TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy.

abstract：BACKGROUND:There is continued and significant debate regarding the salient etiologies associated with graft loss and racial disparities in kidney transplant recipients. METHODS:This was a longitudinal cohort study of all adult kidney transplant recipients, comparing patients with early graft loss (<5 years) to those w...

journal_title：American journal of nephrology

authors： Taber DJ,Douglass K,Srinivas T,McGillicuddy JW,Bratton CF,Chavin KD,Baliga PK,Egede LE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Upregulation of transforming growth factor beta (TGF-beta)/Smad signaling has been implicated in the primary pathogenesis of renal fibrosis. The ubiquitin-proteasome pathway has an important influence on TGF-beta signaling through regulating Smad degradation. As E3 ubiquitin ligases, both Arkadia and Sm...

journal_title：American journal of nephrology

authors： Liu FY,Li XZ,Peng YM,Liu H,Liu YH

更新日期：2007-01-01 00:00:00

abstract：:Clinical and pathologic findings are described in 14 patients whose main abnormality was an excessively thin glomerular basement membrane (GBM). The subjects were aged 11-51 years, the majority males: most were referred because of hematuria, but proteinuria was the main problem in 2, while hypertension or renal functi...

journal_title：American journal of nephrology

authors： Dische FE,Weston MJ,Parsons V

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...

journal_title：American journal of nephrology

authors： Payan Schober F,Jobson MA,Poulton CJ,Singh HK,Nickeleit V,Falk RJ,Jennette JC,Nachman PH,Pendergraft Iii WF

更新日期：2017-01-01 00:00:00

abstract：:The substitution of recombinant human erythropoietin (rhEPO) in chronic hemodialysis patients is often associated with the development of severe hypertension. In the present study, a systematical echocardiographic analysis was performed in 25 patients on maintenance hemodialysis during rhEPO therapy for at least 4 mon...

journal_title：American journal of nephrology

authors： Löw-Friedrich I,Grützmacher P,März W,Bergmann M,Schoeppe W

更新日期：1991-01-01 00:00:00

abstract：:A renal transplant recipient with a remote history of end-stage renal disease due to postpartum hemolytic-uremic syndrome (HUS) presented with acute renal failure after having stable renal allograft function for 9 years. A diagnosis of thrombotic microangiopathy was made based on clinical and histologic findings at re...

journal_title：American journal of nephrology

authors： Gohh RY,Williams ME,Crosson AW,Federman M,Zambetti FX

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Most studies evaluating predictors of renal replacement therapy (RRT) following cardiac surgery use arbitrary defined limits of preoperative serum creatinine. The aim of this study was to evaluate the effect of preoperative renal function using either estimated-glomerular filtration rate (eGFR) derived using...

journal_title：American journal of nephrology

authors： Drosos G,Ampatzidou F,Sarafidis P,Karaiskos T,Madesis A,Boutou AK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Pseudotumors of the craniovertebral junction (PTCVJ) are observed in long-term hemodialysis (HD) patients. There are neither criteria for diagnosis nor guidelines for screening. We attempted to determine magnetic resonance imaging (MRI) findings that could be used to detect PTCVJ, to determine the preva...

journal_title：American journal of nephrology

authors： Maruyama H,Tanizawa T,Uchiyama S,Higuchi T,Ei K,Oda M,Ei I,Oya M,Kishimoto H,Saito T,Miyamura S,Takano Y,Hasegawa S,Kawada K,Ueki K,Iwafuchi Y,Arakawa M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that L-type Ca2+ channel (LCC) blockers prevent the afferent arteriolar (AA) vasoconstriction elicited by angiotensin II (Ang II), but do not influence its vasoconstrictor effect on efferent arterioles (EA). The present study tested the hypothesis that Ang II-mediated constri...

journal_title：American journal of nephrology

authors： Feng MG,Navar LG

更新日期：2004-11-01 00:00:00

abstract：:Heavy proteinuria in patients with essential hypertension raises the question of underlying primary renal disease. While malignant hypertension may be associated with proteinuria in the nephrotic range, it is generally held that protein excretion in benign nephrosclerosis is almost invariably less than 0.5-1.0 g/24 h....

journal_title：American journal of nephrology

authors： Mujais SK,Emmanouel DS,Kasinath BS,Spargo BH

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) impairs intestinal barrier function which by allowing influx of noxious products causes systemic inflammation. We have recently shown that intestinal barrier dysfunction in CKD is due to degradation of epithelial tight junction (TJ) which is, in part, mediated by influx of urea a...

journal_title：American journal of nephrology

authors： Vaziri ND,Yuan J,Khazaeli M,Masuda Y,Ichii H,Liu S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this...

journal_title：American journal of nephrology

authors： Lee T,Thamer M,Zhang Q,Zhang Y,Allon M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these v...

journal_title：American journal of nephrology

authors： Aprile DC,Oneda B,Gusmão JL,Costa LA,Forjaz CL,Mion D Jr,Tinucci T

更新日期：2016-01-01 00:00:00

abstract：:To elucidate the relationship between the renal regulation of sodium and calcium excretion at extremes of sodium intake, we studied 6 normal men ingesting a fixed, 400 mg/day calcium intake and four levels of sodium intake from 10 to 1,500 mEq/day. Serum ionized calcium was not influenced by sodium intake. Blood press...

journal_title：American journal of nephrology

authors： McCarron DA,Rankin LI,Bennett WM,Krutzik S,McClung MR,Luft FC

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:The value of chronic kidney disease (CKD) screening in the general population remains unclear but may be beneficial in populations with high disease prevalence. We examined risk factors for albuminuria among participants in a state-wide CKD screening program in Hawaii. METHODS:The National Kidney Foundation...

journal_title：American journal of nephrology

authors： Wong LL,Kalantar-Zadeh K,Page V,Hayashida G,You AS,Rhee CM

更新日期：2017-01-01 00:00:00

abstract：:Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, with just two previous descriptions of 4 cases in the literature. We describe a 5th case. The reaction may be mediated by the presence of antibodies reactive against platelets in the presence of quinine. Treatment has included use o...

journal_title：American journal of nephrology

authors： Hagley MT,Hosney IA,Hulisz DT,Davis HH

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Published reports examining the efficacy and safety of glucocorticoids for preserving renal function in immunoglobulin A nephropathy (IgAN) have yielded conflicting results. To systematically evaluate the efficacy and safety of glucocorticoids agents for IgAN, we conducted a meta-analysis of the published ra...

journal_title：American journal of nephrology

authors： Cheng J,Zhang X,Zhang W,He Q,Tao X,Chen J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model o...

journal_title：American journal of nephrology

authors： Raphael KL,Strait KA,Stricklett PK,Baird BC,Piontek K,Germino GG,Kohan DE

更新日期：2009-01-01 00:00:00

abstract：:The glomerular ultrastructure was retrospectively reviewed from 45 renal transplant biopsies with the clinical and light microscopic diagnosis of acute rejection (25 cases) and chronic rejection (20 cases). Three grades of morphologic alteration were ultrastructurally defined. In acute rejection, capillary lumenal obl...

journal_title：American journal of nephrology

authors： Verani RR,Bergman D,Kerman RH

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal (GI) symptoms in renal transplant recipients may be caused due to mycophenolic acid (MPA) toxicity. Using small bowel capsule endoscopy (SBCE) we examined the impact of conversion from Mycophenolate Mofetil (MMF) to enteric-coated formulation of Mycophenolate Sodium (EC-MPS) given to tr...

journal_title：American journal of nephrology

authors： Bunnapradist S,Sampaio MS,Wilkinson AH,Pham PT,Huang E,Kuo HT,Anastasi B,Danovitch GM,Lo SK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Hyperoxaluria may result from increased endogenous production or overabsorption of dietary oxalate in the gastrointestinal tract leading to nephrolithiasis and, in some, to oxalate nephropathy and chronic kidney disease. ALLN-177 is an oral formulation of a recombinant, oxalate specific, microbial enzyme oxa...

journal_title：American journal of nephrology

authors： Langman CB,Grujic D,Pease RM,Easter L,Nezzer J,Margolin A,Brettman L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Current status of primary hyperoxaluria (PH) has not been surveyed in Japan. METHODS:Japanese patients with PH were reviewed in the published literature. RESULTS:Fifty-nine patients were diagnosed as PH from 1962 to 2003. The median ages both at diagnosis and at the onset of initial symptoms were 17 (...

journal_title：American journal of nephrology

authors： Takayama T,Nagata M,Ichiyama A,Ozono S

更新日期：2005-05-01 00:00:00

abstract：:Thirty-one renal transplant recipients, submitted to treatment with cyclosporin in association with other immunosuppressive agents, were also treated for 9 months with two hydroxymethylglutaryl coenzyme A reductase inhibitors, simvastatin (10 mg/day) or pravastatin (20 mg/day), for concomitant hypercholesterolemia and...

journal_title：American journal of nephrology

authors： Capone D,Stanziale P,Gentile A,Imperatore P,Pellegrino T,Basile V

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Evidence using real-world data is sparse regarding the effects of oral anticoagulants (OACs) among patients with kidney disease. The aim of this study was to investigate the effects of kidney disease on ischemic stroke (IS) or systemic embolism (SE) among patients taking OAC, using large-scale real-world d...

journal_title：American journal of nephrology

authors： Maeda T,Nishi T,Funakoshi S,Tada K,Tsuji M,Satoh A,Kawazoe M,Yoshimura C,Arima H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Medullary sponge kidney (MSK) is characterized by malformation of the terminal collecting ducts and is associated with an increased risk of nephrolithiasis, nephrocalcinosis, urinary tract infections, renal acidification defects, and reduced bone density. It has been historically diagnosed with intravenous p...

journal_title：American journal of nephrology

authors： Koraishy FM,Ngo TT,Israel GM,Dahl NK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Ischemia/reperfusion (I/R) injury is characterized by cytoskeletal reorganization and loss of polarity in proximal tubule epithelial cells. Previously, we showed that myofibrillogenesis regulator (MR)-1 promoted actin organization in cardiomyocytes. MR-1 is also expressed in the kidney. METHODS:In this...

journal_title：American journal of nephrology

authors： Wang X,Tao T,Ding R,Song D,Liu M,Xie Y,Liu X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In autosomal dominant polycystic kidney disease, renoprotective treatment with a vasopressin V2 receptor antagonist (V2RA) is given in a fixed dose (FD). Disease progression and drug habituation could diminish treatment efficacy. We investigated whether the renoprotective effect of the V2RA can be improved b...

journal_title：American journal of nephrology

authors： Zittema D,Versteeg IB,Gansevoort RT,van Goor H,de Heer E,Veraar KA,Peters DJ,Meijer E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hemodialysis treatment requires a well-functioning vascular access. Access patency is limited by the development of venous intimal hyperplasia, which predisposes to fistula stenosis and subsequent thrombosis. In animal models, the renin-angiotensin system has a major role in the development of intimal h...

journal_title：American journal of nephrology

authors： Heine GH,Ulrich C,Köhler H,Girndt M

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiate...

journal_title：American journal of nephrology

authors： Nee R,Moon DS,Jindal RM,Hurst FP,Yuan CM,Agodoa LY,Abbott KC

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Almost 20 million people in the US have chronic kidney disease (CKD). Cardiovascular disease and arterial wall abnormalities are common in this population. Because angiotensin II may have adverse effects on the arterial wall, we hypothesized that an angiotensin receptor blocker (ARB) would improve arterial c...

journal_title：American journal of nephrology

authors： Garg JP,Ellis R,Elliott WJ,Hasabou N,Chua D,Chertow GM,Bakris GL

更新日期：2005-07-01 00:00:00