthesis in rat mesangial cells via ERK1/2-stimulated Na-H+ exchanger isoform 1.

    abstract:BACKGROUND:Aldosterone plays an important role in fibrosis. Recent studies showed that Na(+)-H(+) exchanger isoform 1 (NHE1) is involved in mineralocorticoid-induced organ fibrosis. In this study, we examined the role of NHE1 in aldosterone-induced fibronectin accumulation in rat mesangial cells and the signaling pathw...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000256665

    authors: Zhang M,Chen J,Lai L,You L,Lin S,Hao C,Gu Y

    更新日期:2010-01-01 00:00:00

  • Death with functioning graft in living donor kidney transplantation: analysis of risk factors.

    abstract:BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000070864

    authors: El-Agroudy AE,Bakr MA,Shehab El-Dein AB,Ghoneim MA

    更新日期:2003-05-01 00:00:00

  • Long-term erythropoietin therapy does not affect metalloproteinases and their inhibitor levels, oxidative stress and inflammation in hemodialyzed patients.

    abstract:BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000101191

    authors: Pawlak K,Pawlak D,Mysliwiec M

    更新日期:2007-01-01 00:00:00

  • Applying an artificial neural network to predict total body water in hemodialysis patients.

    abstract:BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000088279

    authors: Chiu JS,Chong CF,Lin YF,Wu CC,Wang YF,Li YC

    更新日期:2005-09-01 00:00:00

  • Determinants of rhabdomyolysis in the diabetic state.

    abstract::To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168357

    authors: Singhal PC,Abramovici M,Ayer S,Desroches L

    更新日期:1991-01-01 00:00:00

  • Seasonal maintenance of influenza vaccine-induced antibody response in kidney transplant recipients.

    abstract:BACKGROUND/AIMS:Although annual influenza vaccination is recommended for kidney transplant recipients, efficacy as reflected by serum antibody titers has not been well studied beyond 1 month in kidney transplant recipients. METHODS:We performed a single-center prospective cohort study of 51 kidney transplant recipient...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000341653

    authors: Birdwell KA,Ikizler MR,Wang L,Byrne DW,Sannella EC,Wright PF,Ikizler TA

    更新日期:2012-01-01 00:00:00

  • Albuminuria Testing by Race and Ethnicity among Patients with Hypertension with and without Diabetes.

    abstract:BACKGROUND:Detection of chronic kidney disease (CKD) with urine albumin-to-creatinine ratio (UACR) among patients with hypertension (HTN) provides an opportunity for early treatment, potentially mitigating risk of CKD progression and cardiovascular complications. Differences in UACR testing patterns among racial/ethnic...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000500706

    authors: Lee J,Chu C,Guzman D,Fontil V,Velasquez A,Powe NR,Tuot DS

    更新日期:2019-01-01 00:00:00

  • Influence of erythropoietin on arterial stiffness and endothelial function in renal transplant recipients.

    abstract:BACKGROUND/AIMS:Recent retrospective studies suggest an association of therapy with erythropoiesis-stimulating agents (ESAs) and increased mortality in renal transplant recipients (RTR). Large artery structure and function are significantly impaired in RTR which contributes to their high cardiovascular morbidity and co...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000343140

    authors: Bartels V,Hillebrand U,Kosch M,Hausberg M,Kisters K,Di Marco GS,Reiermann S,Pavenstaedt H,Lang D

    更新日期:2012-01-01 00:00:00

  • Increasing Medical Student Interest in Nephrology.

    abstract:BACKGROUND:Interest in nephrology careers is declining, possibly due to perceptions of the field and/or training aspects. Understanding practices of medical schools successfully instilling nephrology interest could inform efforts to attract leading candidates to the specialty. METHODS:The American Society of Nephrolog...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000501058

    authors: Sozio SM,Pivert KA,Shah HH,Chakkera HA,Asmar AR,Varma MR,Morrow BD,Patel AB,Leight K,Parker MG

    更新日期:2019-01-01 00:00:00

  • Cognitive Function and White Matter Changes Associated with Renal Transplantation.

    abstract:BACKGROUND:End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cogniti...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000444334

    authors: Gupta A,Lepping RJ,Yu AS,Perea RD,Honea RA,Johnson DK,Brooks WM,Burns JM

    更新日期:2016-01-01 00:00:00

  • Therapy with recombinant human erythropoietin reduces cardiac size and improves heart function in chronic hemodialysis patients.

    abstract::The substitution of recombinant human erythropoietin (rhEPO) in chronic hemodialysis patients is often associated with the development of severe hypertension. In the present study, a systematical echocardiographic analysis was performed in 25 patients on maintenance hemodialysis during rhEPO therapy for at least 4 mon...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168273

    authors: Löw-Friedrich I,Grützmacher P,März W,Bergmann M,Schoeppe W

    更新日期:1991-01-01 00:00:00

  • Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer.

    abstract::The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000447954

    authors: Darshi M,Van Espen B,Sharma K

    更新日期:2016-01-01 00:00:00

  • Histopathologic Features that Predict Transplant Glomerulopathy Progression in a Chinese Cohort.

    abstract:BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000500043

    authors: Li X,Chen J,Cheng D,Wang W,Xie K,Zhang M,Xu F,Wen J,Tang Z

    更新日期:2019-01-01 00:00:00

  • Internet claims on dietary and herbal supplements in advanced nephropathy: truth or myth.

    abstract:BACKGROUND:The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. AIM:To systematically evaluate the dietary an...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000368724

    authors: Vamenta-Morris H,Dreisbach A,Shoemaker-Moyle M,Abdel-Rahman EM

    更新日期:2014-01-01 00:00:00

  • Use of Renin-Angiotensin System Blockers Increases Serum Potassium in Anuric Hemodialysis Patients.

    abstract:BACKGROUND:Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are increasingly used in uremic patients (pts). However, their effect on serum potassium (sK) concentrations in anuric pts on chronic hemodialysis treatment (HD) is controversial. The aim of the study was to evaluate sK b...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000491552

    authors: Movilli E,Camerini C,Gaggia P,Zubani R,Cancarini G

    更新日期:2018-01-01 00:00:00

  • Glomerulopathy in acute and chronic rejection: relationship of ultrastructure to graft survival.

    abstract::The glomerular ultrastructure was retrospectively reviewed from 45 renal transplant biopsies with the clinical and light microscopic diagnosis of acute rejection (25 cases) and chronic rejection (20 cases). Three grades of morphologic alteration were ultrastructurally defined. In acute rejection, capillary lumenal obl...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166725

    authors: Verani RR,Bergman D,Kerman RH

    更新日期:1983-09-01 00:00:00

  • Thymoglobulin and its use in renal transplantation: a review.

    abstract::Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a polyclonal antibody which has been used in the field of transplantation over the last four decades. With an initial hesitancy, it is widely used now in the prevention and treatment of rejection following renal transplantation. Thymoglobulin's lack of ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000351643

    authors: Thiyagarajan UM,Ponnuswamy A,Bagul A

    更新日期:2013-01-01 00:00:00

  • A population-based assessment of the familial component of chronic kidney disease mortality.

    abstract:BACKGROUND/AIM:While the familial nature of chronic kidney disease (CKD) has been recognized, it has primarily been defined from studies of first-degree relatives of selected sets of cases. The goal of this study is an evaluation of the familial clustering of end-stage renal disease (ESRD) and CKD mortality using a pop...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000092280

    authors: Goldfarb-Rumyantzev AS,Cheung AK,Habib AN,Wang BJ,Lin SJ,Baird BC,Naiman N,Cannon-Albright L

    更新日期:2006-01-01 00:00:00

  • A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy.

    abstract::A 23-year-old female with acute renal failure associated with acute tubulointerstitial nephritis and uveitis is reported. Renal tubular acidosis and inflammatory reactions consisting of markedly increased erythrocyte sedimentation rate and high serum immunoglobulin levels were seen on admission. Light microscopy revea...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168020

    authors: Hirano K,Tomino Y,Mikami H,Ota K,Aikawa Y,Shirato I,Koide H

    更新日期:1989-01-01 00:00:00

  • Health Insurance Status Is Related to Risk of Mortality and Hospitalization in Korean Maintenance Hemodialysis Patients: A Longitudinal Cohort Study.

    abstract:BACKGROUND:There has been an increasing incidence of hemodialysis (HD) due to old age and comorbid condition such as diabetes. In general, socioeconomic status (SES) is known as one of the most important risk factors for patient mortality and morbidity. Whether low SES is associated with poorer outcome in HD patients i...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000512855

    authors: Park HC,Kwon YE,Choi HY,Oh HJ,Chang TI,Kang EW,Park KS,Yang KH,Won EM,Shin JH,Ryu DR,Lee YK

    更新日期:2021-01-13 00:00:00

  • Late renal allograft failure secondary to thrombotic microangiopathy associated with disseminated malignancy.

    abstract::A renal transplant recipient with a remote history of end-stage renal disease due to postpartum hemolytic-uremic syndrome (HUS) presented with acute renal failure after having stable renal allograft function for 9 years. A diagnosis of thrombotic microangiopathy was made based on clinical and histologic findings at re...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000169094

    authors: Gohh RY,Williams ME,Crosson AW,Federman M,Zambetti FX

    更新日期:1997-01-01 00:00:00

  • HFE genotype influences erythropoiesis support requirement in hemodialysis patients: a prospective study.

    abstract:BACKGROUND/AIMS:HFE protein controls iron absorption and cycling, and HFE mutations influence iron status. The aim was to evaluate the effect of the HFE genotype on the need for iron and erythropoietin in Italian hemodialysis patients. METHODS:Ninety-six prevalent patients were evaluated at the time of enrolment and p...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000111387

    authors: Valenti L,Valenti G,Como G,Santorelli G,Dongiovanni P,Rametta R,Fracanzani AL,Tavazzi D,Messa PG,Fargion S

    更新日期:2008-01-01 00:00:00

  • Nephrology Provider Surprise Question Response and Hospitalizations in Older Adults with Advanced CKD.

    abstract:BACKGROUND:Older adults with advanced non-dialysis-dependent chronic kidney disease (NDD-CKD) face a high risk of hospitalization and related adverse events. METHODS:This prospective cohort study followed nephrology clinic patients ≥60 years old with NDD-CKD stages 4-5. After an eligible patient's office visit, study ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000509046

    authors: Ramer SJ,Baddour NA,Siew ED,Salat H,Bian A,Stewart TG,Wong SPY,Jhamb M,Abdel-Kader K

    更新日期:2020-01-01 00:00:00

  • Dialysis for chronic renal failure: comorbidity and treatment differences by disease etiology.

    abstract::A national sample of dialysis physicians was used to obtain data for a comparison of patient characteristics, comorbid conditions and treatment patterns associated with the five leading causes of end-stage renal disease (ESRD). The data are used to assess trends in physician care for ESRD patients and likely changes i...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167949

    authors: Radecki SE,Nissenson AR

    更新日期:1989-01-01 00:00:00

  • Hepatitis C associated glomerulonephritis.

    abstract::To determine the prevalence and type of glomerulonephritis (GN) associated with hepatitis C virus (HCV) cirrhosis, we prospectively evaluated 28 consecutive Saudi patients with HCV cirrhosis for liver transplantation. Six patients (21%) underwent kidney biopsies for proteinuria, unexplained elevated serum creatinine o...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168874

    authors: Altraif IH,Abdulla AS,al Sebayel MI,Said RA,al Suhaibani MO,Jones AA

    更新日期:1995-01-01 00:00:00

  • Clinical Features and Outcomes of a Racially Diverse Population with Fibrillary Glomerulonephritis.

    abstract:BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000455390

    authors: Payan Schober F,Jobson MA,Poulton CJ,Singh HK,Nickeleit V,Falk RJ,Jennette JC,Nachman PH,Pendergraft Iii WF

    更新日期:2017-01-01 00:00:00

  • Renal allograft rupture: a report of three cases and review of the literature.

    abstract::This report reviews the features of 149 cases of renal allograft rupture, while adding a detailed description of 3 more cases to the English literature. From November, 1973 to November, 1979, 3 cases of renal allograft rupture occurred in 100 renal transplants performed at Research Medical Center, Kansas City, Mo., an...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166577

    authors: Thukral R,Mir AR,Jacobson MP

    更新日期:1982-01-01 00:00:00

  • Morphologic variants of light-chain deposition disease in the kidney.

    abstract::A variety of histologic changes have been observed in the kidneys of patients with light-chain deposition disease. We report 3 cases with kappa light chain deposition who presented with diverse clinical, histological, and ultrastructural features. All the cases were diagnosed by the presence of monoclonal kappa light ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167600

    authors: Venkataseshan VS,Faraggiana T,Hughson MD,Buchwald D,Olesnicky L,Goldstein MH

    更新日期:1988-01-01 00:00:00

  • Profound persistent eosinophilia in a patient with spontaneous renal atheroembolic disease.

    abstract::We describe an elderly women who died of renal failure secondary to spontaneous renal atheroembolic disease. The sole clinical clue to this diagnosis was a profound eosinophilia up to 19,100/mm3 and a relative eosinophil count of 80%. Renal atheroembolic disease should be a prominent consideration in any patient with ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000168476

    authors: Levine J,Rennke HG,Idelson BA

    更新日期:1992-01-01 00:00:00

  • Racial Disparities in End-of-Life Communication and Preferences among Chronic Kidney Disease Patients.

    abstract:BACKGROUND:Previous studies on end-of-life (EOL) care among patients with chronic kidney disease (CKD) have been largely limited to White hemodialysis patients. In this study, we sought to explore racial variability in EOL communication, care preferences and advance care planning (ACP) among patients with advanced CKD ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000447097

    authors: Eneanya ND,Wenger JB,Waite K,Crittenden S,Hazar DB,Volandes A,Temel JS,Thadhani R,Paasche-Orlow MK

    更新日期:2016-01-01 00:00:00