Effect of pioglitazone on survival and renal function in a mouse model of polycystic kidney disease.

abstract：BACKGROUND/AIMS:Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A(1) receptors (A1Rs). We studied the effect of the orally active, A1R antagonist tonapofylline (BG9928) on biochemical measures of re...

journal_title：American journal of nephrology

authors： Gill A,Wortham K,Costa D,Davis W,Ticho B,Whalley E

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Tacrolimus has been reported to be effective in refractory nephrotic syndrome, such as focal segmental glomerulosclerosis and membranous nephropathy. Some IgA nephropathy (IgAN) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy...

journal_title：American journal of nephrology

authors： Zhang Q,Shi SF,Zhu L,Lv JC,Liu LJ,Chen YQ,Zhang H,Wang HY

更新日期：2012-01-01 00:00:00

abstract：:In 1828, Friedrich Wöhler, a German physician and chemist by training, published a paper that describes the formation of urea, known since 1773 to be a major component of mammalian urine, by combining cyanic acid and ammonium in vitro. In these experiments the synthesis of an organic compound from two inorganic molecu...

journal_title：American journal of nephrology

authors： Kinne-Saffran E,Kinne RK

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...

journal_title：American journal of nephrology

authors： Li X,Chen J,Cheng D,Wang W,Xie K,Zhang M,Xu F,Wen J,Tang Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Inflammation and increased erythropoiesis stimulating agents (ESA) requirement are frequently associated in patients on dialysis. On-line hemodiafiltration (ol-HDF), putting together high levels of diffusion, and convection could improve both conditions. However, it is still not known which depurative compon...

journal_title：American journal of nephrology

authors： Movilli E,Camerini C,Gaggia P,Zubani R,Feller P,Salviani C,Facchini A,Cancarini G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Increased mortality and morbidity are reported in association with high ultrafiltration rate (UFR) and with long dialysis recovery time (DRT). We studied the association between UFR and DRT. METHODS:This is a cross-sectional, observational study was conducted. Patients on thrice-weekly hemodialysis (HD) wit...

journal_title：American journal of nephrology

authors： Hussein WF,Arramreddy R,Sun SJ,Reiterman M,Schiller B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:The shortage in organ supply has required the use of expanded criteria donors (ECD) for kidney transplantation. Current pre-transplant evaluations of ECD organs are based on histological, clinical or mixed criteria. This monocentric study investigates the predictivity of Karpinski's histological score o...

journal_title：American journal of nephrology

authors： La Manna G,Comai G,Cappuccilli ML,Liviano D'Arcangelo G,Fabbrizio B,Valentini C,Carretta E,Ravaioli M,Scolari MP,Ridolfi L,Feliciangeli G,Grigioni FW,Pinna AD,Stefoni S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...

journal_title：American journal of nephrology

authors： El-Agroudy AE,Bakr MA,Shehab El-Dein AB,Ghoneim MA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...

journal_title：American journal of nephrology

authors： Jia L,Li X,Gu Y,Cui W

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Most studies evaluating predictors of renal replacement therapy (RRT) following cardiac surgery use arbitrary defined limits of preoperative serum creatinine. The aim of this study was to evaluate the effect of preoperative renal function using either estimated-glomerular filtration rate (eGFR) derived using...

journal_title：American journal of nephrology

authors： Drosos G,Ampatzidou F,Sarafidis P,Karaiskos T,Madesis A,Boutou AK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:A recent study suggests that inflammation and malnutrition are strongly associated with cardiovascular disease in dialysis patients. Endothelial lipase (EL) is a newly cloned physiological regulator of high-density lipoprotein cholesterol (HDL), which is associated with the progression of atherosclerosi...

journal_title：American journal of nephrology

authors： Fujii H,Fukuda A,Tanaka M,Kojima Y,Ishida T,Hirata K,Fukagawa M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:While chronic dialysis treatment has been suggested to increase pulmonary pressure values, right ventricular dysfunction (RVD) is a major cause of death in patients with end-stage renal disease. We investigated the impact of different dialysis treatments on right ventricular function. METHODS:We examined 22...

journal_title：American journal of nephrology

authors： Paneni F,Gregori M,Ciavarella GM,Sciarretta S,De Biase L,Marino L,Tocci G,Principe F,Domenici A,Luciani R,Punzo G,Menè P,Volpe M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate a nomogram for predicting DN in T2D patients with kidney disease. METHODS:A total of 302 consecutive patients with T2D wh...

journal_title：American journal of nephrology

authors： Jiang S,Fang J,Yu T,Liu L,Zou G,Gao H,Zhuo L,Li W

更新日期：2020-01-01 00:00:00

abstract：AIMS:This study investigated the protective effect of the angiotensin-converting enzyme inhibitor, enalapril, and the vitamin D analog, paricalcitol, alone or in combination, on cardiac oxidative stress in uremic rats. METHODS:Rats were made uremic by 5/6 nephrectomy and treated for 4 months as follows: (1) uremic + v...

journal_title：American journal of nephrology

authors： Husain K,Ferder L,Mizobuchi M,Finch J,Slatopolsky E

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein A1 (APOL1) gene variants occurring in people of West African descent contribute to the greater burden of kidney disease among African Americans. These variants are associated with increased risk of nondiabetic nephropathy, more rapid progression of chronic kidney disease, and shorter survival ...

journal_title：American journal of nephrology

authors： Young BA,Blacksher E,Cavanaugh KL,Freedman BI,Fullerton SM,Kopp JB,Umeukeje EM,West KM,Wilson JG,Burke W,APOL1 Stakeholders Project.

更新日期：2019-01-01 00:00:00

abstract：:Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this persp...

journal_title：American journal of nephrology

authors： Camer D,Huang XF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a prevalent condition; however, little is known about healthcare resource utilization (HRU) by CKD patients. METHODS:This analysis included NHANES participants aged > or =18 years, with serum creatinine, urine protein, and hemoglobin measurements. We assessed the association ...

journal_title：American journal of nephrology

authors： Alexander M,Bradbury BD,Kewalramani R,Barlev A,Mohanty SA,Globe D

更新日期：2009-01-01 00:00:00

abstract：:A patient with advanced chronic renal failure secondary to polycystic kidney disease suffered an episode of volume contraction during which his urinary sodium concentration fell to less than 5 mEq daily. Urine sodium excretion remained at this level when later in his course he became clinically volume expanded. The pa...

journal_title：American journal of nephrology

authors： Danovitch GM,Jacobson E,Licht A

更新日期：1981-01-01 00:00:00

abstract：:The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatr...

journal_title：American journal of nephrology

authors： Oh MS,Choi KC,Uribarri J,Sher J,Rao C,Carroll HJ

更新日期：1990-01-01 00:00:00

abstract：:Accelerated atherosclerosis is both a cause and a consequence of chronic renal failure. Vascular smooth muscle cells (VSMCs) are an important component of atherosclerotic plaques, responsible for promoting plaque stability in advanced lesions. In contrast, VSMC apoptosis has been implicated in a number of deleterious ...

journal_title：American journal of nephrology

authors： Clarke M,Bennett M

更新日期：2006-01-01 00:00:00

abstract：:The current study focused on the effect of continuous ambulatory peritoneal dialysis (CAPD) dialysate obtained following different intraperitoneal dwell periods on the release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) from mononuclear leukocytes (PBMC). Aliquots of 5 x 10(6)/ml healthy periph...

journal_title：American journal of nephrology

authors： Jörres A,Topley N,Steenweg L,Müller C,Köttgen E,Gahl GM

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Predicting the mortality risk of patients un-dergoing hemodialysis (HD) is challenging. Cell-free DNA (cfDNA) is released into circulation from dying cells, and its elevation is predictive of unfavorable outcome. In a pilot study, we found post-HD cfDNA level to be a predictor of all-cause mortality. Thus, t...

journal_title：American journal of nephrology

authors： Einbinder Y,Shnaider A,Ghanayem K,Basok A,Rogachev B,Lior Y,Haviv YS,Cohen-Hagai K,Nacasch N,Rozenberg I,Benchetrit S,Zitman-Gal T,Douvdevani A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Overt albuminuria (urinary albumin-creatinine ratio [ACR] > 300 mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether a reduction in ACR translates into a reduction in mortality and/or cardiovascular (CV) events among insulin-treated patients with type 2 dia...

journal_title：American journal of nephrology

authors： Anyanwagu U,Donnelly R,Idris I

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Ischemia/reperfusion (I/R) injury is characterized by cytoskeletal reorganization and loss of polarity in proximal tubule epithelial cells. Previously, we showed that myofibrillogenesis regulator (MR)-1 promoted actin organization in cardiomyocytes. MR-1 is also expressed in the kidney. METHODS:In this...

journal_title：American journal of nephrology

authors： Wang X,Tao T,Ding R,Song D,Liu M,Xie Y,Liu X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, and a strong correlation between MIS and morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there is no cut-off value of MIS to ca...

journal_title：American journal of nephrology

authors： Ho LC,Wang HH,Peng YS,Chiang CK,Huang JW,Hung KY,Hu FC,Wu KD

更新日期：2008-01-01 00:00:00

abstract：AIMS:This study was conducted prospectively to ascertain the prevalence of anticardiolipin antibodies (ACAs) in patients with lupus nephritis and to determine whether this subgroup of patients differed clinically and histologically from patients without the antibody. PATIENTS AND METHODS:40 SLE patients (26 Blacks, 14...

journal_title：American journal of nephrology

authors： Naiker IP,Rughubar KN,Duursma J,Pudifin DJ,Seedat YK

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Chronic metabolic acidosis is a common metabolic disturbance and its clinical impact can be severe and extensive. The role and the change of the intrarenal renin-angiotensin system (RAS) during metabolic acidosis are uncertain, and whether acidosis can evoke inflammation remains unclear. METHODS:Male Spragu...

journal_title：American journal of nephrology

authors： Ng HY,Chen HC,Tsai YC,Yang YK,Lee CT

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS:We utilized a nationally representative database, the Nationwi...

journal_title：American journal of nephrology

authors： Chan L,Saha A,Poojary P,Chauhan K,Naik N,Coca S,Garimella PS,Nadkarni GN

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In the US, native kidney biopsies are usually inpatient procedures. We developed an outpatient biopsy protocol for low-risk patients and assessed its safety and efficacy. METHODS:Patients with an SBP <140 mm Hg and a BMI ≤35 who were not taking anticoagulants, ASA and NSAIDS in the preceding week were inclu...

journal_title：American journal of nephrology

authors： McMahon GM,McGovern ME,Bijol V,Benson CB,Foley R,Munkley K,Schnipper J,Franz C,Lin J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. METHODS:This...

journal_title：American journal of nephrology

authors： Lewis JR,Lim WH,Zhu K,Wong G,Dhaliwal SS,Lim EM,Ueland T,Bollerslev J,Prince RL

更新日期：2014-01-01 00:00:00