Abstract：
:Historically, stroke, heart failure and renal insufficiency were seen as the major complications of untreated hypertension. More recently, it has become evident that coronary heart disease is probably the most common outcome of this condition. Unlike the other complications of hypertension, coronary events have not been reduced in a meaningful fashion by traditional antihypertensive drug therapy. A partial explanation may lie in the fact that hypertension typically consists of a syndrome of inherited metabolic and cardiovascular abnormalities, and treatment that focuses primarily on blood pressure without taking into account the other factors that contribute to atherosclerotic disease can have only limited protective effects. The coronary hypothesis in hypertension extends this reasoning into 3 separate components. First is an intrinsic tendency to excessive proliferative and hypertrophic activity in vascular tissue, presumably reflecting growth-promoting activity stimulated by increased endocrine and local paracrine effects; second is the impact of the commonly encountered concomitant risk factors, including high blood pressure, that exaggerate and accelerate development of the underlying atherosclerotic lesions; third are hemodynamic factors, including increased variability and sustained elevations of blood pressure, that can destabilize vascular lesions and precipitate acute events. Treatment of these hemodynamic factors in elderly patients, whose underlying vascular changes are already well advanced, is likely to effectively reduce the incidence of vascular endpoints. In younger patients, ongoing vascular proliferative changes and the impact of concomitant risk factors are equally as important as hemodynamic forces in producing coronary disease, and effective treatment must take all these issues into account.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Weber MAdoi
10.1159/000169000subject
Has Abstractpub_date
1996-01-01 00:00:00pages
210-6issue
3eissn
0250-8095issn
1421-9670journal_volume
16pub_type
杂志文章,评审abstract：BACKGROUND/AIMS:Patients with chronic kidney disease (CKD) have a high prevalence of periodontal disease that may predispose to tooth loss and inflammation. The goal of this study was to test the hypotheses that a genetic rat model of progressive CKD would exhibit altered oral bone properties and that treatment with ei...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000356335
更新日期：2013-01-01 00:00:00
abstract：:To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168357
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS:This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from t...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1159/000455388
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:Anthropometric parameters may play a role in modulating the risk of kidney dysfunction. The aim of this study was to evaluate whether anthropometric indices and the metabolic syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients. METHOD...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000109239
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND/AIMS:The susceptibility of patients on maintenance hemodialysis (MHD) to infections is a major cause of mortality and morbidity. Natural resistance-associated macrophage protein 1 (Nramp1) regulates intracellular pathogen proliferation, and its mRNA expression is highest in polymorphonuclear leukocytes (PMNL...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000337742
更新日期：2012-01-01 00:00:00
abstract：:Forty-eight chronic hemodialysis patients were divided comparably into two groups (24 patients in each). Two micrograms of 1 alpha(OH)D3 was administered to one group for 3 months and its placebo to the other group. In the 1 alpha(OH)D3-treated group, serum total calcium increased from 7.82 +/- 0.11 (mean +/- SEM) to ...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000167658
更新日期：1988-01-01 00:00:00
abstract：:This study investigated the possible beneficial effect of intraperitoneal proteolytic enzyme administration on the development of hypertension-induced renal injury in the rat model of 2-kidney 1-clip (2K1C) Goldblatt hypertension. Male Wistar rats (120-150 g) underwent either sham surgery (control, n = 5) or clipping ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013411
更新日期：1998-01-01 00:00:00
abstract：:A national sample of dialysis physicians was used to obtain data for a comparison of patient characteristics, comorbid conditions and treatment patterns associated with the five leading causes of end-stage renal disease (ESRD). The data are used to assess trends in physician care for ESRD patients and likely changes i...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167949
更新日期：1989-01-01 00:00:00
abstract：:Autopsy reports on 155 successive end-stage renal disease (ESRD) patients and 147 control patients without ESRD, matched for age, race and gender, were collected. Cystic transformation of the kidneys was noted in 58% of the ESRD patients and 13.6% of the control patients. There were 25 ESRD patients with renal adenoma...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167988
更新日期：1989-01-01 00:00:00
abstract：:We analyzed routine serum potassium concentration measurements and conditions temporally associated with abnormalities in potassium concentration in outpatients on chronic hemodialysis (136 nondiabetics, 36 diabetics) and continuous ambulatory peritoneal dialysis (16 nondiabetics, 10 diabetics). The following potassiu...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167443
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND/AIMS:Although HIV-infected persons are at higher risk for acute kidney injury (AKI) during hospitalization compared with their uninfected counterparts, risk factors for AKI are not well-defined. We aimed to describe the evolving incidence of AKI among HIV-infected individuals and to identify important AKI ri...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000337151
更新日期：2012-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:In the Systolic Blood Pressure Intervention Trial, the possible relationships between acute kidney injury (AKI) and risk of major cardiovascular events and death are not known. STUDY DESIGN:Post hoc analysis of a multicenter, randomized, controlled, open-label clinical trial. SETTING AND PARTI...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1159/000499574
更新日期：2019-01-01 00:00:00
abstract：UNLABELLED:Although it is anticipated that most patients with renal insufficiency will progress towards end-stage renal disease (ESRD) there have been few population-based studies to validate this assumption. We examined serial creatinines from 3,874 anonymous patients at an urban VA medical center who had a baseline c...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000046280
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. AIM:To systematically evaluate the dietary an...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000368724
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening. METHODS:The Heart and Soul Study is a longitudinal study of patients with ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000343495
更新日期：2012-01-01 00:00:00
abstract：:Dialysis patients have increased susceptibility to infection and this is, in part, due to impaired phagocytic and bactericidal activities of polymorphonuclear leukocytes (PMNL). The mechanisms responsible for the reduced phagocytosis are not known. Dialysis patients have elevated blood levels of parathyroid hormone (P...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168284
更新日期：1991-01-01 00:00:00
abstract：AIMS:Although there are plenty of data about the differences in left ventricular tissue Doppler (TD) velocities by preload reduction, only a few studies regarding right ventricular function are found in the literature. We investigated the effect of intravascular volume reduction on right ventricular function by ultrafi...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000086080
更新日期：2005-05-01 00:00:00
abstract：:A multicentre trial (11 nephrology centres) was carried out to test the effects of ibopamine, an orally active dopamine-like drug, on the progression of chronic renal failure. For a 2-year period 189 chronic renal failure patients (serum creatinine level 1.5-4.0 mg/dl) were observed. They were homogeneous for basic ne...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1159/000169049
更新日期：1996-01-01 00:00:00
abstract：:A young woman presented with nephrotic syndrome due to membranous nephropathy and a localized form of giant lymph node hyperplasia (Castleman's disease) occurring as a large intra-abdominal mass. Five months after surgical removal of the mass, only mild proteinuria persisted. Twenty months later a second kidney biopsy...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168127
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Most studies evaluating predictors of renal replacement therapy (RRT) following cardiac surgery use arbitrary defined limits of preoperative serum creatinine. The aim of this study was to evaluate the effect of preoperative renal function using either estimated-glomerular filtration rate (eGFR) derived using...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000492182
更新日期：2018-01-01 00:00:00
abstract：:Tubulointerstitial disease is an invariant finding in proteinuric renal disease regardless of the underlying disease or the compartment in which the disease originates. Such histologic changes are functionally significant in that scores of such injury rather than glomerular histologic injury correlate with decrements ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168652
更新日期：1993-01-01 00:00:00
abstract：:To determine the effect of multiple dialyzer use on intradialytic symptoms, data from 26,592 successive dialyses on 147 patients were analyzed. Over the 26-month period of study 4,933 new dialyzers were used. All symptoms, considered together, occurred 1.3 times more frequently during the initial than during the subse...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167063
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000450838
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we asse...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000485845
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:We determined the familial aggregation of end-stage renal disease (ESRD) in a large, population-based sample of incident ESRD cases to assess the feasibility of developing a targeted screening and prevention program directed at members of families at high risk for kidney disease. METHODS:Between January 1, ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000088491
更新日期：2005-11-01 00:00:00
abstract：:Hepatic dysfunction was observed in 34 patients with nontraumatic rhabdomyolysis. The serum levels of lactic dehydrogenase were markedly elevated in all patients. The peak values occurred within 72 h of hospitalization. There was no significant difference among patients with (9,044 +/- 1,154 U/l) and without acute ren...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168053
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. METHODS:This...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000357787
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseli...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1159/000446122
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Oxidative stress and inflammation are known to play central roles in the development of diabetic nephropathy (DN). Febuxostat is a novel non-purine xanthine oxidase (XO)-specific inhibitor developed to treat hyperuricemia. In this study, we investigated whether febuxostat could ameliorate DN via renoprotecti...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000363421
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as nonclassical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with common carotid artery intima media...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000109397
更新日期：2008-01-01 00:00:00
