Effect of proteinuria on renal interstitium: effect of products of nitrogen metabolism.

abstract：BACKGROUND:To promote understanding of immunoglobulin A nephropathy (IgAN) pathophysiology, we tried to elucidate glomerular protein profiles in IgAN, using microsieving that we established recently to isolate glomeruli from renal biopsy samples and proteomic approaches. METHODS:Glomeruli were isolated from renal biop...

journal_title：American journal of nephrology

authors： Kojima S,Koitabashi K,Iizuka N,Okamoto K,Arito M,Sato T,Kurokawa MS,Suematsu N,Shibagaki Y,Yasuda T,Kimura K,Kato T

更新日期：2014-01-01 00:00:00

abstract：:Acute hyperammonemia is an emergent cause of central nervous system dysfunction for which renal replacement therapy is advocated. We report the successful use of continuous venovenous hemodiafiltration in this metabolic emergency, and report the calculated ammonia clearances for both continuous venovenous hemofiltrati...

journal_title：American journal of nephrology

authors： Braun MC,Welch TR

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:The value of neutrophil-gelatinase-associated lipocalin (NGAL), a novel biomarker in the detection of acute renal failure in children after cardiac surgery, has been highlighted in previous studies. The incidence of percutaneous coronary intervention (PCI) increases, which may possibly result in increas...

journal_title：American journal of nephrology

authors： Bachorzewska-Gajewska H,Malyszko J,Sitniewska E,Malyszko JS,Dobrzycki S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Pseudotumors of the craniovertebral junction (PTCVJ) are observed in long-term hemodialysis (HD) patients. There are neither criteria for diagnosis nor guidelines for screening. We attempted to determine magnetic resonance imaging (MRI) findings that could be used to detect PTCVJ, to determine the preva...

journal_title：American journal of nephrology

authors： Maruyama H,Tanizawa T,Uchiyama S,Higuchi T,Ei K,Oda M,Ei I,Oya M,Kishimoto H,Saito T,Miyamura S,Takano Y,Hasegawa S,Kawada K,Ueki K,Iwafuchi Y,Arakawa M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Patients on chronic hemodialysis have a high prevalence of heart disease and poor self-reported physical function. The association between structural heart disease and self-reported physical function in patients on hemodialysis is unknown. METHODS:We studied the association between elevated pulmonary a...

journal_title：American journal of nephrology

authors： Abreo AP,Herzog CA,Kutner NG,Lea J,Johansen KL

更新日期：2015-01-01 00:00:00

abstract：:Berengario da Carpi was magister of anatomy and surgery at the University of Bologna from 1502 to 1527. Eustachio and Falloppia defined him as 'the restaurator of anatomy'. He was a great surgeon, anatomist and physician of illustrious patients including Lorenzo II dei Medici, Giovanni dalle Bande Nere, Galeazzo Palla...

journal_title：American journal of nephrology

authors： De Santo NG,Bisaccia C,De Santo LS,De Santo RM,Di Leo VA,Papalia T,Cirillo M,Touwaide A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...

journal_title：American journal of nephrology

authors： Jia L,Li X,Gu Y,Cui W

更新日期：2016-01-01 00:00:00

abstract：:Bicarbonate dialysate is claimed to be superior to acetate for both chronic and acute hemodialysis. We compared acetate and bicarbonate dialysates in 30 acute renal failure patients during 120 dialyses. 4 patients were diabetic and 2 had liver failure. Patients were dialyzed alternating acetate and bicarbonate dialysa...

journal_title：American journal of nephrology

authors： Borges HF,Fryd DS,Rosa AA,Kjellstrand CM

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:The identification of nephrin and CD2AP, podocyte proteins which modulate the properties of glomerular barrier selectivity, has made it possible to unravel the mechanisms undergoing foot process effacement and proteinuria. Here we explored the role of nephrin and CD2AP together with the integrity of the slit...

journal_title：American journal of nephrology

authors： Gagliardini E,Benigni A,Tomasoni S,Abbate M,Kalluri R,Remuzzi G

更新日期：2003-07-01 00:00:00

abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...

journal_title：American journal of nephrology

authors： Wesson DE,Foley R,Sabatini S,Wharton J,Kapusnik J,Kurtzman NA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce. METHODS:We used data from a multicenter, prospective, randomized trial among 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) and its observational follow-up study. The associatio...

journal_title：American journal of nephrology

authors： Triebswetter S,Gutjahr-Lengsfeld LJ,Schmidt KR,Drechsler C,Wanner C,Krane V

更新日期：2018-01-01 00:00:00

abstract：:To elucidate the prevalence and clinical implications of antineutrophil cytoplasmic antibody (ANCA) in lupus nephritis (LN), we examined ANCA by indirect immunofluorescence and by ELISA against antilactoferrin (anti-LF) and antimyeloperoxidase (anti-MPO) antibody. To discriminate perinuclear ANCA (pANCA) with antinucl...

journal_title：American journal of nephrology

authors： Chin HJ,Ahn C,Lim CS,Chung HK,Lee JG,Song YW,Lee HS,Han JS,Kim S,Lee JS

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:To determine the association of vancomycin with acute kidney injury (AKI) in relation to its serum concentration value and to examine the risk of AKI in patients treated with vancomycin when compared with a matched cohort of patients receiving non-glycopeptide antibiotics (linezolid/daptomycin). METHODS:Fro...

journal_title：American journal of nephrology

authors： Gyamlani G,Potukuchi PK,Thomas F,Akbilgic O,Soohoo M,Streja E,Naseer A,Sumida K,Molnar MZ,Kalantar-Zadeh K,Kovesdy CP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Although there is a very high mortality rate (>50%) with acute renal failure (ARF) in the intensive care unit (ICU), there is no general consensus on the best dialysis treatment for this condition. METHODS:We surveyed by mail questionnaire, all adult academic and community registered Canadian nephrology cen...

journal_title：American journal of nephrology

authors： Hyman A,Mendelssohn DC

更新日期：2002-01-01 00:00:00

abstract：:The purpose of our study was to investigate the feasibility of using lactate as a complete or partial substitute for acetate in hemodialysis solutions. Six patients, each serving as his own control, were dialyzed once against a dialysis solution containing 40 mM acetate, once against a dialysis solution containing 40 ...

journal_title：American journal of nephrology

authors： Nawab ZM,Armstrong MK,Weissberger LE,Ing TS,Hayashi JA,Daugirdas JT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) occurs frequently in the intensive care unit. A primary cause is renal ischemia/reperfusion (I/R) injury, during which excess reactive oxygen species (ROS) are produced. ROS subsequently damage renal cells, leading to the development of AKI. Here, we investigated whether renal I/R i...

journal_title：American journal of nephrology

authors： Yamamoto S,Hagiwara S,Hidaka S,Shingu C,Goto K,Kashima K,Noguchi T

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:Although it is anticipated that most patients with renal insufficiency will progress towards end-stage renal disease (ESRD) there have been few population-based studies to validate this assumption. We examined serial creatinines from 3,874 anonymous patients at an urban VA medical center who had a baseline c...

journal_title：American journal of nephrology

authors： Fink JC,Salmanullah M,Blahut SA,Weir MR,Sawyer R,Henrich WL,Hise MK

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as ...

journal_title：American journal of nephrology

authors： Tsuji S,Suruda C,Hashiyada M,Kimata T,Yamanouchi S,Kitao T,Kino J,Akane A,Kaneko K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:A poor nutritional state is associated with an increased risk of cardiovascular events in end-stage renal disease. It is unclear whether malnutrition itself can induce cardiovascular disease (CVD). We examined the impact of nutritional status on patients' arterial stiffness in peritoneal dialysis (PD) patien...

journal_title：American journal of nephrology

authors： Tang W,Cheng LT,Lu XH,Wang T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and tr...

journal_title：American journal of nephrology

authors： Udomkarnjananun S,Townamchai N,Chariyavilaskul P,Iampenkhae K,Pongpirul K,Sirichindakul B,Panumatrassamee K,Vanichanan J,Avihingsanon Y,Eiam-Ong S,Praditpornsilpa K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:The mesothelium of patients undergoing peritoneal dialysis (PD) is exposed to glucose in dialysate. Glucose metabolites 3-deoxyglucosone and advanced glycation endproducts (AGEs) in the PD fluid induce peritoneal damage. Circulating factors also affect the peritoneum in the uremic model and predialysis ...

journal_title：American journal of nephrology

authors： Hasuike Y,Moriguchi R,Hata R,Miyagawa K,Kuragano T,Aizawa M,Yamamoto S,Yanase K,Izumi M,Tanimoto T,Nakanishi T

更新日期：2007-01-01 00:00:00

abstract：:A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed, and prev...

journal_title：American journal of nephrology

authors： Rabetoy GM,Price CA,Findlay JW,Sailstad JM

更新日期：1990-01-01 00:00:00

abstract：:Most pretransplant malignancies require a tumor-free waiting period before transplantation. End-stage renal disease (ESRD) patients have an increased risk of renal cell carcinoma (RCC), which is mostly detected from routine screening during pre-kidney transplant evaluation. RCC must be quiescent prior to kidney transp...

journal_title：American journal of nephrology

authors： Tantisattamo E,Elam A,Cobb J,Ellis CL,Bailey JL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this...

journal_title：American journal of nephrology

authors： Lee T,Thamer M,Zhang Q,Zhang Y,Allon M

更新日期：2016-01-01 00:00:00

abstract：:Bacterial endocarditis, particularly involving the left side, has been shown to occur in patients in regular hemodialysis. We report a case of right-sided endocarditis characterized by a very torpid evolution. Although the diagnosis was suspected early in the course, confirmation was obtained 2 months after the onset....

journal_title：American journal of nephrology

authors： Ferrer C,Jakob E,Pastorino G,Juncos LI

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Henoch-Schönlein purpura (HSP) is a form of systemic vasculitis that can progress to Henoch-Schönlein purpura nephritis (HSPN), and the most effective treatment remains controversial. Our aim was to compare the effects of oral mycophenolate mofetil (MMF) with low-dose prednisone and the full-dose corticoster...

journal_title：American journal of nephrology

authors： Ren P,Han F,Chen L,Xu Y,Wang Y,Chen J

更新日期：2012-01-01 00:00:00

abstract：:Radioisotopic methods for the determination of the glomerular filtration rate (GFR) are highly accurate but require the collection of multiple blood and urine samples and are costly to perform due to personnel, material, and analysis costs. Nonradioactive methods of GFR determination have the potential of minimizing p...

journal_title：American journal of nephrology

authors： Rocco MV,Buckalew VM Jr,Moore LC,Shihabi ZK

更新日期：1996-01-01 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism. In this study, we examined whether measurement of hepcidin is useful in assessing recombinant human erythropoietin (rHuEPO) responsiveness in regular hemodialysis (HD) patients in a cross-sectional fashion. We examined the association between serum prohepcidin, a prohorm...

journal_title：American journal of nephrology

authors： Kato A,Tsuji T,Luo J,Sakao Y,Yasuda H,Hishida A

更新日期：2008-01-01 00:00:00

abstract：:This study was carried out to find out whether Ramadan fasting would affect the renal function in kidney transplant recipients with normal or impaired graft function. Twenty-three transplant recipients, 17 with a normal function and 6 with an impaired but stable function with plasma creatinine levels not exceeding 300...

journal_title：American journal of nephrology

authors： Abdalla AH,Shaheen FA,Rassoul Z,Owda AK,Popovich WF,Mousa DH,al-Hawas F,al-Sulaiman MH,al-Khader AA

更新日期：1998-01-01 00:00:00

abstract：:The platelet content of adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin and ouabain-insensitive, magnesium-dependent adenosine triphosphatase (ATPase) was determined in patients with chronic renal failure, patients on chronic hemodialysis, and kidney transplant recipients. Platelet ATP content was...

journal_title：American journal of nephrology

authors： Eknoyan G,Brown CH 3rd

更新日期：1981-01-01 00:00:00