Abstract：
BACKGROUND:Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening. METHODS:The Heart and Soul Study is a longitudinal study of patients with stable coronary heart disease. Measures of baseline kidney function included: serum creatinine, creatinine-derived estimated glomerular filtration rate (eGFR(CKD-EPI)), 24-hour urine measured creatinine clearance, cystatin C, cystatin C-derived estimated glomerular filtration rate (eGFRcys) and urine albumin to creatinine ratio. Telomere length was measured from peripheral blood leukocytes at baseline (n = 954) and 5 years later (n = 608). Linear regression models were used to test the association of kidney function with (i) baseline telomere length and (ii) change in telomere length over 5 years. RESULTS:At baseline, mean eGFR(CKD-EPI) was 72.6 (±21.5) ml/min/1.73 m(2), eGFRcys was 71.0 (±23.1) ml/min/1.73 m(2) and ACR was 8.6 (±12.3) mg/g. Only lower baseline eGFR(CKD-EPI) was associated with shorter baseline telomere length (9.1 (95% CI 1.2-16.9) fewer base pairs for every 5 ml/min/1.73 m(2) lower eGFR(CKD-EPI)). Lower baseline eGFR(CKD-EPI) (and all other measures of kidney function) predicted more rapid telomere shortening (10.8 (95% CI 4.3-17.3) decrease in base pairs over 5 years for every 5 ml/min/1.73 m(2) lower eGFR(CKD-EPI)). After adjustment for age, these associations were no longer statistically significant. CONCLUSIONS:In patients with coronary heart disease, reduced kidney function is associated with (i) shorter baseline telomere length and (ii) more rapid telomere shortening over 5 years; however, these associations are entirely explained by older age.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Bansal N,Whooley MA,Regan M,McCulloch CE,Ix JH,Epel E,Blackburn E,Lin J,Hsu CYdoi
10.1159/000343495subject
Has Abstractpub_date
2012-01-01 00:00:00pages
405-11issue
5eissn
0250-8095issn
1421-9670pii
000343495journal_volume
36pub_type
杂志文章abstract：BACKGROUND:Serum phosphorus concentrations reflect a dynamic balance between generation, exchanges, and removal. Time-averaged phosphorus concentrations (TAC(phos)) reflect the overall exposure better than single time-point concentrations, especially in dialysis patients treated with an intermittent modality. The prese...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000336308
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND/AIMS:Current status of primary hyperoxaluria (PH) has not been surveyed in Japan. METHODS:Japanese patients with PH were reviewed in the published literature. RESULTS:Fifty-nine patients were diagnosed as PH from 1962 to 2003. The median ages both at diagnosis and at the onset of initial symptoms were 17 (...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000086361
更新日期：2005-05-01 00:00:00
abstract：:The purpose of our study was to investigate the feasibility of using lactate as a complete or partial substitute for acetate in hemodialysis solutions. Six patients, each serving as his own control, were dialyzed once against a dialysis solution containing 40 mM acetate, once against a dialysis solution containing 40 ...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000167515
更新日期：1987-01-01 00:00:00
abstract：:This study investigated the possible beneficial effect of intraperitoneal proteolytic enzyme administration on the development of hypertension-induced renal injury in the rat model of 2-kidney 1-clip (2K1C) Goldblatt hypertension. Male Wistar rats (120-150 g) underwent either sham surgery (control, n = 5) or clipping ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013411
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited. METH...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.1159/000494840
更新日期：2018-01-01 00:00:00
abstract：:Recent studies have focused attention on the possible role of zinc depletion in the pathogenesis of uremic symptoms such as dysgeusia and impotence. The present studies were undertaken to evaluate the prevalence of zinc deficiency and abnormalities of zinc metabolism in patients with end-stage renal disease. A total o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167247
更新日期：1986-01-01 00:00:00
abstract：:Two patients who developed bilateral renal cortical necrosis as a consequence of Neisseria meningitidis infections are described: 1 patient had meningococcemia and the other had meningococcal meningitis. Both patients developed a Shwartzman-like reaction, disseminated intravascular coagulation and irreversible renal f...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168348
更新日期：1991-01-01 00:00:00
abstract：:To evaluate the therapeutic effect of recombinant human alpha-interferon (alpha-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of proteinuria, the hepatitis B viral markers and urinary protein were monitored during alpha...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169083
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Hypercholesterolemia is one of the major manifestations of nephrotic syndrome. We have previously shown that nephrotic hypercholesterolemia is associated with and, in part, due to dysregulation of hepatic HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase (ACAT) and cholesterol 7alpha-hydroxylase, as we...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000082510
更新日期：2004-11-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000328386
更新日期：2011-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000381464
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Nephrology research is expanding, and harnessing the much-needed information and data for the practice of evidence-based medicine is becoming more challenging. In this study, we used the natural language processing and text mining approach to mitigate some of these challenges. METHODS:We analyzed 17,412 abs...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
abstract：:Fifty-four patients with noninsulin-dependent diabetes mellitus, who had established nephropathy, were examined to evaluate the risk factors for the progression of diabetic nephropathy. Time-averaged values of blood pressure, serum total cholesterol and fasting plasma glucose concentrations, and the degree of proteinu...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168891
更新日期：1995-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000256659
更新日期：2010-01-01 00:00:00
abstract：UNLABELLED:Although it is anticipated that most patients with renal insufficiency will progress towards end-stage renal disease (ESRD) there have been few population-based studies to validate this assumption. We examined serial creatinines from 3,874 anonymous patients at an urban VA medical center who had a baseline c...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000046280
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVES AND METHODS:Altered plasma high-sensitivity C-reactive protein (hs-CRP) and adiponectin (ADP) may contribute to increased vascular inflammation and accelerated atherosclerosis in patients with end-stage renal disease (ESRD) and co-morbid diabetes. Common carotid artery intima-media thickness (CCA-IMT) and at...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000094403
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) impairs intestinal barrier function which by allowing influx of noxious products causes systemic inflammation. We have recently shown that intestinal barrier dysfunction in CKD is due to degradation of epithelial tight junction (TJ) which is, in part, mediated by influx of urea a...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000351171
更新日期：2013-01-01 00:00:00
abstract：:The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatr...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168071
更新日期：1990-01-01 00:00:00
abstract：:Pasteurella multocida has been reported only once previously as a cause of peritonitis in a patient undergoing chronic peritoneal dialysis. The present report describes findings associated with a case of P. multocida peritonitis in a human immunodeficiency virus (HIV)-positive patient in which renal replacement therap...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168274
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND/AIMS:Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare renal tubular disorder complicated by progressive renal failure during childhood or adolescence. Recently, causative mutations in the CLDN19 gene have been identified in FHHNC patients presenting with severe ocular involv...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000330854
更新日期：2011-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000092280
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000080464
更新日期：2004-07-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167949
更新日期：1989-01-01 00:00:00
abstract：:Investigations of biopsy material from human kidneys with different forms of glomerulonephritis (n = 1,240) and with diabetic glomerulosclerosis (n = 406) performed in order to find changes caused by hyperperfusion of the kidney tissue gave the following results: (1) Hyperperfusion injury occurs in the different forms...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167579
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Oxidative stress and inflammation are known to play central roles in the development of diabetic nephropathy (DN). Febuxostat is a novel non-purine xanthine oxidase (XO)-specific inhibitor developed to treat hyperuricemia. In this study, we investigated whether febuxostat could ameliorate DN via renoprotecti...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000363421
更新日期：2014-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000337151
更新日期：2012-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000111826
更新日期：2008-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000368563
更新日期：2014-01-01 00:00:00
abstract：:Extraskeletal tumoral calcinosis occur in uremic patients with high calcium phosphorus (Ca x P) product and progressive secondary hyperparathyroidism. However, cases are also described in which this association cannot be confirmed. The influence of aluminum, vitamins D and K, alkalosis, magnesium and local lesions is ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000169078
更新日期：1997-01-01 00:00:00
abstract：:During the period from April 4, 1988, to April 20, 1988, nine pyrogenic reactions and five gram-negative bacteremias occurred in 11 patients undergoing dialysis. All pyrogenic reactions and gram-negative bacteremias occurred among patients in whom a reprocessed dialyzer was used. The rate of pyrogenic reactions or bac...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168155
更新日期：1990-01-01 00:00:00
